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The map label for this gene is serC

Identifier: 108757347

GI number: 108757347

Start: 6190518

End: 6191606

Strand: Reverse

Name: serC

Synonym: MXAN_4948

Alternate gene names: 108757347

Gene position: 6191606-6190518 (Counterclockwise)

Preceding gene: 108757592

Following gene: 108764016

Centisome position: 67.74

GC content: 65.2

Gene sequence:

>1089_bases
ATGCGCGTCATCAACTTCAACGCCGGCCCGGCCGGATTGCCACTACCGGCCCTCGAGCGGGCTCGGGACGAACTGATTGA
CTTCCAGGGCTCCGGCATGTCGGTGATGGAGCACAGCCACCGGGGACGGGAATACGAGGGGGTCCACGACGAAGCCATCT
CCCTGTTGACCCGGCTGCTGGGGATTCCCGACACCCACCAGGTCCTGTTCCTCACTGGCGGCGCCTCCCAGCAGTTCGCC
CAGGTGCCGATGAACTTCCTGAGGCCCGGGGCCAGCGCGGACTACCTCATGACGGGCGTGTGGAGCGAGAAGGCCTTCGA
CGAGGCGAAGTACTACGGCACGCCGCGCGTCGCGGTGAGCACTGCGCGGCCGGACAAGCGTTACACGCGGGTGCCCCGCC
AGGATGAGCTGCGCCTCGAGTCGAGCGCGGCGTATGTCCACCTGACGAGCAACAACACCATCTTCGGCACCCAGTGGCAC
ACCTTCCCGGACGTGGGGAACGTGCCGTTGGTGGCGGACATGAGCTCGGACTTCCTGTGGAAGGGCTTCGATGTCAGCCG
CTTCGGCCTCATCTACGCGGGCGCGCAGAAGAACCTGGGGCCCTCCGGCGTGACGCTGGTGGTGGCTGACAAGGCGTTCA
TCGCGCGGGGCCGGACGGACATTCCGAAGATCTTCCGCTACACCACCCACGCGGAGAACAACTCGCTCTACAACACGCCG
CCTACCCTGGCCATCTACCTGGTGCGCAACGTCCTGGCCTGGATTCAGTCGGTGGGGGGGCTCGCGCAGTTGGAGCAGTG
GAACCGGGAAAAGGCGGCGTTGCTCTACGGGGCCGTGGATCGGCACCCGGAATTCTACCGCGCGCCGGTGGAGCGCGAAT
CCCGTTCAGTGATGAACGTTGTCTTCCAGTTGCCCACGGAAGCATTGGATGCGTCCTTCGTCGCTGACGCGAAGCAGCAA
GGAATGGTGGGCCTCAAGGGGCACCGGACGGCCGGAGGAATCCGCGTTTCCATGTACAACGCGGTGAGCGTCGAAAATGT
GCGCACGTTGGCCGCCTTCATGGACCACTTCGTGAAGACGCGCGGGTAG

Upstream 100 bases:

>100_bases
CCATGGAAGCAAGCGGGCAACCTTCTTCTCGCTGGCACCCGGGGGGGCGCTGGGGGGAAGAATGTCTCCGCGGCCGTTCA
TTTCAAGAAGGGACACTGAC

Downstream 100 bases:

>100_bases
GCTGCGTCCAACCGCACGGATTACCCTCACCCGGAGGATTCATGAAAGCCACGCTGACCGCCGTCGTGCTGTCCCTGATG
TTCGCCGCTCCGGCCTTCGC

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MRVINFNAGPAGLPLPALERARDELIDFQGSGMSVMEHSHRGREYEGVHDEAISLLTRLLGIPDTHQVLFLTGGASQQFA
QVPMNFLRPGASADYLMTGVWSEKAFDEAKYYGTPRVAVSTARPDKRYTRVPRQDELRLESSAAYVHLTSNNTIFGTQWH
TFPDVGNVPLVADMSSDFLWKGFDVSRFGLIYAGAQKNLGPSGVTLVVADKAFIARGRTDIPKIFRYTTHAENNSLYNTP
PTLAIYLVRNVLAWIQSVGGLAQLEQWNREKAALLYGAVDRHPEFYRAPVERESRSVMNVVFQLPTEALDASFVADAKQQ
GMVGLKGHRTAGGIRVSMYNAVSVENVRTLAAFMDHFVKTRG

Sequences:

>Translated_362_residues
MRVINFNAGPAGLPLPALERARDELIDFQGSGMSVMEHSHRGREYEGVHDEAISLLTRLLGIPDTHQVLFLTGGASQQFA
QVPMNFLRPGASADYLMTGVWSEKAFDEAKYYGTPRVAVSTARPDKRYTRVPRQDELRLESSAAYVHLTSNNTIFGTQWH
TFPDVGNVPLVADMSSDFLWKGFDVSRFGLIYAGAQKNLGPSGVTLVVADKAFIARGRTDIPKIFRYTTHAENNSLYNTP
PTLAIYLVRNVLAWIQSVGGLAQLEQWNREKAALLYGAVDRHPEFYRAPVERESRSVMNVVFQLPTEALDASFVADAKQQ
GMVGLKGHRTAGGIRVSMYNAVSVENVRTLAAFMDHFVKTRG
>Mature_362_residues
MRVINFNAGPAGLPLPALERARDELIDFQGSGMSVMEHSHRGREYEGVHDEAISLLTRLLGIPDTHQVLFLTGGASQQFA
QVPMNFLRPGASADYLMTGVWSEKAFDEAKYYGTPRVAVSTARPDKRYTRVPRQDELRLESSAAYVHLTSNNTIFGTQWH
TFPDVGNVPLVADMSSDFLWKGFDVSRFGLIYAGAQKNLGPSGVTLVVADKAFIARGRTDIPKIFRYTTHAENNSLYNTP
PTLAIYLVRNVLAWIQSVGGLAQLEQWNREKAALLYGAVDRHPEFYRAPVERESRSVMNVVFQLPTEALDASFVADAKQQ
GMVGLKGHRTAGGIRVSMYNAVSVENVRTLAAFMDHFVKTRG

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=365, Percent_Identity=41.6438356164384, Blast_Score=305, Evalue=3e-83,
Organism=Homo sapiens, GI10863955, Length=361, Percent_Identity=37.1191135734072, Blast_Score=254, Evalue=7e-68,
Organism=Escherichia coli, GI1787136, Length=362, Percent_Identity=42.8176795580111, Blast_Score=292, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI17506897, Length=364, Percent_Identity=41.7582417582418, Blast_Score=301, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6324758, Length=383, Percent_Identity=37.597911227154, Blast_Score=257, Evalue=2e-69,
Organism=Drosophila melanogaster, GI21356589, Length=365, Percent_Identity=43.013698630137, Blast_Score=308, Evalue=3e-84,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_MYXXD (Q1D2L9)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_633104.1
- ProteinModelPortal:   Q1D2L9
- SMR:   Q1D2L9
- STRING:   Q1D2L9
- GeneID:   4104614
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_4948
- TIGR:   MXAN_4948
- eggNOG:   COG1932
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- PhylomeDB:   Q1D2L9
- ProtClustDB:   PRK05355
- BioCyc:   MXAN246197:MXAN_4948-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 40154; Mature: 40154

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 41-41 BINDING 101-101 BINDING 153-153 BINDING 173-173 BINDING 196-196

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVINFNAGPAGLPLPALERARDELIDFQGSGMSVMEHSHRGREYEGVHDEAISLLTRLL
CEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHH
GIPDTHQVLFLTGGASQQFAQVPMNFLRPGASADYLMTGVWSEKAFDEAKYYGTPRVAVS
CCCCCCEEEEEECCCCHHHHHCCHHHHCCCCCCCCEEEECCCHHHHHHHHHCCCCCEEEE
TARPDKRYTRVPRQDELRLESSAAYVHLTSNNTIFGTQWHTFPDVGNVPLVADMSSDFLW
CCCCCHHHHCCCCHHHCEEECCEEEEEEECCCEEEECCCCCCCCCCCCCEEEECCCCCEE
KGFDVSRFGLIYAGAQKNLGPSGVTLVVADKAFIARGRTDIPKIFRYTTHAENNSLYNTP
CCCCCCCCEEEEECCCCCCCCCCEEEEEECHHHHHCCCCCCHHHHHEEECCCCCCCCCCC
PTLAIYLVRNVLAWIQSVGGLAQLEQWNREKAALLYGAVDRHPEFYRAPVERESRSVMNV
CHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHEEEEECHHCCCHHHCCCHHHHHHHHHHH
VFQLPTEALDASFVADAKQQGMVGLKGHRTAGGIRVSMYNAVSVENVRTLAAFMDHFVKT
HHHCCHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHC
RG
CC
>Mature Secondary Structure
MRVINFNAGPAGLPLPALERARDELIDFQGSGMSVMEHSHRGREYEGVHDEAISLLTRLL
CEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHH
GIPDTHQVLFLTGGASQQFAQVPMNFLRPGASADYLMTGVWSEKAFDEAKYYGTPRVAVS
CCCCCCEEEEEECCCCHHHHHCCHHHHCCCCCCCCEEEECCCHHHHHHHHHCCCCCEEEE
TARPDKRYTRVPRQDELRLESSAAYVHLTSNNTIFGTQWHTFPDVGNVPLVADMSSDFLW
CCCCCHHHHCCCCHHHCEEECCEEEEEEECCCEEEECCCCCCCCCCCCCEEEECCCCCEE
KGFDVSRFGLIYAGAQKNLGPSGVTLVVADKAFIARGRTDIPKIFRYTTHAENNSLYNTP
CCCCCCCCEEEEECCCCCCCCCCEEEEEECHHHHHCCCCCCHHHHHEEECCCCCCCCCCC
PTLAIYLVRNVLAWIQSVGGLAQLEQWNREKAALLYGAVDRHPEFYRAPVERESRSVMNV
CHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHEEEEECHHCCCHHHCCCHHHHHHHHHHH
VFQLPTEALDASFVADAKQQGMVGLKGHRTAGGIRVSMYNAVSVENVRTLAAFMDHFVKT
HHHCCHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHC
RG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA