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The map label for this gene is mscM [H]

Identifier: 108756819

GI number: 108756819

Start: 5059847

End: 5061118

Strand: Direct

Name: mscM [H]

Synonym: MXAN_4113

Alternate gene names: 108756819

Gene position: 5059847-5061118 (Clockwise)

Preceding gene: 108757810

Following gene: 108760140

Centisome position: 55.36

GC content: 66.27

Gene sequence:

>1272_bases
GTGACGATCCTGCCGTGGCTGAGCGCGCTTCAACGCCAGCTGGAGCCCTGGCCGATGGCCTGGCCGGTCACTGTGCTGGC
GGCGCTGCTGGGGGTGGCCTGGCTGGCCAACTTCGTCACCAAGAAGATCCTGCTGCGCGGCCTGCACCATGTGATCGAGC
GGCTGTCCGGCCCCGAGCACGACACCCGGCTGGCCTTGCGCGCGGTGGAGCGCCTGTCCAACGTGGTGCCGTCGGTGGTG
ATCGCCTCCGGGCTGTCGCTGGTGCCGGGTCTGCCGGCAGCGCTGGTGGTCCTGCTCCAGGGCGCCTGCCACGTGTGGAC
AGTGGCCACGCTCGCGCTGGCCGCCAGCCATGCCTTCGACGCTTCCAACGCGTTCTACGAACGCCGCCCGGATGCGCGGA
ACAAGCCGATCAAGGGCTACCTGCAGGTGGCCAAGATCATCGTCTTCGTACTGGCCGGCCTGTCCATCGTGGCCACCCTG
GCCGGCGTGAAGCTGCTGCATGTGCTCACCGGTCTGGGCGCGGCCACGGCGGTGCTGATGCTGATCTTCCAGGACACGCT
CCTGTCGCTGGTGGCCAGCGTGCAGATCAGCGGCGATGGTCGCGTGCGCATCGGTGACTGGATCGAGATGCCCAGCCAGA
ACGCCGACGGTGATGTGATCGATATTGCCCTGCACACGGTGACGGTGCAGAACTGGGACAAGACCATCACCACCATCCCG
ACCAAGAAGTTGATCAGCGACTCGTTCAAGAACTGGCGCGGCATGCGGCAGAGCGGTGGCCGCCGGATCAAGCGCTCGAT
CTACCTGGATCAGCACAGCGTGCGCTTCCTGGATGATGCGTTGCAGCCACGCATCTACCAGTTCGCATTGCTCGATGATT
ACCTGGCCAGCAAGCGCGAGGAGCTGGGGCAGTGGAATGCCCAAGTGGCCGCCGTGCATCCCGAGCCCGTCAATGCCCGC
CGGCTGACCAACCTGGGCACGTTCCGCGCCTATGTGGAGCGCTACCTGCGCACCCACCCGCGCATCAACCAGAACATGAC
CCTACTGGTGCGTCAGATGGCACCGACCGAGCACGGCCTGCCCCTGGAGATCTACTGTTTCACCGCCTCCACGGCCTGGG
CCGAGTACGAGGCGACCCAGTCGGACATCTTCGACCACCTGCTGGCGATCCTGCCCGAGTTCGGTCTGCGCGTGTTCCAG
CAGTCCTCCGATGCGATGTTCATGGGCCTGCAGCGCGCCCAGGACTGTGCCACGCCGGTGGTGCGCGGCTGA

Upstream 100 bases:

>100_bases
TGGCGCGCGCGGTGGGGGTGCTCATCGAACGTAGCCGTCAAGACGGCTGACCGCACCCAAGCCAAGGAGGTATTACCTGC
TCATGAATGTGCAACAACCC

Downstream 100 bases:

>100_bases
GAGGCCGGGCCTGCCGACCCGGTGTCATCCACGCAAAAGGCCGGGCAATGCCCGGCCTTTTACGTGTGCGAAGGCGCTTA
CTGGCCCTTGGGCGTGAGCT

Product: mechanosensitive ion channel family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MTILPWLSALQRQLEPWPMAWPVTVLAALLGVAWLANFVTKKILLRGLHHVIERLSGPEHDTRLALRAVERLSNVVPSVV
IASGLSLVPGLPAALVVLLQGACHVWTVATLALAASHAFDASNAFYERRPDARNKPIKGYLQVAKIIVFVLAGLSIVATL
AGVKLLHVLTGLGAATAVLMLIFQDTLLSLVASVQISGDGRVRIGDWIEMPSQNADGDVIDIALHTVTVQNWDKTITTIP
TKKLISDSFKNWRGMRQSGGRRIKRSIYLDQHSVRFLDDALQPRIYQFALLDDYLASKREELGQWNAQVAAVHPEPVNAR
RLTNLGTFRAYVERYLRTHPRINQNMTLLVRQMAPTEHGLPLEIYCFTASTAWAEYEATQSDIFDHLLAILPEFGLRVFQ
QSSDAMFMGLQRAQDCATPVVRG

Sequences:

>Translated_423_residues
MTILPWLSALQRQLEPWPMAWPVTVLAALLGVAWLANFVTKKILLRGLHHVIERLSGPEHDTRLALRAVERLSNVVPSVV
IASGLSLVPGLPAALVVLLQGACHVWTVATLALAASHAFDASNAFYERRPDARNKPIKGYLQVAKIIVFVLAGLSIVATL
AGVKLLHVLTGLGAATAVLMLIFQDTLLSLVASVQISGDGRVRIGDWIEMPSQNADGDVIDIALHTVTVQNWDKTITTIP
TKKLISDSFKNWRGMRQSGGRRIKRSIYLDQHSVRFLDDALQPRIYQFALLDDYLASKREELGQWNAQVAAVHPEPVNAR
RLTNLGTFRAYVERYLRTHPRINQNMTLLVRQMAPTEHGLPLEIYCFTASTAWAEYEATQSDIFDHLLAILPEFGLRVFQ
QSSDAMFMGLQRAQDCATPVVRG
>Mature_422_residues
TILPWLSALQRQLEPWPMAWPVTVLAALLGVAWLANFVTKKILLRGLHHVIERLSGPEHDTRLALRAVERLSNVVPSVVI
ASGLSLVPGLPAALVVLLQGACHVWTVATLALAASHAFDASNAFYERRPDARNKPIKGYLQVAKIIVFVLAGLSIVATLA
GVKLLHVLTGLGAATAVLMLIFQDTLLSLVASVQISGDGRVRIGDWIEMPSQNADGDVIDIALHTVTVQNWDKTITTIPT
KKLISDSFKNWRGMRQSGGRRIKRSIYLDQHSVRFLDDALQPRIYQFALLDDYLASKREELGQWNAQVAAVHPEPVNARR
LTNLGTFRAYVERYLRTHPRINQNMTLLVRQMAPTEHGLPLEIYCFTASTAWAEYEATQSDIFDHLLAILPEFGLRVFQQ
SSDAMFMGLQRAQDCATPVVRG

Specific function: Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1786791, Length=303, Percent_Identity=49.1749174917492, Blast_Score=308, Evalue=3e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 46928; Mature: 46797

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILPWLSALQRQLEPWPMAWPVTVLAALLGVAWLANFVTKKILLRGLHHVIERLSGPEH
CCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
DTRLALRAVERLSNVVPSVVIASGLSLVPGLPAALVVLLQGACHVWTVATLALAASHAFD
HHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
ASNAFYERRPDARNKPIKGYLQVAKIIVFVLAGLSIVATLAGVKLLHVLTGLGAATAVLM
CCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LIFQDTLLSLVASVQISGDGRVRIGDWIEMPSQNADGDVIDIALHTVTVQNWDKTITTIP
HHHHHHHHHHHHHHEECCCCCEEECHHHCCCCCCCCCCEEEEEEEEEEECCCCCHHHCCC
TKKLISDSFKNWRGMRQSGGRRIKRSIYLDQHSVRFLDDALQPRIYQFALLDDYLASKRE
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
ELGQWNAQVAAVHPEPVNARRLTNLGTFRAYVERYLRTHPRINQNMTLLVRQMAPTEHGL
HHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCC
PLEIYCFTASTAWAEYEATQSDIFDHLLAILPEFGLRVFQQSSDAMFMGLQRAQDCATPV
CEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
VRG
CCC
>Mature Secondary Structure 
TILPWLSALQRQLEPWPMAWPVTVLAALLGVAWLANFVTKKILLRGLHHVIERLSGPEH
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
DTRLALRAVERLSNVVPSVVIASGLSLVPGLPAALVVLLQGACHVWTVATLALAASHAFD
HHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
ASNAFYERRPDARNKPIKGYLQVAKIIVFVLAGLSIVATLAGVKLLHVLTGLGAATAVLM
CCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LIFQDTLLSLVASVQISGDGRVRIGDWIEMPSQNADGDVIDIALHTVTVQNWDKTITTIP
HHHHHHHHHHHHHHEECCCCCEEECHHHCCCCCCCCCCEEEEEEEEEEECCCCCHHHCCC
TKKLISDSFKNWRGMRQSGGRRIKRSIYLDQHSVRFLDDALQPRIYQFALLDDYLASKRE
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
ELGQWNAQVAAVHPEPVNARRLTNLGTFRAYVERYLRTHPRINQNMTLLVRQMAPTEHGL
HHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCC
PLEIYCFTASTAWAEYEATQSDIFDHLLAILPEFGLRVFQQSSDAMFMGLQRAQDCATPV
CEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
VRG
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 7813889 [H]