Click here to switch to the map view.

The map label for this gene is hsaA [H]

Identifier: 108756875

GI number: 108756875

Start: 1091117

End: 1092286

Strand: Reverse

Name: hsaA [H]

Synonym: MXAN_0950

Alternate gene names: 108756875

Gene position: 1092286-1091117 (Counterclockwise)

Preceding gene: 108762961

Following gene: 108761217

Centisome position: 11.95

GC content: 70.51

Gene sequence:

>1170_bases
ATGACGCTGGATGCCGGAGCGAACCTGCTACATGCGGTACGTGAGTTGGCCCCTGCCCTCTCCGCTCGCAGTGGGGAGAT
TGAGCAGGCACGGCAGCTCCCCTTGGACCTCATCGCCACGCTGAAGGACATCGGCGTCTACCGGATGCTTGTCCCTCGCA
GCCATGGCGGGCTGGAGCTGAATCTTGTCACCGGGCTGGACGTCCTCTCCGAGCTGGCCCGCGCGGACGCCTCCACCGCC
TGGACGATGATGATAGCCACGGAGAGCCCCCAACTCTTCGCCCTCCTCCTCCGCGAGGAGTTCGATGCCGTCTACGCCGC
CGGGCCCAATGCCACCGTGGGCGGCGCCTTCAATGCCCAGGGCAAGGCCGTGCAGGTGGACGGCGGCTACCGCGTCACCG
GCCACTGGAACTTCGCCACCGGCTGCCGCCAGAGTGAATGGCTGTTCGGCAACTGTGTCGTCCTTGGCCCAGACGGCACG
CCCCGCGCTGGCCCCGCCGAGGGCATGCCCGAGACGCGCGCCATGCTGCTCCCCGCCAGCGAGGTCCGCATCATCGAGCA
CTGGGACGTGCTCGGCCTGCGCGGCACCGGCAGCCACGACATCGCCATCGACGCCTTCGTCCCCCAGCAACGCACCTTCG
ACATCTTCACCGGCCAGCCCTCCGTGCCGGGCGCCAACTTCGTGGTGCCGGTGCTGCACTACGCCATGCACATCGGCGCG
GTGGCGGTGGGCATCGCCCAGGGCGCGGTGGACGACCTGCTCACCCTGGCCCGCTCGGGCAAGCGCCGGCTGTATGCGCG
CACCTCGCTCGTGGACTCCCCTGTGTTCCGCAACCGGCTGGGCCGCGCGGAGACGGGCGCCCGCGCCGCTCACGACGCCC
TCCGCCGCATGGGCGAGGTGTTCTGGGACGCCTGCCAGCAGTCCCCGATGAAGGCCTTCGCCCTCGCGCCGCAGGTGTCC
GCCACCCTGACGTGGGCCGTGGAGACAGCCGCCGAGGTCGTGACGGCCTGCTACCACGCGGGCGGCGCCACGTCCGTGCG
CGATGGCGCATCACTCCAGCGCCGTTTCCGCGACATCCACACCCTCACCCAGCACGCGGCCGTGGCGGAGGGCTGGTTCA
CCCAGGAAGGCAGCGCGCTCCTGGGCTTCCCCGTCCTCTTCGAAGCCTGA

Upstream 100 bases:

>100_bases
AATGCCCTGGCGCGCAGGACCTGAAAGCATTAGCGCACTGCACCTTTCACAGACATCGAGCATCAGGCATCTTTGAGGCT
CTCTTTCCGGAGCCTCGACC

Downstream 100 bases:

>100_bases
CGGCGCGCCCGCTACGTCCGCGTGGTGCGCAGCTCCGCGCGGCGAATCTTCCCGCTCACCGTCTTGGGCAGCTCGGTGAC
GAACTCGATTTCGCGCGGGT

Product: hypothetical protein

Products: NA

Alternate protein names: 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MTLDAGANLLHAVRELAPALSARSGEIEQARQLPLDLIATLKDIGVYRMLVPRSHGGLELNLVTGLDVLSELARADASTA
WTMMIATESPQLFALLLREEFDAVYAAGPNATVGGAFNAQGKAVQVDGGYRVTGHWNFATGCRQSEWLFGNCVVLGPDGT
PRAGPAEGMPETRAMLLPASEVRIIEHWDVLGLRGTGSHDIAIDAFVPQQRTFDIFTGQPSVPGANFVVPVLHYAMHIGA
VAVGIAQGAVDDLLTLARSGKRRLYARTSLVDSPVFRNRLGRAETGARAAHDALRRMGEVFWDACQQSPMKAFALAPQVS
ATLTWAVETAAEVVTACYHAGGATSVRDGASLQRRFRDIHTLTQHAAVAEGWFTQEGSALLGFPVLFEA

Sequences:

>Translated_389_residues
MTLDAGANLLHAVRELAPALSARSGEIEQARQLPLDLIATLKDIGVYRMLVPRSHGGLELNLVTGLDVLSELARADASTA
WTMMIATESPQLFALLLREEFDAVYAAGPNATVGGAFNAQGKAVQVDGGYRVTGHWNFATGCRQSEWLFGNCVVLGPDGT
PRAGPAEGMPETRAMLLPASEVRIIEHWDVLGLRGTGSHDIAIDAFVPQQRTFDIFTGQPSVPGANFVVPVLHYAMHIGA
VAVGIAQGAVDDLLTLARSGKRRLYARTSLVDSPVFRNRLGRAETGARAAHDALRRMGEVFWDACQQSPMKAFALAPQVS
ATLTWAVETAAEVVTACYHAGGATSVRDGASLQRRFRDIHTLTQHAAVAEGWFTQEGSALLGFPVLFEA
>Mature_388_residues
TLDAGANLLHAVRELAPALSARSGEIEQARQLPLDLIATLKDIGVYRMLVPRSHGGLELNLVTGLDVLSELARADASTAW
TMMIATESPQLFALLLREEFDAVYAAGPNATVGGAFNAQGKAVQVDGGYRVTGHWNFATGCRQSEWLFGNCVVLGPDGTP
RAGPAEGMPETRAMLLPASEVRIIEHWDVLGLRGTGSHDIAIDAFVPQQRTFDIFTGQPSVPGANFVVPVLHYAMHIGAV
AVGIAQGAVDDLLTLARSGKRRLYARTSLVDSPVFRNRLGRAETGARAAHDALRRMGEVFWDACQQSPMKAFALAPQVSA
TLTWAVETAAEVVTACYHAGGATSVRDGASLQRRFRDIHTLTQHAAVAEGWFTQEGSALLGFPVLFEA

Specific function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol. Also catalyzes the o-hydroxylation of a range of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 41622; Mature: 41491

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDAGANLLHAVRELAPALSARSGEIEQARQLPLDLIATLKDIGVYRMLVPRSHGGLEL
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHCCEEEEEEECCCCCEEE
NLVTGLDVLSELARADASTAWTMMIATESPQLFALLLREEFDAVYAAGPNATVGGAFNAQ
EEEHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHCEEEECCCCCCCCCCCCCC
GKAVQVDGGYRVTGHWNFATGCRQSEWLFGNCVVLGPDGTPRAGPAEGMPETRAMLLPAS
CCEEEECCCEEEEEECCHHCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCEEEECHH
EVRIIEHWDVLGLRGTGSHDIAIDAFVPQQRTFDIFTGQPSVPGANFVVPVLHYAMHIGA
HEEEEEECCEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
VAVGIAQGAVDDLLTLARSGKRRLYARTSLVDSPVFRNRLGRAETGARAAHDALRRMGEV
HHHHHHHHHHHHHHHHHHCCCHHEEEHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHH
FWDACQQSPMKAFALAPQVSATLTWAVETAAEVVTACYHAGGATSVRDGASLQRRFRDIH
HHHHHHCCCCHHHHCCCCCHHEEEHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
TLTQHAAVAEGWFTQEGSALLGFPVLFEA
HHHHHHHHHCCCCCCCCCEEECCCEEECC
>Mature Secondary Structure 
TLDAGANLLHAVRELAPALSARSGEIEQARQLPLDLIATLKDIGVYRMLVPRSHGGLEL
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHCCEEEEEEECCCCCEEE
NLVTGLDVLSELARADASTAWTMMIATESPQLFALLLREEFDAVYAAGPNATVGGAFNAQ
EEEHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHCEEEECCCCCCCCCCCCCC
GKAVQVDGGYRVTGHWNFATGCRQSEWLFGNCVVLGPDGTPRAGPAEGMPETRAMLLPAS
CCEEEECCCEEEEEECCHHCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCEEEECHH
EVRIIEHWDVLGLRGTGSHDIAIDAFVPQQRTFDIFTGQPSVPGANFVVPVLHYAMHIGA
HEEEEEECCEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
VAVGIAQGAVDDLLTLARSGKRRLYARTSLVDSPVFRNRLGRAETGARAAHDALRRMGEV
HHHHHHHHHHHHHHHHHHCCCHHEEEHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHH
FWDACQQSPMKAFALAPQVSATLTWAVETAAEVVTACYHAGGATSVRDGASLQRRFRDIH
HHHHHHCCCCHHHHCCCCCHHEEEHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
TLTQHAAVAEGWFTQEGSALLGFPVLFEA
HHHHHHHHHCCCCCCCCCEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]