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The map label for this gene is trxC [H]

Identifier: 108757067

GI number: 108757067

Start: 2608714

End: 2611011

Strand: Direct

Name: trxC [H]

Synonym: MXAN_2256

Alternate gene names: 108757067

Gene position: 2608714-2611011 (Clockwise)

Preceding gene: 108759059

Following gene: 108763750

Centisome position: 28.54

GC content: 68.19

Gene sequence:

>2298_bases
TTGGCAGGACAGACCGTTGAGTTGACCCAGGAGAACTTCGAGCGCATCACCCAGGAGGCCGGGGTGTGCGTGGTGGACTT
CTGGGCGGAGTGGTGTGGTCCCTGCCGCGGCTTCGCGCCGACCTTCGAGGCCGCCGCGAAGGAGTTCCCGAACATCACCT
TCGGCAAGCTCGATACGGAGGCGCAGGAAGAGGTCTCCGGCCGGATGGAGATTCGCTCCATTCCCACGCTGGTGGCCTTC
AAGGATGGCGTCGAGGTCCGGCGCGCCTCGGGCGCGATGTCGGCCTCGGCGTTCGCGACCTGGCTGAGCAAGCTGGACTC
CGTGGACCTGGCCGTCGAGCAGCAGCGGGCGGCGAACCGCAAGCTGACGGAGGAGGGGACGCCGCCGCCTGGCATTCCGC
CCCACGCGGAATGGGACGCCGGAGACGAGGAGTGGTGCTCCGGCGACACCGACGAGGAGGGTGAGAAGCACGGCCCCTGG
AAGTACTGGCGCGCGGATGGAACCCTCTGCAACGAGTGCATCTTCGTCCACGGCAAGCCCCACGGCCCCTTCAAGCGCTT
CCATGAGAGCGGAGAGGTGTCCCAGGATGGCGCGTTCGAGCAGGGCAATCTGCACGGCCCGCGCACCTGGTACGCGTCCG
ACCAATTCACCACCGAGCGGATGCATGAGAACGGCGTCAGCGAGAAGGTCCGCCGCACGGTGATGGTCTACGCGAACGGC
CGCGTGACGCAGGTGCTGCACTACAATGGCGCCGGCGAACGCGTGGTGCCCTCCACCGGAGAGCCGTACCCCACGCGGCC
CGCGAACCTCCCCGAGAAGGCTGAGTACCGCGAGGACCAGGACCAGTGGGCGTCCGTGTCGCTCAACGCGAAGGCCGAGC
GGCACGGGCTGTGCCGATTCTGGGACCGGGAGGGGCAGCTCCTCTGGGAGTGCGAATTCCACGAAGGCAGCCGGCATGGC
CGCTATCACTCCCGCGCCGTGGACGAGTACGCGGACCCTCGGGTGCGGTTCGACGAAGGGGAGATGGAGGACGACTTCGC
GTGCGGCACGTGGAAGTTGCTGGATGCGGAGGGCAACGCTGTCGTCACCCGGGACCTGGGCGTTGTCCAGGACCACGAGA
CGTTGGATGCCTCGGAGGTGTTCTCGAACCTTCCGAGGAGCGCCGCTGAATGGCGTGCGTTCGCCGAGCAGGCTCGGGCG
GACCGGCGATACCGGGAGGCGCTGCTGGCCATGGCGCGGGCAAGCGCCGTGTCGCTGGATGCGGGCCCGCTGAAGGCATG
GCTCGAGTCGCTCACCCTGCCTCGAACGGAGGCGAGTGCTCGCGAGAATGCCGAAGGCGTGATGAACAGCGCGGGGGATG
AGCGGGCGGCGTTGGCGGATGCGATGATGCGTGGCGCGGAGGCCGCGATGTTGCTTCGGGGCTTCGCGGTGCTCCACGAC
CAGCAGGACCGGCCCCGGGCGGCGTTGGACTTCATCCTGGCCGCGATGCTGCTCGCGCCGGAGCGCTCGGCGTACCTGTT
CACTCGGAGCCTCATCCTGGCGAACCTGGGGCTGGGCGAGCAGATGCAGAAGGACGCGGAGGCGCTGGCGCCGGCGGAGC
CGGATTCGTGGAAGTTCCTCTCGGCTTACCGGCGGGTGCTGTTTCCGCGCTTCGAGTTCTGGCCGGGACGTGAGCCCGCG
CACTGCACGTTCGATGAGGTCCCCGACGGGCCCACGAAGGAGCTGGACGCGGTGCAGGCCGTGGTCCGCAAGTACGCCAC
TCGACTCCAGTTGCTGCGCGCGGAGATTCTCTCCCGCTTCAAGCCCGGCACGAACGTGCCCTGGCTGCCGCCCGATGTGT
CGTCCTTGCTGCCGGACGGGCCCGTCGAACTGGAGCAGACGGAGGTCGAGGACGCGGATGGTGACTCGGTGGATGTCGAC
GAGACGCTGTCCACGAAGGGGATGGGGATTCCGGCCTTGTCCCGTGCGGCCCGTGGAGACTGGAGCGCGCTGACCTGGCT
CTTGTGGGCGTGCGGGGTGGATTCGATTCGGATGCCGGATGCGCTGACGCCTCCGGCCGACTTCGGTCAGGCCGCGGGAC
AGGCCACGCAGCGGCTGTGGCAGTGCCGCAACCGGCGGTCCCGTGGTCGCATCGACCCGGACCTGCCAACGTTCGATTTC
GAAGGGGTTGCCCTCCAGGAGCTGCATCCCAATCTGGCGGGGATTGCCGAAGAGCAGTACGCGGAGACGCAGGCGATGTT
CTTCTGGCTGACCGACGCGAACCACGTGTCTCCGTGGCAGGCCAATCTGAGGGGGTAG

Upstream 100 bases:

>100_bases
GCGGTGTTCGAGCGTCGCGTGTGCCGTTCGTGAACTGCACCGTTGACGTGAGGGCCCTCGCTCATTTCTATCGTCCCACG
CATCTCGCGAGGGAGTCGCC

Downstream 100 bases:

>100_bases
TCATGAAGCGGATTCGTCAGACGATTGAAGTCTCCGAGCCCCTGTGGCGGGCGCTGGAATTGATGAGCCGCGACATGGGC
GTGGACCGGGATGCGCTGGT

Product: putative thioredoxin

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 765; Mature: 764

Protein sequence:

>765_residues
MAGQTVELTQENFERITQEAGVCVVDFWAEWCGPCRGFAPTFEAAAKEFPNITFGKLDTEAQEEVSGRMEIRSIPTLVAF
KDGVEVRRASGAMSASAFATWLSKLDSVDLAVEQQRAANRKLTEEGTPPPGIPPHAEWDAGDEEWCSGDTDEEGEKHGPW
KYWRADGTLCNECIFVHGKPHGPFKRFHESGEVSQDGAFEQGNLHGPRTWYASDQFTTERMHENGVSEKVRRTVMVYANG
RVTQVLHYNGAGERVVPSTGEPYPTRPANLPEKAEYREDQDQWASVSLNAKAERHGLCRFWDREGQLLWECEFHEGSRHG
RYHSRAVDEYADPRVRFDEGEMEDDFACGTWKLLDAEGNAVVTRDLGVVQDHETLDASEVFSNLPRSAAEWRAFAEQARA
DRRYREALLAMARASAVSLDAGPLKAWLESLTLPRTEASARENAEGVMNSAGDERAALADAMMRGAEAAMLLRGFAVLHD
QQDRPRAALDFILAAMLLAPERSAYLFTRSLILANLGLGEQMQKDAEALAPAEPDSWKFLSAYRRVLFPRFEFWPGREPA
HCTFDEVPDGPTKELDAVQAVVRKYATRLQLLRAEILSRFKPGTNVPWLPPDVSSLLPDGPVELEQTEVEDADGDSVDVD
ETLSTKGMGIPALSRAARGDWSALTWLLWACGVDSIRMPDALTPPADFGQAAGQATQRLWQCRNRRSRGRIDPDLPTFDF
EGVALQELHPNLAGIAEEQYAETQAMFFWLTDANHVSPWQANLRG

Sequences:

