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The map label for this gene is acdA [H]

Identifier: 108757986

GI number: 108757986

Start: 4478003

End: 4479148

Strand: Direct

Name: acdA [H]

Synonym: MXAN_3760

Alternate gene names: 108757986

Gene position: 4478003-4479148 (Clockwise)

Preceding gene: 108758347

Following gene: 108757250

Centisome position: 48.99

GC content: 67.36

Gene sequence:

>1146_bases
ATGGATTTTGACCTTCCAGAAAGCCATCGCGCCCTCCAGTCCTCCATCCGTGACTTCTGCGAACGGCGGGTGAAGCCGTA
TGCCCGTGAGTGGGACAAGGACGAGACGTTCCCCATGGAAGTTGTCCGGGAGCTGGGGCAGCTCGGGGTGATGGGCATGC
TCGTCGCCGAGGAGTTCGGCGGAGCGGCCATGGACTCGCTCGCCGTGGCGGTGGCGGTGGAAGAGATCGCCCGCTACGAC
GGCTCGCTGGCGCTGACGGTGGCCAGCCACAACGGCCTGGGCACCAGCCACCTGCGCGTCTTCGGTTCGGACGCGCAGCG
CCAGAAGTACCTGCCCAAGCTGGCCACGGGTGAGTACCTGGGCGCATGGGGCCTGACGGAGCCGGGGTCCGGCTCGGACG
CGTCGAGCATGAAGACCACGGCCATGCGCAAGGGCGACGGCTGGGTACTCAACGGCGCCAAGATGTTCATCACCCAGGGC
ACGGTGGGTGACGTGTTCGTGGTGCTGGCCGTCACCTCGCCGCAGAAGCGGCAGAAGGGCATCACCGCCTTCCTGCTGGA
GAAGGGCCTGCCGGGCTTCAGCCAGCGCGCCATCCACGGGAAGCTGGGCATGCGCTCGTCGGACACGGCCGAGCTCGTCC
TGGAGAACGTGGAGGTGCCGGACTCGGCGCGCGTGGGTGAGCTGGACCACGGCTTCATCGACACGATGAAGATCCTGGAC
CGCGGCCGCATCACCATCGGCGCGCTGGCGGTGGGTCTGGGCCGGGGCGCCCTGGAGGAGTCCATTGGCTACTCGCGCGA
GCGCACCGCGTTCGGCCAGCCCATCAGCGAGTTCCAGGGACTGCGCTGGATGATGGCGGACATGAAGACGGAGCTGGACG
CCGCCCGGCTCCTGGTCCACCGCGCTGCCAAGCTGGCCGACGAAGGCAAGCCGTACTCGCGCGAGGCCTCCATGGGGAAG
CTGTTCGCCTCCGAGGCCGCCATGCGGGCTTGCAACAAGGCCGTGCAGATCCACGGTGGGTACGGTTACACCCGCGAATT
CCCGGTCGAGCGCTACCTGCGCGACGCCAAGCTGTGTGAGATCGGCGAGGGAACCAGCGAGATCCAGCGTACAATCATCG
CCCGGGAAACCTTCAAAGGGGCTTGA

Upstream 100 bases:

>100_bases
AAAAGAAACACGGTGTCTATCCGGTTTGAGTAGGTAGCGTTACCCCACCTCCAAGGCCCGGGCTGCGCTTGGGCCGTCTG
CTATAGATCCTGCTGACACC

Downstream 100 bases:

>100_bases
TGGACACCGCGCGGCTGGAAGGTCTCGGGCTGCAGTTGCGGGAGGACGCGGCCGGCACCGAGGCGGTGCTGGACCTTGAG
TCGTCCCCGCTGGTCAATCC

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; SCAD [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MDFDLPESHRALQSSIRDFCERRVKPYAREWDKDETFPMEVVRELGQLGVMGMLVAEEFGGAAMDSLAVAVAVEEIARYD
GSLALTVASHNGLGTSHLRVFGSDAQRQKYLPKLATGEYLGAWGLTEPGSGSDASSMKTTAMRKGDGWVLNGAKMFITQG
TVGDVFVVLAVTSPQKRQKGITAFLLEKGLPGFSQRAIHGKLGMRSSDTAELVLENVEVPDSARVGELDHGFIDTMKILD
RGRITIGALAVGLGRGALEESIGYSRERTAFGQPISEFQGLRWMMADMKTELDAARLLVHRAAKLADEGKPYSREASMGK
LFASEAAMRACNKAVQIHGGYGYTREFPVERYLRDAKLCEIGEGTSEIQRTIIARETFKGA

Sequences:

>Translated_381_residues
MDFDLPESHRALQSSIRDFCERRVKPYAREWDKDETFPMEVVRELGQLGVMGMLVAEEFGGAAMDSLAVAVAVEEIARYD
GSLALTVASHNGLGTSHLRVFGSDAQRQKYLPKLATGEYLGAWGLTEPGSGSDASSMKTTAMRKGDGWVLNGAKMFITQG
TVGDVFVVLAVTSPQKRQKGITAFLLEKGLPGFSQRAIHGKLGMRSSDTAELVLENVEVPDSARVGELDHGFIDTMKILD
RGRITIGALAVGLGRGALEESIGYSRERTAFGQPISEFQGLRWMMADMKTELDAARLLVHRAAKLADEGKPYSREASMGK
LFASEAAMRACNKAVQIHGGYGYTREFPVERYLRDAKLCEIGEGTSEIQRTIIARETFKGA
>Mature_381_residues
MDFDLPESHRALQSSIRDFCERRVKPYAREWDKDETFPMEVVRELGQLGVMGMLVAEEFGGAAMDSLAVAVAVEEIARYD
GSLALTVASHNGLGTSHLRVFGSDAQRQKYLPKLATGEYLGAWGLTEPGSGSDASSMKTTAMRKGDGWVLNGAKMFITQG
TVGDVFVVLAVTSPQKRQKGITAFLLEKGLPGFSQRAIHGKLGMRSSDTAELVLENVEVPDSARVGELDHGFIDTMKILD
RGRITIGALAVGLGRGALEESIGYSRERTAFGQPISEFQGLRWMMADMKTELDAARLLVHRAAKLADEGKPYSREASMGK
LFASEAAMRACNKAVQIHGGYGYTREFPVERYLRDAKLCEIGEGTSEIQRTIIARETFKGA

Specific function: Unknown

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=371, Percent_Identity=43.3962264150943, Blast_Score=311, Evalue=6e-85,
Organism=Homo sapiens, GI4501859, Length=365, Percent_Identity=39.1780821917808, Blast_Score=283, Evalue=1e-76,
Organism=Homo sapiens, GI226958412, Length=377, Percent_Identity=40.053050397878, Blast_Score=279, Evalue=3e-75,
Organism=Homo sapiens, GI226958414, Length=338, Percent_Identity=41.1242603550296, Blast_Score=265, Evalue=6e-71,
Organism=Homo sapiens, GI7656849, Length=376, Percent_Identity=36.1702127659575, Blast_Score=254, Evalue=7e-68,
Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=35.5614973262032, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI4557231, Length=380, Percent_Identity=35.7894736842105, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI187960098, Length=380, Percent_Identity=35.7894736842105, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI21361497, Length=355, Percent_Identity=37.4647887323944, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI4557235, Length=374, Percent_Identity=34.4919786096257, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI76496475, Length=374, Percent_Identity=34.4919786096257, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI4503943, Length=366, Percent_Identity=31.6939890710383, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI7669494, Length=343, Percent_Identity=32.0699708454811, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI48976061, Length=393, Percent_Identity=24.4274809160305, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI211971008, Length=393, Percent_Identity=24.4274809160305, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI38505218, Length=287, Percent_Identity=22.9965156794425, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI87081958, Length=382, Percent_Identity=34.5549738219895, Blast_Score=198, Evalue=5e-52,
Organism=Escherichia coli, GI1786223, Length=380, Percent_Identity=27.8947368421053, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI87082384, Length=273, Percent_Identity=27.4725274725275, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87081702, Length=171, Percent_Identity=28.0701754385965, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=42.2163588390501, Blast_Score=296, Evalue=8e-81,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=39.8921832884097, Blast_Score=283, Evalue=9e-77,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=38.8140161725067, Blast_Score=273, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=36.1477572559367, Blast_Score=254, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=36.3874345549738, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17569725, Length=378, Percent_Identity=35.978835978836, Blast_Score=247, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI71990804, Length=308, Percent_Identity=40.5844155844156, Blast_Score=231, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI17533517, Length=360, Percent_Identity=33.3333333333333, Blast_Score=220, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI71985184, Length=351, Percent_Identity=35.042735042735, Blast_Score=219, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17505929, Length=374, Percent_Identity=32.8877005347594, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17551932, Length=379, Percent_Identity=32.1899736147757, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17534353, Length=373, Percent_Identity=29.7587131367292, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=33.5766423357664, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71985192, Length=298, Percent_Identity=33.2214765100671, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI32563615, Length=229, Percent_Identity=37.9912663755458, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=33.4728033472803, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17531913, Length=174, Percent_Identity=33.9080459770115, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17562446, Length=289, Percent_Identity=25.6055363321799, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI86563383, Length=315, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI86563381, Length=315, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=42.6666666666667, Blast_Score=316, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=41.3333333333333, Blast_Score=298, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24666513, Length=371, Percent_Identity=38.544474393531, Blast_Score=284, Evalue=7e-77,
Organism=Drosophila melanogaster, GI24660351, Length=383, Percent_Identity=36.8146214099217, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI21355753, Length=378, Percent_Identity=38.8888888888889, Blast_Score=250, Evalue=9e-67,
Organism=Drosophila melanogaster, GI281363737, Length=381, Percent_Identity=32.0209973753281, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI19920834, Length=379, Percent_Identity=27.7044854881267, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24652780, Length=363, Percent_Identity=24.7933884297521, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 41581; Mature: 41581

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFDLPESHRALQSSIRDFCERRVKPYAREWDKDETFPMEVVRELGQLGVMGMLVAEEFG
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GAAMDSLAVAVAVEEIARYDGSLALTVASHNGLGTSHLRVFGSDAQRQKYLPKLATGEYL
CHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCHHHHHHCCCCCCCCCC
GAWGLTEPGSGSDASSMKTTAMRKGDGWVLNGAKMFITQGTVGDVFVVLAVTSPQKRQKG
CCCCCCCCCCCCCHHHHHHHHEECCCCEEEECEEEEEECCCCCCEEEEEEECCCHHHHCC
ITAFLLEKGLPGFSQRAIHGKLGMRSSDTAELVLENVEVPDSARVGELDHGFIDTMKILD
HHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
RGRITIGALAVGLGRGALEESIGYSRERTAFGQPISEFQGLRWMMADMKTELDAARLLVH
CCCEEEHHHHHHHCCHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RAAKLADEGKPYSREASMGKLFASEAAMRACNKAVQIHGGYGYTREFPVERYLRDAKLCE
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHH
IGEGTSEIQRTIIARETFKGA
CCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDFDLPESHRALQSSIRDFCERRVKPYAREWDKDETFPMEVVRELGQLGVMGMLVAEEFG
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GAAMDSLAVAVAVEEIARYDGSLALTVASHNGLGTSHLRVFGSDAQRQKYLPKLATGEYL
CHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCHHHHHHCCCCCCCCCC
GAWGLTEPGSGSDASSMKTTAMRKGDGWVLNGAKMFITQGTVGDVFVVLAVTSPQKRQKG
CCCCCCCCCCCCCHHHHHHHHEECCCCEEEECEEEEEECCCCCCEEEEEEECCCHHHHCC
ITAFLLEKGLPGFSQRAIHGKLGMRSSDTAELVLENVEVPDSARVGELDHGFIDTMKILD
HHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
RGRITIGALAVGLGRGALEESIGYSRERTAFGQPISEFQGLRWMMADMKTELDAARLLVH
CCCEEEHHHHHHHCCHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RAAKLADEGKPYSREASMGKLFASEAAMRACNKAVQIHGGYGYTREFPVERYLRDAKLCE
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHH
IGEGTSEIQRTIIARETFKGA
CCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]