Click here to switch to the map view.

The map label for this gene is metG [H]

Identifier: 108563402

GI number: 108563402

Start: 1026759

End: 1028690

Strand: Reverse

Name: metG [H]

Synonym: HPAG1_0977

Alternate gene names: 108563402

Gene position: 1028690-1026759 (Counterclockwise)

Preceding gene: 108563404

Following gene: 108563401

Centisome position: 64.44

GC content: 38.35

Gene sequence:

>1932_bases
ATGCAAAAATCACTGATCACAACCCCCATTTATTATGTGAATGATATTCCCCATATTGGCCATGCTTATACGACTTTGAT
TGCGGATACTTTAAAGAAGTATTACACGCTTCAAGGCGAAGAAGTCTTTTTTTTAACCGGCACCGATGAGCATGGGCAAA
AGATCGAACAAAGCGCGAGATTGAGAAATCAAAGCCCTAAAGCTTACGCCGATAGCATTAGCGCGATTTTTAAAGACCAG
TGGGATTTTTTCAATTTAGATTATGATGGTTTTATCCGCACCACAGACAGCGAGCATCAAAAATGCGTGCAAAACGCCTT
TGAAATCATGTTTGAAAAAGGGGATATTTATAAAGGCACTTATAGTGGGTATTATTGCGTGAGCTGTGAGAGTTATTGCG
CGATTTCTAAAACGGACAACACGAACGATAAAGTCTTATGCCCTGATTGCTTGAGGGAGACCACGCTTTTAGAAGAAGAG
AGTTATTTTTTTAAATTGAGCACGTATGAGAAGCCTTTATTGGATTTTTACGCTAAAAACCCTGAAGCGATTTTGCCTAT
TTATCGTAAAAATGAGGTAACTTCTTTTATTGAGCAGGGTTTATTGGATCTGTCTATCACGCGCACGAGTTTTGAATGGG
GCATTCCTTTGCCTAAAAAAATGAACGATCCTAAACATGTGGTGTATGTTTGGCTGGACGCTTTATTGAATTATGCGAGC
ATGTTAGGGTATTTGAATGGTTTAGACAATAAAATGGCGCATTTTGAATGCGCTAGGCATATTGTGGGTAAGGATATTTT
ACGCTTCCATGCCATTTATTGGCCGGCTTTTTTGATGAGTTTGAATTTGCCCCTATTCAAACAGCTTTGCGTGCATGGGT
GGTGGACGATAGAGGGCGTGAAAATGAGTAAGAGCTTGGGTAATGTTTTAGACGCTCAAAAGCTCGCCATGGAGTATGGG
ATTGAAGAATTGCGTTATTTTTTATTGCGTGAGGTGCCTTTTGGGCAAGATGGGGATTTTTCTAAAAAAGCGTTAATAGA
AAGGATCAACGCGAATTTGAATAACGATTTGGGGAATTTGCTGAACCGCTTGCTAGGCATGGCTAAAAAATATTTCAATT
ATTCTCTAAAAAGTGCCAAAATCACCGCTTATTATTCTAAAGAGCTAGAAAAAGCGCATCAAATTTTAGATAACGCTAAT
TCTTTTGTGCCTAAAATGCAATTGCATAAAGCTTTAGAGGAATTGTTTAACGTTTATGATTTTTTAAACAAACTCATCGC
TAAAGAAGAGCCATGGGTTTTGCACAAAAACAACGAATCAGAAAAACTAGAAGCCTTATTGAGTTTGATCGCAAACGTGC
TGTTACAATCAAGCTTTTTACTTTATGCGTTCATGCCAAAGAGCGCGACTAAATTAGCGAGCGCTTTTCGTGTAGAAATC
ACGCCCAATAATTACGAACGCTTTTTTAAAGCTAAAAAATTACAAGATATGATTTTACAAGACACCGAGCCTTTATTTTC
CAAAATGGAGAAAGTGGAGAAAACAACCCTAGCCAAAAAAGAAGAAGAAAAAAAGCCAGAAGAAAAAGCCCCACTAAAGC
AAGAAAACTATATCAGCATTGAGAATTTCAAAAAAGTAGAGATCAAAGTGGGGCTTATCAAAGAAGCTCAAAGGATTGAA
AAATCCAGTAAATTACTGCGCTTAAAAGTGGATTTAGGCGAAGGTTATTTGAGGCAGATTATTTCAGGGATCGCTTTGGA
TTATGAGCCTGAAAGTTTGGTGGGGCAAATGGTGTGCGTGGTGGCTAATTTAAAGCCTGCAAAGCTTATGGGCGAAATGA
GTGAGGGCATGATTTTAACGGTGCGAGATAATGATAATCTGGCTTTAATTAGCCCTACCAAAGAAAAAATTGCAGGAAGT
TTGATCAGCTAA

Upstream 100 bases:

>100_bases
CCCCACAAATAAGCATAAATTCAACCTCTATTCTCTAAATTTTTAAAAGCATGTTAAAATTAAGAGATTTAAACAAATTT
AAGGTAACACGATTATAAAG

Downstream 100 bases:

>100_bases
ATGCGATTAGGGGTGAATGAAGCCGTAGAATTGAGTTTGGGCGAATTGCAAAACACGCCCTCAATCAGCTATTTTAATTC
TATTGTTTTGTCTTTAAACA

Product: methionyl-tRNA synthetase

Products: NA

Alternate protein names: Methionine--tRNA ligase; MetRS [H]

Number of amino acids: Translated: 643; Mature: 643

Protein sequence:

>643_residues
MQKSLITTPIYYVNDIPHIGHAYTTLIADTLKKYYTLQGEEVFFLTGTDEHGQKIEQSARLRNQSPKAYADSISAIFKDQ
WDFFNLDYDGFIRTTDSEHQKCVQNAFEIMFEKGDIYKGTYSGYYCVSCESYCAISKTDNTNDKVLCPDCLRETTLLEEE
SYFFKLSTYEKPLLDFYAKNPEAILPIYRKNEVTSFIEQGLLDLSITRTSFEWGIPLPKKMNDPKHVVYVWLDALLNYAS
MLGYLNGLDNKMAHFECARHIVGKDILRFHAIYWPAFLMSLNLPLFKQLCVHGWWTIEGVKMSKSLGNVLDAQKLAMEYG
IEELRYFLLREVPFGQDGDFSKKALIERINANLNNDLGNLLNRLLGMAKKYFNYSLKSAKITAYYSKELEKAHQILDNAN
SFVPKMQLHKALEELFNVYDFLNKLIAKEEPWVLHKNNESEKLEALLSLIANVLLQSSFLLYAFMPKSATKLASAFRVEI
TPNNYERFFKAKKLQDMILQDTEPLFSKMEKVEKTTLAKKEEEKKPEEKAPLKQENYISIENFKKVEIKVGLIKEAQRIE
KSSKLLRLKVDLGEGYLRQIISGIALDYEPESLVGQMVCVVANLKPAKLMGEMSEGMILTVRDNDNLALISPTKEKIAGS
LIS

Sequences:

>Translated_643_residues
MQKSLITTPIYYVNDIPHIGHAYTTLIADTLKKYYTLQGEEVFFLTGTDEHGQKIEQSARLRNQSPKAYADSISAIFKDQ
WDFFNLDYDGFIRTTDSEHQKCVQNAFEIMFEKGDIYKGTYSGYYCVSCESYCAISKTDNTNDKVLCPDCLRETTLLEEE
SYFFKLSTYEKPLLDFYAKNPEAILPIYRKNEVTSFIEQGLLDLSITRTSFEWGIPLPKKMNDPKHVVYVWLDALLNYAS
MLGYLNGLDNKMAHFECARHIVGKDILRFHAIYWPAFLMSLNLPLFKQLCVHGWWTIEGVKMSKSLGNVLDAQKLAMEYG
IEELRYFLLREVPFGQDGDFSKKALIERINANLNNDLGNLLNRLLGMAKKYFNYSLKSAKITAYYSKELEKAHQILDNAN
SFVPKMQLHKALEELFNVYDFLNKLIAKEEPWVLHKNNESEKLEALLSLIANVLLQSSFLLYAFMPKSATKLASAFRVEI
TPNNYERFFKAKKLQDMILQDTEPLFSKMEKVEKTTLAKKEEEKKPEEKAPLKQENYISIENFKKVEIKVGLIKEAQRIE
KSSKLLRLKVDLGEGYLRQIISGIALDYEPESLVGQMVCVVANLKPAKLMGEMSEGMILTVRDNDNLALISPTKEKIAGS
LIS
>Mature_643_residues
MQKSLITTPIYYVNDIPHIGHAYTTLIADTLKKYYTLQGEEVFFLTGTDEHGQKIEQSARLRNQSPKAYADSISAIFKDQ
WDFFNLDYDGFIRTTDSEHQKCVQNAFEIMFEKGDIYKGTYSGYYCVSCESYCAISKTDNTNDKVLCPDCLRETTLLEEE
SYFFKLSTYEKPLLDFYAKNPEAILPIYRKNEVTSFIEQGLLDLSITRTSFEWGIPLPKKMNDPKHVVYVWLDALLNYAS
MLGYLNGLDNKMAHFECARHIVGKDILRFHAIYWPAFLMSLNLPLFKQLCVHGWWTIEGVKMSKSLGNVLDAQKLAMEYG
IEELRYFLLREVPFGQDGDFSKKALIERINANLNNDLGNLLNRLLGMAKKYFNYSLKSAKITAYYSKELEKAHQILDNAN
SFVPKMQLHKALEELFNVYDFLNKLIAKEEPWVLHKNNESEKLEALLSLIANVLLQSSFLLYAFMPKSATKLASAFRVEI
TPNNYERFFKAKKLQDMILQDTEPLFSKMEKVEKTTLAKKEEEKKPEEKAPLKQENYISIENFKKVEIKVGLIKEAQRIE
KSSKLLRLKVDLGEGYLRQIISGIALDYEPESLVGQMVCVVANLKPAKLMGEMSEGMILTVRDNDNLALISPTKEKIAGS
LIS

Specific function: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation [H]

COG id: COG0143

COG function: function code J; Methionyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 tRNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI24308436, Length=512, Percent_Identity=34.375, Blast_Score=281, Evalue=1e-75,
Organism=Homo sapiens, GI14043022, Length=517, Percent_Identity=25.9187620889749, Blast_Score=152, Evalue=6e-37,
Organism=Escherichia coli, GI1788432, Length=678, Percent_Identity=26.5486725663717, Blast_Score=221, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI212645096, Length=483, Percent_Identity=33.9544513457557, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI71992781, Length=373, Percent_Identity=32.4396782841823, Blast_Score=174, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17540794, Length=508, Percent_Identity=26.7716535433071, Blast_Score=162, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6321610, Length=479, Percent_Identity=34.2379958246347, Blast_Score=265, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6321704, Length=512, Percent_Identity=25, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21358483, Length=556, Percent_Identity=32.0143884892086, Blast_Score=271, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24655311, Length=554, Percent_Identity=26.5342960288809, Blast_Score=166, Evalue=4e-41,

Paralogues:

None

Copy number: 871 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015413
- InterPro:   IPR004495
- InterPro:   IPR014758
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR014729
- InterPro:   IPR002547
- InterPro:   IPR009080 [H]

Pfam domain/function: PF09334 tRNA-synt_1g; PF01588 tRNA_bind [H]

EC number: =6.1.1.10 [H]

Molecular weight: Translated: 73903; Mature: 73903

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50886 TRBD ; PS00284 SERPIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKSLITTPIYYVNDIPHIGHAYTTLIADTLKKYYTLQGEEVFFLTGTDEHGQKIEQSAR
CCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHH
LRNQSPKAYADSISAIFKDQWDFFNLDYDGFIRTTDSEHQKCVQNAFEIMFEKGDIYKGT
HCCCCCHHHHHHHHHHHHCCCCEECCCCCCEEECCCHHHHHHHHHHHHHHHHCCCEEECC
YSGYYCVSCESYCAISKTDNTNDKVLCPDCLRETTLLEEESYFFKLSTYEKPLLDFYAKN
CCCEEEEECCCEEEEECCCCCCCCEECHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCC
PEAILPIYRKNEVTSFIEQGLLDLSITRTSFEWGIPLPKKMNDPKHVVYVWLDALLNYAS
CCEEEEEECCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
MLGYLNGLDNKMAHFECARHIVGKDILRFHAIYWPAFLMSLNLPLFKQLCVHGWWTIEGV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEECE
KMSKSLGNVLDAQKLAMEYGIEELRYFLLREVPFGQDGDFSKKALIERINANLNNDLGNL
EHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHH
LNRLLGMAKKYFNYSLKSAKITAYYSKELEKAHQILDNANSFVPKMQLHKALEELFNVYD
HHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHCHHHHCHHHHHHHHHHHHHHHHH
FLNKLIAKEEPWVLHKNNESEKLEALLSLIANVLLQSSFLLYAFMPKSATKLASAFRVEI
HHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCHHEEEECCCHHHHHHHEEEEEE
TPNNYERFFKAKKLQDMILQDTEPLFSKMEKVEKTTLAKKEEEKKPEEKAPLKQENYISI
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEC
ENFKKVEIKVGLIKEAQRIEKSSKLLRLKVDLGEGYLRQIISGIALDYEPESLVGQMVCV
CCCEEEEEEEEHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHH
VANLKPAKLMGEMSEGMILTVRDNDNLALISPTKEKIAGSLIS
HHCCCHHHHHHHCCCCEEEEEECCCCEEEECCCHHHHHCCCCC
>Mature Secondary Structure
MQKSLITTPIYYVNDIPHIGHAYTTLIADTLKKYYTLQGEEVFFLTGTDEHGQKIEQSAR
CCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHH
LRNQSPKAYADSISAIFKDQWDFFNLDYDGFIRTTDSEHQKCVQNAFEIMFEKGDIYKGT
HCCCCCHHHHHHHHHHHHCCCCEECCCCCCEEECCCHHHHHHHHHHHHHHHHCCCEEECC
YSGYYCVSCESYCAISKTDNTNDKVLCPDCLRETTLLEEESYFFKLSTYEKPLLDFYAKN
CCCEEEEECCCEEEEECCCCCCCCEECHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCC
PEAILPIYRKNEVTSFIEQGLLDLSITRTSFEWGIPLPKKMNDPKHVVYVWLDALLNYAS
CCEEEEEECCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
MLGYLNGLDNKMAHFECARHIVGKDILRFHAIYWPAFLMSLNLPLFKQLCVHGWWTIEGV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEECE
KMSKSLGNVLDAQKLAMEYGIEELRYFLLREVPFGQDGDFSKKALIERINANLNNDLGNL
EHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHH
LNRLLGMAKKYFNYSLKSAKITAYYSKELEKAHQILDNANSFVPKMQLHKALEELFNVYD
HHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHCHHHHCHHHHHHHHHHHHHHHHH
FLNKLIAKEEPWVLHKNNESEKLEALLSLIANVLLQSSFLLYAFMPKSATKLASAFRVEI
HHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCHHEEEECCCHHHHHHHEEEEEE
TPNNYERFFKAKKLQDMILQDTEPLFSKMEKVEKTTLAKKEEEKKPEEKAPLKQENYISI
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEC
ENFKKVEIKVGLIKEAQRIEKSSKLLRLKVDLGEGYLRQIISGIALDYEPESLVGQMVCV
CCCEEEEEEEEHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHH
VANLKPAKLMGEMSEGMILTVRDNDNLALISPTKEKIAGSLIS
HHCCCHHHHHHHCCCCEEEEEECCCCEEEECCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]