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The map label for this gene is cysK [H]

Identifier: 108756930

GI number: 108756930

Start: 1148048

End: 1149013

Strand: Reverse

Name: cysK [H]

Synonym: MXAN_0992

Alternate gene names: 108756930

Gene position: 1149013-1148048 (Counterclockwise)

Preceding gene: 108762553

Following gene: 108759579

Centisome position: 12.57

GC content: 70.7

Gene sequence:

>966_bases
ATGCGTCCTCCCTGTCGCCCTCTTCCCGCGGACGGCCGCTTCCTCCAGGCCGTGGGTCCCACTCCGCTCGTCCCCGTACG
TCTCCACGAGGAGGGCCCCACCATCTGGTGCAAGCTGGAGTTCCTCAACCCCAGCGGCTCCACCAAGGACCGCATCGCGC
GCTACATGCTGGAGAAGGCGTGGCGCCAGGGGGAGCTCGTCCCCGGCGGCGAGGTCATCGAGGCGTCCAGCGGCTCCACG
AGCATCGCCCTTGCGCTGGCTTGCGCCCAGATGGGCCTGCGCTTCACGGCGGTGATGCCGGAGGGCGTCACCGGGGAGCG
CATCCTCACCATCCGCGCCTATGGTGGTGACGTGGTGCTGGTGCCGCGCGAAGCCGGCGTGCACGGCGCCATCGTGAAGG
CGGAGGAGCTGGCGCGTGAGCGCAAGGCCTTCGCGCCGCGTCAGTTCGAGAACCTGGACAACGCCGAGGCCCACCGGGTG
TGGACGGGCCAGGAGATTCTGTCGCAAATCCCGGGCGGGCTGGTGCACGGCGTGGTCAGCGGCGTAGGCACGGGCGGCAC
CGTGGTGGGCCTGTACCAGGCCTTCGCGGAAGCAGGCTGTCCGGTGACGGCCTTCGTGGCGCGCCCCATCGCCGGCCTGG
GCTGCGACATCGAATGTTGCAGCTTCAGCCCCCGCGTCCCGGGCGTGGTGGATGGCATGTCCCGGCTGTACCGCGAGGCC
GACATGCCGGGCCGCGTTGAAATCGACGTGTCGGACGACGTCGCCATGAGCACCGCCAGGGCGCTCATCCGCCGCGGCTT
CCCGGTGGGACCGTCGTCCGGCCTCAACTACGTCGCCGCGGTGGAAGCCGCGAAGCGACTGGGCCCGGGGGCGCAGGTGG
TGACGGTGTTCCCCGACCGCATGGAGCGCTACTTCTCCACCGAGCTCATCCAGCCTAAGCCCGTGCCAGCACGCGGCGCG
GCATGA

Upstream 100 bases:

>100_bases
GGGCGCGCTGTCGGGGCAGGCACACAAGCGACTGTCCAGGAACCCAGCAAAAAGTTCATGGCCAGTGCCGAACGAGCCGT
TTCGCGATAGGGAAGGCCGC

Downstream 100 bases:

>100_bases
GTTGAAAGGGAATGACGTGGCGCGTGCGGAGTTGCACGCGCCGTCCCGCCGCGCTATCTGCTGGGCAAGCCCACGTTCAT
GCTCGTCCGAGTCCTGACAG

Product: putative cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MRPPCRPLPADGRFLQAVGPTPLVPVRLHEEGPTIWCKLEFLNPSGSTKDRIARYMLEKAWRQGELVPGGEVIEASSGST
SIALALACAQMGLRFTAVMPEGVTGERILTIRAYGGDVVLVPREAGVHGAIVKAEELARERKAFAPRQFENLDNAEAHRV
WTGQEILSQIPGGLVHGVVSGVGTGGTVVGLYQAFAEAGCPVTAFVARPIAGLGCDIECCSFSPRVPGVVDGMSRLYREA
DMPGRVEIDVSDDVAMSTARALIRRGFPVGPSSGLNYVAAVEAAKRLGPGAQVVTVFPDRMERYFSTELIQPKPVPARGA
A

Sequences:

>Translated_321_residues
MRPPCRPLPADGRFLQAVGPTPLVPVRLHEEGPTIWCKLEFLNPSGSTKDRIARYMLEKAWRQGELVPGGEVIEASSGST
SIALALACAQMGLRFTAVMPEGVTGERILTIRAYGGDVVLVPREAGVHGAIVKAEELARERKAFAPRQFENLDNAEAHRV
WTGQEILSQIPGGLVHGVVSGVGTGGTVVGLYQAFAEAGCPVTAFVARPIAGLGCDIECCSFSPRVPGVVDGMSRLYREA
DMPGRVEIDVSDDVAMSTARALIRRGFPVGPSSGLNYVAAVEAAKRLGPGAQVVTVFPDRMERYFSTELIQPKPVPARGA
A
>Mature_321_residues
MRPPCRPLPADGRFLQAVGPTPLVPVRLHEEGPTIWCKLEFLNPSGSTKDRIARYMLEKAWRQGELVPGGEVIEASSGST
SIALALACAQMGLRFTAVMPEGVTGERILTIRAYGGDVVLVPREAGVHGAIVKAEELARERKAFAPRQFENLDNAEAHRV
WTGQEILSQIPGGLVHGVVSGVGTGGTVVGLYQAFAEAGCPVTAFVARPIAGLGCDIECCSFSPRVPGVVDGMSRLYREA
DMPGRVEIDVSDDVAMSTARALIRRGFPVGPSSGLNYVAAVEAAKRLGPGAQVVTVFPDRMERYFSTELIQPKPVPARGA
A

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=329, Percent_Identity=32.2188449848024, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI295821200, Length=329, Percent_Identity=32.2188449848024, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI4557415, Length=329, Percent_Identity=32.2188449848024, Blast_Score=125, Evalue=5e-29,
Organism=Escherichia coli, GI2367138, Length=302, Percent_Identity=37.0860927152318, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1788754, Length=315, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17562970, Length=307, Percent_Identity=36.4820846905537, Blast_Score=127, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17535051, Length=311, Percent_Identity=34.4051446945338, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI32566674, Length=303, Percent_Identity=35.6435643564356, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI115535073, Length=301, Percent_Identity=34.8837209302326, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17561720, Length=313, Percent_Identity=34.5047923322684, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25147552, Length=337, Percent_Identity=31.7507418397626, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17534315, Length=349, Percent_Identity=31.8051575931232, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI32566672, Length=221, Percent_Identity=34.3891402714932, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71996324, Length=319, Percent_Identity=26.0188087774295, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=320, Percent_Identity=31.5625, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6321449, Length=341, Percent_Identity=30.2052785923754, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24643623, Length=324, Percent_Identity=32.7160493827161, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI20129101, Length=324, Percent_Identity=32.7160493827161, Blast_Score=117, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34143; Mature: 34143

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPPCRPLPADGRFLQAVGPTPLVPVRLHEEGPTIWCKLEFLNPSGSTKDRIARYMLEKA
CCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCEEEEEEEEECCCCCCHHHHHHHHHHHH
WRQGELVPGGEVIEASSGSTSIALALACAQMGLRFTAVMPEGVTGERILTIRAYGGDVVL
HHCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEEECCCCEEE
VPREAGVHGAIVKAEELARERKAFAPRQFENLDNAEAHRVWTGQEILSQIPGGLVHGVVS
EECCCCCCCEEECHHHHHHHHHHCCCHHHHCCCCCCHHEEECHHHHHHHCCCHHHHHHHH
GVGTGGTVVGLYQAFAEAGCPVTAFVARPIAGLGCDIECCSFSPRVPGVVDGMSRLYREA
CCCCCCHHHHHHHHHHHCCCCEEHHHHCCHHCCCCCEEECCCCCCCCHHHHHHHHHHHHC
DMPGRVEIDVSDDVAMSTARALIRRGFPVGPSSGLNYVAAVEAAKRLGPGAQVVTVFPDR
CCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECHHH
MERYFSTELIQPKPVPARGAA
HHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRPPCRPLPADGRFLQAVGPTPLVPVRLHEEGPTIWCKLEFLNPSGSTKDRIARYMLEKA
CCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCEEEEEEEEECCCCCCHHHHHHHHHHHH
WRQGELVPGGEVIEASSGSTSIALALACAQMGLRFTAVMPEGVTGERILTIRAYGGDVVL
HHCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEEECCCCEEE
VPREAGVHGAIVKAEELARERKAFAPRQFENLDNAEAHRVWTGQEILSQIPGGLVHGVVS
EECCCCCCCEEECHHHHHHHHHHCCCHHHHCCCCCCHHEEECHHHHHHHCCCHHHHHHHH
GVGTGGTVVGLYQAFAEAGCPVTAFVARPIAGLGCDIECCSFSPRVPGVVDGMSRLYREA
CCCCCCHHHHHHHHHHHCCCCEEHHHHCCHHCCCCCEEECCCCCCCCHHHHHHHHHHHHC
DMPGRVEIDVSDDVAMSTARALIRRGFPVGPSSGLNYVAAVEAAKRLGPGAQVVTVFPDR
CCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECHHH
MERYFSTELIQPKPVPARGAA
HHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA