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The map label for this gene is tcmP [H]

Identifier: 108756995

GI number: 108756995

Start: 6478606

End: 6479430

Strand: Reverse

Name: tcmP [H]

Synonym: MXAN_5185

Alternate gene names: 108756995

Gene position: 6479430-6478606 (Counterclockwise)

Preceding gene: 108758233

Following gene: 108761115

Centisome position: 70.89

GC content: 68.36

Gene sequence:

>825_bases
ATGCAGACGCGGTACGTGCCGAACCTCACGGGGATTCCGGAGACGATGCTCTGGACGCTTCATTCCCGGGCAGGGGAGGC
GAAGCGGCCGGACGGCGTCCTGAAGGACGCGGAGGCGCTGCGCATCTACGGCGCCATCGACTACGACTTCGAGAAGTCCT
TTGGCCGCGCGGAGCCGTCCCTCGCGATTCGCGCGGTGGAGATGGACCGGAGCATTCGCGCGTGGCTGGCCACGCACCCT
GACGGCTTCGTGGTGTCGCTGGGAGAGGGGCTGGAGACGCAGGCGCAGCGGCTGGACAACGGGCGGCTGCGCTGGCTGAG
CGTGGACCTGCCGGAAGCCGTGGCCATCCGGGAGCGCTTCCTCACGCCGAACGAGCGGCTGATGCACTTCCCGGTGAGCG
CCATGGACCGCGCATGGATGGACCGCGTGGACGCCAGCAAGGGCGTGTTCATCGTCGCGCAGGGCCTCTTCATGTACTTC
GAGGAAGACGACGTCCGTCGGCTCATCGTGGACATCGCCGAGCGCTTCCCGGGCGCCGAGCTCCTCTTCGACACGATTCC
CCGCTGGCTCTCACGGCGCACGCTCAAGGGGCTGCACCGCACCCGCGCGTACCAGGTGCCACCCATGCCCTGGGGCATCA
ACCGCGACGCGCTGGAGGCGACGCTGCGGCGGTGGGCGCCGCGAATCCGCCAGGTGGAATTGAAGCCCTACACCTTCCCG
CGGGGCTTCTTCCGGTACGGTTACAACGGTCTCAACATGCTGCCCTGGGTGAAGGAACGGTTGCCCGCGCTGGTCCACGT
CCGCTTCGCGGAGCGCAGCGTCTGA

Upstream 100 bases:

>100_bases
GCGGGCGTCATCGTCATCAATACCTTCTCCAGGTCGGCGGCGCACTGAGGCGCCTGGCGGAGCTCGCCCGGGAGGTGTCG
TTGATATCAGGAGGGGGACG

Downstream 100 bases:

>100_bases
GTCAGGCCGCGCGCGGCAGCACGAGGCTGAAGCGCGCGCCGTGGCCGGGCTCTCCGCCCACCTCCAGTTTGCCGCCGTGC
TCCTGGAGGATGCGCGAGGC

Product: putative O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MQTRYVPNLTGIPETMLWTLHSRAGEAKRPDGVLKDAEALRIYGAIDYDFEKSFGRAEPSLAIRAVEMDRSIRAWLATHP
DGFVVSLGEGLETQAQRLDNGRLRWLSVDLPEAVAIRERFLTPNERLMHFPVSAMDRAWMDRVDASKGVFIVAQGLFMYF
EEDDVRRLIVDIAERFPGAELLFDTIPRWLSRRTLKGLHRTRAYQVPPMPWGINRDALEATLRRWAPRIRQVELKPYTFP
RGFFRYGYNGLNMLPWVKERLPALVHVRFAERSV

Sequences:

>Translated_274_residues
MQTRYVPNLTGIPETMLWTLHSRAGEAKRPDGVLKDAEALRIYGAIDYDFEKSFGRAEPSLAIRAVEMDRSIRAWLATHP
DGFVVSLGEGLETQAQRLDNGRLRWLSVDLPEAVAIRERFLTPNERLMHFPVSAMDRAWMDRVDASKGVFIVAQGLFMYF
EEDDVRRLIVDIAERFPGAELLFDTIPRWLSRRTLKGLHRTRAYQVPPMPWGINRDALEATLRRWAPRIRQVELKPYTFP
RGFFRYGYNGLNMLPWVKERLPALVHVRFAERSV
>Mature_274_residues
MQTRYVPNLTGIPETMLWTLHSRAGEAKRPDGVLKDAEALRIYGAIDYDFEKSFGRAEPSLAIRAVEMDRSIRAWLATHP
DGFVVSLGEGLETQAQRLDNGRLRWLSVDLPEAVAIRERFLTPNERLMHFPVSAMDRAWMDRVDASKGVFIVAQGLFMYF
EEDDVRRLIVDIAERFPGAELLFDTIPRWLSRRTLKGLHRTRAYQVPPMPWGINRDALEATLRRWAPRIRQVELKPYTFP
RGFFRYGYNGLNMLPWVKERLPALVHVRFAERSV

Specific function: O-methyltransferase that catalyzes the methylation of the C-9 carboxy group of tetracenomycin E (TCM E) to yield TCM A2. Catalyzes as well the following side reactions:methylation of 8- O-methyl-TCM D3 to 9-carboxymethyl-8-O-methyl-TCM D3; and of TCM B3 t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007213
- InterPro:   IPR016874 [H]

Pfam domain/function: PF04072 LCM [H]

EC number: NA

Molecular weight: Translated: 31798; Mature: 31798

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTRYVPNLTGIPETMLWTLHSRAGEAKRPDGVLKDAEALRIYGAIDYDFEKSFGRAEPS
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCHHHHCCCCCCC
LAIRAVEMDRSIRAWLATHPDGFVVSLGEGLETQAQRLDNGRLRWLSVDLPEAVAIRERF
CEEEEEHHCCHHHHHHHCCCCCEEEECCCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHH
LTPNERLMHFPVSAMDRAWMDRVDASKGVFIVAQGLFMYFEEDDVRRLIVDIAERFPGAE
CCCCHHEEECCHHHHHHHHHHHHCCCCCEEEEEECEEEEECHHHHHHHHHHHHHHCCCHH
LLFDTIPRWLSRRTLKGLHRTRAYQVPPMPWGINRDALEATLRRWAPRIRQVELKPYTFP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCHHHHEEEECCCCCC
RGFFRYGYNGLNMLPWVKERLPALVHVRFAERSV
CHHHHHCCCCCCCCHHHHHCCCHHEEEHHHHCCC
>Mature Secondary Structure
MQTRYVPNLTGIPETMLWTLHSRAGEAKRPDGVLKDAEALRIYGAIDYDFEKSFGRAEPS
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCHHHHCCCCCCC
LAIRAVEMDRSIRAWLATHPDGFVVSLGEGLETQAQRLDNGRLRWLSVDLPEAVAIRERF
CEEEEEHHCCHHHHHHHCCCCCEEEECCCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHH
LTPNERLMHFPVSAMDRAWMDRVDASKGVFIVAQGLFMYFEEDDVRRLIVDIAERFPGAE
CCCCHHEEECCHHHHHHHHHHHHCCCCCEEEEEECEEEEECHHHHHHHHHHHHHHCCCHH
LLFDTIPRWLSRRTLKGLHRTRAYQVPPMPWGINRDALEATLRRWAPRIRQVELKPYTFP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCHHHHEEEECCCCCC
RGFFRYGYNGLNMLPWVKERLPALVHVRFAERSV
CHHHHHCCCCCCCCHHHHHCCCHHEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8509339 [H]