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The map label for this gene is cyaA [H]

Identifier: 108756913

GI number: 108756913

Start: 1321465

End: 1322766

Strand: Direct

Name: cyaA [H]

Synonym: MXAN_1134

Alternate gene names: 108756913

Gene position: 1321465-1322766 (Clockwise)

Preceding gene: 108762674

Following gene: 108761383

Centisome position: 14.46

GC content: 68.51

Gene sequence:

>1302_bases
GTGCTCGTCACCATGCGCCGCAGCGACAAAGCCACATCACACTCCAACGAAGATGTGGTGCTGGCAACCAGCTCGCTTCA
GGGCGAGCGCCGCGTGGCCATCGTCCGCGTCCTGGTGGTGTTGCTGATGGCGGTCAGCCAGGTCGTCATCGCCTGGGGCG
GAGGGGAGACGTACTCGGCACCGGTGGACGGCGTGCGCCTGCAGGCGATGGCCGCGTACGTGCTCTTCTCCGTCGTCGCC
ATCGCCGTGCTGCTGCTCCAGAAGCCGCACCCGAAGCGGGCGCGGTGGCTGCCCGTGCCCACGACGCTGGCGGACACCAG
CTTCTTCTCCTTCATGGCGTGGCACACCTGGCGCATCTCCGGCGTCTTCGATGCCGGCATGTTGTGCGCCAGCCTGGGCA
TGGTGCTGGCGTTCTCCGTGGTGCGTTACTCGTGGTGGCACGTGCTGTTATCCACGGTGCTGTCCAGCGGCGCCTATGCG
CTGCTCGCGTGGATGACGGGGCACGGCTCGGTGGCGCGCACCAGCTTCGTTCTCATCTGCTACGCCGCCTTGGGCGGGCT
CATCGCGCTGACGAACTCGGAAGTGGGGGGCATGTTCCTCAATTTGCGGCGCCGCGACGGCCTGTCCCGCTTCCTGCCCC
GGCAGGTGGTGGAGCGGGTGATGCAACTGGGGGATGCCTCCCTCCAGCCGGTGCAGCGCGACGTCACCATCCTCTTCAGC
GACATCCGCGACTTCACCACGCTGAGCGAGACGCTGGACCCGGGACAGGTGCTGGAGTTGCTGGACGACTACTTCGGGCA
CATGGCCCACATCGTCATGGCGCGCCACGGCATCGTGAACAAGTTCCTGGGCGACGGGATGCTCGCGTGCTGGGGCGTTC
CGGATGCGCGCGAGAACCACGCGGAGCTGGCCATGCGGGCGGCGCTCGACATGCGCGCCAAGCTGGAGGACATCAACGCC
CAGCGCGTGCAGCGAGGTCTGCCGCCGCTGCGCATCGGCATCGGGCTGCACACCGGCATGGTGGCGGCGGGCATGCTCGG
CGGCGCCGAGCAGCACGAGTACACCGTCATCGGTGACGCGGTGAACCTGGCGTCTCGCGTGGAGGGCCTCACCAAGTCCC
ACGGCGTGGACATCCTGGTGAGCGAGCGGACGTGGCAGATGAGCGGCGGGCATTTCACGGGCGAGCGCCTGGGTGAAGCG
CACGTGAAGGGCCGGCGGGAGTCCGTGGTCGTCTACTCCCTGCACGGCCCGCGCACCCATGAGGACGTACCGCCCGTGCT
CAAGGCCGCGGCGGGCACGTAG

Upstream 100 bases:

>100_bases
AGTTGCTCCGTACGCGTCCTGGCGTGCGCAAAAGATGCGCTGACTGCGGAAGCCCAGGGTCCTCGCTGTCCGTGGGGGAG
TTGAGGCACGATAGCGGGCA

Downstream 100 bases:

>100_bases
CGCCTCGCCGCGGCGTGGGTGCTCAGGCGGGCTGTGACTCGCCGGGGCCCGTCATCACCTCGGCCCGCAGCGTCTGCTTC
ATGCCCAGCGAGAACAGGGC

Product: adenylate/guanylate cyclase domain-containing protein

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MLVTMRRSDKATSHSNEDVVLATSSLQGERRVAIVRVLVVLLMAVSQVVIAWGGGETYSAPVDGVRLQAMAAYVLFSVVA
IAVLLLQKPHPKRARWLPVPTTLADTSFFSFMAWHTWRISGVFDAGMLCASLGMVLAFSVVRYSWWHVLLSTVLSSGAYA
LLAWMTGHGSVARTSFVLICYAALGGLIALTNSEVGGMFLNLRRRDGLSRFLPRQVVERVMQLGDASLQPVQRDVTILFS
DIRDFTTLSETLDPGQVLELLDDYFGHMAHIVMARHGIVNKFLGDGMLACWGVPDARENHAELAMRAALDMRAKLEDINA
QRVQRGLPPLRIGIGLHTGMVAAGMLGGAEQHEYTVIGDAVNLASRVEGLTKSHGVDILVSERTWQMSGGHFTGERLGEA
HVKGRRESVVVYSLHGPRTHEDVPPVLKAAAGT

Sequences:

>Translated_433_residues
MLVTMRRSDKATSHSNEDVVLATSSLQGERRVAIVRVLVVLLMAVSQVVIAWGGGETYSAPVDGVRLQAMAAYVLFSVVA
IAVLLLQKPHPKRARWLPVPTTLADTSFFSFMAWHTWRISGVFDAGMLCASLGMVLAFSVVRYSWWHVLLSTVLSSGAYA
LLAWMTGHGSVARTSFVLICYAALGGLIALTNSEVGGMFLNLRRRDGLSRFLPRQVVERVMQLGDASLQPVQRDVTILFS
DIRDFTTLSETLDPGQVLELLDDYFGHMAHIVMARHGIVNKFLGDGMLACWGVPDARENHAELAMRAALDMRAKLEDINA
QRVQRGLPPLRIGIGLHTGMVAAGMLGGAEQHEYTVIGDAVNLASRVEGLTKSHGVDILVSERTWQMSGGHFTGERLGEA
HVKGRRESVVVYSLHGPRTHEDVPPVLKAAAGT
>Mature_433_residues
MLVTMRRSDKATSHSNEDVVLATSSLQGERRVAIVRVLVVLLMAVSQVVIAWGGGETYSAPVDGVRLQAMAAYVLFSVVA
IAVLLLQKPHPKRARWLPVPTTLADTSFFSFMAWHTWRISGVFDAGMLCASLGMVLAFSVVRYSWWHVLLSTVLSSGAYA
LLAWMTGHGSVARTSFVLICYAALGGLIALTNSEVGGMFLNLRRRDGLSRFLPRQVVERVMQLGDASLQPVQRDVTILFS
DIRDFTTLSETLDPGQVLELLDDYFGHMAHIVMARHGIVNKFLGDGMLACWGVPDARENHAELAMRAALDMRAKLEDINA
QRVQRGLPPLRIGIGLHTGMVAAGMLGGAEQHEYTVIGDAVNLASRVEGLTKSHGVDILVSERTWQMSGGHFTGERLGEA
HVKGRRESVVVYSLHGPRTHEDVPPVLKAAAGT

