Click here to switch to the map view.

The map label for this gene is cadA [H]

Identifier: 108563201

GI number: 108563201

Start: 814903

End: 816963

Strand: Reverse

Name: cadA [H]

Synonym: HPAG1_0776

Alternate gene names: 108563201

Gene position: 816963-814903 (Counterclockwise)

Preceding gene: 108563202

Following gene: 108563200

Centisome position: 51.18

GC content: 43.23

Gene sequence:

>2061_bases
ATGCAAGAATACCACATTCACAATTTGGATTGCCCTGATTGCGCGTCTAAATTAGAAAGGGATTTAAACAAATTAGACTA
TGTGAAAAAAGCTCAAATCAATTTTAGCACCAGTAAGTTGTTTTTGGATACGAGCGATTTTGAAAAAGTTAAGGCTTTCA
TCAAGCAGAATGAACCGCATTTGAGCCTGTCTTTTAAAGAGGCCACAGAAAAGCCCTTGAGTTTTACACCACTCATCATT
ACGATCATAGTCTTTTTGGGCGCGATTTTAATCTTGCACCTAAACCCTAGCCCTTTGATTGAAAAGGCTATGTTTTTCGT
GTTGGCTTTAGTGTATCTAGTGAGCGGTAAAGATGTGATTTTAGGGGCGTTTCGTGGGCTTAGAAAAGGGCAATTTTTTG
ATGAAAACGCTTTGATGCTCATTGCGACTATTGCGGCTTTTTTTGTGGGGGCTTATGAAGAGAGCGTGTCTATTATGGTG
TTTTATTCAGCGGGCGAGTTTTTGCAAAAACTCGCTATCTCTCGCTCTAAAAAATCCCTTAAGGCTTTAGTGGATGTCGC
TCCTAATTTGGCTTATTTGAAAAAGGGCGATGCATTAGTGAGCGTTGCGCCTGAAGATTTAAGAGTCAATGACATTGTGG
TGGTGAAAGTCGGCGAAAAAGTGCCTGTGGATGGCGTGGTAGTTAAGGGCGAAAGCTTGCTAGATGAAAGGGCGTTGAGT
GGGGAGTCTATGCCTGTTAATGTCAGCGAACGCTCTAAAGTTTTAGGGGGGAGCTTGAATTTAAAAGCGGTCCTTGAAAT
TAAAGTAGAAAAAATGTATAAAGATTCTTCTATCGCTAAAGTGGTGGATTTAGTCCAACAAGCCACGAATGAAAAGAGCG
AAACCGAGAAATTCATCACTAAATTTTCACGCTACTACACCCCAAGCGTTTTATTCATTGCGCTAATGATTGCTATATTA
CCGCCCTTGTTTTCTATGGGGAGCTTTGATGAGTGGATTTATAGGGGGCTTGTGGCTTTAATGGTGAGCTGCCCTTGCGC
GTTAGTGATTTCTGTGCCTTTAGGGTATTTTGGGGGCGTGGGAGCGGCGAGCCGAAAGGGCATTTTAATGAAAGGCGTGC
ATGTTTTAGAGGTGCTTACCCAAGCTAAAAGCATCGCCTTTGATAAAACCGGCACTTTGACTAAAGGCGTTTTTAAAGTA
ACAGATATTGTGCCGCAAAACGGGCATTCTAAAGAAGAAGTTTTGCATTACGCTTCTTGTTCGCAGCTCTTATCCACGCA
CCCTATCGCTTTATCCATTCAAAAAGCATGCGAAGAAATGCTAAAAGACGATAAGCACCAGCATGACATTAAAAATTACG
AAGAATTGAGCGGGATGGGGGTTAAAGCGCAATGCCATACGGATCTAATCATCGCAGGGAATGAAAAAATGCTCGATCAA
TTCCATATCGCGCACAGCCCTTCCAAAGAAAACGGCACGATCGTGCATGTGGCTTTTAACCAAACTTATATCGGCTATAT
CGTCATTAGCGATGAGATTAAAGATGACGCCATAGAGTGCTTAAGGGATTTAAAAGCGCAAGGGATAGAAAATTTTTGCA
TTTTGAGCGGGGACAGGAAAAGCGCAACTGAGAGCATCGCTCAAACTCTAGGCTGTGAATATTATGCGAGCTTGTTGCCT
GAAGAAAAAACGAGCGTGTTTAAAACTTTTAAAGAACGCTATAAAGCCCCGGCGATTTTTGTAGGCGATGGCATCAATGA
CGCTCCGACTCTAGCGAGCGCTGATGTGGGGATTGGCATGGGGAAAGGCTCAGAATTGAGCAAGCAAAGCGCGGACATTG
TGATCACTAACGACTCCTTAAATTCGTTGGTGAAAGTTTTAGCGATCGCTAAAAAAACTAAAAGCATCATTTGGCAAAAT
ATCTTGTTCGCTTTGGGGATTAAAGCCGTTTTTATCGTGCTAGGGCTTATGGGGGTAGCGAGCTTGTGGGAGGCGGTCTT
TGGCGATGTGGGGGTTACGCTTTTGGCCTTAGCCAATTCCATGCGCGCGATGAGGGCTTAA

Upstream 100 bases:

>100_bases
TGCGGATTTAAACGCTTGCGAGAATATAGAAAAATCTCATGTGCTTAAAGCGCTGAGTTTTAGAAAGATTTCTTAAAAGG
ATTTTTATAAGGGAGAGAAA

Downstream 100 bases:

>100_bases
AGCCTTGAATCTATCATCAAAGAGTTAGAAGGGGAGCCAAATGCATAAAATAGAGCGCTTACTCCAAACTCTAGCGCCTA
AGGGGGTGGAGTTTAGGAAG

Product: cadmium-transporting ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 686; Mature: 686

Protein sequence:

>686_residues
MQEYHIHNLDCPDCASKLERDLNKLDYVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPHLSLSFKEATEKPLSFTPLII
TIIVFLGAILILHLNPSPLIEKAMFFVLALVYLVSGKDVILGAFRGLRKGQFFDENALMLIATIAAFFVGAYEESVSIMV
FYSAGEFLQKLAISRSKKSLKALVDVAPNLAYLKKGDALVSVAPEDLRVNDIVVVKVGEKVPVDGVVVKGESLLDERALS
GESMPVNVSERSKVLGGSLNLKAVLEIKVEKMYKDSSIAKVVDLVQQATNEKSETEKFITKFSRYYTPSVLFIALMIAIL
PPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGVGAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKV
TDIVPQNGHSKEEVLHYASCSQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEELSGMGVKAQCHTDLIIAGNEKMLDQ
FHIAHSPSKENGTIVHVAFNQTYIGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRKSATESIAQTLGCEYYASLLP
EEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGMGKGSELSKQSADIVITNDSLNSLVKVLAIAKKTKSIIWQN
ILFALGIKAVFIVLGLMGVASLWEAVFGDVGVTLLALANSMRAMRA

Sequences:

>Translated_686_residues
MQEYHIHNLDCPDCASKLERDLNKLDYVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPHLSLSFKEATEKPLSFTPLII
TIIVFLGAILILHLNPSPLIEKAMFFVLALVYLVSGKDVILGAFRGLRKGQFFDENALMLIATIAAFFVGAYEESVSIMV
FYSAGEFLQKLAISRSKKSLKALVDVAPNLAYLKKGDALVSVAPEDLRVNDIVVVKVGEKVPVDGVVVKGESLLDERALS
GESMPVNVSERSKVLGGSLNLKAVLEIKVEKMYKDSSIAKVVDLVQQATNEKSETEKFITKFSRYYTPSVLFIALMIAIL
PPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGVGAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKV
TDIVPQNGHSKEEVLHYASCSQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEELSGMGVKAQCHTDLIIAGNEKMLDQ
FHIAHSPSKENGTIVHVAFNQTYIGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRKSATESIAQTLGCEYYASLLP
EEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGMGKGSELSKQSADIVITNDSLNSLVKVLAIAKKTKSIIWQN
ILFALGIKAVFIVLGLMGVASLWEAVFGDVGVTLLALANSMRAMRA
>Mature_686_residues
MQEYHIHNLDCPDCASKLERDLNKLDYVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPHLSLSFKEATEKPLSFTPLII
TIIVFLGAILILHLNPSPLIEKAMFFVLALVYLVSGKDVILGAFRGLRKGQFFDENALMLIATIAAFFVGAYEESVSIMV
FYSAGEFLQKLAISRSKKSLKALVDVAPNLAYLKKGDALVSVAPEDLRVNDIVVVKVGEKVPVDGVVVKGESLLDERALS
GESMPVNVSERSKVLGGSLNLKAVLEIKVEKMYKDSSIAKVVDLVQQATNEKSETEKFITKFSRYYTPSVLFIALMIAIL
PPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGVGAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKV
TDIVPQNGHSKEEVLHYASCSQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEELSGMGVKAQCHTDLIIAGNEKMLDQ
FHIAHSPSKENGTIVHVAFNQTYIGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRKSATESIAQTLGCEYYASLLP
EEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGMGKGSELSKQSADIVITNDSLNSLVKVLAIAKKTKSIIWQN
ILFALGIKAVFIVLGLMGVASLWEAVFGDVGVTLLALANSMRAMRA

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=798, Percent_Identity=24.812030075188, Blast_Score=208, Evalue=2e-53,
Organism=Homo sapiens, GI115529486, Length=681, Percent_Identity=26.1380323054332, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI55743073, Length=518, Percent_Identity=26.6409266409266, Blast_Score=174, Evalue=2e-43,
Organism=Escherichia coli, GI1789879, Length=691, Percent_Identity=34.5875542691751, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1786691, Length=505, Percent_Identity=28.7128712871287, Blast_Score=209, Evalue=6e-55,
Organism=Escherichia coli, GI1786914, Length=526, Percent_Identity=24.7148288973384, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17556548, Length=690, Percent_Identity=26.231884057971, Blast_Score=178, Evalue=9e-45,
Organism=Saccharomyces cerevisiae, GI6320475, Length=540, Percent_Identity=27.4074074074074, Blast_Score=207, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6319772, Length=619, Percent_Identity=25.2019386106624, Blast_Score=174, Evalue=5e-44,
Organism=Drosophila melanogaster, GI221329854, Length=594, Percent_Identity=23.9057239057239, Blast_Score=122, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 75032; Mature: 75032

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEYHIHNLDCPDCASKLERDLNKLDYVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCHHHHHHHHHHCCCCC
LSLSFKEATEKPLSFTPLIITIIVFLGAILILHLNPSPLIEKAMFFVLALVYLVSGKDVI
EEEEEHHHCCCCCCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHCCCHHH
LGAFRGLRKGQFFDENALMLIATIAAFFVGAYEESVSIMVFYSAGEFLQKLAISRSKKSL
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHH
KALVDVAPNLAYLKKGDALVSVAPEDLRVNDIVVVKVGEKVPVDGVVVKGESLLDERALS
HHHHHHCCCHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCEEECCHHHHHHHHCC
GESMPVNVSERSKVLGGSLNLKAVLEIKVEKMYKDSSIAKVVDLVQQATNEKSETEKFIT
CCCCCCCHHHHHHHHCCCCCEEEEEEEHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHH
KFSRYYTPSVLFIALMIAILPPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGV
HHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHCCCC
GAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKVTDIVPQNGHSKEEVLHYASC
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
SQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEELSGMGVKAQCHTDLIIAGNEKMLDQ
HHHHHCCCHHEEHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEECCEEEEECCHHHHHH
FHIAHSPSKENGTIVHVAFNQTYIGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRK
HHHCCCCCCCCCEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCH
SATESIAQTLGCEYYASLLPEEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGM
HHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCC
GKGSELSKQSADIVITNDSLNSLVKVLAIAKKTKSIIWQNILFALGIKAVFIVLGLMGVA
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLWEAVFGDVGVTLLALANSMRAMRA
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQEYHIHNLDCPDCASKLERDLNKLDYVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCHHHHHHHHHHCCCCC
LSLSFKEATEKPLSFTPLIITIIVFLGAILILHLNPSPLIEKAMFFVLALVYLVSGKDVI
EEEEEHHHCCCCCCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHCCCHHH
LGAFRGLRKGQFFDENALMLIATIAAFFVGAYEESVSIMVFYSAGEFLQKLAISRSKKSL
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHH
KALVDVAPNLAYLKKGDALVSVAPEDLRVNDIVVVKVGEKVPVDGVVVKGESLLDERALS
HHHHHHCCCHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCEEECCHHHHHHHHCC
GESMPVNVSERSKVLGGSLNLKAVLEIKVEKMYKDSSIAKVVDLVQQATNEKSETEKFIT
CCCCCCCHHHHHHHHCCCCCEEEEEEEHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHH
KFSRYYTPSVLFIALMIAILPPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGV
HHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHCCCC
GAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKVTDIVPQNGHSKEEVLHYASC
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
SQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEELSGMGVKAQCHTDLIIAGNEKMLDQ
HHHHHCCCHHEEHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEECCEEEEECCHHHHHH
FHIAHSPSKENGTIVHVAFNQTYIGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRK
HHHCCCCCCCCCEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCH
SATESIAQTLGCEYYASLLPEEKTSVFKTFKERYKAPAIFVGDGINDAPTLASADVGIGM
HHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCC
GKGSELSKQSADIVITNDSLNSLVKVLAIAKKTKSIIWQNILFALGIKAVFIVLGLMGVA
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLWEAVFGDVGVTLLALANSMRAMRA
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]