>Translated_765_residues
MAGQTVELTQENFERITQEAGVCVVDFWAEWCGPCRGFAPTFEAAAKEFPNITFGKLDTEAQEEVSGRMEIRSIPTLVAF
KDGVEVRRASGAMSASAFATWLSKLDSVDLAVEQQRAANRKLTEEGTPPPGIPPHAEWDAGDEEWCSGDTDEEGEKHGPW
KYWRADGTLCNECIFVHGKPHGPFKRFHESGEVSQDGAFEQGNLHGPRTWYASDQFTTERMHENGVSEKVRRTVMVYANG
RVTQVLHYNGAGERVVPSTGEPYPTRPANLPEKAEYREDQDQWASVSLNAKAERHGLCRFWDREGQLLWECEFHEGSRHG
RYHSRAVDEYADPRVRFDEGEMEDDFACGTWKLLDAEGNAVVTRDLGVVQDHETLDASEVFSNLPRSAAEWRAFAEQARA
DRRYREALLAMARASAVSLDAGPLKAWLESLTLPRTEASARENAEGVMNSAGDERAALADAMMRGAEAAMLLRGFAVLHD
QQDRPRAALDFILAAMLLAPERSAYLFTRSLILANLGLGEQMQKDAEALAPAEPDSWKFLSAYRRVLFPRFEFWPGREPA
HCTFDEVPDGPTKELDAVQAVVRKYATRLQLLRAEILSRFKPGTNVPWLPPDVSSLLPDGPVELEQTEVEDADGDSVDVD
ETLSTKGMGIPALSRAARGDWSALTWLLWACGVDSIRMPDALTPPADFGQAAGQATQRLWQCRNRRSRGRIDPDLPTFDF
EGVALQELHPNLAGIAEEQYAETQAMFFWLTDANHVSPWQANLRG
>Mature_764_residues
AGQTVELTQENFERITQEAGVCVVDFWAEWCGPCRGFAPTFEAAAKEFPNITFGKLDTEAQEEVSGRMEIRSIPTLVAFK
DGVEVRRASGAMSASAFATWLSKLDSVDLAVEQQRAANRKLTEEGTPPPGIPPHAEWDAGDEEWCSGDTDEEGEKHGPWK
YWRADGTLCNECIFVHGKPHGPFKRFHESGEVSQDGAFEQGNLHGPRTWYASDQFTTERMHENGVSEKVRRTVMVYANGR
VTQVLHYNGAGERVVPSTGEPYPTRPANLPEKAEYREDQDQWASVSLNAKAERHGLCRFWDREGQLLWECEFHEGSRHGR
YHSRAVDEYADPRVRFDEGEMEDDFACGTWKLLDAEGNAVVTRDLGVVQDHETLDASEVFSNLPRSAAEWRAFAEQARAD
RRYREALLAMARASAVSLDAGPLKAWLESLTLPRTEASARENAEGVMNSAGDERAALADAMMRGAEAAMLLRGFAVLHDQ
QDRPRAALDFILAAMLLAPERSAYLFTRSLILANLGLGEQMQKDAEALAPAEPDSWKFLSAYRRVLFPRFEFWPGREPAH
CTFDEVPDGPTKELDAVQAVVRKYATRLQLLRAEILSRFKPGTNVPWLPPDVSSLLPDGPVELEQTEVEDADGDSVDVDE
TLSTKGMGIPALSRAARGDWSALTWLLWACGVDSIRMPDALTPPADFGQAAGQATQRLWQCRNRRSRGRIDPDLPTFDFE
GVALQELHPNLAGIAEEQYAETQAMFFWLTDANHVSPWQANLRG

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4758304, Length=83, Percent_Identity=38.5542168674699, Blast_Score=74, Evalue=6e-13,
Organism=Homo sapiens, GI21361657, Length=104, Percent_Identity=37.5, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1788936, Length=103, Percent_Identity=42.7184466019417, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=34.6153846153846, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=96, Percent_Identity=39.5833333333333, Blast_Score=74, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193209454, Length=105, Percent_Identity=32.3809523809524, Blast_Score=70, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=105, Percent_Identity=32.3809523809524, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17569137, Length=105, Percent_Identity=32.3809523809524, Blast_Score=69, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=88, Percent_Identity=37.5, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=73, Percent_Identity=43.8356164383562, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI18859803, Length=126, Percent_Identity=31.7460317460317, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 85303; Mature: 85171

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGQTVELTQENFERITQEAGVCVVDFWAEWCGPCRGFAPTFEAAAKEFPNITFGKLDTE
CCCCEEHHHHHHHHHHHHHCCCEEEEHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCH
AQEEVSGRMEIRSIPTLVAFKDGVEVRRASGAMSASAFATWLSKLDSVDLAVEQQRAANR
HHHHHHCCEEHHHCCEEEEECCCHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCC
KLTEEGTPPPGIPPHAEWDAGDEEWCSGDTDEEGEKHGPWKYWRADGTLCNECIFVHGKP
CCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEEECCCCEECCEEEEECCC
HGPFKRFHESGEVSQDGAFEQGNLHGPRTWYASDQFTTERMHENGVSEKVRRTVMVYANG
CCHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHCCHHHHHHEEEEEEECC
RVTQVLHYNGAGERVVPSTGEPYPTRPANLPEKAEYREDQDQWASVSLNAKAERHGLCRF
CEEEEEEECCCCCEECCCCCCCCCCCCCCCCCHHHHCCCCHHHEEEEECCCHHHCCCHHE
WDREGQLLWECEFHEGSRHGRYHSRAVDEYADPRVRFDEGEMEDDFACGTWKLLDAEGNA
ECCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCCCCEEEEEECCCCE
VVTRDLGVVQDHETLDASEVFSNLPRSAAEWRAFAEQARADRRYREALLAMARASAVSLD
EEEECCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AGPLKAWLESLTLPRTEASARENAEGVMNSAGDERAALADAMMRGAEAAMLLRGFAVLHD
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
QQDRPRAALDFILAAMLLAPERSAYLFTRSLILANLGLGEQMQKDAEALAPAEPDSWKFL
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHH
SAYRRVLFPRFEFWPGREPAHCTFDEVPDGPTKELDAVQAVVRKYATRLQLLRAEILSRF
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KPGTNVPWLPPDVSSLLPDGPVELEQTEVEDADGDSVDVDETLSTKGMGIPALSRAARGD
CCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHCCC
WSALTWLLWACGVDSIRMPDALTPPADFGQAAGQATQRLWQCRNRRSRGRIDPDLPTFDF
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
EGVALQELHPNLAGIAEEQYAETQAMFFWLTDANHVSPWQANLRG
CCCCHHHHCCCHHHHHHHHHHCCEEEEEEEECCCCCCCCHHCCCC
>Mature Secondary Structure 
AGQTVELTQENFERITQEAGVCVVDFWAEWCGPCRGFAPTFEAAAKEFPNITFGKLDTE
CCCEEHHHHHHHHHHHHHCCCEEEEHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCH
AQEEVSGRMEIRSIPTLVAFKDGVEVRRASGAMSASAFATWLSKLDSVDLAVEQQRAANR
HHHHHHCCEEHHHCCEEEEECCCHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCC
KLTEEGTPPPGIPPHAEWDAGDEEWCSGDTDEEGEKHGPWKYWRADGTLCNECIFVHGKP
CCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEEECCCCEECCEEEEECCC
HGPFKRFHESGEVSQDGAFEQGNLHGPRTWYASDQFTTERMHENGVSEKVRRTVMVYANG
CCHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHCCHHHHHHEEEEEEECC
RVTQVLHYNGAGERVVPSTGEPYPTRPANLPEKAEYREDQDQWASVSLNAKAERHGLCRF
CEEEEEEECCCCCEECCCCCCCCCCCCCCCCCHHHHCCCCHHHEEEEECCCHHHCCCHHE
WDREGQLLWECEFHEGSRHGRYHSRAVDEYADPRVRFDEGEMEDDFACGTWKLLDAEGNA
ECCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCCCCEEEEEECCCCE
VVTRDLGVVQDHETLDASEVFSNLPRSAAEWRAFAEQARADRRYREALLAMARASAVSLD
EEEECCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AGPLKAWLESLTLPRTEASARENAEGVMNSAGDERAALADAMMRGAEAAMLLRGFAVLHD
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
QQDRPRAALDFILAAMLLAPERSAYLFTRSLILANLGLGEQMQKDAEALAPAEPDSWKFL
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHH
SAYRRVLFPRFEFWPGREPAHCTFDEVPDGPTKELDAVQAVVRKYATRLQLLRAEILSRF
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KPGTNVPWLPPDVSSLLPDGPVELEQTEVEDADGDSVDVDETLSTKGMGIPALSRAARGD
CCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHCCC
WSALTWLLWACGVDSIRMPDALTPPADFGQAAGQATQRLWQCRNRRSRGRIDPDLPTFDF
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
EGVALQELHPNLAGIAEEQYAETQAMFFWLTDANHVSPWQANLRG
CCCCHHHHCCCHHHHHHHHHHCCEEEEEEEECCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]