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The map label for this gene is moaA [H]

Identifier: 108563178

GI number: 108563178

Start: 788461

End: 789426

Strand: Reverse

Name: moaA [H]

Synonym: HPAG1_0753

Alternate gene names: 108563178

Gene position: 789426-788461 (Counterclockwise)

Preceding gene: 108563181

Following gene: 108563177

Centisome position: 49.45

GC content: 35.82

Gene sequence:

>966_bases
GTGTTAGTAGATAGTTTTAATAGGGTTATTGACTATATTAGAGTTTCTGTAACCAAACAATGCAATTTCAGGTGTCAGTA
TTGCATGCCTGCTACGCCATTAAATTTTTTTGATAATGAAGAATTATTGCCTTTGGATAATGTTTTAGAATTTCTTAAAA
TCGCCATTGATGAAGGCGTTAAAAAAATCAGAATCACGGGTGGGGAGCCGCTATTACGCAAGGGTTTAGACGAGTTTATC
GCTAAACTACATGCTTACAATAAGGAAGTGGCGTTAGTTTTAAGCACTAATGGTTTTTTGCTCAAAAAAATGGCTAAGGA
TTTAAAAAAGGCCGGGTTATCACGAGTGAATGTTTCATTAGATTCTTTAAAAAGCGATAGGGTTTTAAAAATCTCTCAAA
AAGACGCTCTTAAAAACACGCTAGAAGGGATTGAAGAGTCCTTGAAAGTGGGTTTAAAACTCAAATTAAACACGGTTGTG
ATGAAAAGCGTTAATGGTGATGAAATTTTAGATCTTTTAGAATACGCAAAAAACAGGCGCATACAAATCCGCTACATTGA
ATTTATGGAAAACACGCATGCTAAGAGCTTTGTCAAAGGCTTGAAAGAGGAAGAAATTTTAGATTTGATCGCTCAAAAAT
ACAAAATAATGGAGACAGAAAAACCCAAACAAGGGTCTTCTAAAATCTACACGCTAGAAAATGGCTATCAATTTGGCATT
ATCGCTCCGCATAGCGATGATTTTTGCCAATCTTGCAATCGTATCCGTTTGGCTTCTGATGGCAAAATTTGCCCATGTTT
ATACTATCAAGACGCCATAGACGCTAAAGAGGCGATCATAAATAAAGATACAAAAATGATGAAAAGGCTTTTAAAACAAT
CTGTCATCAATAAACCAGAAAAAAACATGTGGAATGATAAAAACAGCGAAACTCCCACAAGGGCGTTTTACTACACAGGG
GGGTAG

Upstream 100 bases:

>100_bases
ATAGGGTTTTTCAAAAGATTTATCCATGTTTAATGTTGTTAAGTCATTGTTTATTATGTTACACTAAAAGCTTAAATAAA
GGGCATAAGGGATAAAGGGA

Downstream 100 bases:

>100_bases
GGAAAATATTTATTATTTTAAACCTTTTTATTAAAAATAAGGCGGTTTGTTTAGGATTTTTGGTTATAGTGGCTAGGATC
AAACAATAAGGAGGTCTTTA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MLVDSFNRVIDYIRVSVTKQCNFRCQYCMPATPLNFFDNEELLPLDNVLEFLKIAIDEGVKKIRITGGEPLLRKGLDEFI
AKLHAYNKEVALVLSTNGFLLKKMAKDLKKAGLSRVNVSLDSLKSDRVLKISQKDALKNTLEGIEESLKVGLKLKLNTVV
MKSVNGDEILDLLEYAKNRRIQIRYIEFMENTHAKSFVKGLKEEEILDLIAQKYKIMETEKPKQGSSKIYTLENGYQFGI
IAPHSDDFCQSCNRIRLASDGKICPCLYYQDAIDAKEAIINKDTKMMKRLLKQSVINKPEKNMWNDKNSETPTRAFYYTG
G

Sequences:

>Translated_321_residues
MLVDSFNRVIDYIRVSVTKQCNFRCQYCMPATPLNFFDNEELLPLDNVLEFLKIAIDEGVKKIRITGGEPLLRKGLDEFI
AKLHAYNKEVALVLSTNGFLLKKMAKDLKKAGLSRVNVSLDSLKSDRVLKISQKDALKNTLEGIEESLKVGLKLKLNTVV
MKSVNGDEILDLLEYAKNRRIQIRYIEFMENTHAKSFVKGLKEEEILDLIAQKYKIMETEKPKQGSSKIYTLENGYQFGI
IAPHSDDFCQSCNRIRLASDGKICPCLYYQDAIDAKEAIINKDTKMMKRLLKQSVINKPEKNMWNDKNSETPTRAFYYTG
G
>Mature_321_residues
MLVDSFNRVIDYIRVSVTKQCNFRCQYCMPATPLNFFDNEELLPLDNVLEFLKIAIDEGVKKIRITGGEPLLRKGLDEFI
AKLHAYNKEVALVLSTNGFLLKKMAKDLKKAGLSRVNVSLDSLKSDRVLKISQKDALKNTLEGIEESLKVGLKLKLNTVV
MKSVNGDEILDLLEYAKNRRIQIRYIEFMENTHAKSFVKGLKEEEILDLIAQKYKIMETEKPKQGSSKIYTLENGYQFGI
IAPHSDDFCQSCNRIRLASDGKICPCLYYQDAIDAKEAIINKDTKMMKRLLKQSVINKPEKNMWNDKNSETPTRAFYYTG
G

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI22027536, Length=328, Percent_Identity=30.4878048780488, Blast_Score=177, Evalue=8e-45,
Organism=Homo sapiens, GI116734668, Length=328, Percent_Identity=30.4878048780488, Blast_Score=177, Evalue=8e-45,
Organism=Escherichia coli, GI1786999, Length=325, Percent_Identity=27.3846153846154, Blast_Score=169, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI32566329, Length=328, Percent_Identity=31.4024390243902, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17561210, Length=327, Percent_Identity=32.4159021406728, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI32566331, Length=321, Percent_Identity=31.4641744548287, Blast_Score=180, Evalue=8e-46,
Organism=Drosophila melanogaster, GI28574488, Length=282, Percent_Identity=34.7517730496454, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI28574490, Length=282, Percent_Identity=34.7517730496454, Blast_Score=188, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 36713; Mature: 36713

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVDSFNRVIDYIRVSVTKQCNFRCQYCMPATPLNFFDNEELLPLDNVLEFLKIAIDEGV
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
KKIRITGGEPLLRKGLDEFIAKLHAYNKEVALVLSTNGFLLKKMAKDLKKAGLSRVNVSL
EEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEH
DSLKSDRVLKISQKDALKNTLEGIEESLKVGLKLKLNTVVMKSVNGDEILDLLEYAKNRR
HHCCCCCEEEECHHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCHHHHHHHHHHHHCCC
IQIRYIEFMENTHAKSFVKGLKEEEILDLIAQKYKIMETEKPKQGSSKIYTLENGYQFGI
EEEEEEHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCEEEEE
IAPHSDDFCQSCNRIRLASDGKICPCLYYQDAIDAKEAIINKDTKMMKRLLKQSVINKPE
ECCCCCHHHHCCCCEEECCCCCEEEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
KNMWNDKNSETPTRAFYYTGG
HHCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MLVDSFNRVIDYIRVSVTKQCNFRCQYCMPATPLNFFDNEELLPLDNVLEFLKIAIDEGV
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
KKIRITGGEPLLRKGLDEFIAKLHAYNKEVALVLSTNGFLLKKMAKDLKKAGLSRVNVSL
EEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEH
DSLKSDRVLKISQKDALKNTLEGIEESLKVGLKLKLNTVVMKSVNGDEILDLLEYAKNRR
HHCCCCCEEEECHHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCHHHHHHHHHHHHCCC
IQIRYIEFMENTHAKSFVKGLKEEEILDLIAQKYKIMETEKPKQGSSKIYTLENGYQFGI
EEEEEEHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCEEEEE
IAPHSDDFCQSCNRIRLASDGKICPCLYYQDAIDAKEAIINKDTKMMKRLLKQSVINKPE
ECCCCCHHHHCCCCEEECCCCCEEEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
KNMWNDKNSETPTRAFYYTGG
HHCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA