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The map label for this gene is pdxA [H]

Identifier: 108563956

GI number: 108563956

Start: 1591685

End: 1592608

Strand: Direct

Name: pdxA [H]

Synonym: HPAG1_1531

Alternate gene names: 108563956

Gene position: 1591685-1592608 (Clockwise)

Preceding gene: 108563955

Following gene: 108563957

Centisome position: 99.71

GC content: 41.99

Gene sequence:

>924_bases
ATGGCTAAAAAGAAAATTGCGATCAGTTGTGGGGATATTCAAGGCGTAGGCTTAGAATTGATTTTAAAAAGCCATAAGGA
AGTGAGTGCGTTTTGTGAGCCGTTGTATCTCATTGATGGCGAACTTTTAGAGCGAGCCAATCAATTGCTTCATAACGCTT
ATGAAACTAAAACGCTTAACACACTCGCTATCCATTCCCCCTTACCCTTATTGAACTCTAGCACGATAGGCAAAGTCAGC
GCTCAAAGCGGGGCGTATAGTTTTGAGAGTTTTAAAAAGGCTTGCGAGTTAGCGGATGATAAAGAAGTGGATGGCGTTTG
CACTTTGCCTATCAACAAACTCGCATGGCAACAAGCCCAAATCCCTTTTGTGGGGCATACCGATTTTTTAAAACAACGCT
ATAAAGATCATCAAATCATCATGATGCTTGGGTGTTCAAAACTCTTTGTGGGGCTATTTAGCGACCATGTGCCTTTAGGG
GCGGTTTCTCAACTTATTCAAGTTAAAGAGTTAGTTAAGTTTTTATTAGCGTTTCAAAAAAGCACTCAAGCCAAAATCGT
TCAAGTGTGTGGCTTTAACCCCCATGCGGGCGAAGAGGGCTTGTTTGGGGAAGAAGATGAAAAGATTTTAAAAGCCATTC
AAAAGAGCAACCAAACGCTAGGCTTTGAATGCTTTTTAGGGCCACTGCCTGCTGATAGCGCTTTTGCCCCCAATAAGCGC
AAAATAACCCCTTTTTATGTGAGCATGAGCCATGATGTGGGGCTAGCCCCTTTAAAAGCGCTCTATTTTGATGAAAGCAT
CAATGTGAGTTTGAACGCTCCCATTTTACGCGCTTCCACTGACCATGGCACAGCGTTTGATATTGCTTATCAAAACAAAG
CGAACAACAAAAGCTATTTGAATGCGATCAAATATTTGGCTTAA

Upstream 100 bases:

>100_bases
TTAAGAGAGCTTAATATCGGTCATAGCGTGGTTTCAAAAGCGGTTTTAGTGGGATTAGAAAAAGCGATTTTAGAAATGGC
ACAACTTATCAAGCGATAAA

Downstream 100 bases:

>100_bases
AGATTTTAAAATACAAGCCAACAAAGTATAATTCAAGCAAAAATACCACCCAAAGATAAAGATAATGATTTTAAGCATTG
AAAGTTCTTGCGATGACAGC

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MAKKKIAISCGDIQGVGLELILKSHKEVSAFCEPLYLIDGELLERANQLLHNAYETKTLNTLAIHSPLPLLNSSTIGKVS
AQSGAYSFESFKKACELADDKEVDGVCTLPINKLAWQQAQIPFVGHTDFLKQRYKDHQIIMMLGCSKLFVGLFSDHVPLG
AVSQLIQVKELVKFLLAFQKSTQAKIVQVCGFNPHAGEEGLFGEEDEKILKAIQKSNQTLGFECFLGPLPADSAFAPNKR
KITPFYVSMSHDVGLAPLKALYFDESINVSLNAPILRASTDHGTAFDIAYQNKANNKSYLNAIKYLA

Sequences:

>Translated_307_residues
MAKKKIAISCGDIQGVGLELILKSHKEVSAFCEPLYLIDGELLERANQLLHNAYETKTLNTLAIHSPLPLLNSSTIGKVS
AQSGAYSFESFKKACELADDKEVDGVCTLPINKLAWQQAQIPFVGHTDFLKQRYKDHQIIMMLGCSKLFVGLFSDHVPLG
AVSQLIQVKELVKFLLAFQKSTQAKIVQVCGFNPHAGEEGLFGEEDEKILKAIQKSNQTLGFECFLGPLPADSAFAPNKR
KITPFYVSMSHDVGLAPLKALYFDESINVSLNAPILRASTDHGTAFDIAYQNKANNKSYLNAIKYLA
>Mature_306_residues
AKKKIAISCGDIQGVGLELILKSHKEVSAFCEPLYLIDGELLERANQLLHNAYETKTLNTLAIHSPLPLLNSSTIGKVSA
QSGAYSFESFKKACELADDKEVDGVCTLPINKLAWQQAQIPFVGHTDFLKQRYKDHQIIMMLGCSKLFVGLFSDHVPLGA
VSQLIQVKELVKFLLAFQKSTQAKIVQVCGFNPHAGEEGLFGEEDEKILKAIQKSNQTLGFECFLGPLPADSAFAPNKRK
ITPFYVSMSHDVGLAPLKALYFDESINVSLNAPILRASTDHGTAFDIAYQNKANNKSYLNAIKYLA

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=319, Percent_Identity=28.8401253918495, Blast_Score=145, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 33780; Mature: 33649

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKKIAISCGDIQGVGLELILKSHKEVSAFCEPLYLIDGELLERANQLLHNAYETKTLN
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCHHEECHHHHHHHHHHHHHHHHHCCCE
TLAIHSPLPLLNSSTIGKVSAQSGAYSFESFKKACELADDKEVDGVCTLPINKLAWQQAQ
EEEECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHCC
IPFVGHTDFLKQRYKDHQIIMMLGCSKLFVGLFSDHVPLGAVSQLIQVKELVKFLLAFQK
CCCCCCHHHHHHHCCCCEEEEEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
STQAKIVQVCGFNPHAGEEGLFGEEDEKILKAIQKSNQTLGFECFLGPLPADSAFAPNKR
CCHHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCC
KITPFYVSMSHDVGLAPLKALYFDESINVSLNAPILRASTDHGTAFDIAYQNKANNKSYL
CCCEEEEEECCCCCCHHHHHHEECCCCCEEECCCEEEECCCCCCEEEEEECCCCCCHHHH
NAIKYLA
HHHHHCC
>Mature Secondary Structure 
AKKKIAISCGDIQGVGLELILKSHKEVSAFCEPLYLIDGELLERANQLLHNAYETKTLN
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCHHEECHHHHHHHHHHHHHHHHHCCCE
TLAIHSPLPLLNSSTIGKVSAQSGAYSFESFKKACELADDKEVDGVCTLPINKLAWQQAQ
EEEECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHCC
IPFVGHTDFLKQRYKDHQIIMMLGCSKLFVGLFSDHVPLGAVSQLIQVKELVKFLLAFQK
CCCCCCHHHHHHHCCCCEEEEEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
STQAKIVQVCGFNPHAGEEGLFGEEDEKILKAIQKSNQTLGFECFLGPLPADSAFAPNKR
CCHHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCC
KITPFYVSMSHDVGLAPLKALYFDESINVSLNAPILRASTDHGTAFDIAYQNKANNKSYL
CCCEEEEEECCCCCCHHHHHHEECCCCCEEECCCEEEECCCCCCEEEEEECCCCCCHHHH
NAIKYLA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA