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The map label for this gene is blh [H]

Identifier: 108757180

GI number: 108757180

Start: 5317585

End: 5318286

Strand: Direct

Name: blh [H]

Synonym: MXAN_4319

Alternate gene names: 108757180

Gene position: 5317585-5318286 (Clockwise)

Preceding gene: 108757111

Following gene: 108757932

Centisome position: 58.18

GC content: 68.23

Gene sequence:

>702_bases
ATGATTTTCCGGCAGCTTTTCGATTCCGAGTCCTCGACGTACACGTACCTCATCGGCGACGAGGCCACGCGCCAGGCCGT
CCTCATCGACCCCGTGCTGGAGCAGGTCGACCGCGACCTGCAAATGGTGGCCGAGCTGGACCTCACCCTCACCCACGTCT
TCGACACCCACGTCCACGCCGACCACATCACCGCATCGGGCGCGCTGCGGGAGCGCACGCAGGCCACGGTGGTGGGGAGC
GTGAACGGCGCCAGTTGCGCCAACGTCCAGGTCCGCCACGGGGACGAGGTGCGCGTCGGGCAGCTCGTCTTCCAGGTGCT
CGCCACCCCGGGGCACACGGACGACAGCATCAGCTACCTGCTCGGCGACCGCGTCTTCACCGGGGATGCGCTGCTCGTGC
GCGGCAACGGCCGCACCGACTTCCAGAACGGGAACGCGAGCCAGCTCTACGACAGCCTCACGCGCGTCCTCTTCACCCTC
CCCGATGAGACGCTCGTCTACCCCGGCCACGACTACAAGGGCCGCACGGTGACGAGCATCGCCGAGGAGAAGCGGCACAA
CCCTCGCGTGGCCGGCAAGAGCCGGGAGGAGTTCATCCACATCATGGAGAACCTCAACCTGCCCAGGCCCAAGCTGATTG
ACGCCGCCGTCCCGGCCAACCGCGCCTGTGGGCACACGGCGCCCTCACCCCAGGGGGCCTGA

Upstream 100 bases:

>100_bases
CAGGCTCCAAAGAAAGGATTCAGCAGGGCCTGAGAATGGATTCAGCAGGGCCTGAATCCTTCTTCCACGCCCCGGCCTCT
CATGGACAGGAGGCTTCGAC

Downstream 100 bases:

>100_bases
GTCCCCTGGCCACTTCGCAGGAGTCCCGACCATGACACTCCGCCCCTATCAGGACATCACGCCCTCGCAGCTCGACACGC
TCGGCCCCGAGGTGCGGCGC

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MIFRQLFDSESSTYTYLIGDEATRQAVLIDPVLEQVDRDLQMVAELDLTLTHVFDTHVHADHITASGALRERTQATVVGS
VNGASCANVQVRHGDEVRVGQLVFQVLATPGHTDDSISYLLGDRVFTGDALLVRGNGRTDFQNGNASQLYDSLTRVLFTL
PDETLVYPGHDYKGRTVTSIAEEKRHNPRVAGKSREEFIHIMENLNLPRPKLIDAAVPANRACGHTAPSPQGA

Sequences:

>Translated_233_residues
MIFRQLFDSESSTYTYLIGDEATRQAVLIDPVLEQVDRDLQMVAELDLTLTHVFDTHVHADHITASGALRERTQATVVGS
VNGASCANVQVRHGDEVRVGQLVFQVLATPGHTDDSISYLLGDRVFTGDALLVRGNGRTDFQNGNASQLYDSLTRVLFTL
PDETLVYPGHDYKGRTVTSIAEEKRHNPRVAGKSREEFIHIMENLNLPRPKLIDAAVPANRACGHTAPSPQGA
>Mature_233_residues
MIFRQLFDSESSTYTYLIGDEATRQAVLIDPVLEQVDRDLQMVAELDLTLTHVFDTHVHADHITASGALRERTQATVVGS
VNGASCANVQVRHGDEVRVGQLVFQVLATPGHTDDSISYLLGDRVFTGDALLVRGNGRTDFQNGNASQLYDSLTRVLFTL
PDETLVYPGHDYKGRTVTSIAEEKRHNPRVAGKSREEFIHIMENLNLPRPKLIDAAVPANRACGHTAPSPQGA

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=233, Percent_Identity=48.9270386266094, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI46361987, Length=167, Percent_Identity=37.125748502994, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI14150041, Length=167, Percent_Identity=37.125748502994, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI94538320, Length=176, Percent_Identity=31.8181818181818, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI94538322, Length=214, Percent_Identity=29.4392523364486, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI116642887, Length=172, Percent_Identity=38.3720930232558, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI21703352, Length=172, Percent_Identity=38.3720930232558, Blast_Score=81, Evalue=8e-16,
Organism=Escherichia coli, GI1786406, Length=161, Percent_Identity=35.4037267080745, Blast_Score=64, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17538952, Length=227, Percent_Identity=47.136563876652, Blast_Score=204, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17536925, Length=183, Percent_Identity=30.0546448087432, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320478, Length=201, Percent_Identity=27.8606965174129, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324614, Length=190, Percent_Identity=28.4210526315789, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221330176, Length=227, Percent_Identity=52.863436123348, Blast_Score=243, Evalue=8e-65,
Organism=Drosophila melanogaster, GI24667703, Length=168, Percent_Identity=35.1190476190476, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24667711, Length=168, Percent_Identity=35.1190476190476, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21356335, Length=168, Percent_Identity=35.1190476190476, Blast_Score=88, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005939
- InterPro:   IPR001279 [H]

Pfam domain/function: PF04273 DUF442; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 25589; Mature: 25589

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFRQLFDSESSTYTYLIGDEATRQAVLIDPVLEQVDRDLQMVAELDLTLTHVFDTHVHA
CCHHHHHCCCCCEEEEEECCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHEEHHHCCCCC
DHITASGALRERTQATVVGSVNGASCANVQVRHGDEVRVGQLVFQVLATPGHTDDSISYL
CCEECCCHHHHCCCEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHH
LGDRVFTGDALLVRGNGRTDFQNGNASQLYDSLTRVLFTLPDETLVYPGHDYKGRTVTSI
HCCEEEECCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHH
AEEKRHNPRVAGKSREEFIHIMENLNLPRPKLIDAAVPANRACGHTAPSPQGA
HHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIFRQLFDSESSTYTYLIGDEATRQAVLIDPVLEQVDRDLQMVAELDLTLTHVFDTHVHA
CCHHHHHCCCCCEEEEEECCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHEEHHHCCCCC
DHITASGALRERTQATVVGSVNGASCANVQVRHGDEVRVGQLVFQVLATPGHTDDSISYL
CCEECCCHHHHCCCEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHH
LGDRVFTGDALLVRGNGRTDFQNGNASQLYDSLTRVLFTLPDETLVYPGHDYKGRTVTSI
HCCEEEECCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHH
AEEKRHNPRVAGKSREEFIHIMENLNLPRPKLIDAAVPANRACGHTAPSPQGA
HHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]