Click here to switch to the map view.

The map label for this gene is dapA [H]

Identifier: 108562858

GI number: 108562858

Start: 441485

End: 442387

Strand: Reverse

Name: dapA [H]

Synonym: HPAG1_0433

Alternate gene names: 108562858

Gene position: 442387-441485 (Counterclockwise)

Preceding gene: 108562859

Following gene: 108562857

Centisome position: 27.71

GC content: 43.08

Gene sequence:

>903_bases
ATGCAATTCCATTCATCTAGCGCGTTAATTACGCCTTTTAAAAAAGATTTGAGCGTTGATGAGGCCGCTTATGAATCCTT
GATCAAGCGCCAAATTCTTCAGGGCATGGACGCATGCGTGCCTGTTGGCACGACAGGAGAATCCGCCACGCTCACCCATA
AAGAGCACATGCGTTGCATTGAAATCGCCATAGAGACTTGCAAAAACACTAAAACGCCCTCAAATTCGTGCATGAAAGTG
TTAGCCGGCGTGGGCAGTAACGCCACGAGCGAGTCCCTTTCTTTGGCAAAGTTCGCTCAAAAAATCGGCGCGGATGCGAT
TTTATGCGTAAGCCCCTATTATAACCGCCCCACCCAACAAGGCTTGTTTGAACATTATAAAACCATCGCTCAATCGGTGG
AAATCCCTGTCATGCTTTATGATGTGCCAAGTAGAACAGGCGTGTCTATTGAAGTCCCAACCGCTCTCAAACTCTTTAGA
GAAGTCCCTAACATTAAAGCCATTAAGGAAGCGTCTGGCTCTTTGAAAAGAGTAACAGAATTGCATTATTATGAAAAAGA
CTTTAAAATTTTTAGTGGGGAAGATTCACTCAACCACTCTATCATGTTTTCAGGGGGGTGCGGCGTGATTTCAGTGACCG
GTAATTTAATGCCTAATCTGATTTCACAGATGGTCAATTGTGCGCTCAAACAAAAATACCAACAAGCCCTAGAAATCCAA
AATAAGCTTTTTCATTTGCACCAAGCCCTTTTTGTAGAAACAAATCCCATCCCCATTAAAATGGCTATGCATTTAGCCGG
CTTGATTGAAAACCCAAGCTACAGACTGCCTTTAGTGGCCCCAAGCAAAGAAACGATTCAACTTTTAGAAAAAACTTTAC
AACAATATGAGGTAATTGCATGA

Upstream 100 bases:

>100_bases
TGGATTTAAAAGTGAGCGATTTGGTGCGTGTGGCTAATGAATATTTTAAAGACACCCAATCAACCACCGTGTTTTTGAAA
CCTTAAAAGAGCCTTATAAC

Downstream 100 bases:

>100_bases
ATGGTTCCAATCACATGAAAAATAAAACCCTAGTGATCAGCGGCGCGACTAGAGGGATTGGCAAGGCGATATTGTATCGT
TTCGCTCAAAGCGGCGTGAA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MQFHSSSALITPFKKDLSVDEAAYESLIKRQILQGMDACVPVGTTGESATLTHKEHMRCIEIAIETCKNTKTPSNSCMKV
LAGVGSNATSESLSLAKFAQKIGADAILCVSPYYNRPTQQGLFEHYKTIAQSVEIPVMLYDVPSRTGVSIEVPTALKLFR
EVPNIKAIKEASGSLKRVTELHYYEKDFKIFSGEDSLNHSIMFSGGCGVISVTGNLMPNLISQMVNCALKQKYQQALEIQ
NKLFHLHQALFVETNPIPIKMAMHLAGLIENPSYRLPLVAPSKETIQLLEKTLQQYEVIA

Sequences:

>Translated_300_residues
MQFHSSSALITPFKKDLSVDEAAYESLIKRQILQGMDACVPVGTTGESATLTHKEHMRCIEIAIETCKNTKTPSNSCMKV
LAGVGSNATSESLSLAKFAQKIGADAILCVSPYYNRPTQQGLFEHYKTIAQSVEIPVMLYDVPSRTGVSIEVPTALKLFR
EVPNIKAIKEASGSLKRVTELHYYEKDFKIFSGEDSLNHSIMFSGGCGVISVTGNLMPNLISQMVNCALKQKYQQALEIQ
NKLFHLHQALFVETNPIPIKMAMHLAGLIENPSYRLPLVAPSKETIQLLEKTLQQYEVIA
>Mature_300_residues
MQFHSSSALITPFKKDLSVDEAAYESLIKRQILQGMDACVPVGTTGESATLTHKEHMRCIEIAIETCKNTKTPSNSCMKV
LAGVGSNATSESLSLAKFAQKIGADAILCVSPYYNRPTQQGLFEHYKTIAQSVEIPVMLYDVPSRTGVSIEVPTALKLFR
EVPNIKAIKEASGSLKRVTELHYYEKDFKIFSGEDSLNHSIMFSGGCGVISVTGNLMPNLISQMVNCALKQKYQQALEIQ
NKLFHLHQALFVETNPIPIKMAMHLAGLIENPSYRLPLVAPSKETIQLLEKTLQQYEVIA

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=282, Percent_Identity=24.468085106383, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI13540533, Length=307, Percent_Identity=25.0814332247557, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1788823, Length=284, Percent_Identity=38.7323943661972, Blast_Score=201, Evalue=4e-53,
Organism=Escherichia coli, GI87082415, Length=288, Percent_Identity=29.8611111111111, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1789620, Length=277, Percent_Identity=27.0758122743682, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1786463, Length=248, Percent_Identity=26.6129032258064, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 33152; Mature: 33152

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFHSSSALITPFKKDLSVDEAAYESLIKRQILQGMDACVPVGTTGESATLTHKEHMRCI
CCCCCCCCEECCHHHCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCEECHHHHHHHH
EIAIETCKNTKTPSNSCMKVLAGVGSNATSESLSLAKFAQKIGADAILCVSPYYNRPTQQ
HHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHH
GLFEHYKTIAQSVEIPVMLYDVPSRTGVSIEVPTALKLFREVPNIKAIKEASGSLKRVTE
HHHHHHHHHHHHCCCCEEEEECCCCCCCEEECHHHHHHHHHCCCHHHHHHHCCHHHHHHH
LHYYEKDFKIFSGEDSLNHSIMFSGGCGVISVTGNLMPNLISQMVNCALKQKYQQALEIQ
HHHHHCCCEEECCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
NKLFHLHQALFVETNPIPIKMAMHLAGLIENPSYRLPLVAPSKETIQLLEKTLQQYEVIA
HHHHHHHHHHHEECCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQFHSSSALITPFKKDLSVDEAAYESLIKRQILQGMDACVPVGTTGESATLTHKEHMRCI
CCCCCCCCEECCHHHCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCEECHHHHHHHH
EIAIETCKNTKTPSNSCMKVLAGVGSNATSESLSLAKFAQKIGADAILCVSPYYNRPTQQ
HHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHH
GLFEHYKTIAQSVEIPVMLYDVPSRTGVSIEVPTALKLFREVPNIKAIKEASGSLKRVTE
HHHHHHHHHHHHCCCCEEEEECCCCCCCEEECHHHHHHHHHCCCHHHHHHHCCHHHHHHH
LHYYEKDFKIFSGEDSLNHSIMFSGGCGVISVTGNLMPNLISQMVNCALKQKYQQALEIQ
HHHHHCCCEEECCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
NKLFHLHQALFVETNPIPIKMAMHLAGLIENPSYRLPLVAPSKETIQLLEKTLQQYEVIA
HHHHHHHHHHHEECCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA