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The map label for this gene is ctaB

Identifier: 108757480

GI number: 108757480

Start: 6620268

End: 6621152

Strand: Reverse

Name: ctaB

Synonym: MXAN_5318

Alternate gene names: 108757480

Gene position: 6621152-6620268 (Counterclockwise)

Preceding gene: 108759093

Following gene: 108762202

Centisome position: 72.44

GC content: 70.51

Gene sequence:

>885_bases
GTGAACGCGCGTGCCGAGTCCTTGCCGACAGTCGCGTCCGACCTGATCTCCCTCACCAAGCCGCGCCTCTCCTCCCTGGT
GCTCGTCACCGCGGCGGGGGGCATGTGGCTGGCGCCCGGCCACATGGGCGCCGTCAACGCGCTGGTGACGCTGCTGGCCA
CGGCGGGAACCGTGGGCGCGGCCAATGCCCTCAACTGCTACTGGGAGCGGCACAGCGACCAGTTCATGGACCGCACCCGC
AACCGGCCGCTGCCCTCCGGGCGCATGGAGCCGGCGGTGGCGCTGTGGTTCGGCATCTCCCTGGCGGCCGTGTCGCTTCC
GGCGCTGGCCCTGGGCGCCAACGTGCTCACCGCCGCGCTGGGCCTGGTGGCGCTGCTGAGCTATGTGCTGGCCTACACGC
CGCTGAAGGCGCGCACGTCCGCGGCCATGCTGGTGGGCGGGGTGCCCGGCGCGCTGCCTCCGCTCATGGGCTGGACGGCG
GTGACCAACCAGATGGACGTGGGGGGCTTCTCGCTCTTCGCCATCATGTTCCTCTGGCAGATGCCGCACTTCATCGCCAT
CGCGCTCTTCCGCAAGGAGGAGTACCGGGCGGCGGGCCTCACGTCGGTGCCCCTGGAGCGGGGTGACGAGTCCAGCCGCG
CGCAGGTGGTGCTCTACCTGGTGGCGCTGATTCCGATGACGCTCCTGCCCTTCCAACTCCACATCGCCGGCGCGTGGTAC
TTGGCCGCGGCGGTGCTCCTGGGGCTGAGCTTCCTCGGGCTGGGGGCGTGGGGCTTCTTCCGGCGGCTGGGAAACACCTG
GGCCCGCCAGACGTTCTTCTTCTCACTCATCTACCTCACCGGCCTGTTCGCCGCGCTGGCGCTGGACCGAGTTCCTCGCG
AATAG

Upstream 100 bases:

>100_bases
CGGGGGCGCCGTGTCCTTGCCCACCCCCGGGTGGTGCCTGTATGGGGAAGGCCGTTACCGCGCCGGCAGCGTGTCTGTCG
TGCCTACCTCTGGAGTCTGT

Downstream 100 bases:

>100_bases
CGTCCGGGGCGAACGGGGGACGCCCGCTCATGCCCGAAGTCCTGCTTTCCACTGCCACCTCTCAGCCGCTGCTCCAGTTG
GAGGGGCTCACGCGTCGCTT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MNARAESLPTVASDLISLTKPRLSSLVLVTAAGGMWLAPGHMGAVNALVTLLATAGTVGAANALNCYWERHSDQFMDRTR
NRPLPSGRMEPAVALWFGISLAAVSLPALALGANVLTAALGLVALLSYVLAYTPLKARTSAAMLVGGVPGALPPLMGWTA
VTNQMDVGGFSLFAIMFLWQMPHFIAIALFRKEEYRAAGLTSVPLERGDESSRAQVVLYLVALIPMTLLPFQLHIAGAWY
LAAAVLLGLSFLGLGAWGFFRRLGNTWARQTFFFSLIYLTGLFAALALDRVPRE

Sequences:

>Translated_294_residues
MNARAESLPTVASDLISLTKPRLSSLVLVTAAGGMWLAPGHMGAVNALVTLLATAGTVGAANALNCYWERHSDQFMDRTR
NRPLPSGRMEPAVALWFGISLAAVSLPALALGANVLTAALGLVALLSYVLAYTPLKARTSAAMLVGGVPGALPPLMGWTA
VTNQMDVGGFSLFAIMFLWQMPHFIAIALFRKEEYRAAGLTSVPLERGDESSRAQVVLYLVALIPMTLLPFQLHIAGAWY
LAAAVLLGLSFLGLGAWGFFRRLGNTWARQTFFFSLIYLTGLFAALALDRVPRE
>Mature_294_residues
MNARAESLPTVASDLISLTKPRLSSLVLVTAAGGMWLAPGHMGAVNALVTLLATAGTVGAANALNCYWERHSDQFMDRTR
NRPLPSGRMEPAVALWFGISLAAVSLPALALGANVLTAALGLVALLSYVLAYTPLKARTSAAMLVGGVPGALPPLMGWTA
VTNQMDVGGFSLFAIMFLWQMPHFIAIALFRKEEYRAAGLTSVPLERGDESSRAQVVLYLVALIPMTLLPFQLHIAGAWY
LAAAVLLGLSFLGLGAWGFFRRLGNTWARQTFFFSLIYLTGLFAALALDRVPRE

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=199, Percent_Identity=40.7035175879397, Blast_Score=136, Evalue=2e-32,
Organism=Escherichia coli, GI1786631, Length=276, Percent_Identity=34.0579710144928, Blast_Score=142, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71998235, Length=266, Percent_Identity=30.4511278195489, Blast_Score=97, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6325085, Length=187, Percent_Identity=35.2941176470588, Blast_Score=99, Evalue=9e-22,
Organism=Drosophila melanogaster, GI19921064, Length=270, Percent_Identity=34.0740740740741, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_MYXXD (Q1D1K4)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_633469.1
- STRING:   Q1D1K4
- GeneID:   4101920
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_5318
- TIGR:   MXAN_5318
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   SYYQLTK
- PhylomeDB:   Q1D1K4
- ProtClustDB:   CLSK945329
- BioCyc:   MXAN246197:MXAN_5318-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 31492; Mature: 31492

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x91f9ed4)-; HASH(0x157442c0)-; HASH(0x1674d9b8)-; HASH(0x164f63a4)-; HASH(0x18db7250)-; HASH(0x16d301c4)-; HASH(0x1656bce0)-; HASH(0x16489adc)-; HASH(0x1687ef0c)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNARAESLPTVASDLISLTKPRLSSLVLVTAAGGMWLAPGHMGAVNALVTLLATAGTVGA
CCCCHHHHHHHHHHHHHHCCHHHHHEEEEEECCCEEECCCCHHHHHHHHHHHHHCCCCCC
ANALNCYWERHSDQFMDRTRNRPLPSGRMEPAVALWFGISLAAVSLPALALGANVLTAAL
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLVALLSYVLAYTPLKARTSAAMLVGGVPGALPPLMGWTAVTNQMDVGGFSLFAIMFLWQ
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MPHFIAIALFRKEEYRAAGLTSVPLERGDESSRAQVVLYLVALIPMTLLPFQLHIAGAWY
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAAVLLGLSFLGLGAWGFFRRLGNTWARQTFFFSLIYLTGLFAALALDRVPRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure
MNARAESLPTVASDLISLTKPRLSSLVLVTAAGGMWLAPGHMGAVNALVTLLATAGTVGA
CCCCHHHHHHHHHHHHHHCCHHHHHEEEEEECCCEEECCCCHHHHHHHHHHHHHCCCCCC
ANALNCYWERHSDQFMDRTRNRPLPSGRMEPAVALWFGISLAAVSLPALALGANVLTAAL
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLVALLSYVLAYTPLKARTSAAMLVGGVPGALPPLMGWTAVTNQMDVGGFSLFAIMFLWQ
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MPHFIAIALFRKEEYRAAGLTSVPLERGDESSRAQVVLYLVALIPMTLLPFQLHIAGAWY
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAAVLLGLSFLGLGAWGFFRRLGNTWARQTFFFSLIYLTGLFAALALDRVPRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA