Click here to switch to the map view.

The map label for this gene is hldE [H]

Identifier: 108563266

GI number: 108563266

Start: 876206

End: 877597

Strand: Reverse

Name: hldE [H]

Synonym: HPAG1_0841

Alternate gene names: 108563266

Gene position: 877597-876206 (Counterclockwise)

Preceding gene: 108563267

Following gene: 108563265

Centisome position: 54.97

GC content: 41.31

Gene sequence:

>1392_bases
ATGAAAAAAATCTTAGTCATAGGCGATCTGATCGCTGATTATTATTTGTGGGGGAAGAGCGAACGCCTTTCTCCTGAAGC
CCCTGTGCCTGTTTTAGAAGTCAAAAAAGAGAGCAAGAATTTAGGCGGAGCGGCCAATGTGGCTAATAACCTTATCTCTT
TAAAAGCTAAAGTCTTTTTATGTGGGGTGGTGGGCGATGATTTAGAGGGCAAGCATTTCATTAGCGCTTTAAAAGCAAGA
GAGATTGACACTTCAGGCATTTTAACAGATAAAACCCGTTGCACCACGCTTAAGACGCGCATCATCGCGCAAAACCAGCA
AATCGTACGCGTGGATAAGGAAATCAAAGACCCCTTAAACGCTGATTTAAGAAAAAAACTTTTAGATTTTTTCACAGAAA
AAATCCAAGAAATAGATGGCGTGATCCTTTCAGATTACAATAAGGGCGTGTTGGATTTTGAACTCACTCAAAAAATGATC
ACTCTAGCCAACCAACACCACAAGCTCATTTTATGCGACCCTAAAGGAAAGGATTATAGCAAATATTCCCATGCGAGTTT
GATCACGCCTAATCGCGCTGAATTAGAGCATGCGCTCCATTTGAAGTTAGACAGCCATGCGAATTTATCAAAAGCGCTCC
AAATCTTAAAAGAAACTTATCAAATCGCTATGCCTTTAGTTACTTTGAGCGAACAAGGCATCGCTTTTTTAGAAAAAGGC
GAGCTAGTCAATTGCCCCACTATCGCTAAAGAGGTTTATGATGTAACTGGGGCAGGCGATACGGTGATCGCGTCTTTAAC
GCTCTCTTTATTAGAATCGATGAGCCTAAAAGATGCTTGCGAGTTTGCCAATGCGGCTGCGGCGGTGGTGGTGGGTAAAA
TGGGGAGCGCATTAGCGAGTTTAGAAGAAATCGCTTTGATTTTAAACCAAACGCACCCCAAAATCCTCCCTTTAGAAAAG
CTGTTAGAAACTTTAGAACACCATCAGCAAAAAATCGTTTTCACCAATGGCTGTTTTGACCTCCTCCATAAAGGGCATGC
GAGCTATTTGCAAAAGGCTAAAGCTTTAGGGGATATTCTTGTTGTGGGGTTAAATAGCGATAATTCCATTAAAAGGCTTA
AAGGGAATAAACGTCCCATAGTGAGCGAAAAAGACAGGGCGTTTCTTTTAGCGAGTTTGTCTTGCGTGGATTATGTCGTG
GTGTTTGAAGAAGATGCACCCATCAAATTAATTCAAGCCCTAAAGCCTGATATTTTAGTCAAGGGAGCGGACTACCTCAA
TAAAGAAGTCATAGGGAGCGAGTTTGCTAAAGAAACCCATTTGATGGAGTTTGAAGAAGGTTATTCCACAAGCGCTATCA
TAGAAAAAATTAAAAGGACACATAATGATTGA

Upstream 100 bases:

>100_bases
CTGCTATTTTGGATTTAGATTACACCCCTTTATACGATTTAGAAAGCGGTATTGAAGATTATTTGCCCCATATCCATGCG
ATTTTTAAAGAACAATGCGC

Downstream 100 bases:

>100_bases
TGATTTGATTCAAAAAGAATTTTTAGCCCATAAGGAAGCGTTAGAAAAAAGTTTAGAGAGTTTGCAAGAAGCGTTAAAAC
AAAGCGTTCATCTTTTGATA

Product: ADP-heptose synthase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MKKILVIGDLIADYYLWGKSERLSPEAPVPVLEVKKESKNLGGAANVANNLISLKAKVFLCGVVGDDLEGKHFISALKAR
EIDTSGILTDKTRCTTLKTRIIAQNQQIVRVDKEIKDPLNADLRKKLLDFFTEKIQEIDGVILSDYNKGVLDFELTQKMI
TLANQHHKLILCDPKGKDYSKYSHASLITPNRAELEHALHLKLDSHANLSKALQILKETYQIAMPLVTLSEQGIAFLEKG
ELVNCPTIAKEVYDVTGAGDTVIASLTLSLLESMSLKDACEFANAAAAVVVGKMGSALASLEEIALILNQTHPKILPLEK
LLETLEHHQQKIVFTNGCFDLLHKGHASYLQKAKALGDILVVGLNSDNSIKRLKGNKRPIVSEKDRAFLLASLSCVDYVV
VFEEDAPIKLIQALKPDILVKGADYLNKEVIGSEFAKETHLMEFEEGYSTSAIIEKIKRTHND

Sequences:

>Translated_463_residues
MKKILVIGDLIADYYLWGKSERLSPEAPVPVLEVKKESKNLGGAANVANNLISLKAKVFLCGVVGDDLEGKHFISALKAR
EIDTSGILTDKTRCTTLKTRIIAQNQQIVRVDKEIKDPLNADLRKKLLDFFTEKIQEIDGVILSDYNKGVLDFELTQKMI
TLANQHHKLILCDPKGKDYSKYSHASLITPNRAELEHALHLKLDSHANLSKALQILKETYQIAMPLVTLSEQGIAFLEKG
ELVNCPTIAKEVYDVTGAGDTVIASLTLSLLESMSLKDACEFANAAAAVVVGKMGSALASLEEIALILNQTHPKILPLEK
LLETLEHHQQKIVFTNGCFDLLHKGHASYLQKAKALGDILVVGLNSDNSIKRLKGNKRPIVSEKDRAFLLASLSCVDYVV
VFEEDAPIKLIQALKPDILVKGADYLNKEVIGSEFAKETHLMEFEEGYSTSAIIEKIKRTHND
>Mature_463_residues
MKKILVIGDLIADYYLWGKSERLSPEAPVPVLEVKKESKNLGGAANVANNLISLKAKVFLCGVVGDDLEGKHFISALKAR
EIDTSGILTDKTRCTTLKTRIIAQNQQIVRVDKEIKDPLNADLRKKLLDFFTEKIQEIDGVILSDYNKGVLDFELTQKMI
TLANQHHKLILCDPKGKDYSKYSHASLITPNRAELEHALHLKLDSHANLSKALQILKETYQIAMPLVTLSEQGIAFLEKG
ELVNCPTIAKEVYDVTGAGDTVIASLTLSLLESMSLKDACEFANAAAAVVVGKMGSALASLEEIALILNQTHPKILPLEK
LLETLEHHQQKIVFTNGCFDLLHKGHASYLQKAKALGDILVVGLNSDNSIKRLKGNKRPIVSEKDRAFLLASLSCVDYVV
VFEEDAPIKLIQALKPDILVKGADYLNKEVIGSEFAKETHLMEFEEGYSTSAIIEKIKRTHND

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=471, Percent_Identity=39.9150743099788, Blast_Score=321, Evalue=7e-89,
Organism=Caenorhabditis elegans, GI193203447, Length=70, Percent_Identity=41.4285714285714, Blast_Score=65, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI193209647, Length=71, Percent_Identity=42.2535211267606, Blast_Score=65, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17509873, Length=70, Percent_Identity=41.4285714285714, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI19921220, Length=96, Percent_Identity=37.5, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45550975, Length=96, Percent_Identity=37.5, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI45550974, Length=96, Percent_Identity=37.5, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI45550973, Length=96, Percent_Identity=37.5, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.-

Molecular weight: Translated: 51143; Mature: 51143

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILVIGDLIADYYLWGKSERLSPEAPVPVLEVKKESKNLGGAANVANNLISLKAKVFL
CCEEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHEEEEEE
CGVVGDDLEGKHFISALKAREIDTSGILTDKTRCTTLKTRIIAQNQQIVRVDKEIKDPLN
EEECCCCCCHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHCCCHHEECCHHHCCCCC
ADLRKKLLDFFTEKIQEIDGVILSDYNKGVLDFELTQKMITLANQHHKLILCDPKGKDYS
HHHHHHHHHHHHHHHHHHCCEEEECCCCCEEHHHHHHHHHHHHCCCCEEEEECCCCCCCC
KYSHASLITPNRAELEHALHLKLDSHANLSKALQILKETYQIAMPLVTLSEQGIAFLEKG
CCCCCEECCCCHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHEECCCCCEEEECC
ELVNCPTIAKEVYDVTGAGDTVIASLTLSLLESMSLKDACEFANAAAAVVVGKMGSALAS
CEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LEEIALILNQTHPKILPLEKLLETLEHHQQKIVFTNGCFDLLHKGHASYLQKAKALGDIL
HHHHHHHHHCCCCCEECHHHHHHHHHHHCCEEEEECCHHHHHHCCHHHHHHHHHHCCCEE
VVGLNSDNSIKRLKGNKRPIVSEKDRAFLLASLSCVDYVVVFEEDAPIKLIQALKPDILV
EEEECCCCCHHHHCCCCCCCCCCCCCCCEEEHHHHEEEEEEECCCCCHHHHHHCCCCEEE
KGADYLNKEVIGSEFAKETHLMEFEEGYSTSAIIEKIKRTHND
ECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKILVIGDLIADYYLWGKSERLSPEAPVPVLEVKKESKNLGGAANVANNLISLKAKVFL
CCEEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHEEEEEE
CGVVGDDLEGKHFISALKAREIDTSGILTDKTRCTTLKTRIIAQNQQIVRVDKEIKDPLN
EEECCCCCCHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHCCCHHEECCHHHCCCCC
ADLRKKLLDFFTEKIQEIDGVILSDYNKGVLDFELTQKMITLANQHHKLILCDPKGKDYS
HHHHHHHHHHHHHHHHHHCCEEEECCCCCEEHHHHHHHHHHHHCCCCEEEEECCCCCCCC
KYSHASLITPNRAELEHALHLKLDSHANLSKALQILKETYQIAMPLVTLSEQGIAFLEKG
CCCCCEECCCCHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHEECCCCCEEEECC
ELVNCPTIAKEVYDVTGAGDTVIASLTLSLLESMSLKDACEFANAAAAVVVGKMGSALAS
CEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LEEIALILNQTHPKILPLEKLLETLEHHQQKIVFTNGCFDLLHKGHASYLQKAKALGDIL
HHHHHHHHHCCCCCEECHHHHHHHHHHHCCEEEEECCHHHHHHCCHHHHHHHHHHCCCEE
VVGLNSDNSIKRLKGNKRPIVSEKDRAFLLASLSCVDYVVVFEEDAPIKLIQALKPDILV
EEEECCCCCHHHHCCCCCCCCCCCCCCCEEEHHHHEEEEEEECCCCCHHHHHHCCCCEEE
KGADYLNKEVIGSEFAKETHLMEFEEGYSTSAIIEKIKRTHND
ECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA