Click here to switch to the map view.

The map label for this gene is pth

Identifier: 108757656

GI number: 108757656

Start: 6351362

End: 6351937

Strand: Direct

Name: pth

Synonym: MXAN_5077

Alternate gene names: 108757656

Gene position: 6351362-6351937 (Clockwise)

Preceding gene: 108763637

Following gene: 108760551

Centisome position: 69.49

GC content: 67.88

Gene sequence:

>576_bases
ATGAAGCTCATCGTCGGACTGGGCAATCCGGGGCGCGAGTACGAGCGGCACCGGCACAACATCGGGTTCATGGTGGTGGA
GGCGCTGCTGTCGCGCGCGCGGGCGCAGCTCAACCAGGAGAAGTTCGCGGCCAAGGTCGGCCAGGGCACCCTGGCGGGCG
AGCGCGTCCTCTTCGTGGAGCCCCAGACGTTCATGAACCTGTCGGGCCGCTCCGTCGCGGAGGCGGCGCGCTTCTTCAAG
GTGCCGGTCGCGGACGTGCTCGTCATTCATGACGAGTTGGACCTGCCCCTGGGCCGACTGCAGCTCAAGGCCGGCGGCGG
CAGCGGCGGCCACAACGGCCTCAAGAGCATCGTCTCCAGCCTGGGCGACGAGAGCTTCATCCGCCTGCGCTTCGGCATCG
GCAAGCCGGAGGGCCCCAATGCCCGCGAGCGCGTGTCCGACTACGTCCTGTCCAACTTCGACGACGGCGAGCGCCGGGAG
ATGGATGCGCTCATCGACCGGGCCATGGACATGACGGAGCTGTGGATCCGCGAAGGGCTGTCAGTGGCCATGAACCGGTT
CAACCGGAAGGCCTGA

Upstream 100 bases:

>100_bases
GGCCCCGGCGAAGAAGTAGTCTGTCGCCTTCAGCGGTCCTTCTGGAGCGGGGCCGGCCCGGTAAGGGGCTGGCCCCGTTT
CTCGTTTCGGGAGCCACGTC

Downstream 100 bases:

>100_bases
GGCAGGCCCCCAGGCTCCCCCACGGGCTGGCGGACGGGGCGCCCGGCCGCTTGACTTGGCGGGGGGCCCCCCATAGAAGG
CCCCTTCCCTCATCGGGGAT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MKLIVGLGNPGREYERHRHNIGFMVVEALLSRARAQLNQEKFAAKVGQGTLAGERVLFVEPQTFMNLSGRSVAEAARFFK
VPVADVLVIHDELDLPLGRLQLKAGGGSGGHNGLKSIVSSLGDESFIRLRFGIGKPEGPNARERVSDYVLSNFDDGERRE
MDALIDRAMDMTELWIREGLSVAMNRFNRKA

Sequences:

>Translated_191_residues
MKLIVGLGNPGREYERHRHNIGFMVVEALLSRARAQLNQEKFAAKVGQGTLAGERVLFVEPQTFMNLSGRSVAEAARFFK
VPVADVLVIHDELDLPLGRLQLKAGGGSGGHNGLKSIVSSLGDESFIRLRFGIGKPEGPNARERVSDYVLSNFDDGERRE
MDALIDRAMDMTELWIREGLSVAMNRFNRKA
>Mature_191_residues
MKLIVGLGNPGREYERHRHNIGFMVVEALLSRARAQLNQEKFAAKVGQGTLAGERVLFVEPQTFMNLSGRSVAEAARFFK
VPVADVLVIHDELDLPLGRLQLKAGGGSGGHNGLKSIVSSLGDESFIRLRFGIGKPEGPNARERVSDYVLSNFDDGERRE
MDALIDRAMDMTELWIREGLSVAMNRFNRKA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=179, Percent_Identity=39.6648044692737, Blast_Score=122, Evalue=2e-28,
Organism=Escherichia coli, GI1787455, Length=190, Percent_Identity=48.4210526315789, Blast_Score=140, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6321983, Length=169, Percent_Identity=34.3195266272189, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_MYXXD (Q1D292)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_633231.1
- ProteinModelPortal:   Q1D292
- SMR:   Q1D292
- STRING:   Q1D292
- GeneID:   4105297
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_5077
- TIGR:   MXAN_5077
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- PhylomeDB:   Q1D292
- ProtClustDB:   PRK05426
- BioCyc:   MXAN246197:MXAN_5077-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21166; Mature: 21166

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIVGLGNPGREYERHRHNIGFMVVEALLSRARAQLNQEKFAAKVGQGTLAGERVLFVE
CEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEC
PQTFMNLSGRSVAEAARFFKVPVADVLVIHDELDLPLGRLQLKAGGGSGGHNGLKSIVSS
CHHHHCCCCCHHHHHHHHHHCCHHHEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHH
LGDESFIRLRFGIGKPEGPNARERVSDYVLSNFDDGERREMDALIDRAMDMTELWIREGL
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SVAMNRFNRKA
HHHHHHHCCCC
>Mature Secondary Structure
MKLIVGLGNPGREYERHRHNIGFMVVEALLSRARAQLNQEKFAAKVGQGTLAGERVLFVE
CEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEC
PQTFMNLSGRSVAEAARFFKVPVADVLVIHDELDLPLGRLQLKAGGGSGGHNGLKSIVSS
CHHHHCCCCCHHHHHHHHHHCCHHHEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHH
LGDESFIRLRFGIGKPEGPNARERVSDYVLSNFDDGERREMDALIDRAMDMTELWIREGL
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SVAMNRFNRKA
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA