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The map label for this gene is hldD [H]

Identifier: 108563267

GI number: 108563267

Start: 877594

End: 878586

Strand: Reverse

Name: hldD [H]

Synonym: HPAG1_0842

Alternate gene names: 108563267

Gene position: 878586-877594 (Counterclockwise)

Preceding gene: 108563268

Following gene: 108563266

Centisome position: 55.04

GC content: 38.67

Gene sequence:

>993_bases
ATGCGTTATATTGATGATGGATTAGAAAATCAAACGATTTTAATCACCGGTGGGGCTGGCTTTGTAGGCAGTAATTTGGC
CTTTTATTTTCAAGAGAACCACCCTAAAGCTAAAGTAGTCATTTTGGATAAATTCCGCAGTAACACGCTCTCCAGTAATA
ACCGCCCGAGTTCTTTAGGGCATTTTAAGAATTTGATCGGTTTTAAGGGTGAGGTGATTGTAGCTGATATTAATAACCCC
TTAGATTTAAGGCGTTTAGAAAAATTGCATTTTGATTATTTGTTCCACCAGGCCGCTGTCTCTGATACGACCATGCTGGA
TCAAGAATTAGTGATGAAAACCAACTATCAGGCTTTTTTAAACCTTTTAGAAATCGCTCGCTCCAAAAAGGCTAAAGTGA
TTTACGCTTCTTCAGCGGGCGTTTATGGCAACACCAAAGCCCCCAATGTGGTGGGCAAAAACGAAAGCCCTGAAAATGTT
TATGGCTTTTCCAAGCTTTGCATGGACGAATTTATTCTTTCGCATTCAAGCGATAACATTCAAGTGGGATTAAGGTATTT
TAATGTCTATGGGCCTAGGGAATTTTATAAAGAAAAAACCGCTTCCATGGTTTTGCAACTCGCTTTGCAAGCGCTGGCGT
TTAAGGAAGTCAAGCTTTTTGAATTTGGCGAGCAATTAAGGGATTTTGTCTATATTGAAGATGTGATCCAAGCGAATGTG
AAAGCGATGAAGGTTCAAAAAAGCGGGGTTTATAATGTGGGTTATTCCCAAGCCAGAAGTTATAATGAAATCGTTAGCAT
TTTAAAAGAGCATTTAGGGGATTTTAAAGTGAGCTATATTAAAAACCCTTACGCTTTTTTCCAAAAGCACACCCAAGCGC
ATATTGAACCTGCTATTTTGGATTTAGATTACACCCCTTTATACGATTTAGAAAGCGGTATTGAAGATTATTTGCCCCAT
ATCCATGCGATTTTTAAAGAACAATGCGCATGA

Upstream 100 bases:

>100_bases
ATAACCTTTTATTGAGCACAAATTTTTTAAAAACTCCTCATTCTTGGATACAATGTAAAGATCTTAAAGAGATGATGGAA
CTAATCAAATAAGGATAAGA

Downstream 100 bases:

>100_bases
AAAAAATCTTAGTCATAGGCGATCTGATCGCTGATTATTATTTGTGGGGGAAGAGCGAACGCCTTTCTCCTGAAGCCCCT
GTGCCTGTTTTAGAAGTCAA

Product: ADP-L-glycero-D-mannoheptose-6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MRYIDDGLENQTILITGGAGFVGSNLAFYFQENHPKAKVVILDKFRSNTLSSNNRPSSLGHFKNLIGFKGEVIVADINNP
LDLRRLEKLHFDYLFHQAAVSDTTMLDQELVMKTNYQAFLNLLEIARSKKAKVIYASSAGVYGNTKAPNVVGKNESPENV
YGFSKLCMDEFILSHSSDNIQVGLRYFNVYGPREFYKEKTASMVLQLALQALAFKEVKLFEFGEQLRDFVYIEDVIQANV
KAMKVQKSGVYNVGYSQARSYNEIVSILKEHLGDFKVSYIKNPYAFFQKHTQAHIEPAILDLDYTPLYDLESGIEDYLPH
IHAIFKEQCA

Sequences:

>Translated_330_residues
MRYIDDGLENQTILITGGAGFVGSNLAFYFQENHPKAKVVILDKFRSNTLSSNNRPSSLGHFKNLIGFKGEVIVADINNP
LDLRRLEKLHFDYLFHQAAVSDTTMLDQELVMKTNYQAFLNLLEIARSKKAKVIYASSAGVYGNTKAPNVVGKNESPENV
YGFSKLCMDEFILSHSSDNIQVGLRYFNVYGPREFYKEKTASMVLQLALQALAFKEVKLFEFGEQLRDFVYIEDVIQANV
KAMKVQKSGVYNVGYSQARSYNEIVSILKEHLGDFKVSYIKNPYAFFQKHTQAHIEPAILDLDYTPLYDLESGIEDYLPH
IHAIFKEQCA
>Mature_330_residues
MRYIDDGLENQTILITGGAGFVGSNLAFYFQENHPKAKVVILDKFRSNTLSSNNRPSSLGHFKNLIGFKGEVIVADINNP
LDLRRLEKLHFDYLFHQAAVSDTTMLDQELVMKTNYQAFLNLLEIARSKKAKVIYASSAGVYGNTKAPNVVGKNESPENV
YGFSKLCMDEFILSHSSDNIQVGLRYFNVYGPREFYKEKTASMVLQLALQALAFKEVKLFEFGEQLRDFVYIEDVIQANV
KAMKVQKSGVYNVGYSQARSYNEIVSILKEHLGDFKVSYIKNPYAFFQKHTQAHIEPAILDLDYTPLYDLESGIEDYLPH
IHAIFKEQCA

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=322, Percent_Identity=26.3975155279503, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1790049, Length=326, Percent_Identity=30.6748466257669, Blast_Score=129, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17539532, Length=277, Percent_Identity=27.0758122743682, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI115532424, Length=326, Percent_Identity=24.5398773006135, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356223, Length=322, Percent_Identity=29.8136645962733, Blast_Score=91, Evalue=9e-19,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 37504; Mature: 37504

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYIDDGLENQTILITGGAGFVGSNLAFYFQENHPKAKVVILDKFRSNTLSSNNRPSSLG
CCCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCHHH
HFKNLIGFKGEVIVADINNPLDLRRLEKLHFDYLFHQAAVSDTTMLDQELVMKTNYQAFL
HHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHH
NLLEIARSKKAKVIYASSAGVYGNTKAPNVVGKNESPENVYGFSKLCMDEFILSHSSDNI
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCE
QVGLRYFNVYGPREFYKEKTASMVLQLALQALAFKEVKLFEFGEQLRDFVYIEDVIQANV
EEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
KAMKVQKSGVYNVGYSQARSYNEIVSILKEHLGDFKVSYIKNPYAFFQKHTQAHIEPAIL
HHEEEECCCCCCCCHHHHCCHHHHHHHHHHHHCCEEEEHHCCHHHHHHHHHHHCCCEEEE
DLDYTPLYDLESGIEDYLPHIHAIFKEQCA
ECCCCCCHHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRYIDDGLENQTILITGGAGFVGSNLAFYFQENHPKAKVVILDKFRSNTLSSNNRPSSLG
CCCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCHHH
HFKNLIGFKGEVIVADINNPLDLRRLEKLHFDYLFHQAAVSDTTMLDQELVMKTNYQAFL
HHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHH
NLLEIARSKKAKVIYASSAGVYGNTKAPNVVGKNESPENVYGFSKLCMDEFILSHSSDNI
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCE
QVGLRYFNVYGPREFYKEKTASMVLQLALQALAFKEVKLFEFGEQLRDFVYIEDVIQANV
EEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
KAMKVQKSGVYNVGYSQARSYNEIVSILKEHLGDFKVSYIKNPYAFFQKHTQAHIEPAIL
HHEEEECCCCCCCCHHHHCCHHHHHHHHHHHHCCEEEEHHCCHHHHHHHHHHHCCCEEEE
DLDYTPLYDLESGIEDYLPHIHAIFKEQCA
ECCCCCCHHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA