Click here to switch to the map view.

The map label for this gene is thiM [H]

Identifier: 108563255

GI number: 108563255

Start: 864034

End: 864816

Strand: Reverse

Name: thiM [H]

Synonym: HPAG1_0830

Alternate gene names: 108563255

Gene position: 864816-864034 (Counterclockwise)

Preceding gene: 108563256

Following gene: 108563254

Centisome position: 54.17

GC content: 42.66

Gene sequence:

>783_bases
GTGGTGTTAAAAGAACTACGACAAAAACGCCCTTTAGTGCATAATATCACCAATTATGTGGCGGCACAATTTGTGGCTAA
TGGTTTATTAGCTTTAGGGGCATCGCCTTTAATGAGTGATGCGATTGATGAGATGCAAGATTTAGCGAAAATTTCTGACG
CGCTCGCTATCAATATTGGCACCATCAATGAACGCGCTATTTTATGCGCTAAAGAGGCTATCAAACATTACAAGGCTTTG
AACAAACCCATTGTGTTAGATCCCGTGGGGTGTTCAGCGAGCGCTTTGCGTCATGACACAAGTTTAGAGCTTTTGAAAAG
TGGTGGGATTAGCGCGCTTAGGGGCAATGCTGCAGAATTAGGCTCTTTAGTGGGTATTTCTTGCGAAAGTAAGGGGTTAG
ACTCTCAAGATGCCAACACGCCTGTAGAAATAATCAAACGAGTGGCTCAAAAATATTTTGTGATAGCGGTAATGACGGGT
AAAACAGATTACGTGAGCGATGGGAAAAAAGTTTTGAGTATTACTGGGGGGAGCGAGTATTTAGCGCTCATTACTGGGGC
TGGGTGTTTGCACACAGCAGCGTGCGCGAGCTTTTTAGGTTTGAAAAAAGACCCCTTAGATTCTATGGCGCAACTTTGCG
CGCTCTATAAACAAGCCTCTTTTAACGCGCAAAAAAAAGCGTTGGAAAATAACGGCTCTAATGGTTCGTTCTTGTTTTAT
TTTTTAGACGCTCTGAGCTTGCCCATAAAGTTAGAAAATAGCCTTATTAAGGAAGTATTGTGA

Upstream 100 bases:

>100_bases
GGTTAATGAAAAATAGTTCATGAACGCTTTTGTATTAAGGCTCAAAAAAAGCGCCGTTTAATGGATTTTTTGTAAAATAA
AAGAAATTTTAAGGAGGCTT

Downstream 100 bases:

>100_bases
AAATTTACCCGCAAGTTTTAAGCATTGCTGGCAGCGATAGCGGTGGGGGCGCTGGGATACAAGCCGATTTGAAAGCGTTC
CAAACTTTGGGTGTGTTTGG

Product: hydroxyethylthiazole kinase

Products: NA

Alternate protein names: 4-methyl-5-beta-hydroxyethylthiazole kinase; TH kinase; Thz kinase [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MVLKELRQKRPLVHNITNYVAAQFVANGLLALGASPLMSDAIDEMQDLAKISDALAINIGTINERAILCAKEAIKHYKAL
NKPIVLDPVGCSASALRHDTSLELLKSGGISALRGNAAELGSLVGISCESKGLDSQDANTPVEIIKRVAQKYFVIAVMTG
KTDYVSDGKKVLSITGGSEYLALITGAGCLHTAACASFLGLKKDPLDSMAQLCALYKQASFNAQKKALENNGSNGSFLFY
FLDALSLPIKLENSLIKEVL

Sequences:

>Translated_260_residues
MVLKELRQKRPLVHNITNYVAAQFVANGLLALGASPLMSDAIDEMQDLAKISDALAINIGTINERAILCAKEAIKHYKAL
NKPIVLDPVGCSASALRHDTSLELLKSGGISALRGNAAELGSLVGISCESKGLDSQDANTPVEIIKRVAQKYFVIAVMTG
KTDYVSDGKKVLSITGGSEYLALITGAGCLHTAACASFLGLKKDPLDSMAQLCALYKQASFNAQKKALENNGSNGSFLFY
FLDALSLPIKLENSLIKEVL
>Mature_260_residues
MVLKELRQKRPLVHNITNYVAAQFVANGLLALGASPLMSDAIDEMQDLAKISDALAINIGTINERAILCAKEAIKHYKAL
NKPIVLDPVGCSASALRHDTSLELLKSGGISALRGNAAELGSLVGISCESKGLDSQDANTPVEIIKRVAQKYFVIAVMTG
KTDYVSDGKKVLSITGGSEYLALITGAGCLHTAACASFLGLKKDPLDSMAQLCALYKQASFNAQKKALENNGSNGSFLFY
FLDALSLPIKLENSLIKEVL

Specific function: Thiamine biosynthesis. [C]

COG id: COG2145

COG function: function code H; Hydroxyethylthiazole kinase, sugar kinase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Thz kinase family [H]

Homologues:

Organism=Escherichia coli, GI1788421, Length=244, Percent_Identity=37.2950819672131, Blast_Score=148, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6325042, Length=283, Percent_Identity=33.9222614840989, Blast_Score=112, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000417 [H]

Pfam domain/function: PF02110 HK [H]

EC number: =2.7.1.50 [H]

Molecular weight: Translated: 27672; Mature: 27672

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLKELRQKRPLVHNITNYVAAQFVANGLLALGASPLMSDAIDEMQDLAKISDALAINIG
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEC
TINERAILCAKEAIKHYKALNKPIVLDPVGCSASALRHDTSLELLKSGGISALRGNAAEL
CCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHCHHHHHHHHCCCCHHHCCCHHHH
GSLVGISCESKGLDSQDANTPVEIIKRVAQKYFVIAVMTGKTDYVSDGKKVLSITGGSEY
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEECCCCCCCCCCEEEEEECCCCE
LALITGAGCLHTAACASFLGLKKDPLDSMAQLCALYKQASFNAQKKALENNGSNGSFLFY
EEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHE
FLDALSLPIKLENSLIKEVL
EHHHHCCCHHHHHHHHHHHC
>Mature Secondary Structure
MVLKELRQKRPLVHNITNYVAAQFVANGLLALGASPLMSDAIDEMQDLAKISDALAINIG
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEC
TINERAILCAKEAIKHYKALNKPIVLDPVGCSASALRHDTSLELLKSGGISALRGNAAEL
CCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHCHHHHHHHHCCCCHHHCCCHHHH
GSLVGISCESKGLDSQDANTPVEIIKRVAQKYFVIAVMTGKTDYVSDGKKVLSITGGSEY
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEECCCCCCCCCCEEEEEECCCCE
LALITGAGCLHTAACASFLGLKKDPLDSMAQLCALYKQASFNAQKKALENNGSNGSFLFY
EEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHE
FLDALSLPIKLENSLIKEVL
EHHHHCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA