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The map label for this gene is folB [H]

Identifier: 108757810

GI number: 108757810

Start: 5059523

End: 5059780

Strand: Direct

Name: folB [H]

Synonym: MXAN_4112

Alternate gene names: 108757810

Gene position: 5059523-5059780 (Clockwise)

Preceding gene: 108761004

Following gene: 108756819

Centisome position: 55.36

GC content: 65.5

Gene sequence:

>258_bases
GTGTTCGATCTGGAAATGGGCGTTGACAACCGCAAGCCCGCCGCCACCGACGACATCGCGCACACCCTCAACTACAAGGC
CGTCTCCAAGCGACTGATCGAGTTCGTCGGCCAGTCTGACTTCGGTCTGGTGGAGACCCTGGCCGAGCGTTGCGCGGCCA
TCGTGCTGGAGGAGTTCGGCGTGCAGTGGCTGCGCCTGAAGCTGTCCAAGCCCGGCGCGGTACGTGGCGCGCGCGGTGGG
GGTGCTCATCGAACGTAG

Upstream 100 bases:

>100_bases
CACCCCGGGGGCCCACTTCACGTACGCCAAGACCCGCCGCCTGCCTCCACACCTCACGCAGCCGAACACGTCGACGTCCT
CCTGCATCCGCCAGACCCTG

Downstream 100 bases:

>100_bases
CCGTCAAGACGGCTGACCGCACCCAAGCCAAGGAGGTATTACCTGCTCATGAATGTGCAACAACCCGTGACGATCCTGCC
GTGGCTGAGCGCGCTTCAAC

Product: FolB domain-containing protein

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 85; Mature: 85

Protein sequence:

>85_residues
MFDLEMGVDNRKPAATDDIAHTLNYKAVSKRLIEFVGQSDFGLVETLAERCAAIVLEEFGVQWLRLKLSKPGAVRGARGG
GAHRT

Sequences:

>Translated_85_residues
MFDLEMGVDNRKPAATDDIAHTLNYKAVSKRLIEFVGQSDFGLVETLAERCAAIVLEEFGVQWLRLKLSKPGAVRGARGG
GAHRT
>Mature_85_residues
MFDLEMGVDNRKPAATDDIAHTLNYKAVSKRLIEFVGQSDFGLVETLAERCAAIVLEEFGVQWLRLKLSKPGAVRGARGG
GAHRT

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimeriza

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=81, Percent_Identity=44.4444444444444, Blast_Score=75, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 9301; Mature: 9301

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDLEMGVDNRKPAATDDIAHTLNYKAVSKRLIEFVGQSDFGLVETLAERCAAIVLEEFG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC
VQWLRLKLSKPGAVRGARGGGAHRT
HHHEEHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFDLEMGVDNRKPAATDDIAHTLNYKAVSKRLIEFVGQSDFGLVETLAERCAAIVLEEFG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC
VQWLRLKLSKPGAVRGARGGGAHRT
HHHEEHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]