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The map label for this gene is clpP

Identifier: 108563204

GI number: 108563204

Start: 819043

End: 819633

Strand: Reverse

Name: clpP

Synonym: HPAG1_0779

Alternate gene names: 108563204

Gene position: 819633-819043 (Counterclockwise)

Preceding gene: 108563205

Following gene: 108563203

Centisome position: 51.34

GC content: 43.82

Gene sequence:

>591_bases
ATGATGGGATACATTCCTTATGTAATAGAGAATACCGATCGTGGGGAGCGCAGCTATGATATTTACTCGCGCCTTTTAAA
GGATCGCATTGTTTTATTGAGCGGTGAAATTAATGACAGCGTGGCGTCTTCTATCGTGGCCCAACTTTTGTTTTTGGAAG
CTGAAGACCCTGAAAAAGACATTGGCTTGTATATCAATTCTCCCGGTGGGGTGATAACAAGCGGTCTTAGCATTTATGAT
ACGATGAATTTTATCCGCCCCGATGTCTCCACGATTTGCATCGGTCAAGCGGCTTCTATGGGGGCGTTTTTACTGAGCTG
TGGGGCTAAGGGCAAGCGCTTTTCACTGCCCCATTCAAGGATTATGATCCACCAGCCTTTAGGGGGGGCTCAAGGGCAAG
CGAGCGATATTGAAATCATTTCTAATGAGATTCTTAGGCTTAAGGGTTTGATGAATTCTATTTTGGCTCAAAACTCAGGG
CAGAGTTTGGAACAAATCGCTAAAGACACGGACAGGGATTTTTACATGAGCGCTAAAGAAGCTAAAGAGTATGGCTTGAT
TGATAAAGTGTTACAGAAAAATGTGAAGTGA

Upstream 100 bases:

>100_bases
TGTTGGATAAAAACCTGCCTAAAGAGCAACAAGAAATTTTGGAAAAAATGAGACCCAACGCTCAAAAAATTCAAGCGGGT
TAAACGGCTAAAAAGGAGAG

Downstream 100 bases:

>100_bases
TTGCATGGCGTTATTAGAGATTATCCATTACCCTTCTAAAATTTTAAGAACGATTTCTAAAGAAGTCGTTTCTTTTGATG
CAAAACTCCACCAACAGCTA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MMGYIPYVIENTDRGERSYDIYSRLLKDRIVLLSGEINDSVASSIVAQLLFLEAEDPEKDIGLYINSPGGVITSGLSIYD
TMNFIRPDVSTICIGQAASMGAFLLSCGAKGKRFSLPHSRIMIHQPLGGAQGQASDIEIISNEILRLKGLMNSILAQNSG
QSLEQIAKDTDRDFYMSAKEAKEYGLIDKVLQKNVK

Sequences:

>Translated_196_residues
MMGYIPYVIENTDRGERSYDIYSRLLKDRIVLLSGEINDSVASSIVAQLLFLEAEDPEKDIGLYINSPGGVITSGLSIYD
TMNFIRPDVSTICIGQAASMGAFLLSCGAKGKRFSLPHSRIMIHQPLGGAQGQASDIEIISNEILRLKGLMNSILAQNSG
QSLEQIAKDTDRDFYMSAKEAKEYGLIDKVLQKNVK
>Mature_196_residues
MMGYIPYVIENTDRGERSYDIYSRLLKDRIVLLSGEINDSVASSIVAQLLFLEAEDPEKDIGLYINSPGGVITSGLSIYD
TMNFIRPDVSTICIGQAASMGAFLLSCGAKGKRFSLPHSRIMIHQPLGGAQGQASDIEIISNEILRLKGLMNSILAQNSG
QSLEQIAKDTDRDFYMSAKEAKEYGLIDKVLQKNVK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=187, Percent_Identity=58.8235294117647, Blast_Score=231, Evalue=3e-61,
Organism=Escherichia coli, GI1786641, Length=190, Percent_Identity=70, Blast_Score=290, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17538017, Length=190, Percent_Identity=55.2631578947368, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=54.2553191489362, Blast_Score=228, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_HELPY (P56156)

Other databases:

- EMBL:   AE000511
- PIR:   B64619
- RefSeq:   NP_207587.1
- PDB:   2ZL0
- PDB:   2ZL2
- PDB:   2ZL3
- PDB:   2ZL4
- PDBsum:   2ZL0
- PDBsum:   2ZL2
- PDBsum:   2ZL3
- PDBsum:   2ZL4
- ProteinModelPortal:   P56156
- SMR:   P56156
- DIP:   DIP-3357N
- MINT:   MINT-179817
- MEROPS:   S14.001
- GeneID:   898920
- GenomeReviews:   AE000511_GR
- KEGG:   hpy:HP0794
- TIGR:   HP_0794
- HOGENOM:   HBG558421
- OMA:   DTFLEAE
- ProtClustDB:   PRK00277
- BRENDA:   3.4.21.92
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21526; Mature: 21526

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 99-99 ACT_SITE 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGYIPYVIENTDRGERSYDIYSRLLKDRIVLLSGEINDSVASSIVAQLLFLEAEDPEKD
CCCCCCEEEECCCCCCHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCC
IGLYINSPGGVITSGLSIYDTMNFIRPDVSTICIGQAASMGAFLLSCGAKGKRFSLPHSR
CCEEECCCCCCCCCCHHHHHHHHHHCCCHHHEECCCHHHHHHHHHHCCCCCCEECCCCCE
IMIHQPLGGAQGQASDIEIISNEILRLKGLMNSILAQNSGQSLEQIAKDTDRDFYMSAKE
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCHHH
AKEYGLIDKVLQKNVK
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMGYIPYVIENTDRGERSYDIYSRLLKDRIVLLSGEINDSVASSIVAQLLFLEAEDPEKD
CCCCCCEEEECCCCCCHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCC
IGLYINSPGGVITSGLSIYDTMNFIRPDVSTICIGQAASMGAFLLSCGAKGKRFSLPHSR
CCEEECCCCCCCCCCHHHHHHHHHHCCCHHHEECCCHHHHHHHHHHCCCCCCEECCCCCE
IMIHQPLGGAQGQASDIEIISNEILRLKGLMNSILAQNSGQSLEQIAKDTDRDFYMSAKE
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCHHH
AKEYGLIDKVLQKNVK
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9252185