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The map label for this gene is degP [H]

Identifier: 108757100

GI number: 108757100

Start: 2417226

End: 2418485

Strand: Reverse

Name: degP [H]

Synonym: MXAN_2084

Alternate gene names: 108757100

Gene position: 2418485-2417226 (Counterclockwise)

Preceding gene: 108759646

Following gene: 108761829

Centisome position: 26.46

GC content: 70.95

Gene sequence:

>1260_bases
ATGGGCAGGGCGCGAGGCAAGAGTGTCATCCTGTTCGCCGCGCTGGTGTGCGCGCTGGTGCTGCCAGCGCAAGCCACCGG
CCGCGAGCGAAATCGGTTGTGGGTGGAGTCACAGAACCGCGCCCTCCAGAAGCAACGCTCCACGCTGAGCGACGTCGCCC
GGCGCGCCATGCCCGCCGTGGTGTCCATCACCACACAGCAGGCTGCCGACGTGCAGGCCGTCGCCGCTGGAGAAGAAGCG
CAGAAGGGCATCGGCTCCGGCTTCATCATCCATCCGGACGGCTACATCCTCACCAGCGCGCACGTGGTGGAGGGCGCGGC
GGAGGTCATCGTCTCCGTCCTGCACCCGCGCGGCTACGTGGAGGAGTTCGAGGCCATCGTGGTGGGCGAGGACGCCCGCA
CCGACTGCGCGCTGCTGAAAATCGCCGCGCCCCGCAAGCTGCCCGTGCTGAAACTGGCCTCCGCGTCGCACGTGCGCTCG
GCGGATTGGATTGTCGTCATCGGCAACCCGTTCGGGCTGACCCACTCGGTGACGGTGGGCGTGGTCAGCTACATGGGCCG
CACGGACGTGACGCCCAACGGGCGCGACGGCGACTTCGACTACATGCAGATGGACGCCTCCATCAACCCGGGCAACTCCG
GTGGGCCGGTGTTGGACCTGCACGGTGACGTGGTGGCGGTGGCCAACGCGGTCAACGTTGCGGGCCAGGGCATCGGCTTC
GCCATCCCCATCGACATCGCGAAGACGGTGATTCCGCACCTCAAGTCCCACGGCCGCGTGCGCCGCGGATGGCTGGGCAT
GAGCGTGCAGGACTTCTCTCCGGAGGTGGCCGAGGCCTTCAACCTGCGGCGCGGCCGCGGGGTGGTGGTGACGGACATCG
TCGAAGGCGGCCCGGCCGAGCGCGCGGGCCTGCAGGTGGGCGACGTCATCGTCAGGGTGGACCAGCGGAGCGTGCGCCGG
GCGCATGCGCTGCGCTGGCAGGTGGCCGCCCGGGGCGTGGGCCGCGACGTGAAGTTCCAGGTCCACCGGTTGGGGCGCCC
GATGAAGCTGACCCTGAAGCTGGACGAGATGCCCTCCGAGGAGACGCCCCTGCCCACCGTGGCGAGCACCGCGCCTGGGC
GGCACGCGGGGGCCCCTCAGCCGGTGTTGGACGACCTGCTGTCGCCGGTGCCCCGCTCGAAGGGCCGCCGGGCGACTCCG
CCCTCCGGGGAAGCAGCCCCCGGGACGGGGGGTTCTGGACAAGACGCCCCCGCGCCCTGA

Upstream 100 bases:

>100_bases
ATCGCGCAGAAGAAGTAGTTCGCCTCCGGGCCCGCTTCCCCTGGCCTCCCCTCCTCCTTAGGTTGCACGGGAGGCGGCTG
GTCGGGGTGGAGGCGGGGCC

Downstream 100 bases:

>100_bases
AGTCCGGACGGGTCCGCGCTGAACCCTGGTTTCCCGGGCTCCTTGCGTTCGAGTGTCATGGGCGCTAGACAGTGCGCCTT
TTTCCGTACCCTTGCGGCGG

Product: S1C family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MGRARGKSVILFAALVCALVLPAQATGRERNRLWVESQNRALQKQRSTLSDVARRAMPAVVSITTQQAADVQAVAAGEEA
QKGIGSGFIIHPDGYILTSAHVVEGAAEVIVSVLHPRGYVEEFEAIVVGEDARTDCALLKIAAPRKLPVLKLASASHVRS
ADWIVVIGNPFGLTHSVTVGVVSYMGRTDVTPNGRDGDFDYMQMDASINPGNSGGPVLDLHGDVVAVANAVNVAGQGIGF
AIPIDIAKTVIPHLKSHGRVRRGWLGMSVQDFSPEVAEAFNLRRGRGVVVTDIVEGGPAERAGLQVGDVIVRVDQRSVRR
AHALRWQVAARGVGRDVKFQVHRLGRPMKLTLKLDEMPSEETPLPTVASTAPGRHAGAPQPVLDDLLSPVPRSKGRRATP
PSGEAAPGTGGSGQDAPAP

Sequences:

>Translated_419_residues
MGRARGKSVILFAALVCALVLPAQATGRERNRLWVESQNRALQKQRSTLSDVARRAMPAVVSITTQQAADVQAVAAGEEA
QKGIGSGFIIHPDGYILTSAHVVEGAAEVIVSVLHPRGYVEEFEAIVVGEDARTDCALLKIAAPRKLPVLKLASASHVRS
ADWIVVIGNPFGLTHSVTVGVVSYMGRTDVTPNGRDGDFDYMQMDASINPGNSGGPVLDLHGDVVAVANAVNVAGQGIGF
AIPIDIAKTVIPHLKSHGRVRRGWLGMSVQDFSPEVAEAFNLRRGRGVVVTDIVEGGPAERAGLQVGDVIVRVDQRSVRR
AHALRWQVAARGVGRDVKFQVHRLGRPMKLTLKLDEMPSEETPLPTVASTAPGRHAGAPQPVLDDLLSPVPRSKGRRATP
PSGEAAPGTGGSGQDAPAP
>Mature_418_residues
GRARGKSVILFAALVCALVLPAQATGRERNRLWVESQNRALQKQRSTLSDVARRAMPAVVSITTQQAADVQAVAAGEEAQ
KGIGSGFIIHPDGYILTSAHVVEGAAEVIVSVLHPRGYVEEFEAIVVGEDARTDCALLKIAAPRKLPVLKLASASHVRSA
DWIVVIGNPFGLTHSVTVGVVSYMGRTDVTPNGRDGDFDYMQMDASINPGNSGGPVLDLHGDVVAVANAVNVAGQGIGFA
IPIDIAKTVIPHLKSHGRVRRGWLGMSVQDFSPEVAEAFNLRRGRGVVVTDIVEGGPAERAGLQVGDVIVRVDQRSVRRA
HALRWQVAARGVGRDVKFQVHRLGRPMKLTLKLDEMPSEETPLPTVASTAPGRHAGAPQPVLDDLLSPVPRSKGRRATPP
SGEAAPGTGGSGQDAPAP

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=295, Percent_Identity=33.5593220338983, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI24308541, Length=245, Percent_Identity=35.5102040816327, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI22129776, Length=294, Percent_Identity=31.9727891156463, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI7019477, Length=290, Percent_Identity=32.7586206896552, Blast_Score=129, Evalue=4e-30,
Organism=Escherichia coli, GI1789629, Length=327, Percent_Identity=34.2507645259939, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1786356, Length=277, Percent_Identity=35.0180505415162, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1789630, Length=354, Percent_Identity=31.638418079096, Blast_Score=165, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24646839, Length=254, Percent_Identity=33.4645669291339, Blast_Score=136, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 44237; Mature: 44106

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRARGKSVILFAALVCALVLPAQATGRERNRLWVESQNRALQKQRSTLSDVARRAMPAV
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCE
VSITTQQAADVQAVAAGEEAQKGIGSGFIIHPDGYILTSAHVVEGAAEVIVSVLHPRGYV
EEEECHHHHCHHHHHCCHHHHHCCCCCEEECCCCEEEECHHHHHHHHHHHHHHHCCCCCH
EEFEAIVVGEDARTDCALLKIAAPRKLPVLKLASASHVRSADWIVVIGNPFGLTHSVTVG
HHCCEEEECCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCHHHHHH
VVSYMGRTDVTPNGRDGDFDYMQMDASINPGNSGGPVLDLHGDVVAVANAVNVAGQGIGF
HHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEECCCEEEEHHHHHHCCCCCCE
AIPIDIAKTVIPHLKSHGRVRRGWLGMSVQDFSPEVAEAFNLRRGRGVVVTDIVEGGPAE
EEEHHHHHHHHHHHHHCCCEEECEECCCHHHCCHHHHHHHHCCCCCCEEEEEECCCCCCH
RAGLQVGDVIVRVDQRSVRRAHALRWQVAARGVGRDVKFQVHRLGRPMKLTLKLDEMPSE
HCCCEECCEEEEECHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEEECCCCCC
ETPLPTVASTAPGRHAGAPQPVLDDLLSPVPRSKGRRATPPSGEAAPGTGGSGQDAPAP
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GRARGKSVILFAALVCALVLPAQATGRERNRLWVESQNRALQKQRSTLSDVARRAMPAV
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCE
VSITTQQAADVQAVAAGEEAQKGIGSGFIIHPDGYILTSAHVVEGAAEVIVSVLHPRGYV
EEEECHHHHCHHHHHCCHHHHHCCCCCEEECCCCEEEECHHHHHHHHHHHHHHHCCCCCH
EEFEAIVVGEDARTDCALLKIAAPRKLPVLKLASASHVRSADWIVVIGNPFGLTHSVTVG
HHCCEEEECCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCHHHHHH
VVSYMGRTDVTPNGRDGDFDYMQMDASINPGNSGGPVLDLHGDVVAVANAVNVAGQGIGF
HHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEECCCEEEEHHHHHHCCCCCCE
AIPIDIAKTVIPHLKSHGRVRRGWLGMSVQDFSPEVAEAFNLRRGRGVVVTDIVEGGPAE
EEEHHHHHHHHHHHHHCCCEEECEECCCHHHCCHHHHHHHHCCCCCCEEEEEECCCCCCH
RAGLQVGDVIVRVDQRSVRRAHALRWQVAARGVGRDVKFQVHRLGRPMKLTLKLDEMPSE
HCCCEECCEEEEECHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEEECCCCCC
ETPLPTVASTAPGRHAGAPQPVLDDLLSPVPRSKGRRATPPSGEAAPGTGGSGQDAPAP
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]