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The map label for this gene is pgsA [H]

Identifier: 108562855

GI number: 108562855

Start: 439546

End: 440148

Strand: Reverse

Name: pgsA [H]

Synonym: HPAG1_0430

Alternate gene names: 108562855

Gene position: 440148-439546 (Counterclockwise)

Preceding gene: 108562856

Following gene: 108562854

Centisome position: 27.57

GC content: 37.81

Gene sequence:

>603_bases
GTGTGTGGCGCTTGGCTTTTTGGCACGCGCGTTTTTGAATTTTTCACAAGTCTTTTTGAAAGCATGAAAGTTTTAAAACT
CCTGCCTAATTTTTTGACGATTTTACGCATTGTCTTATCCTTGTTTTTATTATTTTTATTGTTAAACACGCGCACTTATT
TTAGTTTTTTAACCCCCTTTCACATTAACATGATCTCTTCATTGGTTTTTTTGTTTGCCGCACTCACGGATTTATTGGAC
GGCTACATCGCTAGAAGCTATAAAGCCAAATCGCGCTTTGGGGAAATCTTTGATCCTTTAGCGGATAAAATCCTTATTTT
GAGCGCGTTTTTAGGGTTAGTTTATTTGGATCGTGTGAATGCGTGGATCCCGTTTGTGATTTTAGGGCGCGAATTTTTTA
TTTCAGGGCTTAGGGTTTTAGCCGCTAATGAAAAAAAGGATATTCCTGTCAATGCACTAGGCAAGTATAAAACCGTTTCT
CAAGTCGTGGCGATTGGCGCTTTATTGGCTGATGTAACTTACTCTTATGCGCTTGTGGCCATAGCGGTTTTTTTAACCCT
TTATTCGGGGATAGATTACACCATTAAATATTATAAATCTTAA

Upstream 100 bases:

>100_bases
GCGGGTTTAGATTACTGCTTTTTAGTTTCATGTTGGCTCTTTTAGGGATTTTAGCACAAGCGTTAGTTATCATTTTTTTA
ACGATCGCTGTGATTTTAAT

Downstream 100 bases:

>100_bases
TGTTTTAAAAGGAGTTTTTAGCGTTCTTTAAAAAACCTTAAAACGCTTAAAAAGCTATCGCTTGATCAAGCTCTTTTACT
ATTTAATCTTTAAAAAATGC

Product: phosphatidylglycerophosphate synthase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MCGAWLFGTRVFEFFTSLFESMKVLKLLPNFLTILRIVLSLFLLFLLLNTRTYFSFLTPFHINMISSLVFLFAALTDLLD
GYIARSYKAKSRFGEIFDPLADKILILSAFLGLVYLDRVNAWIPFVILGREFFISGLRVLAANEKKDIPVNALGKYKTVS
QVVAIGALLADVTYSYALVAIAVFLTLYSGIDYTIKYYKS

Sequences:

>Translated_200_residues
MCGAWLFGTRVFEFFTSLFESMKVLKLLPNFLTILRIVLSLFLLFLLLNTRTYFSFLTPFHINMISSLVFLFAALTDLLD
GYIARSYKAKSRFGEIFDPLADKILILSAFLGLVYLDRVNAWIPFVILGREFFISGLRVLAANEKKDIPVNALGKYKTVS
QVVAIGALLADVTYSYALVAIAVFLTLYSGIDYTIKYYKS
>Mature_200_residues
MCGAWLFGTRVFEFFTSLFESMKVLKLLPNFLTILRIVLSLFLLFLLLNTRTYFSFLTPFHINMISSLVFLFAALTDLLD
GYIARSYKAKSRFGEIFDPLADKILILSAFLGLVYLDRVNAWIPFVILGREFFISGLRVLAANEKKDIPVNALGKYKTVS
QVVAIGALLADVTYSYALVAIAVFLTLYSGIDYTIKYYKS

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1788220, Length=176, Percent_Identity=32.9545454545455, Blast_Score=84, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24650130, Length=128, Percent_Identity=33.59375, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650126, Length=128, Percent_Identity=33.59375, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650128, Length=128, Percent_Identity=33.59375, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 22655; Mature: 22655

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGAWLFGTRVFEFFTSLFESMKVLKLLPNFLTILRIVLSLFLLFLLLNTRTYFSFLTPF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HINMISSLVFLFAALTDLLDGYIARSYKAKSRFGEIFDPLADKILILSAFLGLVYLDRVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWIPFVILGREFFISGLRVLAANEKKDIPVNALGKYKTVSQVVAIGALLADVTYSYALVA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAVFLTLYSGIDYTIKYYKS
HHHHHHHHHCCCHHHHEECC
>Mature Secondary Structure
MCGAWLFGTRVFEFFTSLFESMKVLKLLPNFLTILRIVLSLFLLFLLLNTRTYFSFLTPF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HINMISSLVFLFAALTDLLDGYIARSYKAKSRFGEIFDPLADKILILSAFLGLVYLDRVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWIPFVILGREFFISGLRVLAANEKKDIPVNALGKYKTVSQVVAIGALLADVTYSYALVA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAVFLTLYSGIDYTIKYYKS
HHHHHHHHHCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7750561; 9384377 [H]