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The map label for this gene is gcp [H]

Identifier: 108563957

GI number: 108563957

Start: 1592673

End: 1593695

Strand: Direct

Name: gcp [H]

Synonym: HPAG1_1532

Alternate gene names: 108563957

Gene position: 1592673-1593695 (Clockwise)

Preceding gene: 108563956

Following gene: 108563958

Centisome position: 99.77

GC content: 41.64

Gene sequence:

>1023_bases
ATGATTTTAAGCATTGAAAGTTCTTGCGATGACAGCTCTTTAGCCCTTACAAGAATAAAGGACGCTCAACTCATCGCTCA
TTTTAAAATCTCTCAAGAAAAGCACCACAGCTCTTATGGAGGCGTTGTGCCTGAGCTTGCATCGCGCTTGCATGCTGAGA
ATTTGCCGCTCTTATTAGAACGCATTAAAATCAGCTTGAATAGGGATTTTTCCAAGCTCAAAGCCATCGCTATCACTAAC
CAGCCAGGTTTGAGCGTTACCTTAATAGAAGGTTTGATGATGGCGAAAGCCTTGAGCTTGTCTTTGAATTTACCCTTGAT
TTTAGAAGATCATTTGAGAGGGCATGTGTATTCGCTCTTTATCAATGAAAAACAAACATGCATGCCTTTAAGCGCGCTCT
TAGTCTCTGGGGGGCATTCTTTGATTTTAGAGGCTAGAGATTATGAAGACATTAAAATCGTTGCCACGAGTTTAGACGAT
AGCTTTGGAGAGAGTTTTGATAAGGTTTCCAAAATGCTTGATTTAGGCTATCCAGGAGGCCCCATAGTGGAAAAATTAGC
CCTTGATTACGCGCGCCAAAACGAGCCTTTAATGTTCCCTATCCCTTTAAAAAACAGCCCGAATTTGGCTTTTAGTTTTT
CAGGTTTAAAAAATGCGGTGCGTTTGGAGGCTGAAAAAAACGCCCCCAATTTGAATGAAGCGATCAAGCAAAAGATTGCC
TATCATTTCCAAAGCGCAGCGATTGAGCATTTAATCCAGCAGACTAAACGCTATTTTAAAATCAAACGCCCTAAAATTTT
TGGCATTGTGGGAGGAGCGAGCCAGAATCTGGCTTTAAGAAAGGCGTTTGAAAACTTGTGCGCTGAGTTTGATTGCAAGC
TTGTTTTAGCCCCTTTAGAATTTTGCAGCGACAATGCCGCCATGATAGGGCGATCCAGCCTAGAATCTTATCAAAAAAAG
CGCTTTGTCCCTTTAGAAAAGGCCAACATTTCGCCAAGAACGCTGTTAAAAAGTTTTGAGTGA

Upstream 100 bases:

>100_bases
AAAAGCTATTTGAATGCGATCAAATATTTGGCTTAAAGATTTTAAAATACAAGCCAACAAAGTATAATTCAAGCAAAAAT
ACCACCCAAAGATAAAGATA

Downstream 100 bases:

>100_bases
ATGGGTGCGAAAAGAAAGCGCATAATCAAACGCCCTAAAATTTATCAATCTTTTATCTGTATTTGAGAGATTAAATTTGA
ATAAAAGCGTATTAAAACTG

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MILSIESSCDDSSLALTRIKDAQLIAHFKISQEKHHSSYGGVVPELASRLHAENLPLLLERIKISLNRDFSKLKAIAITN
QPGLSVTLIEGLMMAKALSLSLNLPLILEDHLRGHVYSLFINEKQTCMPLSALLVSGGHSLILEARDYEDIKIVATSLDD
SFGESFDKVSKMLDLGYPGGPIVEKLALDYARQNEPLMFPIPLKNSPNLAFSFSGLKNAVRLEAEKNAPNLNEAIKQKIA
YHFQSAAIEHLIQQTKRYFKIKRPKIFGIVGGASQNLALRKAFENLCAEFDCKLVLAPLEFCSDNAAMIGRSSLESYQKK
RFVPLEKANISPRTLLKSFE

Sequences:

>Translated_340_residues
MILSIESSCDDSSLALTRIKDAQLIAHFKISQEKHHSSYGGVVPELASRLHAENLPLLLERIKISLNRDFSKLKAIAITN
QPGLSVTLIEGLMMAKALSLSLNLPLILEDHLRGHVYSLFINEKQTCMPLSALLVSGGHSLILEARDYEDIKIVATSLDD
SFGESFDKVSKMLDLGYPGGPIVEKLALDYARQNEPLMFPIPLKNSPNLAFSFSGLKNAVRLEAEKNAPNLNEAIKQKIA
YHFQSAAIEHLIQQTKRYFKIKRPKIFGIVGGASQNLALRKAFENLCAEFDCKLVLAPLEFCSDNAAMIGRSSLESYQKK
RFVPLEKANISPRTLLKSFE
>Mature_340_residues
MILSIESSCDDSSLALTRIKDAQLIAHFKISQEKHHSSYGGVVPELASRLHAENLPLLLERIKISLNRDFSKLKAIAITN
QPGLSVTLIEGLMMAKALSLSLNLPLILEDHLRGHVYSLFINEKQTCMPLSALLVSGGHSLILEARDYEDIKIVATSLDD
SFGESFDKVSKMLDLGYPGGPIVEKLALDYARQNEPLMFPIPLKNSPNLAFSFSGLKNAVRLEAEKNAPNLNEAIKQKIA
YHFQSAAIEHLIQQTKRYFKIKRPKIFGIVGGASQNLALRKAFENLCAEFDCKLVLAPLEFCSDNAAMIGRSSLESYQKK
RFVPLEKANISPRTLLKSFE

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family [H]

Homologues:

Organism=Homo sapiens, GI116812636, Length=338, Percent_Identity=29.2899408284024, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI8923380, Length=334, Percent_Identity=21.2574850299401, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1789445, Length=333, Percent_Identity=32.7327327327327, Blast_Score=180, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17557464, Length=331, Percent_Identity=32.3262839879154, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71995670, Length=320, Percent_Identity=26.25, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320099, Length=354, Percent_Identity=29.6610169491525, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI20129063, Length=340, Percent_Identity=29.4117647058824, Blast_Score=148, Evalue=6e-36,
Organism=Drosophila melanogaster, GI21357207, Length=345, Percent_Identity=24.6376811594203, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861 [H]

Pfam domain/function: PF00814 Peptidase_M22 [H]

EC number: =3.4.24.57 [H]

Molecular weight: Translated: 37780; Mature: 37780

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILSIESSCDDSSLALTRIKDAQLIAHFKISQEKHHSSYGGVVPELASRLHAENLPLLLE
CEEEECCCCCCCCEEEEEECCHHEEEEEECCHHHCCCCCCCHHHHHHHHHCCCCCHHHHH
RIKISLNRDFSKLKAIAITNQPGLSVTLIEGLMMAKALSLSLNLPLILEDHLRGHVYSLF
HHHHHCCCCHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEHHCCCCEEEEEE
INEKQTCMPLSALLVSGGHSLILEARDYEDIKIVATSLDDSFGESFDKVSKMLDLGYPGG
ECCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCC
PIVEKLALDYARQNEPLMFPIPLKNSPNLAFSFSGLKNAVRLEAEKNAPNLNEAIKQKIA
HHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHH
YHFQSAAIEHLIQQTKRYFKIKRPKIFGIVGGASQNLALRKAFENLCAEFDCKLVLAPLE
HHHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEHH
FCSDNAAMIGRSSLESYQKKRFVPLEKANISPRTLLKSFE
HCCCCHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHCCC
>Mature Secondary Structure
MILSIESSCDDSSLALTRIKDAQLIAHFKISQEKHHSSYGGVVPELASRLHAENLPLLLE
CEEEECCCCCCCCEEEEEECCHHEEEEEECCHHHCCCCCCCHHHHHHHHHCCCCCHHHHH
RIKISLNRDFSKLKAIAITNQPGLSVTLIEGLMMAKALSLSLNLPLILEDHLRGHVYSLF
HHHHHCCCCHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEHHCCCCEEEEEE
INEKQTCMPLSALLVSGGHSLILEARDYEDIKIVATSLDDSFGESFDKVSKMLDLGYPGG
ECCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCC
PIVEKLALDYARQNEPLMFPIPLKNSPNLAFSFSGLKNAVRLEAEKNAPNLNEAIKQKIA
HHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHH
YHFQSAAIEHLIQQTKRYFKIKRPKIFGIVGGASQNLALRKAFENLCAEFDCKLVLAPLE
HHHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEHH
FCSDNAAMIGRSSLESYQKKRFVPLEKANISPRTLLKSFE
HCCCCHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA