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The map label for this gene is pcrA [H]

Identifier: 108756911

GI number: 108756911

Start: 2325474

End: 2327549

Strand: Direct

Name: pcrA [H]

Synonym: MXAN_1992

Alternate gene names: 108756911

Gene position: 2325474-2327549 (Clockwise)

Preceding gene: 108757806

Following gene: 108760943

Centisome position: 25.44

GC content: 66.57

Gene sequence:

>2076_bases
ATGGACCTCTCGAAGCTCAATCCTCCGCAGCGCGAGGCCGTGGTGACCCTGGAGGGACCGCTCCTCGTGCTGGCAGGCGC
AGGCAGCGGCAAGACTCGCGTCATCACCCACCGCATCGTCCACCTGCTCAACGAGCGGCCGGGCCTCATCATGGCCCGCA
ACATCCTGGCGGTGACCTTCACCAACAAGGCCGCCACGGAGATGAAGGAGCGCCTGGTCCACATGGCGGGACCTCGGGCG
CAGGGCGTGCTGGTGTGCACCTTCCACGCCTTTGGCGCGGAGATGCTCCGCGAGGACATCCACCGGCTGGGGTGGCCCAA
GAAGTTCGCCATCGCCGACATGGGCGACCAGCTGGCCAACATCCGGCGCGCGATGCGCGAGCACAAAATCGACGACCGCT
CGTTCGACGCGCGCAAGGTGCTCAACCTCATCTCCAAGGCGAAGAACTCCGGCAAGGCGCCGGAGCCCAAGCCGGAGGGG
ATTGGGGATGATTACGACCTCATCACCCACATGGTGTACCCGGACTATCAGCTGTCGCTGAAGGCGCAGGGGTCGGTGGA
CTTCGACGACCTGCTGCTGCTGCCCGCGCGCCTCCTGCGCGAGCACCCGGACCTCTACGAGAAGTACACCAAGCGCTTCC
GCTACCTGCTGGTGGACGAGTTCCAGGACACCAACACCGCGCAGTTGGAACTGCTGAAGCTGCTGGCGGGCCGCTCCCGC
AACGTGTGCGCGGTGGGTGACGACGACCAGTGCATCTATTCGTGGCGGGGCGCGGAGGTGCGCAACATCCTCGACTTCGA
CCGCCTCTTCCCGGGAGGGAAGGAGGTCCGGTTGGAGCAGAACTACCGCTCCGTCCAGACGGTCCTGGACGCGGCCAACG
CCGTCATCGCCAAGAACCCCGAGCGCAAGGCCAAGCAGATGTGGACCGACCGCACGGGGGGAACGAAGGTGAAGGTGGTG
ACGTGTCCCAATGACGAAGAGGAGGCCCGCTTCGTCGCGCACGAAATCCAGAAGCACATGGCCCTGGGCATCTCCGCGGA
CGACATCGCCGTGCTCTACCGGACCAACGGCCAGTCCCGCCCCATCGAGGAGACGCTGCGGGAGAAGAACATCGGCTACG
AGGTGGTGGGCGGCAGCGAGTTCTTCGACCGGCGCGAGGTGAAGGACGTCATCGCGTACTTCAAGGTCATCGTGAACAAG
CTGGACGAAATCTCGCTCCTTCGCATCGTCAACGTGCCCTCGCGCGGCATTGGCGACGTGACGATGGAGCGCCTGAACGT
CCACGCGCGGGGCGAGGGCGTCACGCTGTGGACGGTGATGAAGAAGGCCACCGACTACGAGGACCTGCCGCCCGGGGCCG
GGGCCCGGGTGATGGACTTCGTGGACCTGGTGGAGCGCTACCGCGCCGCGTACGAGCACGGCCAGTTGGCCAACGTGACG
CGCAAGCTGCTGGAGGAGATTGGCTTTCGCGAGGCCACCCGCGCCCACGCCACCAGCGCCACCGCCGCGGACAAGAAGCT
CAAGGGCGTGGACGGCGTGCTCAACTCGCTGGAGAACTTCGAAAAGCGCGAGGGCCCCAAGGCGAGCCTGCCGACGTACC
TCAACCGCCTGAGCCTGGACACCCGGCAGGAGGAAGAGGAGGTGCCGGGCGCCAACCGCCGCGTCACCTTGATGACGGTG
CACGCCTCCAAGGGCCTGGAATACCGGCTCGTCTTCTTCATCGGTATGGAGGAGGACCTGATGCCCCACGGAGGCATGCA
GGGCGAGGCGCAGAACCTCGAGGAGGAGCGGCGCCTCTGCTACGTGGGCATCACCCGCGCCAAGGAGGTCCTCTACCTCA
CCCGCGCGGCCACCCGCGTGAAGCGCGGCAAGGAGGTGCCCCGCACGCCCTCGCGCTTCCTGGAGGACCTGCCGCCGGAG
GTGATTGAGGTGGTGGAACTGGACGCGCCGCGTCAGGGGCCTCCCACCACGGAGGAGAAGAACTTCTTCGCCAACTTGAA
GGAGCGCTTCAAGAAACCCGCGATTCCGGGAACGCCTCCGGGTGGCACCGGGCCGTCTGGGGGAGCAGCCAGGTAG

Upstream 100 bases:

>100_bases
GCATCCCGTGCCCAGGACGAGTGCGAGAAGAGCGCCAGAGCGCCTGGGGAAAAAAGAGTCGCGCACGAACGAATCAAAGG
GTATCCCCGCCCCGCGCGCA

Downstream 100 bases:

>100_bases
GTGTCCGCCTCCTGATGGGGGCGTCCTGGCGGGGGTGATCGGGGAATCCGGACGTCTGGTGCGGTGTGACCTTGACTTGA
TCCGCCACACCCACTAGGAC

Product: ATP-dependent DNA helicase UvrD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 691; Mature: 691

Protein sequence:

>691_residues
MDLSKLNPPQREAVVTLEGPLLVLAGAGSGKTRVITHRIVHLLNERPGLIMARNILAVTFTNKAATEMKERLVHMAGPRA
QGVLVCTFHAFGAEMLREDIHRLGWPKKFAIADMGDQLANIRRAMREHKIDDRSFDARKVLNLISKAKNSGKAPEPKPEG
IGDDYDLITHMVYPDYQLSLKAQGSVDFDDLLLLPARLLREHPDLYEKYTKRFRYLLVDEFQDTNTAQLELLKLLAGRSR
NVCAVGDDDQCIYSWRGAEVRNILDFDRLFPGGKEVRLEQNYRSVQTVLDAANAVIAKNPERKAKQMWTDRTGGTKVKVV
TCPNDEEEARFVAHEIQKHMALGISADDIAVLYRTNGQSRPIEETLREKNIGYEVVGGSEFFDRREVKDVIAYFKVIVNK
LDEISLLRIVNVPSRGIGDVTMERLNVHARGEGVTLWTVMKKATDYEDLPPGAGARVMDFVDLVERYRAAYEHGQLANVT
RKLLEEIGFREATRAHATSATAADKKLKGVDGVLNSLENFEKREGPKASLPTYLNRLSLDTRQEEEEVPGANRRVTLMTV
HASKGLEYRLVFFIGMEEDLMPHGGMQGEAQNLEEERRLCYVGITRAKEVLYLTRAATRVKRGKEVPRTPSRFLEDLPPE
VIEVVELDAPRQGPPTTEEKNFFANLKERFKKPAIPGTPPGGTGPSGGAAR

Sequences:

>Translated_691_residues
MDLSKLNPPQREAVVTLEGPLLVLAGAGSGKTRVITHRIVHLLNERPGLIMARNILAVTFTNKAATEMKERLVHMAGPRA
QGVLVCTFHAFGAEMLREDIHRLGWPKKFAIADMGDQLANIRRAMREHKIDDRSFDARKVLNLISKAKNSGKAPEPKPEG
IGDDYDLITHMVYPDYQLSLKAQGSVDFDDLLLLPARLLREHPDLYEKYTKRFRYLLVDEFQDTNTAQLELLKLLAGRSR
NVCAVGDDDQCIYSWRGAEVRNILDFDRLFPGGKEVRLEQNYRSVQTVLDAANAVIAKNPERKAKQMWTDRTGGTKVKVV
TCPNDEEEARFVAHEIQKHMALGISADDIAVLYRTNGQSRPIEETLREKNIGYEVVGGSEFFDRREVKDVIAYFKVIVNK
LDEISLLRIVNVPSRGIGDVTMERLNVHARGEGVTLWTVMKKATDYEDLPPGAGARVMDFVDLVERYRAAYEHGQLANVT
RKLLEEIGFREATRAHATSATAADKKLKGVDGVLNSLENFEKREGPKASLPTYLNRLSLDTRQEEEEVPGANRRVTLMTV
HASKGLEYRLVFFIGMEEDLMPHGGMQGEAQNLEEERRLCYVGITRAKEVLYLTRAATRVKRGKEVPRTPSRFLEDLPPE
VIEVVELDAPRQGPPTTEEKNFFANLKERFKKPAIPGTPPGGTGPSGGAAR
>Mature_691_residues
MDLSKLNPPQREAVVTLEGPLLVLAGAGSGKTRVITHRIVHLLNERPGLIMARNILAVTFTNKAATEMKERLVHMAGPRA
QGVLVCTFHAFGAEMLREDIHRLGWPKKFAIADMGDQLANIRRAMREHKIDDRSFDARKVLNLISKAKNSGKAPEPKPEG
IGDDYDLITHMVYPDYQLSLKAQGSVDFDDLLLLPARLLREHPDLYEKYTKRFRYLLVDEFQDTNTAQLELLKLLAGRSR
NVCAVGDDDQCIYSWRGAEVRNILDFDRLFPGGKEVRLEQNYRSVQTVLDAANAVIAKNPERKAKQMWTDRTGGTKVKVV
TCPNDEEEARFVAHEIQKHMALGISADDIAVLYRTNGQSRPIEETLREKNIGYEVVGGSEFFDRREVKDVIAYFKVIVNK
LDEISLLRIVNVPSRGIGDVTMERLNVHARGEGVTLWTVMKKATDYEDLPPGAGARVMDFVDLVERYRAAYEHGQLANVT
RKLLEEIGFREATRAHATSATAADKKLKGVDGVLNSLENFEKREGPKASLPTYLNRLSLDTRQEEEEVPGANRRVTLMTV
HASKGLEYRLVFFIGMEEDLMPHGGMQGEAQNLEEERRLCYVGITRAKEVLYLTRAATRVKRGKEVPRTPSRFLEDLPPE
VIEVVELDAPRQGPPTTEEKNFFANLKERFKKPAIPGTPPGGTGPSGGAAR

Specific function: Essential helicase [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=674, Percent_Identity=37.240356083086, Blast_Score=423, Evalue=1e-119,
Organism=Escherichia coli, GI48994965, Length=642, Percent_Identity=39.2523364485981, Blast_Score=394, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6322369, Length=754, Percent_Identity=27.8514588859416, Blast_Score=205, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6324477, Length=678, Percent_Identity=21.5339233038348, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 77569; Mature: 77569

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSKLNPPQREAVVTLEGPLLVLAGAGSGKTRVITHRIVHLLNERPGLIMARNILAVTF
CCCCCCCCCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCEEEEEE
TNKAATEMKERLVHMAGPRAQGVLVCTFHAFGAEMLREDIHRLGWPKKFAIADMGDQLAN
CCHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHH
IRRAMREHKIDDRSFDARKVLNLISKAKNSGKAPEPKPEGIGDDYDLITHMVYPDYQLSL
HHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEE
KAQGSVDFDDLLLLPARLLREHPDLYEKYTKRFRYLLVDEFQDTNTAQLELLKLLAGRSR
EECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
NVCAVGDDDQCIYSWRGAEVRNILDFDRLFPGGKEVRLEQNYRSVQTVLDAANAVIAKNP
CEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCC
ERKAKQMWTDRTGGTKVKVVTCPNDEEEARFVAHEIQKHMALGISADDIAVLYRTNGQSR
HHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
PIEETLREKNIGYEVVGGSEFFDRREVKDVIAYFKVIVNKLDEISLLRIVNVPSRGIGDV
CHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHH
TMERLNVHARGEGVTLWTVMKKATDYEDLPPGAGARVMDFVDLVERYRAAYEHGQLANVT
HHHHHEEEECCCCEEEEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHH
RKLLEEIGFREATRAHATSATAADKKLKGVDGVLNSLENFEKREGPKASLPTYLNRLSLD
HHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
TRQEEEEVPGANRRVTLMTVHASKGLEYRLVFFIGMEEDLMPHGGMQGEAQNLEEERRLC
CCHHHHHCCCCCCEEEEEEEECCCCCEEEEEEEEECCHHCCCCCCCCCCHHCHHHHCCEE
YVGITRAKEVLYLTRAATRVKRGKEVPRTPSRFLEDLPPEVIEVVELDAPRQGPPTTEEK
EEEHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHH
NFFANLKERFKKPAIPGTPPGGTGPSGGAAR
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDLSKLNPPQREAVVTLEGPLLVLAGAGSGKTRVITHRIVHLLNERPGLIMARNILAVTF
CCCCCCCCCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCEEEEEE
TNKAATEMKERLVHMAGPRAQGVLVCTFHAFGAEMLREDIHRLGWPKKFAIADMGDQLAN
CCHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHH
IRRAMREHKIDDRSFDARKVLNLISKAKNSGKAPEPKPEGIGDDYDLITHMVYPDYQLSL
HHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEE
KAQGSVDFDDLLLLPARLLREHPDLYEKYTKRFRYLLVDEFQDTNTAQLELLKLLAGRSR
EECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
NVCAVGDDDQCIYSWRGAEVRNILDFDRLFPGGKEVRLEQNYRSVQTVLDAANAVIAKNP
CEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCC
ERKAKQMWTDRTGGTKVKVVTCPNDEEEARFVAHEIQKHMALGISADDIAVLYRTNGQSR
HHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
PIEETLREKNIGYEVVGGSEFFDRREVKDVIAYFKVIVNKLDEISLLRIVNVPSRGIGDV
CHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHH
TMERLNVHARGEGVTLWTVMKKATDYEDLPPGAGARVMDFVDLVERYRAAYEHGQLANVT
HHHHHEEEECCCCEEEEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHH
RKLLEEIGFREATRAHATSATAADKKLKGVDGVLNSLENFEKREGPKASLPTYLNRLSLD
HHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
TRQEEEEVPGANRRVTLMTVHASKGLEYRLVFFIGMEEDLMPHGGMQGEAQNLEEERRLC
CCHHHHHCCCCCCEEEEEEEECCCCCEEEEEEEEECCHHCCCCCCCCCCHHCHHHHCCEE
YVGITRAKEVLYLTRAATRVKRGKEVPRTPSRFLEDLPPEVIEVVELDAPRQGPPTTEEK
EEEHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHH
NFFANLKERFKKPAIPGTPPGGTGPSGGAAR
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA