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The map label for this gene is comEC [H]

Identifier: 108757009

GI number: 108757009

Start: 7088072

End: 7089268

Strand: Direct

Name: comEC [H]

Synonym: MXAN_5720

Alternate gene names: 108757009

Gene position: 7088072-7089268 (Clockwise)

Preceding gene: 108759974

Following gene: 108763415

Centisome position: 77.55

GC content: 71.35

Gene sequence:

>1197_bases
ATGTCCTTTGCCCGGTGGCTCGCACTCCTCGTCCTTCTCCTCGCCTCGGTTCCGGGCCAGGCCCTGGCCCAATCCGCCGG
CCAGCCGCTCACGGTGCATTTCTTCGACGTGGGACAGGGGGACGCCGCGCTCATCATCTCCCCCACCGGCAAGACGGTGC
TCATCGACAGCGGCCCGCCCGACGCGCGGCACCGCCTGGAGCAGCGGCTGCGGGAGTTGGTGAAGGAGCCGCTGGACCTC
GCCATCCTCACGCACCCCCACCTGGACCACCTGGGAGGCATGTCCACCGCGCTGCGCTCGGTGGGGGCCCGGCGCTTCAT
GGACCCGGGGTTCGACCACCCGAGCGAGGCGTACCGCGACCTGCTCAACGTCGTGGGCGACGAAGTGGGCCAGGTGATGA
CGCCCGTTCCCAACCCCCAGGACCCGCGCTCCCTGGTCACCATTGGCCTGGGGGATGGCGCGGCGCTCACCGTGCTGTGG
CCTCGCGTGCCGGAAGATCCCTTCCTCACGGGCACCCGCTCGGACCCGAACTCCAACTCCATCGTCGCCAAGCTGACCTA
CGGCAAGACGGCGTTCCTCTTCACCGGCGACGCCGAGCCGGATACCGAGGCCACGCTGCTACGCAAGCCCATCGACCTCA
CGTCCACCGTGCTGAAGGTGGCCCACCACGGCGGGCGGCACTCGTCCACCGCGGACTTCCTGGCCGCGGTGAAGCCCCAA
GCCGCCGTCATCTCCGTGGGCGCGAAGAACGACTACGGCCACCCCACCTCCGCGGTGCTGGAGCGGCTGCGCGCGGTGAA
GGCCACCGTGTTCCGCACCGACCAGGACGGCGAGGTGGTGGCGACCAGCGACGGCAACGTCGTCTCCCTGCGCGCGGAGA
AGCGCGGAGGGGCGTCGGAGCTGGTTCCCGGAGGCGTGAAGCCCGGCTCGGTCGCGCTCGGGCCCATCACCCGGGGAACG
CGCCGGACCAGCACGCCCCGTGGGCGCGGCGCCGCGTCCGCCCCGGCGGAGGCCCCCGGCACCGACTCCACGCAACGCGA
CACGGACGCGCCCCGATACTTCAGCCTCAAGGGCAGCAAGGTGTTTCACAAAGAGAGCTGCCGGACCCTGAAGCGCTCCA
AGTCGGACCGCACCGCCTATTCGAGCCGCGCCGAAGCCATGCGCGAGCGCCGCCCCGCCGAGGACTGCCACCCATGA

Upstream 100 bases:

>100_bases
GCCCACTTCCAGGCCCTCGGGAAGCGCTCGCGGGAGAAGCGCGCATCATCGGTGCCCCTGGGTGCCAGGGGGGGGACGGA
GCGGTAGAGTCCGCCTCGTG

Downstream 100 bases:

>100_bases
GCTTCCGCCCGCGCGTCCTCCTCCCTGTCCTGCTGGCACTGGCCGCCTGCAAGGAATCACCGCCACCTCCCCCGCAGCCG
GTAGCCACGCGACCGGCGGA

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSFARWLALLVLLLASVPGQALAQSAGQPLTVHFFDVGQGDAALIISPTGKTVLIDSGPPDARHRLEQRLRELVKEPLDL
AILTHPHLDHLGGMSTALRSVGARRFMDPGFDHPSEAYRDLLNVVGDEVGQVMTPVPNPQDPRSLVTIGLGDGAALTVLW
PRVPEDPFLTGTRSDPNSNSIVAKLTYGKTAFLFTGDAEPDTEATLLRKPIDLTSTVLKVAHHGGRHSSTADFLAAVKPQ
AAVISVGAKNDYGHPTSAVLERLRAVKATVFRTDQDGEVVATSDGNVVSLRAEKRGGASELVPGGVKPGSVALGPITRGT
RRTSTPRGRGAASAPAEAPGTDSTQRDTDAPRYFSLKGSKVFHKESCRTLKRSKSDRTAYSSRAEAMRERRPAEDCHP

Sequences:

>Translated_398_residues
MSFARWLALLVLLLASVPGQALAQSAGQPLTVHFFDVGQGDAALIISPTGKTVLIDSGPPDARHRLEQRLRELVKEPLDL
AILTHPHLDHLGGMSTALRSVGARRFMDPGFDHPSEAYRDLLNVVGDEVGQVMTPVPNPQDPRSLVTIGLGDGAALTVLW
PRVPEDPFLTGTRSDPNSNSIVAKLTYGKTAFLFTGDAEPDTEATLLRKPIDLTSTVLKVAHHGGRHSSTADFLAAVKPQ
AAVISVGAKNDYGHPTSAVLERLRAVKATVFRTDQDGEVVATSDGNVVSLRAEKRGGASELVPGGVKPGSVALGPITRGT
RRTSTPRGRGAASAPAEAPGTDSTQRDTDAPRYFSLKGSKVFHKESCRTLKRSKSDRTAYSSRAEAMRERRPAEDCHP
>Mature_397_residues
SFARWLALLVLLLASVPGQALAQSAGQPLTVHFFDVGQGDAALIISPTGKTVLIDSGPPDARHRLEQRLRELVKEPLDLA
ILTHPHLDHLGGMSTALRSVGARRFMDPGFDHPSEAYRDLLNVVGDEVGQVMTPVPNPQDPRSLVTIGLGDGAALTVLWP
RVPEDPFLTGTRSDPNSNSIVAKLTYGKTAFLFTGDAEPDTEATLLRKPIDLTSTVLKVAHHGGRHSSTADFLAAVKPQA
AVISVGAKNDYGHPTSAVLERLRAVKATVFRTDQDGEVVATSDGNVVSLRAEKRGGASELVPGGVKPGSVALGPITRGTR
RTSTPRGRGAASAPAEAPGTDSTQRDTDAPRYFSLKGSKVFHKESCRTLKRSKSDRTAYSSRAEAMRERRPAEDCHP

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 42471; Mature: 42340

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFARWLALLVLLLASVPGQALAQSAGQPLTVHFFDVGQGDAALIISPTGKTVLIDSGPP
CCHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEEEEECCCCCEEEEECCCCCEEEEECCCC
DARHRLEQRLRELVKEPLDLAILTHPHLDHLGGMSTALRSVGARRFMDPGFDHPSEAYRD
HHHHHHHHHHHHHHHCCCCEEEECCCCHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
LLNVVGDEVGQVMTPVPNPQDPRSLVTIGLGDGAALTVLWPRVPEDPFLTGTRSDPNSNS
HHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCC
IVAKLTYGKTAFLFTGDAEPDTEATLLRKPIDLTSTVLKVAHHGGRHSSTADFLAAVKPQ
EEEEEECCCEEEEEECCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCC
AAVISVGAKNDYGHPTSAVLERLRAVKATVFRTDQDGEVVATSDGNVVSLRAEKRGGASE
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCEEEECCCCEEEEEECCCCCCCC
LVPGGVKPGSVALGPITRGTRRTSTPRGRGAASAPAEAPGTDSTQRDTDAPRYFSLKGSK
CCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCC
VFHKESCRTLKRSKSDRTAYSSRAEAMRERRPAEDCHP
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SFARWLALLVLLLASVPGQALAQSAGQPLTVHFFDVGQGDAALIISPTGKTVLIDSGPP
CHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEEEEECCCCCEEEEECCCCCEEEEECCCC
DARHRLEQRLRELVKEPLDLAILTHPHLDHLGGMSTALRSVGARRFMDPGFDHPSEAYRD
HHHHHHHHHHHHHHHCCCCEEEECCCCHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
LLNVVGDEVGQVMTPVPNPQDPRSLVTIGLGDGAALTVLWPRVPEDPFLTGTRSDPNSNS
HHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCC
IVAKLTYGKTAFLFTGDAEPDTEATLLRKPIDLTSTVLKVAHHGGRHSSTADFLAAVKPQ
EEEEEECCCEEEEEECCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCC
AAVISVGAKNDYGHPTSAVLERLRAVKATVFRTDQDGEVVATSDGNVVSLRAEKRGGASE
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCEEEECCCCEEEEEECCCCCCCC
LVPGGVKPGSVALGPITRGTRRTSTPRGRGAASAPAEAPGTDSTQRDTDAPRYFSLKGSK
CCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCC
VFHKESCRTLKRSKSDRTAYSSRAEAMRERRPAEDCHP
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]