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI222080083, Length=201, Percent_Identity=33.8308457711443, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI4580422, Length=200, Percent_Identity=31.5, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI167830411, Length=214, Percent_Identity=31.7757009345794, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI134152694, Length=206, Percent_Identity=30.0970873786408, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4557257, Length=210, Percent_Identity=27.1428571428571, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4504217, Length=164, Percent_Identity=32.9268292682927, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI4557255, Length=164, Percent_Identity=29.2682926829268, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17561804, Length=204, Percent_Identity=37.2549019607843, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17561800, Length=233, Percent_Identity=32.618025751073, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17561802, Length=202, Percent_Identity=34.6534653465347, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17534657, Length=207, Percent_Identity=32.3671497584541, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71995305, Length=202, Percent_Identity=34.1584158415842, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17561810, Length=206, Percent_Identity=28.1553398058252, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI212659371, Length=208, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71982300, Length=168, Percent_Identity=33.9285714285714, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71989805, Length=182, Percent_Identity=32.967032967033, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71989822, Length=182, Percent_Identity=32.967032967033, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17534653, Length=208, Percent_Identity=32.6923076923077, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17568383, Length=225, Percent_Identity=31.1111111111111, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17534649, Length=207, Percent_Identity=32.3671497584541, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17534651, Length=204, Percent_Identity=29.9019607843137, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI212645052, Length=204, Percent_Identity=34.3137254901961, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193207841, Length=208, Percent_Identity=32.6923076923077, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17534655, Length=233, Percent_Identity=30.0429184549356, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17561794, Length=220, Percent_Identity=32.2727272727273, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17508769, Length=144, Percent_Identity=34.7222222222222, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71995300, Length=164, Percent_Identity=35.9756097560976, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI86564713, Length=226, Percent_Identity=25.2212389380531, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71995893, Length=228, Percent_Identity=29.3859649122807, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71995895, Length=228, Percent_Identity=29.3859649122807, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71995899, Length=228, Percent_Identity=29.3859649122807, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17534659, Length=220, Percent_Identity=30.4545454545455, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71985505, Length=220, Percent_Identity=25.9090909090909, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71990146, Length=158, Percent_Identity=31.0126582278481, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71983004, Length=204, Percent_Identity=25.9803921568627, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI193206632, Length=187, Percent_Identity=27.807486631016, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI133931199, Length=161, Percent_Identity=27.3291925465839, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI62484477, Length=207, Percent_Identity=30.9178743961353, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI62484298, Length=207, Percent_Identity=30.9178743961353, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI116008008, Length=207, Percent_Identity=30.9178743961353, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI161078020, Length=200, Percent_Identity=33, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI221330470, Length=225, Percent_Identity=29.3333333333333, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221330468, Length=225, Percent_Identity=29.3333333333333, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24585694, Length=306, Percent_Identity=25.4901960784314, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281366459, Length=242, Percent_Identity=30.5785123966942, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281366457, Length=242, Percent_Identity=30.5785123966942, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281366455, Length=242, Percent_Identity=30.5785123966942, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI56292422, Length=242, Percent_Identity=30.5785123966942, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI56292424, Length=242, Percent_Identity=30.5785123966942, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24666940, Length=242, Percent_Identity=30.5785123966942, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28574512, Length=203, Percent_Identity=32.0197044334975, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161076872, Length=203, Percent_Identity=32.0197044334975, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24667100, Length=199, Percent_Identity=32.1608040201005, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24642014, Length=169, Percent_Identity=31.3609467455621, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583978, Length=141, Percent_Identity=29.7872340425532, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24655923, Length=197, Percent_Identity=29.4416243654822, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24583976, Length=144, Percent_Identity=30.5555555555556, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161084260, Length=170, Percent_Identity=30.5882352941176, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24647268, Length=227, Percent_Identity=31.7180616740088, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281366320, Length=171, Percent_Identity=30.4093567251462, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 47185; Mature: 47185

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVTMRRSDKATSHSNEDVVLATSSLQGERRVAIVRVLVVLLMAVSQVVIAWGGGETYSA
CEEEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCC
PVDGVRLQAMAAYVLFSVVAIAVLLLQKPHPKRARWLPVPTTLADTSFFSFMAWHTWRIS
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEC
GVFDAGMLCASLGMVLAFSVVRYSWWHVLLSTVLSSGAYALLAWMTGHGSVARTSFVLIC
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHH
YAALGGLIALTNSEVGGMFLNLRRRDGLSRFLPRQVVERVMQLGDASLQPVQRDVTILFS
HHHHCCEEEEECCCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
DIRDFTTLSETLDPGQVLELLDDYFGHMAHIVMARHGIVNKFLGDGMLACWGVPDARENH
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHH
AELAMRAALDMRAKLEDINAQRVQRGLPPLRIGIGLHTGMVAAGMLGGAEQHEYTVIGDA
HHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEECCHHHHHHHHHHCCCCCCCCEEEEHHH
VNLASRVEGLTKSHGVDILVSERTWQMSGGHFTGERLGEAHVKGRRESVVVYSLHGPRTH
HHHHHHHHHHHHHCCCEEEEECCEEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCC
EDVPPVLKAAAGT
CCCCHHHHHCCCC
>Mature Secondary Structure
MLVTMRRSDKATSHSNEDVVLATSSLQGERRVAIVRVLVVLLMAVSQVVIAWGGGETYSA
CEEEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCC
PVDGVRLQAMAAYVLFSVVAIAVLLLQKPHPKRARWLPVPTTLADTSFFSFMAWHTWRIS
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEC
GVFDAGMLCASLGMVLAFSVVRYSWWHVLLSTVLSSGAYALLAWMTGHGSVARTSFVLIC
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHH
YAALGGLIALTNSEVGGMFLNLRRRDGLSRFLPRQVVERVMQLGDASLQPVQRDVTILFS
HHHHCCEEEEECCCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
DIRDFTTLSETLDPGQVLELLDDYFGHMAHIVMARHGIVNKFLGDGMLACWGVPDARENH
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHH
AELAMRAALDMRAKLEDINAQRVQRGLPPLRIGIGLHTGMVAAGMLGGAEQHEYTVIGDA
HHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEECCHHHHHHHHHHCCCCCCCCEEEEHHH
VNLASRVEGLTKSHGVDILVSERTWQMSGGHFTGERLGEAHVKGRRESVVVYSLHGPRTH
HHHHHHHHHHHHHCCCEEEEECCEEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCC
EDVPPVLKAAAGT
CCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]