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The map label for this gene is ubiE [H]

Identifier: 108563855

GI number: 108563855

Start: 1487432

End: 1488163

Strand: Direct

Name: ubiE [H]

Synonym: HPAG1_1430

Alternate gene names: 108563855

Gene position: 1487432-1488163 (Clockwise)

Preceding gene: 108563854

Following gene: 108563856

Centisome position: 93.18

GC content: 40.3

Gene sequence:

>732_bases
ATGAAAAAAGAAAATCGCCTCAAGCAAGAAAAAATCATCAACATGTTTGATGATATAGCCAGCTCTTACGATCAAGCCAA
CCGCTTGATGAGTTTTGGTTTAGACGTTAAATGGCGAGAAAGGGCTTGCGAGCATGCGTTTTTGTTTTTGGAAAACAAGA
AAGCGTTAAGGCTTGTGGATGTGGCATGCGGGACGGGGGATATGCTTGTTGCTTGGCAAAAAAGCGCTCTAAATTGCGCT
GTAGAATTTAAGGAATGTTTGGGAATTGACCCCTCTAACAACATGCTTGAATTAGCCGCTAAAAAGCTTGAGAATAAAGC
TTCTTTCATTCAGGCTCAAGCCAAAGATTTGAAAGGCGTTGGAAATAACAGCGTGGATATCCTCTCCATTGCGTATGGCT
TGCGCAATGTCGTGGAAAGACAAGAGGCCTTAAAAGAGTTTTTTAGGGTGTTAAAACCTAGGGGCGTTTTAGTGATTTTA
GAATTTTTAAAAAAGGACAACCCCACATGGCTGGATAAAATCTCAGGGTTTTACACGAATAAGGTTTTGCCTTTAGTGGG
AGGGGCTATCAGTAAGAATTATGGCGCTTATTCTTATTTACCGCAATCCATTGAGGGGTTTTTGAGTTTAGAGGGTTTGA
AACATGAACTAAAAAACGCAGGGTTTGAGATTCTAAGAACACAAGATTCTATCGCTCAAATTTCAACGACCATGCTTGTT
AGAAAAAGCTAA

Upstream 100 bases:

>100_bases
ATCGTGTGTTTAATGAAATACCCACGATTTTAATGATCCTCATTGTGATTTTAGTGGTTGTCAAGCCTTTTTAAAGACAA
GCCATGAAGAAAGAAAAGTC

Downstream 100 bases:

>100_bases
AGGAATGCCATGCAAGATGAATTATTTGAAACCGAAAAAGCCCCCCAAAAAAATACTAAGAACGCTAAAAACGCCCCTAA
AAAAAGCTTTGAAGAGCATG

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MKKENRLKQEKIINMFDDIASSYDQANRLMSFGLDVKWRERACEHAFLFLENKKALRLVDVACGTGDMLVAWQKSALNCA
VEFKECLGIDPSNNMLELAAKKLENKASFIQAQAKDLKGVGNNSVDILSIAYGLRNVVERQEALKEFFRVLKPRGVLVIL
EFLKKDNPTWLDKISGFYTNKVLPLVGGAISKNYGAYSYLPQSIEGFLSLEGLKHELKNAGFEILRTQDSIAQISTTMLV
RKS

Sequences:

>Translated_243_residues
MKKENRLKQEKIINMFDDIASSYDQANRLMSFGLDVKWRERACEHAFLFLENKKALRLVDVACGTGDMLVAWQKSALNCA
VEFKECLGIDPSNNMLELAAKKLENKASFIQAQAKDLKGVGNNSVDILSIAYGLRNVVERQEALKEFFRVLKPRGVLVIL
EFLKKDNPTWLDKISGFYTNKVLPLVGGAISKNYGAYSYLPQSIEGFLSLEGLKHELKNAGFEILRTQDSIAQISTTMLV
RKS
>Mature_243_residues
MKKENRLKQEKIINMFDDIASSYDQANRLMSFGLDVKWRERACEHAFLFLENKKALRLVDVACGTGDMLVAWQKSALNCA
VEFKECLGIDPSNNMLELAAKKLENKASFIQAQAKDLKGVGNNSVDILSIAYGLRNVVERQEALKEFFRVLKPRGVLVIL
EFLKKDNPTWLDKISGFYTNKVLPLVGGAISKNYGAYSYLPQSIEGFLSLEGLKHELKNAGFEILRTQDSIAQISTTMLV
RKS

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=254, Percent_Identity=28.3464566929134, Blast_Score=93, Evalue=2e-19,
Organism=Escherichia coli, GI48994983, Length=223, Percent_Identity=31.390134529148, Blast_Score=108, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17557039, Length=245, Percent_Identity=26.1224489795918, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323526, Length=229, Percent_Identity=29.6943231441048, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 27373; Mature: 27373

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS01183 UBIE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKENRLKQEKIINMFDDIASSYDQANRLMSFGLDVKWRERACEHAFLFLENKKALRLVD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCCEEEEE
VACGTGDMLVAWQKSALNCAVEFKECLGIDPSNNMLELAAKKLENKASFIQAQAKDLKGV
EECCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
GNNSVDILSIAYGLRNVVERQEALKEFFRVLKPRGVLVILEFLKKDNPTWLDKISGFYTN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHC
KVLPLVGGAISKNYGAYSYLPQSIEGFLSLEGLKHELKNAGFEILRTQDSIAQISTTMLV
CHHHHHCCHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHE
RKS
ECC
>Mature Secondary Structure
MKKENRLKQEKIINMFDDIASSYDQANRLMSFGLDVKWRERACEHAFLFLENKKALRLVD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCCEEEEE
VACGTGDMLVAWQKSALNCAVEFKECLGIDPSNNMLELAAKKLENKASFIQAQAKDLKGV
EECCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
GNNSVDILSIAYGLRNVVERQEALKEFFRVLKPRGVLVILEFLKKDNPTWLDKISGFYTN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHC
KVLPLVGGAISKNYGAYSYLPQSIEGFLSLEGLKHELKNAGFEILRTQDSIAQISTTMLV
CHHHHHCCHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHE
RKS
ECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA