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The map label for this gene is Hgd [H]

Identifier: 108563050

GI number: 108563050

Start: 651763

End: 652620

Strand: Direct

Name: Hgd [H]

Synonym: HPAG1_0625

Alternate gene names: 108563050

Gene position: 651763-652620 (Clockwise)

Preceding gene: 108563049

Following gene: 108563051

Centisome position: 40.83

GC content: 41.61

Gene sequence:

>858_bases
ATGAAAATCGGATGGATTGGACTTGGGGCTATGGGGACTCCTATGGCGACTCGTTTGTGCGATGCGGAGTTAGAAGTGTC
GGTTTATAACCGAACAGAGAGCAAAGCAGCCCCTTTAAAAGAAAAGGGCGTAGCGGTTTATACTAACCCTATAGATTTAG
CCGCTAAAGTTGATCTGATTTTTATTATGCTTTCGGATAAAACGGCGATTGATGCTGTTTTAGTGCCAAAATTTTGGGAA
CAGATGTCTAAAAAAATTGTGGTGAATATGAGCACCATCGCCCCTTTGGAAAGCTTGGCTTTAGAAAAAACCGCTCAAAA
GCATCAAGTAACTTACCTTGAAGCGCCTGTTTCAGGATCGGTTGGTGCGGCTAAAGCTGGGGCTTTATTGATTTTAGCGG
CAGGTGAAAAAGAAGTGGTTGCTCAACTCAAACCTATTTTGGCGCATTTGGGGAGTCAGATTTTTTATTTGGGTAAGATT
GGTCAAGGGACAGGGGCTAAATTATCCATTAATAGCCTTTTGGCTCAAATGGGGGTTGCTTATTCAGAAGCTTTACTATT
AGCCAAACATTTAGGGGTTGATGCAGAGTCATTTTTGCAAATTATTGGCCAATCTGGCATGAATTCGCCTCTCTTTCAAG
CTAAAAAAGGCATGTGGCTACAAGATAGCTATCCGGCCGCTTTCAGTTTGAAGCTCATGCTCAAAGACATTCGTTTAGCT
AACAATGAAGCAGGAGAGGCGATTGAATTGCCATTCTTATCTAAAGCAGAAGAGCTTTATTCTCAAGCGGAAAAATCCGG
TTTAGACGAAATGGATATGGCAGCCGTTTATCATTATTTAGAAAAAGGAGAACATTAA

Upstream 100 bases:

>100_bases
CTGATAATTTTGTGTCCAATGAAGTCATTGTCAAAGGTTTGGATTTTAAAAAAGTGGTGCAGCATTTAATGGCGTATTCG
TGCTAATAAGTGAGGATTGA

Downstream 100 bases:

>100_bases
AATGGACAGAGAACAAGTGATTGCTTTACAGCACCAACGATTTGCTGCAAAAAATACGATCCTAATCGTCGTATTTCCCA
AAAGGATTGGGAAGCTTTGG

Product: putative 3-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MKIGWIGLGAMGTPMATRLCDAELEVSVYNRTESKAAPLKEKGVAVYTNPIDLAAKVDLIFIMLSDKTAIDAVLVPKFWE
QMSKKIVVNMSTIAPLESLALEKTAQKHQVTYLEAPVSGSVGAAKAGALLILAAGEKEVVAQLKPILAHLGSQIFYLGKI
GQGTGAKLSINSLLAQMGVAYSEALLLAKHLGVDAESFLQIIGQSGMNSPLFQAKKGMWLQDSYPAAFSLKLMLKDIRLA
NNEAGEAIELPFLSKAEELYSQAEKSGLDEMDMAAVYHYLEKGEH

Sequences:

>Translated_285_residues
MKIGWIGLGAMGTPMATRLCDAELEVSVYNRTESKAAPLKEKGVAVYTNPIDLAAKVDLIFIMLSDKTAIDAVLVPKFWE
QMSKKIVVNMSTIAPLESLALEKTAQKHQVTYLEAPVSGSVGAAKAGALLILAAGEKEVVAQLKPILAHLGSQIFYLGKI
GQGTGAKLSINSLLAQMGVAYSEALLLAKHLGVDAESFLQIIGQSGMNSPLFQAKKGMWLQDSYPAAFSLKLMLKDIRLA
NNEAGEAIELPFLSKAEELYSQAEKSGLDEMDMAAVYHYLEKGEH
>Mature_285_residues
MKIGWIGLGAMGTPMATRLCDAELEVSVYNRTESKAAPLKEKGVAVYTNPIDLAAKVDLIFIMLSDKTAIDAVLVPKFWE
QMSKKIVVNMSTIAPLESLALEKTAQKHQVTYLEAPVSGSVGAAKAGALLILAAGEKEVVAQLKPILAHLGSQIFYLGKI
GQGTGAKLSINSLLAQMGVAYSEALLLAKHLGVDAESFLQIIGQSGMNSPLFQAKKGMWLQDSYPAAFSLKLMLKDIRLA
NNEAGEAIELPFLSKAEELYSQAEKSGLDEMDMAAVYHYLEKGEH

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=296, Percent_Identity=30.4054054054054, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=30.8510638297872, Blast_Score=116, Evalue=2e-26,
Organism=Escherichia coli, GI1786719, Length=293, Percent_Identity=29.6928327645051, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI145693186, Length=286, Percent_Identity=27.972027972028, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1790315, Length=287, Percent_Identity=27.5261324041812, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1789092, Length=283, Percent_Identity=25.0883392226148, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17557316, Length=292, Percent_Identity=28.4246575342466, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28574115, Length=282, Percent_Identity=30.8510638297872, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24655230, Length=290, Percent_Identity=30, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI19922568, Length=290, Percent_Identity=30, Blast_Score=115, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 30670; Mature: 30670

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGWIGLGAMGTPMATRLCDAELEVSVYNRTESKAAPLKEKGVAVYTNPIDLAAKVDLI
CEEEEEECCCCCCHHHHHHCCCCEEEEEECCCCCCCCCHHHCCEEEEECCCCHHEEEEEE
FIMLSDKTAIDAVLVPKFWEQMSKKIVVNMSTIAPLESLALEKTAQKHQVTYLEAPVSGS
EEEECCCCCHHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHEEEEEECCCCCC
VGAAKAGALLILAAGEKEVVAQLKPILAHLGSQIFYLGKIGQGTGAKLSINSLLAQMGVA
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEHHHHHHHHHHH
YSEALLLAKHLGVDAESFLQIIGQSGMNSPLFQAKKGMWLQDSYPAAFSLKLMLKDIRLA
HHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHCCCEEECCCCCHHHHHHHHHHHHHC
NNEAGEAIELPFLSKAEELYSQAEKSGLDEMDMAAVYHYLEKGEH
CCCCCCEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKIGWIGLGAMGTPMATRLCDAELEVSVYNRTESKAAPLKEKGVAVYTNPIDLAAKVDLI
CEEEEEECCCCCCHHHHHHCCCCEEEEEECCCCCCCCCHHHCCEEEEECCCCHHEEEEEE
FIMLSDKTAIDAVLVPKFWEQMSKKIVVNMSTIAPLESLALEKTAQKHQVTYLEAPVSGS
EEEECCCCCHHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHEEEEEECCCCCC
VGAAKAGALLILAAGEKEVVAQLKPILAHLGSQIFYLGKIGQGTGAKLSINSLLAQMGVA
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEHHHHHHHHHHH
YSEALLLAKHLGVDAESFLQIIGQSGMNSPLFQAKKGMWLQDSYPAAFSLKLMLKDIRLA
HHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHCCCEEECCCCCHHHHHHHHHHHHHC
NNEAGEAIELPFLSKAEELYSQAEKSGLDEMDMAAVYHYLEKGEH
CCCCCCEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA