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The map label for this gene is fabL [H]

Identifier: 108562857

GI number: 108562857

Start: 440700

End: 441488

Strand: Reverse

Name: fabL [H]

Synonym: HPAG1_0432

Alternate gene names: 108562857

Gene position: 441488-440700 (Counterclockwise)

Preceding gene: 108562858

Following gene: 108562856

Centisome position: 27.66

GC content: 43.6

Gene sequence:

>789_bases
ATGAATGGTTCCAATCACATGAAAAATAAAACCCTAGTGATCAGCGGCGCGACTAGAGGGATTGGCAAGGCGATATTGTA
TCGTTTCGCTCAAAGCGGCGTGAATATCGCTTTCACTTACAATAAAAATGTTGAAGAAGCCAACAAAATCATAGAAGATG
TGGAGCAAAAATATTCCATTAAAGCCAAAGCCTACCCCCTTAATGTTTTAGAGCCTGATCAATACACAGAGCTTTTTAAA
CAAATTGACGCTGATTTTGACAGAGTGGATTTTTTTATTTCTAACGCCATTATTTATGGGCGCTCTGTCGTGGGGGGATT
TGCGCCGTTTATGCGATTAAAACCTAAGGGGTTAAACAACATTTACACAGCCACCGTGTTAGCGTTTGTCGTAGGGGCTC
AAGAAGCGGCAAAACGCATGCAAAAAATAGGTGGCGGGGCGATCGTGAGCTTAAGCTCTACCGGGAATCTAGTTTATATG
CCTAATTACGCCGGGCATGGCAATTCTAAAAACGCCGTAGAAACCATGGTCAAATACGCTGCCGTGGATTTAGGCGAATT
TAATATTAGAGTGAATGCGGTTAGCGGCGGGCCTATTGATACGGACGCTTTGAAAGCTTTCCCTGATTATGTGGAGATTA
AAGAAAAAGTAGAAGAGCAATCGCCCCTAAAACGCATGGGCAATCCTAACGATCTAGCCGGAGCGGCTTATTTTTTATGC
GATGAAACCCAAAGCGGTTGGCTTACAGGGCAAACGATCGTTGTAGATGGCGGGACCACTTTTAAATAA

Upstream 100 bases:

>100_bases
GCTTGATTGAAAACCCAAGCTACAGACTGCCTTTAGTGGCCCCAAGCAAAGAAACGATTCAACTTTTAGAAAAAACTTTA
CAACAATATGAGGTAATTGC

Downstream 100 bases:

>100_bases
AGATTTTTTTTGCAAAACATTATCCACATCCACCAAAACAAAGAGTTGCAATTCATTAAAAAATGCTTGTTGTGCTATTT
TTTCGCCCCTTTGTGTGGGG

Product: 7-alpha-hydroxysteroid dehydrogenase

Products: NA

Alternate protein names: Enoyl-acyl carrier protein reductase III; NADPH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MNGSNHMKNKTLVISGATRGIGKAILYRFAQSGVNIAFTYNKNVEEANKIIEDVEQKYSIKAKAYPLNVLEPDQYTELFK
QIDADFDRVDFFISNAIIYGRSVVGGFAPFMRLKPKGLNNIYTATVLAFVVGAQEAAKRMQKIGGGAIVSLSSTGNLVYM
PNYAGHGNSKNAVETMVKYAAVDLGEFNIRVNAVSGGPIDTDALKAFPDYVEIKEKVEEQSPLKRMGNPNDLAGAAYFLC
DETQSGWLTGQTIVVDGGTTFK

Sequences:

>Translated_262_residues
MNGSNHMKNKTLVISGATRGIGKAILYRFAQSGVNIAFTYNKNVEEANKIIEDVEQKYSIKAKAYPLNVLEPDQYTELFK
QIDADFDRVDFFISNAIIYGRSVVGGFAPFMRLKPKGLNNIYTATVLAFVVGAQEAAKRMQKIGGGAIVSLSSTGNLVYM
PNYAGHGNSKNAVETMVKYAAVDLGEFNIRVNAVSGGPIDTDALKAFPDYVEIKEKVEEQSPLKRMGNPNDLAGAAYFLC
DETQSGWLTGQTIVVDGGTTFK
>Mature_262_residues
MNGSNHMKNKTLVISGATRGIGKAILYRFAQSGVNIAFTYNKNVEEANKIIEDVEQKYSIKAKAYPLNVLEPDQYTELFK
QIDADFDRVDFFISNAIIYGRSVVGGFAPFMRLKPKGLNNIYTATVLAFVVGAQEAAKRMQKIGGGAIVSLSSTGNLVYM
PNYAGHGNSKNAVETMVKYAAVDLGEFNIRVNAVSGGPIDTDALKAFPDYVEIKEKVEEQSPLKRMGNPNDLAGAAYFLC
DETQSGWLTGQTIVVDGGTTFK

Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=261, Percent_Identity=28.3524904214559, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI126723750, Length=262, Percent_Identity=26.3358778625954, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI40254992, Length=250, Percent_Identity=24.8, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787905, Length=253, Percent_Identity=32.4110671936759, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1788459, Length=247, Percent_Identity=27.1255060728745, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1790717, Length=258, Percent_Identity=25.1937984496124, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI2367365, Length=248, Percent_Identity=27.8225806451613, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI2367175, Length=253, Percent_Identity=28.0632411067194, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787335, Length=253, Percent_Identity=26.0869565217391, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1787545, Length=270, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082160, Length=256, Percent_Identity=27.34375, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI87082100, Length=271, Percent_Identity=26.5682656826568, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789378, Length=257, Percent_Identity=24.9027237354086, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1789208, Length=256, Percent_Identity=24.21875, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1786812, Length=269, Percent_Identity=22.6765799256506, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=268, Percent_Identity=28.3582089552239, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17562910, Length=276, Percent_Identity=27.536231884058, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17536025, Length=258, Percent_Identity=26.3565891472868, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=273, Percent_Identity=28.2051282051282, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115534694, Length=252, Percent_Identity=27.3809523809524, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=278, Percent_Identity=26.978417266187, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=271, Percent_Identity=28.0442804428044, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=260, Percent_Identity=25, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17536651, Length=257, Percent_Identity=26.0700389105058, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=274, Percent_Identity=27.3722627737226, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=255, Percent_Identity=25.0980392156863, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=270, Percent_Identity=26.2962962962963, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=279, Percent_Identity=25.4480286738351, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=278, Percent_Identity=27.3381294964029, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=274, Percent_Identity=26.2773722627737, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=270, Percent_Identity=25.9259259259259, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=267, Percent_Identity=27.3408239700375, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=287, Percent_Identity=27.5261324041812, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=221, Percent_Identity=27.6018099547511, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21355319, Length=259, Percent_Identity=28.5714285714286, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24639444, Length=257, Percent_Identity=26.8482490272374, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24644337, Length=117, Percent_Identity=39.3162393162393, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI23397609, Length=257, Percent_Identity=23.7354085603113, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28571526, Length=262, Percent_Identity=28.2442748091603, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.10 [H]

Molecular weight: Translated: 28534; Mature: 28534

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGSNHMKNKTLVISGATRGIGKAILYRFAQSGVNIAFTYNKNVEEANKIIEDVEQKYSI
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCE
KAKAYPLNVLEPDQYTELFKQIDADFDRVDFFISNAIIYGRSVVGGFAPFMRLKPKGLNN
EEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHEECHHHHHHHHHHHHCCCCCCCH
IYTATVLAFVVGAQEAAKRMQKIGGGAIVSLSSTGNLVYMPNYAGHGNSKNAVETMVKYA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCCCCCCCCHHHHHHHHHHH
AVDLGEFNIRVNAVSGGPIDTDALKAFPDYVEIKEKVEEQSPLKRMGNPNDLAGAAYFLC
HHCCCEEEEEEEEECCCCCCHHHHHHCCHHHHHHHHHHHCCHHHHCCCCCCCCCEEEEEE
DETQSGWLTGQTIVVDGGTTFK
CCCCCCEEECCEEEECCCCCCC
>Mature Secondary Structure
MNGSNHMKNKTLVISGATRGIGKAILYRFAQSGVNIAFTYNKNVEEANKIIEDVEQKYSI
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCE
KAKAYPLNVLEPDQYTELFKQIDADFDRVDFFISNAIIYGRSVVGGFAPFMRLKPKGLNN
EEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHEECHHHHHHHHHHHHCCCCCCCH
IYTATVLAFVVGAQEAAKRMQKIGGGAIVSLSSTGNLVYMPNYAGHGNSKNAVETMVKYA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCCCCCCCCHHHHHHHHHHH
AVDLGEFNIRVNAVSGGPIDTDALKAFPDYVEIKEKVEEQSPLKRMGNPNDLAGAAYFLC
HHCCCEEEEEEEEECCCCCCHHHHHHCCHHHHHHHHHHHCCHHHHCCCCCCCCCEEEEEE
DETQSGWLTGQTIVVDGGTTFK
CCCCCCEEECCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9202460; 9384377 [H]