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The map label for this gene is mrdB [H]

Identifier: 108563152

GI number: 108563152

Start: 765054

End: 766199

Strand: Reverse

Name: mrdB [H]

Synonym: HPAG1_0727

Alternate gene names: 108563152

Gene position: 766199-765054 (Counterclockwise)

Preceding gene: 108563153

Following gene: 108563145

Centisome position: 48.0

GC content: 40.31

Gene sequence:

>1146_bases
ATGGCATTAGACAAAAGGATTTGGATGCATTTTGATCTTTTGCCTTTTGTGTTTATCATCCCCTTGTTGGTGGTTTCTTT
TTTATTGATTTTTGAGAGCAGCGCGGTTTTGAGCTTAAAGCAAGGGGTTTATTATGTGATAGGGTTTATTCTCTTTTGGA
TCGTGTTTTTTATCCCTTTCAGAAAGCTCGATCGCTGGCTCTTTGTGTTTTATTGGGCGTGCGTTATTTTATTGGCGTTA
GTGGATTTTATGGGATATAGTAAGCTTGGGGCGCAACGATGGCTAGTCATTCCTTTTACCTCTATCACTTTACAGCCCAG
CGAACCCGTGAAAATCGCTATCCTTTTGTTATTGGCGCATTTGATTAAAATCAACCCGCCTCCTTTTAAGGGCTATGATT
GGGGCATGTTTTTAAAGCTTAGTTTTTACATTTGCTTACCGGCGGCTTTGATTTTAAAACAGCCTGATTTAGGCACGGCT
CTTATTGTGCTGATCATGGGTTTTGGGATTTTGTTGATCGTGGGTTTAAGGACTAGGGTGTGGCTCCCTCTTTTTATCGC
TCTTTTAGTGGCTTCGCCTATCGCTTATCATTTTTTGCATGATTACCAAAAAAAACGCATCGCAGACTTTCTTTCTGAAA
AGCCTAATTACCATGTCATGCAATCTATTATCGCCATAGGATCGGGCGGGTTTTTAGGCAAATCTAAAGAAGCTTCCACG
CAAACCAAATTCAAATTCTTGCCTATCGCAACGAGCGATTTCATCTTCGCTTACTTCGTGGAGCGTTTTGGGTTTTTAGG
GGCTATGTTGCTTTTTGCGATTTATATAGGCTTGAGTTTGCATTTATTTTTTTACATGTTTGAGAGCAACAGCGATTGGT
TTTTAAAGATTGTAGCCCTTGGGATTTCTATTTTAATCTTTGTTTATTCCAGCGTGAATATCGCCATGACTTTAGGGTTA
GCCCCTGTGGTGGGGATTCCCTTGCCATTATTTAGCTATGGAGGGAGCAGTTTTATCACCTTTATGATCCTGTTTGGGAT
CTTAGAAAACCTGCTTGCTTTTCGCTATATTTTTGGATACAATAGCAAACTATCTTTTGGGAATTTTGGATTCTTAGCTC
AGCTGGTCAGAGCGCTCGGCTCATAA

Upstream 100 bases:

>100_bases
GATGAAGTTGGCATGATAACTTCTCTCTTTAAGGAGAATTATCTCAACTTGGATACAATCAAGAAATTAATACAATAAGA
TTAGGGGTTATAAAAAACGC

Downstream 100 bases:

>100_bases
CCGATTGGTCGTAGGTTCAAGTCCTACAGAATCCACCACTCCCGCTTTTTTATTCCTTTTTTAAGTGAAAAGCGATTGGA
CGCTTTCGTTATGATAAATC

Product: rod shape-determining protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MALDKRIWMHFDLLPFVFIIPLLVVSFLLIFESSAVLSLKQGVYYVIGFILFWIVFFIPFRKLDRWLFVFYWACVILLAL
VDFMGYSKLGAQRWLVIPFTSITLQPSEPVKIAILLLLAHLIKINPPPFKGYDWGMFLKLSFYICLPAALILKQPDLGTA
LIVLIMGFGILLIVGLRTRVWLPLFIALLVASPIAYHFLHDYQKKRIADFLSEKPNYHVMQSIIAIGSGGFLGKSKEAST
QTKFKFLPIATSDFIFAYFVERFGFLGAMLLFAIYIGLSLHLFFYMFESNSDWFLKIVALGISILIFVYSSVNIAMTLGL
APVVGIPLPLFSYGGSSFITFMILFGILENLLAFRYIFGYNSKLSFGNFGFLAQLVRALGS

Sequences:

>Translated_381_residues
MALDKRIWMHFDLLPFVFIIPLLVVSFLLIFESSAVLSLKQGVYYVIGFILFWIVFFIPFRKLDRWLFVFYWACVILLAL
VDFMGYSKLGAQRWLVIPFTSITLQPSEPVKIAILLLLAHLIKINPPPFKGYDWGMFLKLSFYICLPAALILKQPDLGTA
LIVLIMGFGILLIVGLRTRVWLPLFIALLVASPIAYHFLHDYQKKRIADFLSEKPNYHVMQSIIAIGSGGFLGKSKEAST
QTKFKFLPIATSDFIFAYFVERFGFLGAMLLFAIYIGLSLHLFFYMFESNSDWFLKIVALGISILIFVYSSVNIAMTLGL
APVVGIPLPLFSYGGSSFITFMILFGILENLLAFRYIFGYNSKLSFGNFGFLAQLVRALGS
>Mature_380_residues
ALDKRIWMHFDLLPFVFIIPLLVVSFLLIFESSAVLSLKQGVYYVIGFILFWIVFFIPFRKLDRWLFVFYWACVILLALV
DFMGYSKLGAQRWLVIPFTSITLQPSEPVKIAILLLLAHLIKINPPPFKGYDWGMFLKLSFYICLPAALILKQPDLGTAL
IVLIMGFGILLIVGLRTRVWLPLFIALLVASPIAYHFLHDYQKKRIADFLSEKPNYHVMQSIIAIGSGGFLGKSKEASTQ
TKFKFLPIATSDFIFAYFVERFGFLGAMLLFAIYIGLSLHLFFYMFESNSDWFLKIVALGISILIFVYSSVNIAMTLGLA
PVVGIPLPLFSYGGSSFITFMILFGILENLLAFRYIFGYNSKLSFGNFGFLAQLVRALGS

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=319, Percent_Identity=39.1849529780564, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI1786277, Length=317, Percent_Identity=29.9684542586751, Blast_Score=104, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 43229; Mature: 43098

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS00428 FTSW_RODA_SPOVE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALDKRIWMHFDLLPFVFIIPLLVVSFLLIFESSAVLSLKQGVYYVIGFILFWIVFFIPF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RKLDRWLFVFYWACVILLALVDFMGYSKLGAQRWLVIPFTSITLQPSEPVKIAILLLLAH
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCEEEEEEEEEEECCCCCHHHHHHHHHHH
LIKINPPPFKGYDWGMFLKLSFYICLPAALILKQPDLGTALIVLIMGFGILLIVGLRTRV
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
WLPLFIALLVASPIAYHFLHDYQKKRIADFLSEKPNYHVMQSIIAIGSGGFLGKSKEAST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCC
QTKFKFLPIATSDFIFAYFVERFGFLGAMLLFAIYIGLSLHLFFYMFESNSDWFLKIVAL
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHH
GISILIFVYSSVNIAMTLGLAPVVGIPLPLFSYGGSSFITFMILFGILENLLAFRYIFGY
HHHHHHHHHHCCHHHHHHCHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
NSKLSFGNFGFLAQLVRALGS
CCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
ALDKRIWMHFDLLPFVFIIPLLVVSFLLIFESSAVLSLKQGVYYVIGFILFWIVFFIPF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RKLDRWLFVFYWACVILLALVDFMGYSKLGAQRWLVIPFTSITLQPSEPVKIAILLLLAH
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCEEEEEEEEEEECCCCCHHHHHHHHHHH
LIKINPPPFKGYDWGMFLKLSFYICLPAALILKQPDLGTALIVLIMGFGILLIVGLRTRV
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
WLPLFIALLVASPIAYHFLHDYQKKRIADFLSEKPNYHVMQSIIAIGSGGFLGKSKEAST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCC
QTKFKFLPIATSDFIFAYFVERFGFLGAMLLFAIYIGLSLHLFFYMFESNSDWFLKIVAL
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHH
GISILIFVYSSVNIAMTLGLAPVVGIPLPLFSYGGSSFITFMILFGILENLLAFRYIFGY
HHHHHHHHHHCCHHHHHHCHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
NSKLSFGNFGFLAQLVRALGS
CCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]