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The map label for this gene is moaDE [H]

Identifier: 108757602

GI number: 108757602

Start: 2984210

End: 2984890

Strand: Direct

Name: moaDE [H]

Synonym: MXAN_2564

Alternate gene names: 108757602

Gene position: 2984210-2984890 (Clockwise)

Preceding gene: 108759203

Following gene: 108761601

Centisome position: 32.65

GC content: 69.6

Gene sequence:

>681_bases
ATGGCGGACGCCAGGAACGTGCGCATCACCGTCCTCTATTTCGCCGCGGCTCGCGAGCGCACCGGGCAGGTGCGTGAGGC
CCTGGACTTGCCCGAGGGCTCGCATGTTCGGGACGTGTTGCGGCTGCTGAGCGCGAAGTACGCGGCGCTGGCGCCACTCC
TGCCGCACCTTCGTGTGGCCGTGGACCAGGAGTTCGTCGGTCCGGATGCCCCGGTGCGGGATGGGGCGGAGATGGCGCTG
ATTCCCCCCGTGGCGGGAGGCGCACCTGGGAAGTTCCTGGTGGTGGACCGCCCCCTGCGGCTGGAGGAGGTGGTGGAGGC
TGTCAGGGGGGAGTCATACGGCGGGCTGGTGACGTTCAGCGGCTCCGTGCGCAACCAGACGAAGGGCCGCCGCGTGTTGC
GCTTGGAGTACGAGGCCTACGCGCCCATGGCGGAGAAGAAGCTGGCGGAGATTGGCGCGGAGGCCGCGGAGCGGTTTCCC
GGCGTGCGCGTGTCCATCATCCATCGCGTGGGAACGCTGGTGCCCGGCGAGCTGGCCGTCGTCATCGCCGCGGCGTCGCC
GCATCGGAAGGAGGCGTTCGGTGGCTGCGAGTACGCCATCGAGCGGCTCAAGCAGGACGTCCCCATCTGGAAGAAGGAGT
TCTTCGAGGATGGGGAGGTCTGGGTCGGCCTGGGGCCCTGA

Upstream 100 bases:

>100_bases
ACTCGGGCTTCCTCGACTTCAGCCCGGTGGAGGGCGGGGGCCGGCTCAAGGGACGCCTGTCCTTGCGCGCGGAGCAGGAG
GCTTCGCGTTGAGCGGGGGC

Downstream 100 bases:

>100_bases
ATCGCCGCCTCAGCGGACGCGCAGGAAGGCGGGGACCGTGACGTCGTCACCGCCGTCGGGCTGCATGCCGAGCTCTTCAT
CCGTGAGCGGACGCAGTGGC

Product: molybdopterin converting factor, subunits 1/2

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MADARNVRITVLYFAAARERTGQVREALDLPEGSHVRDVLRLLSAKYAALAPLLPHLRVAVDQEFVGPDAPVRDGAEMAL
IPPVAGGAPGKFLVVDRPLRLEEVVEAVRGESYGGLVTFSGSVRNQTKGRRVLRLEYEAYAPMAEKKLAEIGAEAAERFP
GVRVSIIHRVGTLVPGELAVVIAAASPHRKEAFGGCEYAIERLKQDVPIWKKEFFEDGEVWVGLGP

Sequences:

>Translated_226_residues
MADARNVRITVLYFAAARERTGQVREALDLPEGSHVRDVLRLLSAKYAALAPLLPHLRVAVDQEFVGPDAPVRDGAEMAL
IPPVAGGAPGKFLVVDRPLRLEEVVEAVRGESYGGLVTFSGSVRNQTKGRRVLRLEYEAYAPMAEKKLAEIGAEAAERFP
GVRVSIIHRVGTLVPGELAVVIAAASPHRKEAFGGCEYAIERLKQDVPIWKKEFFEDGEVWVGLGP
>Mature_225_residues
ADARNVRITVLYFAAARERTGQVREALDLPEGSHVRDVLRLLSAKYAALAPLLPHLRVAVDQEFVGPDAPVRDGAEMALI
PPVAGGAPGKFLVVDRPLRLEEVVEAVRGESYGGLVTFSGSVRNQTKGRRVLRLEYEAYAPMAEKKLAEIGAEAAERFPG
VRVSIIHRVGTLVPGELAVVIAAASPHRKEAFGGCEYAIERLKQDVPIWKKEFFEDGEVWVGLGP

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=125, Percent_Identity=37.6, Blast_Score=105, Evalue=4e-23,
Organism=Escherichia coli, GI1787003, Length=109, Percent_Identity=44.0366972477064, Blast_Score=93, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17509279, Length=128, Percent_Identity=38.28125, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21356259, Length=127, Percent_Identity=38.5826771653543, Blast_Score=95, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 24617; Mature: 24485

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00131 CARBOXYPEPT_SER_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADARNVRITVLYFAAARERTGQVREALDLPEGSHVRDVLRLLSAKYAALAPLLPHLRVA
CCCCCCEEEEEEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VDQEFVGPDAPVRDGAEMALIPPVAGGAPGKFLVVDRPLRLEEVVEAVRGESYGGLVTFS
HHHHHCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCEEEEC
GSVRNQTKGRRVLRLEYEAYAPMAEKKLAEIGAEAAERFPGVRVSIIHRVGTLVPGELAV
CCCCCCCCCCEEEEEEHHHHCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHCCCCCCEEE
VIAAASPHRKEAFGGCEYAIERLKQDVPIWKKEFFEDGEVWVGLGP
EEEECCCCHHHHCCCHHHHHHHHHHCCCHHHHHHCCCCCEEEECCC
>Mature Secondary Structure 
ADARNVRITVLYFAAARERTGQVREALDLPEGSHVRDVLRLLSAKYAALAPLLPHLRVA
CCCCCEEEEEEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VDQEFVGPDAPVRDGAEMALIPPVAGGAPGKFLVVDRPLRLEEVVEAVRGESYGGLVTFS
HHHHHCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCEEEEC
GSVRNQTKGRRVLRLEYEAYAPMAEKKLAEIGAEAAERFPGVRVSIIHRVGTLVPGELAV
CCCCCCCCCCEEEEEEHHHHCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHCCCCCCEEE
VIAAASPHRKEAFGGCEYAIERLKQDVPIWKKEFFEDGEVWVGLGP
EEEECCCCHHHHCCCHHHHHHHHHHCCCHHHHHHCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]