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The map label for this gene is 108757299

Identifier: 108757299

GI number: 108757299

Start: 6804817

End: 6806523

Strand: Direct

Name: 108757299

Synonym: MXAN_5466

Alternate gene names: NA

Gene position: 6804817-6806523 (Clockwise)

Preceding gene: 108760237

Following gene: 108763826

Centisome position: 74.45

GC content: 67.84

Gene sequence:

>1707_bases
TTGCGAGTGGGGCATACGCCATCACCTCACTCGCCCTGGAAGTCCCTGCACCCGCATTGGCATGCCACATGCTCATGCGG
ACTCCACATCACGCCAGGGAATCCCTCTCACTCCCACGCGCAGGCGATGTCCCCTGCCCTGGCGTTCGCTCTGCAGTGGG
AACACTCCCCATCTACTTCCATGAATCGAATGTCTGATTGGCTTTCTACCGCGGCGATGTTCGCTGGCCTTGCCACCCTG
ACGGGCCTGCCGATGGCCGCCGAGGCCTCGAGCGACGTGTCGCCAGAAATTGTCTCCGCGATGCGTCGGGACCTTGGGCT
CACCGAGCAGCAGGTGCATCAGCGCCTGTCCTTCGAGGCGAAGGCGCCCGGGCTGGAGCAGACGATGCGTGAACAACTTG
GCGACGCCTTCGGTGGCGCCTGGCTCGACGCGGAGGGCGGCCAGCTCATCGTTGGTGTCACCGACGAGGCCCGCCTCGCC
AAGACCCGGGTCGCCGGCGTGCGGACCGTGCACGTGGCGCGGAGCCTGGCGCGGCTGGAGCAGGTGAAGGCGGAACTGGA
CCAGAACGTCCAGGCCCTCTCGCCCGCCATCCACTCCTGGTACGTCGACCTGCCGACGAACAGCGTCGTCGTCTACGTGG
ACGCCTCCAGCCAGACGAAGCTGCGCGCGGATGCCTTCATCGCGCAGAGCTCGGGCCTGAAAGACGGCAGCCTCCGCGTG
GTGGCCTCCACCCACGCGCCCGAGCCCGCCTATGACCTGCGCGGCGGTGACCCCTACTACTTCAGCAACTACCGCTGTTC
GGTGGGCTTCCCCGTCAACGGGGGCTTCGTCACCGCCGGCCACTGCGGCGGCGCCGGCACGCCCACCACGGGGCACAACG
GCGTGGCCCTGGGCACCATCCGTGGCTCCGTCTGGCCCGGCTCCGACTACGGCTGGGTGGCCACCCATGGCTCGTGGACC
CCGCAGCCGTGGGTCAACAACTACAGCGGCGGCAACGTCACCGTCGCGGGCTCCCAGGAGGCTCCGGTGAATGCCTCCAT
CTGCCGCTCCGGCTACACCACCGGCTGGCGGTGCGGCGTGCTCCAGGCGAAGAACATCACCGTCAACTACTCCGTCGGGC
CCGTGTACGGCCTGCACAAGACGAACGCGTGCGCGGACGGCGGCGACTCCGGCGGCTCCGTCATCTCCGGCAACCAGGCC
CAGGGCGTGACGTCCGGCGTGGCGGGCACGTGCGCCAACGGAAATCCGCCGCAGACGTTCTACCAACCCGTCAACCCCAT
CCTGGGCGCCTACGGCCTGACGCTCCGCACGACGGGCGGTGGCGGCAGTGGACGGTCCTTCGTGTCGCGCCTCAACGGCA
AGTGCATCGACGTACCCAACTCCAACTTCTCCGACGGAGTGCAGCTCCAGATGTGGGACTGCAATGGCACGAACGCGCAG
CGGTGGACCTTCATCAACGGCACCGTTCAGGCGGGCGGCAAGTGCATGGACGTGGCCTGGGCCTCCACGGCCAACGGCGC
GGCCATCCAGTTGGCCAACTGCAGCGGCAACCCGGCACAGCAGTTCGTGCTGAGCGGCGCGGGTGACCTCGTCAGCGTGC
TCGCCAACAAGTGCGTGGACATCGTGAACCACAACACGTCCAGCGGCGCCCGGCTCATCATCTACGAGTGCACGGGCAAC
CCGAACCAGAAGTGGGACTACCGCTGA

Upstream 100 bases:

>100_bases
GCAGCAGTCCCAACGTCAGCCAGCTCGATTTCGGCCTGACGCAGGGTGGTAACACCAGTCACCAGCCGAGGACGGCTGTC
ACCACCTGTCCGTCATAAAA

Downstream 100 bases:

>100_bases
ACCCTCCGTCGCCTGACCGAGCGACCCGGGTGCCTGGAGGCGATTCAGGCACCGAGGGCCGCGCGGGCGTGACACGCTGA
GGTCCTCCAGCGCGCCTGGG

Product: S1E family peptidase

Products: NA

Alternate protein names: Serine protease I; RPI [H]

Number of amino acids: Translated: 568; Mature: 568

Protein sequence:

>568_residues
MRVGHTPSPHSPWKSLHPHWHATCSCGLHITPGNPSHSHAQAMSPALAFALQWEHSPSTSMNRMSDWLSTAAMFAGLATL
TGLPMAAEASSDVSPEIVSAMRRDLGLTEQQVHQRLSFEAKAPGLEQTMREQLGDAFGGAWLDAEGGQLIVGVTDEARLA
KTRVAGVRTVHVARSLARLEQVKAELDQNVQALSPAIHSWYVDLPTNSVVVYVDASSQTKLRADAFIAQSSGLKDGSLRV
VASTHAPEPAYDLRGGDPYYFSNYRCSVGFPVNGGFVTAGHCGGAGTPTTGHNGVALGTIRGSVWPGSDYGWVATHGSWT
PQPWVNNYSGGNVTVAGSQEAPVNASICRSGYTTGWRCGVLQAKNITVNYSVGPVYGLHKTNACADGGDSGGSVISGNQA
QGVTSGVAGTCANGNPPQTFYQPVNPILGAYGLTLRTTGGGGSGRSFVSRLNGKCIDVPNSNFSDGVQLQMWDCNGTNAQ
RWTFINGTVQAGGKCMDVAWASTANGAAIQLANCSGNPAQQFVLSGAGDLVSVLANKCVDIVNHNTSSGARLIIYECTGN
PNQKWDYR

Sequences:

>Translated_568_residues
MRVGHTPSPHSPWKSLHPHWHATCSCGLHITPGNPSHSHAQAMSPALAFALQWEHSPSTSMNRMSDWLSTAAMFAGLATL
TGLPMAAEASSDVSPEIVSAMRRDLGLTEQQVHQRLSFEAKAPGLEQTMREQLGDAFGGAWLDAEGGQLIVGVTDEARLA
KTRVAGVRTVHVARSLARLEQVKAELDQNVQALSPAIHSWYVDLPTNSVVVYVDASSQTKLRADAFIAQSSGLKDGSLRV
VASTHAPEPAYDLRGGDPYYFSNYRCSVGFPVNGGFVTAGHCGGAGTPTTGHNGVALGTIRGSVWPGSDYGWVATHGSWT
PQPWVNNYSGGNVTVAGSQEAPVNASICRSGYTTGWRCGVLQAKNITVNYSVGPVYGLHKTNACADGGDSGGSVISGNQA
QGVTSGVAGTCANGNPPQTFYQPVNPILGAYGLTLRTTGGGGSGRSFVSRLNGKCIDVPNSNFSDGVQLQMWDCNGTNAQ
RWTFINGTVQAGGKCMDVAWASTANGAAIQLANCSGNPAQQFVLSGAGDLVSVLANKCVDIVNHNTSSGARLIIYECTGN
PNQKWDYR
>Mature_568_residues
MRVGHTPSPHSPWKSLHPHWHATCSCGLHITPGNPSHSHAQAMSPALAFALQWEHSPSTSMNRMSDWLSTAAMFAGLATL
TGLPMAAEASSDVSPEIVSAMRRDLGLTEQQVHQRLSFEAKAPGLEQTMREQLGDAFGGAWLDAEGGQLIVGVTDEARLA
KTRVAGVRTVHVARSLARLEQVKAELDQNVQALSPAIHSWYVDLPTNSVVVYVDASSQTKLRADAFIAQSSGLKDGSLRV
VASTHAPEPAYDLRGGDPYYFSNYRCSVGFPVNGGFVTAGHCGGAGTPTTGHNGVALGTIRGSVWPGSDYGWVATHGSWT
PQPWVNNYSGGNVTVAGSQEAPVNASICRSGYTTGWRCGVLQAKNITVNYSVGPVYGLHKTNACADGGDSGGSVISGNQA
QGVTSGVAGTCANGNPPQTFYQPVNPILGAYGLTLRTTGGGGSGRSFVSRLNGKCIDVPNSNFSDGVQLQMWDCNGTNAQ
RWTFINGTVQAGGKCMDVAWASTANGAAIQLANCSGNPAQQFVLSGAGDLVSVLANKCVDIVNHNTSSGARLIIYECTGN
PNQKWDYR

Specific function: Major serine protease exhibiting lytic activity toward living yeast cells. Similar to elastase in its substrate specificity and has a lectin-like affinity for mannose. Mannoproteins may be the native substrate for RPI [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ricin B-type lectin domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009003
- InterPro:   IPR004236
- InterPro:   IPR001316
- InterPro:   IPR008997
- InterPro:   IPR000772 [H]

Pfam domain/function: PF02983 Pro_Al_protease; PF00652 Ricin_B_lectin [H]

EC number: NA

Molecular weight: Translated: 59676; Mature: 59676

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50231 RICIN_B_LECTIN ; PS00134 TRYPSIN_HIS ; PS00135 TRYPSIN_SER ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVGHTPSPHSPWKSLHPHWHATCSCGLHITPGNPSHSHAQAMSPALAFALQWEHSPSTS
CCCCCCCCCCCCHHHCCCCCCEEEECCEEECCCCCCCHHHHHHCCEEEEEEEECCCCCCH
MNRMSDWLSTAAMFAGLATLTGLPMAAEASSDVSPEIVSAMRRDLGLTEQQVHQRLSFEA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCC
KAPGLEQTMREQLGDAFGGAWLDAEGGQLIVGVTDEARLAKTRVAGVRTVHVARSLARLE
CCCCHHHHHHHHHHHHHCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
QVKAELDQNVQALSPAIHSWYVDLPTNSVVVYVDASSQTKLRADAFIAQSSGLKDGSLRV
HHHHHHHCCHHHHCCCHHEEEEECCCCCEEEEEECCCCCEEHHHHEEECCCCCCCCCEEE
VASTHAPEPAYDLRGGDPYYFSNYRCSVGFPVNGGFVTAGHCGGAGTPTTGHNGVALGTI
EEECCCCCCCCCCCCCCCEEECCEEEEECCCCCCCEEEECCCCCCCCCCCCCCCEEEEEE
RGSVWPGSDYGWVATHGSWTPQPWVNNYSGGNVTVAGSQEAPVNASICRSGYTTGWRCGV
ECCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHCCCCCCEEEEE
LQAKNITVNYSVGPVYGLHKTNACADGGDSGGSVISGNQAQGVTSGVAGTCANGNPPQTF
EEECEEEEEEECCCEECCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCEECCCCCCCHHH
YQPVNPILGAYGLTLRTTGGGGSGRSFVSRLNGKCIDVPNSNFSDGVQLQMWDCNGTNAQ
HHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCCCCCC
RWTFINGTVQAGGKCMDVAWASTANGAAIQLANCSGNPAQQFVLSGAGDLVSVLANKCVD
EEEEEECEECCCCEEEEEEEECCCCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHH
IVNHNTSSGARLIIYECTGNPNQKWDYR
HHCCCCCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MRVGHTPSPHSPWKSLHPHWHATCSCGLHITPGNPSHSHAQAMSPALAFALQWEHSPSTS
CCCCCCCCCCCCHHHCCCCCCEEEECCEEECCCCCCCHHHHHHCCEEEEEEEECCCCCCH
MNRMSDWLSTAAMFAGLATLTGLPMAAEASSDVSPEIVSAMRRDLGLTEQQVHQRLSFEA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCC
KAPGLEQTMREQLGDAFGGAWLDAEGGQLIVGVTDEARLAKTRVAGVRTVHVARSLARLE
CCCCHHHHHHHHHHHHHCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
QVKAELDQNVQALSPAIHSWYVDLPTNSVVVYVDASSQTKLRADAFIAQSSGLKDGSLRV
HHHHHHHCCHHHHCCCHHEEEEECCCCCEEEEEECCCCCEEHHHHEEECCCCCCCCCEEE
VASTHAPEPAYDLRGGDPYYFSNYRCSVGFPVNGGFVTAGHCGGAGTPTTGHNGVALGTI
EEECCCCCCCCCCCCCCCEEECCEEEEECCCCCCCEEEECCCCCCCCCCCCCCCEEEEEE
RGSVWPGSDYGWVATHGSWTPQPWVNNYSGGNVTVAGSQEAPVNASICRSGYTTGWRCGV
ECCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHCCCCCCEEEEE
LQAKNITVNYSVGPVYGLHKTNACADGGDSGGSVISGNQAQGVTSGVAGTCANGNPPQTF
EEECEEEEEEECCCEECCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCEECCCCCCCHHH
YQPVNPILGAYGLTLRTTGGGGSGRSFVSRLNGKCIDVPNSNFSDGVQLQMWDCNGTNAQ
HHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCCCCCC
RWTFINGTVQAGGKCMDVAWASTANGAAIQLANCSGNPAQQFVLSGAGDLVSVLANKCVD
EEEEEECEECCCCEEEEEEEECCCCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHH
IVNHNTSSGARLIIYECTGNPNQKWDYR
HHCCCCCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339445; 1778983 [H]