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The map label for this gene is pepA [H]

Identifier: 108562974

GI number: 108562974

Start: 567920

End: 569410

Strand: Reverse

Name: pepA [H]

Synonym: HPAG1_0549

Alternate gene names: 108562974

Gene position: 569410-567920 (Counterclockwise)

Preceding gene: 108562975

Following gene: 108562973

Centisome position: 35.67

GC content: 40.98

Gene sequence:

>1491_bases
ATGTTAAAAATCAAATTAGAAAAAACCACTTTTGAAAACGCGAAAGCTGAATGCGGTCTAGTTTTTATTGTCAATAAGGA
TTTTAGCCACGCTTGGGTCAAAAATAAAGAATTGCTAGAAACCTTTAAATACGAAGGCGAAGGCGTATTTTTAGACCAAG
AAAATAAAATCCTGTATGTGGGCGTTAAAGAAGATGATGTGCATTTATTGAGAGAGAGCGCATGTTTAGCCGTTCGCACC
CTTAAAAAACTCGCTTTTAAAAGCGTTAAAGTGGGCGTTTATACTTGTGGTGCGCATTCTAAAGATAACGCGCTTTTAGA
AAACTTGAAAGCGCTGTTTTTGGGCTTGAAATTAGGCTTGTATGAATACGACACTTTTAAATCCAACAAAAAAGAAAGCG
TTTTAAAAGAAGCCATTGTCGCTTTAGAATTGCACAAACCTTGCGAAAAAACTTGCACGAATTCTTTAGAAAAGAGCGCT
AAAGAAGCTTTAAAATACGCTGAAATCATGACAGAAAGCTTGAATATCGTTAGGGATCTAGTCAATACCCCCCCTATGAT
TGGCACTCCGGTTTATATGGCTGAAGTGGCGCAAAAAGTGGCTAAAGAAAACCATTTAGAAATCCATGTTCATGATGAAA
AATTTTTAGAAGAAAAGAAAATGAACGCCTTTTTAGCGGTCAATAAAGCCTCTCTTGGCGTCAATCCTCCCCGCTTGATC
CATTTAGTCTATAAACCCAAAAAAGCGAAGAAAAAAATCGCTTTAGTGGGTAAGGGCTTGACTTATGATTGTGGGGGTTT
GAGCTTGAAACCGGCCGATTACATGGTTACCATGAAAGCGGATAAAGGCGGTGGCTCTGCGGTGATCGGGCTTTTAAACG
CATTAGCCAAACTAGGCGTGGAAGCTGAAGTGCATGGCATTATTGGGGCTACAGAAAACATGATAGGCCCGGCTGCTTAT
AAACCAGATGATATTTTAATCTCCAAAGAAGGCAAGAGCATAGAGGTCCGTAATACCGACGCTGAAGGGCGTTTGGTTTT
AGCGGATTGTTTGAGCTACGCTCAAGACTTGAACCCTGATGTGATCGTGGATTTTGCGACCCTTACTGGGGCATGCGTTG
TGGGCTTAGGCGAATTCACTTCAGCGATCATGGGGCATAATGAAGAGTTGAAAAATCTCTTTGAAACTTCAGGGTTAGAA
TCCGGCGAATTATTAGCCAAACTCCCCTTTAACCGCCATTTGAAGAAATTGATTGAATCTAAAATCGCTGATGTGTGTAA
TATTTCTTCTTCACGCTATGGCGGTGCGATCACTGCGGGCTTGTTTTTAAATGAATTTATTAGAGATGAGTTTAAGGATA
AGTGGCTACACATTGATATTGCAGGCCCTGCTTATGTGGAAAAAGAATGGGATGTGAATAGCTTTGGAGCGAGTGGGGCT
GGGGTTAGGGCTTGCACAGCTTTTGTGGAAGAGCTTTTGAAAAAGGCTTGA

Upstream 100 bases:

>100_bases
TCTTAGCGTTGGTTCTATGGTATTTCCAATACTATAGTAAGAAAAACCGCTAGAGTGCAATACAATTCTTGAAAGATATG
AAATTAAAAAAGGAGACTTT

Downstream 100 bases:

>100_bases
AATGGGCTTGTCTGTAGGCATTGTGGGTTTGCCTAATGTGGGCAAATCCAGCACCTTTAACGCACTCACTAAAACCCAAA
ACGCTCAAAGCGCGAACTAC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MLKIKLEKTTFENAKAECGLVFIVNKDFSHAWVKNKELLETFKYEGEGVFLDQENKILYVGVKEDDVHLLRESACLAVRT
LKKLAFKSVKVGVYTCGAHSKDNALLENLKALFLGLKLGLYEYDTFKSNKKESVLKEAIVALELHKPCEKTCTNSLEKSA
KEALKYAEIMTESLNIVRDLVNTPPMIGTPVYMAEVAQKVAKENHLEIHVHDEKFLEEKKMNAFLAVNKASLGVNPPRLI
HLVYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNALAKLGVEAEVHGIIGATENMIGPAAY
KPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLNPDVIVDFATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLE
SGELLAKLPFNRHLKKLIESKIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVEKEWDVNSFGASGA
GVRACTAFVEELLKKA

Sequences:

>Translated_496_residues
MLKIKLEKTTFENAKAECGLVFIVNKDFSHAWVKNKELLETFKYEGEGVFLDQENKILYVGVKEDDVHLLRESACLAVRT
LKKLAFKSVKVGVYTCGAHSKDNALLENLKALFLGLKLGLYEYDTFKSNKKESVLKEAIVALELHKPCEKTCTNSLEKSA
KEALKYAEIMTESLNIVRDLVNTPPMIGTPVYMAEVAQKVAKENHLEIHVHDEKFLEEKKMNAFLAVNKASLGVNPPRLI
HLVYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNALAKLGVEAEVHGIIGATENMIGPAAY
KPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLNPDVIVDFATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLE
SGELLAKLPFNRHLKKLIESKIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVEKEWDVNSFGASGA
GVRACTAFVEELLKKA
>Mature_496_residues
MLKIKLEKTTFENAKAECGLVFIVNKDFSHAWVKNKELLETFKYEGEGVFLDQENKILYVGVKEDDVHLLRESACLAVRT
LKKLAFKSVKVGVYTCGAHSKDNALLENLKALFLGLKLGLYEYDTFKSNKKESVLKEAIVALELHKPCEKTCTNSLEKSA
KEALKYAEIMTESLNIVRDLVNTPPMIGTPVYMAEVAQKVAKENHLEIHVHDEKFLEEKKMNAFLAVNKASLGVNPPRLI
HLVYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNALAKLGVEAEVHGIIGATENMIGPAAY
KPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLNPDVIVDFATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLE
SGELLAKLPFNRHLKKLIESKIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVEKEWDVNSFGASGA
GVRACTAFVEELLKKA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=399, Percent_Identity=35.0877192982456, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI47155554, Length=299, Percent_Identity=36.4548494983278, Blast_Score=174, Evalue=2e-43,
Organism=Escherichia coli, GI1790710, Length=379, Percent_Identity=35.0923482849604, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI87082123, Length=317, Percent_Identity=33.7539432176656, Blast_Score=153, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17556903, Length=301, Percent_Identity=36.8770764119601, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17565172, Length=229, Percent_Identity=33.1877729257642, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357381, Length=253, Percent_Identity=39.1304347826087, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI221379063, Length=253, Percent_Identity=39.1304347826087, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI221379062, Length=253, Percent_Identity=39.1304347826087, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI21355725, Length=397, Percent_Identity=29.9748110831234, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24661038, Length=392, Percent_Identity=29.5918367346939, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI19922386, Length=357, Percent_Identity=25.2100840336134, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI20129969, Length=299, Percent_Identity=26.7558528428094, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24662227, Length=356, Percent_Identity=24.438202247191, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI20129963, Length=292, Percent_Identity=29.1095890410959, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI21355645, Length=352, Percent_Identity=25, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24662223, Length=352, Percent_Identity=25, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI161077148, Length=308, Percent_Identity=25.6493506493506, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI20130057, Length=308, Percent_Identity=25.6493506493506, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24646701, Length=350, Percent_Identity=29.1428571428571, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24646703, Length=350, Percent_Identity=29.1428571428571, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI21358201, Length=350, Percent_Identity=29.1428571428571, Blast_Score=109, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54446; Mature: 54446

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKIKLEKTTFENAKAECGLVFIVNKDFSHAWVKNKELLETFKYEGEGVFLDQENKILYV
CEEEEEECCCCCCCCCCCCEEEEEECCCCHHHHCCHHHHHHHHCCCCEEEEECCCCEEEE
GVKEDDVHLLRESACLAVRTLKKLAFKSVKVGVYTCGAHSKDNALLENLKALFLGLKLGL
EECCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
YEYDTFKSNKKESVLKEAIVALELHKPCEKTCTNSLEKSAKEALKYAEIMTESLNIVRDL
EECCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNTPPMIGTPVYMAEVAQKVAKENHLEIHVHDEKFLEEKKMNAFLAVNKASLGVNPPRLI
HCCCCCCCCCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCEEEEEECCCCCCCCCCEE
HLVYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNALAKLGV
EEEECCCHHHCEEEEEECCCEECCCCCEECCCCEEEEEEECCCCCHHHHHHHHHHHHCCC
EAEVHGIIGATENMIGPAAYKPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLNPD
CEEEEEEEECCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCEEHHHHHHHHHHCCCC
VIVDFATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLESGELLAKLPFNRHLKKLIES
EEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHH
KIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVEKEWDVNSFGASGA
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCCC
GVRACTAFVEELLKKA
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLKIKLEKTTFENAKAECGLVFIVNKDFSHAWVKNKELLETFKYEGEGVFLDQENKILYV
CEEEEEECCCCCCCCCCCCEEEEEECCCCHHHHCCHHHHHHHHCCCCEEEEECCCCEEEE
GVKEDDVHLLRESACLAVRTLKKLAFKSVKVGVYTCGAHSKDNALLENLKALFLGLKLGL
EECCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
YEYDTFKSNKKESVLKEAIVALELHKPCEKTCTNSLEKSAKEALKYAEIMTESLNIVRDL
EECCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNTPPMIGTPVYMAEVAQKVAKENHLEIHVHDEKFLEEKKMNAFLAVNKASLGVNPPRLI
HCCCCCCCCCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCEEEEEECCCCCCCCCCEE
HLVYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNALAKLGV
EEEECCCHHHCEEEEEECCCEECCCCCEECCCCEEEEEEECCCCCHHHHHHHHHHHHCCC
EAEVHGIIGATENMIGPAAYKPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLNPD
CEEEEEEEECCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCEEHHHHHHHHHHCCCC
VIVDFATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLESGELLAKLPFNRHLKKLIES
EEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHH
KIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAYVEKEWDVNSFGASGA
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCCC
GVRACTAFVEELLKKA
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA