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The map label for this gene is relA [H]

Identifier: 108563185

GI number: 108563185

Start: 795675

End: 798002

Strand: Reverse

Name: relA [H]

Synonym: HPAG1_0760

Alternate gene names: 108563185

Gene position: 798002-795675 (Counterclockwise)

Preceding gene: 108563186

Following gene: 108563184

Centisome position: 49.99

GC content: 38.83

Gene sequence:

>2328_bases
ATGAACGAAATTGATAAATCCGTTGATATCGGATTCTTACGGATTCTTGATGTTATCAAAAAAGTTACGACCCCAAAGGG
TGGCATTGAAATCTTAAGGACTTTAATTGATTTTACGCCCAAAATTGAAAACGCCCTAAATTTAGCGACCAAAAGCCATA
AGGGGCAATACCGAAAGAGCGGCGAGCCTTATATCGTCCATCCTATTTGCGTGGCAAGCTTGGTAGCGTTTTGCGGGGGC
GATGAGGCGATGGTGTGCGCTGCGCTTTTGCATGATGTGGTGGAAGACACGCCTTGTAAGATTGAAACGATTGAGCAAGA
ATTTGGGCAAGATGTGGCTAATTTAGTGGATGCGCTCACTAAAATCACTGAAATCAGGAAAGAAGAGTTAGGAGTGAGCT
CTCAAGATCCCAGAATGGTGGTTTCAGCGCTCACTTTTAGAAAGATTTTAATTAGCGCGATACAAGATCCAAGAGCCTTA
GTGGTAAAAATTAGCGACAGGTTGCACAACATGCTCACCTTAGACGCCTTGCCTCATGACAAGCAAGTGCGTATTTCTAA
AGAGACTCTAGCGGTGTATGCCCCCATAGCGAGCCGATTGGGCATGTCTTCAATCAAAAATGAATTAGAAGACAAGAGCT
TTTATTATATTTATCCGGAAGAATATAAAAATATCAAGGAATATTTGCACAAAAACAAGCAGTCTTTACTCTTAAAACTC
AACGCTTTTGCGAGCAAGTTAGAAAAAAAACTTTTTGATAGCGGGTTTAGCCATTCGGATTTTAAACTCGTTACAAGGGT
GAAACGCCCCTATTCTATCTATCTTAAGATGCAACGAAAGGGCGCGGTCAATATTGATGAAATTTTGGACTTGTTAGCCA
TTAGGATTTTATTGAAAAACCCGATTGATTGCTATAAAGTTTTAGGGATTATCCATTTGAATTTCAAACCCATTGTTTCT
CGTTTTAAAGATTACATCGCTTTGCCCAAAGAAAATGGCTATAAGACGATACACACGACCATTTTTGATGAATCTTCTGT
TTATGAAGTGCAGATTCGCACCTTTGATATGCATATGGGGGCTGAGTATGGTAATTCAGCCCACTGGAAGTATAAAGCCG
GGGGCGTGGATAATGAAGATCATCATGAGGGCATGAGGTGGTTGCAAAATTTTAAATACCATGACAGCGATTTGAAAAAC
GACCCTAAGGAATTTTACGAACTCGCTAAGAACGATTTGTATCGTGAAGATATTGTCGTTTTTTCGCCTCATGGGGACAC
TTACACCTTACCGGTAGGAGCGATTGCGTTAGATTTTGCTTACATGGTGCATAGCGATTTGGGCGATAAAGCCACGGACG
CTTATATTAATAGTAAAAAAGCCTTACTCAATCAAGAATTAAGAAGCGGGGATGTGGTTAAAATCGTTAAAGGCGATAAA
ATAGTACCTCGTTTCATTTGGATGGATCAGCTTAAAACTTCTAAGGCTAAAAACCATTTGCGCATCCAAAGAAGAAACCG
CTTGAAAGAAATTGACACTAAGAGCATGATTAATATCTTAGCGACTTTTTTTGGGCGTTCTGTTTTTGAAGATGTGGGTT
TAAAAGATTATAAAAACTTTGAAGAAAAATTAACAGATTGCGGAGTGGAGACCACTTTAACAGAAGCGATGAAAAGCTTT
GAAAATTTAGCCAAACTCACTGAAGAAATTGAAAATAAGGTGTTTTCTTTAAAAGAAGATGCGATTTTAGAATACCAAGA
GATGAGTTTATGGACTCGAGGTTTAAGGTATTTGGGCTTTAAAACCAATGTCTTGAATTTTTTAGCCCCAAACCGGCAGT
GGCAGTGTAAGGAATTAGAACATTTTAGCGTTTGTTCAAGCAACGCTTTAGAAATCAAACAGGTGTTGTTGAATGATTGT
TGTTACCCTAAATATGGCGATGAAATCATTGCGATTGTAACGGATTTAAAAGATCCAAAAGCGATTGCGCACCATAAATT
TTGCAAAAAAGCGATGGCGGAAGTGGATGCTAAAGTGCCGATGGTTTATATAGAATGGCACAAGCGGGATCGAACGATTT
ATAAAATGATGTTTTATTTAGGCGAAAAAAAGTCGGTTTTAGCGGGTTTATTAACTTTTTTAAACAGGAATGAATGCAAC
ATTGTGGGCGTGTCTTACTTAGGCTATAAAGACAAGTATTCTAGCCATTGTGAAGTGAGTTTTGAAATAGCTACGGATAA
GGCGGATTGGATCAGAGCCTTAATCAATCGCAAATATCAGGATAGGATTGTAGAATTATCCAGTCTGGATGACGCTTATG
AATCATAA

Upstream 100 bases:

>100_bases
GGAGCCAAAACTTTAGTGAATATGGACCCTAAACGCCATAAATTAGTGGATATTGCCATTAGAGAAATCGCTGAAGGGAA
AATTGATATAGACAGGATAG

Downstream 100 bases:

>100_bases
TAAGCCCTAATTAAGGAATGAACATGGAACAAAAAATCAGTACCGCCTTAAAAGAGATCGCTAGAGGCGCTAATGAAATC
ATTGGATTAGAATACATTGA

Product: penta-phosphate guanosine-3'-pyrophosphohydrolase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 775; Mature: 775

Protein sequence:

>775_residues
MNEIDKSVDIGFLRILDVIKKVTTPKGGIEILRTLIDFTPKIENALNLATKSHKGQYRKSGEPYIVHPICVASLVAFCGG
DEAMVCAALLHDVVEDTPCKIETIEQEFGQDVANLVDALTKITEIRKEELGVSSQDPRMVVSALTFRKILISAIQDPRAL
VVKISDRLHNMLTLDALPHDKQVRISKETLAVYAPIASRLGMSSIKNELEDKSFYYIYPEEYKNIKEYLHKNKQSLLLKL
NAFASKLEKKLFDSGFSHSDFKLVTRVKRPYSIYLKMQRKGAVNIDEILDLLAIRILLKNPIDCYKVLGIIHLNFKPIVS
RFKDYIALPKENGYKTIHTTIFDESSVYEVQIRTFDMHMGAEYGNSAHWKYKAGGVDNEDHHEGMRWLQNFKYHDSDLKN
DPKEFYELAKNDLYREDIVVFSPHGDTYTLPVGAIALDFAYMVHSDLGDKATDAYINSKKALLNQELRSGDVVKIVKGDK
IVPRFIWMDQLKTSKAKNHLRIQRRNRLKEIDTKSMINILATFFGRSVFEDVGLKDYKNFEEKLTDCGVETTLTEAMKSF
ENLAKLTEEIENKVFSLKEDAILEYQEMSLWTRGLRYLGFKTNVLNFLAPNRQWQCKELEHFSVCSSNALEIKQVLLNDC
CYPKYGDEIIAIVTDLKDPKAIAHHKFCKKAMAEVDAKVPMVYIEWHKRDRTIYKMMFYLGEKKSVLAGLLTFLNRNECN
IVGVSYLGYKDKYSSHCEVSFEIATDKADWIRALINRKYQDRIVELSSLDDAYES

Sequences:

>Translated_775_residues
MNEIDKSVDIGFLRILDVIKKVTTPKGGIEILRTLIDFTPKIENALNLATKSHKGQYRKSGEPYIVHPICVASLVAFCGG
DEAMVCAALLHDVVEDTPCKIETIEQEFGQDVANLVDALTKITEIRKEELGVSSQDPRMVVSALTFRKILISAIQDPRAL
VVKISDRLHNMLTLDALPHDKQVRISKETLAVYAPIASRLGMSSIKNELEDKSFYYIYPEEYKNIKEYLHKNKQSLLLKL
NAFASKLEKKLFDSGFSHSDFKLVTRVKRPYSIYLKMQRKGAVNIDEILDLLAIRILLKNPIDCYKVLGIIHLNFKPIVS
RFKDYIALPKENGYKTIHTTIFDESSVYEVQIRTFDMHMGAEYGNSAHWKYKAGGVDNEDHHEGMRWLQNFKYHDSDLKN
DPKEFYELAKNDLYREDIVVFSPHGDTYTLPVGAIALDFAYMVHSDLGDKATDAYINSKKALLNQELRSGDVVKIVKGDK
IVPRFIWMDQLKTSKAKNHLRIQRRNRLKEIDTKSMINILATFFGRSVFEDVGLKDYKNFEEKLTDCGVETTLTEAMKSF
ENLAKLTEEIENKVFSLKEDAILEYQEMSLWTRGLRYLGFKTNVLNFLAPNRQWQCKELEHFSVCSSNALEIKQVLLNDC
CYPKYGDEIIAIVTDLKDPKAIAHHKFCKKAMAEVDAKVPMVYIEWHKRDRTIYKMMFYLGEKKSVLAGLLTFLNRNECN
IVGVSYLGYKDKYSSHCEVSFEIATDKADWIRALINRKYQDRIVELSSLDDAYES
>Mature_775_residues
MNEIDKSVDIGFLRILDVIKKVTTPKGGIEILRTLIDFTPKIENALNLATKSHKGQYRKSGEPYIVHPICVASLVAFCGG
DEAMVCAALLHDVVEDTPCKIETIEQEFGQDVANLVDALTKITEIRKEELGVSSQDPRMVVSALTFRKILISAIQDPRAL
VVKISDRLHNMLTLDALPHDKQVRISKETLAVYAPIASRLGMSSIKNELEDKSFYYIYPEEYKNIKEYLHKNKQSLLLKL
NAFASKLEKKLFDSGFSHSDFKLVTRVKRPYSIYLKMQRKGAVNIDEILDLLAIRILLKNPIDCYKVLGIIHLNFKPIVS
RFKDYIALPKENGYKTIHTTIFDESSVYEVQIRTFDMHMGAEYGNSAHWKYKAGGVDNEDHHEGMRWLQNFKYHDSDLKN
DPKEFYELAKNDLYREDIVVFSPHGDTYTLPVGAIALDFAYMVHSDLGDKATDAYINSKKALLNQELRSGDVVKIVKGDK
IVPRFIWMDQLKTSKAKNHLRIQRRNRLKEIDTKSMINILATFFGRSVFEDVGLKDYKNFEEKLTDCGVETTLTEAMKSF
ENLAKLTEEIENKVFSLKEDAILEYQEMSLWTRGLRYLGFKTNVLNFLAPNRQWQCKELEHFSVCSSNALEIKQVLLNDC
CYPKYGDEIIAIVTDLKDPKAIAHHKFCKKAMAEVDAKVPMVYIEWHKRDRTIYKMMFYLGEKKSVLAGLLTFLNRNECN
IVGVSYLGYKDKYSSHCEVSFEIATDKADWIRALINRKYQDRIVELSSLDDAYES

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=694, Percent_Identity=31.9884726224784, Blast_Score=325, Evalue=7e-90,
Organism=Escherichia coli, GI1789147, Length=669, Percent_Identity=26.6068759342302, Blast_Score=236, Evalue=4e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 89062; Mature: 89062

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEIDKSVDIGFLRILDVIKKVTTPKGGIEILRTLIDFTPKIENALNLATKSHKGQYRKS
CCCCCHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCC
GEPYIVHPICVASLVAFCGGDEAMVCAALLHDVVEDTPCKIETIEQEFGQDVANLVDALT
CCCEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHH
KITEIRKEELGVSSQDPRMVVSALTFRKILISAIQDPRALVVKISDRLHNMLTLDALPHD
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHEEECCCCCC
KQVRISKETLAVYAPIASRLGMSSIKNELEDKSFYYIYPEEYKNIKEYLHKNKQSLLLKL
CCEEEEHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCHHHHHHHH
NAFASKLEKKLFDSGFSHSDFKLVTRVKRPYSIYLKMQRKGAVNIDEILDLLAIRILLKN
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCC
PIDCYKVLGIIHLNFKPIVSRFKDYIALPKENGYKTIHTTIFDESSVYEVQIRTFDMHMG
CHHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCEEEEEEEECCCCEEEEEEEEEEEECC
AEYGNSAHWKYKAGGVDNEDHHEGMRWLQNFKYHDSDLKNDPKEFYELAKNDLYREDIVV
CCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEE
FSPHGDTYTLPVGAIALDFAYMVHSDLGDKATDAYINSKKALLNQELRSGDVVKIVKGDK
ECCCCCEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
IVPRFIWMDQLKTSKAKNHLRIQRRNRLKEIDTKSMINILATFFGRSVFEDVGLKDYKNF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EEKLTDCGVETTLTEAMKSFENLAKLTEEIENKVFSLKEDAILEYQEMSLWTRGLRYLGF
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
KTNVLNFLAPNRQWQCKELEHFSVCSSNALEIKQVLLNDCCYPKYGDEIIAIVTDLKDPK
HHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCH
AIAHHKFCKKAMAEVDAKVPMVYIEWHKRDRTIYKMMFYLGEKKSVLAGLLTFLNRNECN
HHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
IVGVSYLGYKDKYSSHCEVSFEIATDKADWIRALINRKYQDRIVELSSLDDAYES
EEEEEECCCCCCCCCCCEEEEEEECCHHHHHHHHHCCHHHHHHHHHHHCCHHHCC
>Mature Secondary Structure
MNEIDKSVDIGFLRILDVIKKVTTPKGGIEILRTLIDFTPKIENALNLATKSHKGQYRKS
CCCCCHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCC
GEPYIVHPICVASLVAFCGGDEAMVCAALLHDVVEDTPCKIETIEQEFGQDVANLVDALT
CCCEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHH
KITEIRKEELGVSSQDPRMVVSALTFRKILISAIQDPRALVVKISDRLHNMLTLDALPHD
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHEEECCCCCC
KQVRISKETLAVYAPIASRLGMSSIKNELEDKSFYYIYPEEYKNIKEYLHKNKQSLLLKL
CCEEEEHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCHHHHHHHH
NAFASKLEKKLFDSGFSHSDFKLVTRVKRPYSIYLKMQRKGAVNIDEILDLLAIRILLKN
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCC
PIDCYKVLGIIHLNFKPIVSRFKDYIALPKENGYKTIHTTIFDESSVYEVQIRTFDMHMG
CHHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCEEEEEEEECCCCEEEEEEEEEEEECC
AEYGNSAHWKYKAGGVDNEDHHEGMRWLQNFKYHDSDLKNDPKEFYELAKNDLYREDIVV
CCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEE
FSPHGDTYTLPVGAIALDFAYMVHSDLGDKATDAYINSKKALLNQELRSGDVVKIVKGDK
ECCCCCEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
IVPRFIWMDQLKTSKAKNHLRIQRRNRLKEIDTKSMINILATFFGRSVFEDVGLKDYKNF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EEKLTDCGVETTLTEAMKSFENLAKLTEEIENKVFSLKEDAILEYQEMSLWTRGLRYLGF
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
KTNVLNFLAPNRQWQCKELEHFSVCSSNALEIKQVLLNDCCYPKYGDEIIAIVTDLKDPK
HHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCH
AIAHHKFCKKAMAEVDAKVPMVYIEWHKRDRTIYKMMFYLGEKKSVLAGLLTFLNRNECN
HHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
IVGVSYLGYKDKYSSHCEVSFEIATDKADWIRALINRKYQDRIVELSSLDDAYES
EEEEEECCCCCCCCCCCEEEEEEECCHHHHHHHHHCCHHHHHHHHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA