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The map label for this gene is hepT [H]

Identifier: 108757727

GI number: 108757727

Start: 4389209

End: 4390207

Strand: Direct

Name: hepT [H]

Synonym: MXAN_3678

Alternate gene names: 108757727

Gene position: 4389209-4390207 (Clockwise)

Preceding gene: 108757534

Following gene: 108761205

Centisome position: 48.02

GC content: 70.47

Gene sequence:

>999_bases
ATGGATCTGGCTCGGGAGCTGACGGATTTTCTGGGGGCGGTGGAGCAGCGGCTTGGCAGCACCCTGGTGGATGGCGATGC
CGGTCCGGACGTGAAGGGCGACACGCTGATGGAGGCGGCCCGCCACCTGTGCCTGGGCAGCGGCAGCAAGCGCGCGCGCC
CCATGCTGGCGCGGCTGTTCGGCGGCGCGGTGGGCGTTCCGGCGGAGCGGCTGGTGGACGTGGCCGTGGCCGCGGAGCTC
ATCCATTCCGCCAGCCTGCTGCACGACGACGTGGTGGACGCGGGCATGTTCCGCCGGGGCCGGCCCACGGTGAACGCGCG
CTGGGGCAACATCGTCGCGGTGATGAGCGGCGACCTCATCCTGTCCACGGGCCTGTTCCAGCTGTCCCAACTGGACGCGC
GGCTGACGCGCAGCGCGCTGTCGGTCGTCTCCGAGATGACCCGCGCCGCCATCGCCGAGGTGGAGGCTCGCGGCGACCTG
GACCTGCCGCTCAATCGGCTGCGCTTCATCGCCGAGGGTAAGACGGGCTCGCTGTTCGGCTGGTGTGGCAACGCGGCGGC
GACGCTGGCGGAGCACCCCGAGGCGGTGGAGCGTTTCGACGGCTTCGGGCGTCACCTGGGCGTGGCGTTCCAGATTGCCG
ACGACATTCGCGACATCCTGGGCACGGACGTAGGCAAGCCGCGTTACGCGGACGTGCACTCGCGCACGCCGTCCATGCCC
ATCCTCCTGGCGGTGGCCAAGGATGAGTCGCTGCGGCGCAAGCTGAAGGACGCGTGGGCGTTTTCGGCGATCACGCCAGA
TCGCACGAAGGAGATTGGCGCGGCCATCGAGGCCACGGGCGCCGTGGATGCCTCGATGGCGCGGATGAACGTCGAAATCG
AGGCGGCGCTCGACAAGCTGGGCCACTTCGCCAAGGAGCCCGCGGGCGCGGAGCTGGTGAGCTGGGCGCGGAAGCTGTCG
GCCGGCATCGCCGAACAAGTCCAGGGGCGCGCTGCATGA

Upstream 100 bases:

>100_bases
TGCTCCGGCACCCGTTCACGTCTGGCTGCTGGGCAGCGCTGGAATCAGGTGCAGTTCAAGCGGTCTTGAACTATATGAAC
GAACGAGGAGACGGCGCACT

Downstream 100 bases:

>100_bases
AAGGCTACCTGTGGACGGGGGGACCCGGGAGCCCTGCCTCGGAGGCGCCGCCAGCGGATGGCCGGCTGGCGCCCTGGGAA
GCCATCGCGGTGGACGCGGT

Product: polyprenyl synthase family protein

Products: NA

Alternate protein names: HEPPP synthase subunit 2 [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MDLARELTDFLGAVEQRLGSTLVDGDAGPDVKGDTLMEAARHLCLGSGSKRARPMLARLFGGAVGVPAERLVDVAVAAEL
IHSASLLHDDVVDAGMFRRGRPTVNARWGNIVAVMSGDLILSTGLFQLSQLDARLTRSALSVVSEMTRAAIAEVEARGDL
DLPLNRLRFIAEGKTGSLFGWCGNAAATLAEHPEAVERFDGFGRHLGVAFQIADDIRDILGTDVGKPRYADVHSRTPSMP
ILLAVAKDESLRRKLKDAWAFSAITPDRTKEIGAAIEATGAVDASMARMNVEIEAALDKLGHFAKEPAGAELVSWARKLS
AGIAEQVQGRAA

Sequences:

>Translated_332_residues
MDLARELTDFLGAVEQRLGSTLVDGDAGPDVKGDTLMEAARHLCLGSGSKRARPMLARLFGGAVGVPAERLVDVAVAAEL
IHSASLLHDDVVDAGMFRRGRPTVNARWGNIVAVMSGDLILSTGLFQLSQLDARLTRSALSVVSEMTRAAIAEVEARGDL
DLPLNRLRFIAEGKTGSLFGWCGNAAATLAEHPEAVERFDGFGRHLGVAFQIADDIRDILGTDVGKPRYADVHSRTPSMP
ILLAVAKDESLRRKLKDAWAFSAITPDRTKEIGAAIEATGAVDASMARMNVEIEAALDKLGHFAKEPAGAELVSWARKLS
AGIAEQVQGRAA
>Mature_332_residues
MDLARELTDFLGAVEQRLGSTLVDGDAGPDVKGDTLMEAARHLCLGSGSKRARPMLARLFGGAVGVPAERLVDVAVAAEL
IHSASLLHDDVVDAGMFRRGRPTVNARWGNIVAVMSGDLILSTGLFQLSQLDARLTRSALSVVSEMTRAAIAEVEARGDL
DLPLNRLRFIAEGKTGSLFGWCGNAAATLAEHPEAVERFDGFGRHLGVAFQIADDIRDILGTDVGKPRYADVHSRTPSMP
ILLAVAKDESLRRKLKDAWAFSAITPDRTKEIGAAIEATGAVDASMARMNVEIEAALDKLGHFAKEPAGAELVSWARKLS
AGIAEQVQGRAA

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=223, Percent_Identity=30.9417040358744, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1789578, Length=208, Percent_Identity=32.6923076923077, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1786623, Length=226, Percent_Identity=32.3008849557522, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17505681, Length=257, Percent_Identity=30.3501945525292, Blast_Score=103, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24651612, Length=242, Percent_Identity=30.9917355371901, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 35327; Mature: 35327

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLARELTDFLGAVEQRLGSTLVDGDAGPDVKGDTLMEAARHLCLGSGSKRARPMLARLF
CCHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
GGAVGVPAERLVDVAVAAELIHSASLLHDDVVDAGMFRRGRPTVNARWGNIVAVMSGDLI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCH
LSTGLFQLSQLDARLTRSALSVVSEMTRAAIAEVEARGDLDLPLNRLRFIAEGKTGSLFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCEEE
WCGNAAATLAEHPEAVERFDGFGRHLGVAFQIADDIRDILGTDVGKPRYADVHSRTPSMP
ECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCC
ILLAVAKDESLRRKLKDAWAFSAITPDRTKEIGAAIEATGAVDASMARMNVEIEAALDKL
EEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
GHFAKEPAGAELVSWARKLSAGIAEQVQGRAA
HHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDLARELTDFLGAVEQRLGSTLVDGDAGPDVKGDTLMEAARHLCLGSGSKRARPMLARLF
CCHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
GGAVGVPAERLVDVAVAAELIHSASLLHDDVVDAGMFRRGRPTVNARWGNIVAVMSGDLI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCH
LSTGLFQLSQLDARLTRSALSVVSEMTRAAIAEVEARGDLDLPLNRLRFIAEGKTGSLFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCEEE
WCGNAAATLAEHPEAVERFDGFGRHLGVAFQIADDIRDILGTDVGKPRYADVHSRTPSMP
ECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCC
ILLAVAKDESLRRKLKDAWAFSAITPDRTKEIGAAIEATGAVDASMARMNVEIEAALDKL
EEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
GHFAKEPAGAELVSWARKLSAGIAEQVQGRAA
HHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7629164 [H]