Click here to switch to the map view.

The map label for this gene is copA [H]

Identifier: 108562800

GI number: 108562800

Start: 386704

End: 388941

Strand: Reverse

Name: copA [H]

Synonym: HPAG1_0375

Alternate gene names: 108562800

Gene position: 388941-386704 (Counterclockwise)

Preceding gene: 108562801

Following gene: 108562799

Centisome position: 24.36

GC content: 39.77

Gene sequence:

>2238_bases
ATGAAAGAATCTTTTTACATAGAGGGAATGACTTGCACGGCGTGTTCTAGTGGGATTGAACGCTCTTTAGGGCGTAAAAG
TTTTGTGAAAAAAATAGAAGTGAGCCTTTTAAATAAGAGCGCTAACATTGAATTTAACGAAAACGAAACCAATTTAGACG
AAATTTTTAAACTCATTGAAAAACTGGGTTATAGCCCCAAAAAAACTCTAGCGGAAGAAAAAAAAGAATTTTTTAGCCCT
AATGTTAAATTAGCGTTGGCGGTTATTTTCACGCTTTTTGTGGTGTATCTTTCTATGGGGGCGATGCTTAGCCCTAGCCT
TTTACCTGAAAGCTTGCTTACGATTAACAACCATAGTAATTTTTTAAACGCTTGCTTACAGCTTATAGGCACGCTCATTG
TCATGCATTGGGGGAGGGATTTTTACATTCAAGGGTTTAAAGCCTTATGGCACAGACAACCCAACATGAGCAGCCTTATC
GCCATAGGCACAAGTGCTGCCTTAATTTCAAGCCTGTGGCAATTGTATTTGGTTTATACCAATCATTATACCGATCAGTG
GTCTTATGGGCATTATTATTTTGAAAGCGTGTGCGTGATTTTAATGTTTGTGATGGTGGGCAAACGCATTGAAAATGTTT
CTAAAGACAAAGCTTTAGACGCTATGCAAGCCTTGATGAAAAACGCCCCAAAAACCGCCCTTAAAATGCAAAATAACCAA
CAGATTGAAGTTTTAGTGGATAGCATTGTGGTGGGGGATATTCTAAAGGTTCTCCCTGGAAGCGCGATTGCGGTGGATGG
CGAAATCATAGAGGGAGAAGGGGAATTAGATGAGAGCATGTTAAGTGGCGAAGCGTTGCCGGTTTATAAAAAAGTCGGCG
ATAAAGTCTTTTCAGGGACATTCAATAGCCACACGAGTTTTTTAATGAAAGCCACGCAAAACAACAAAAACAGCACCTTG
ACTCAAATTATAGAAATGATCCATAACGCTCAAAGCTCAAAGGCAGAGATTTCTCGCTTAGCGGATAAGGTTTCAAGCGT
GTTTGTGCCAAGCGTGATTTCTATCGCTATTTTAGCGTTTGTGGTGTGGCTCATCATCGCACCTAAGCCTGATTTTTGGT
GGAATTTTGGAATCGCTTTAGAAGTGTTTGTATCGGTTTTAGTGATTTCTTGCCCTTGCGCTTTAGGATTGGCCACGCCT
ATGAGCATTTTAGTAGCGAACCAGAAAGCGAGTTCTTTAGGATTATTTTTTAAAGATGCTAAAAGTTTAGAAAAAGCAAG
GCTAGTCAATACGATCGTTTTTGATAAAACCGGCACGCTCACTAACGGCAAGCCTGTCGTTAAAAGCGTCCATTCTAACA
TAGAATTATTAGAGCTATTGAGTTTAGCGGGTAGCATTGAAAAGAGCAGCGAACATGTCATCGCTAAAGGGATTGTAGAA
TACGCCAAAGAGCGTAACGCTCCCTTAAAAGAAATGAGCGAGGTTAAAGTGAAAACGGGTTTTGGCATTAGTGCTAAAAC
AGATTATCAAGGCGCTAAAGAGATCATTAAAGTAGGCAACAGCGAGTTTTTTAACCCTATTAACACGCTAGAAATTAAAG
AAAACGGGATTTTAGTGTTTGTGGGTAGAATGATCAATGAAAAAGAAGACGAGCTTTTAGGGGTGTTTGTTTTAGAAGAT
TTGCCCAAAAAAAGCGTGAAAGAGCATATCGCTCAAATCAAAAATTTAGGCATTAACACTTTTCTTTTAAGTGGGGACAA
TAGGGAAAATGTCAAAAAATGCGCGCTTGAATTAGGAATTGATGGTTATATCAGCAACGCCAAACCACAAGACAAGCTCA
ATAAGATCAAAGAGCTTAAGGAAAAAGGGCAGATCGTTATGATGGTGGGCGATGGCTTGAATGACGCTCCCAGTCTTGCT
ATGAGCGATGTAGCAGTGGTGATGGCTAAAGGGAGCGATGTGAGCGTGCAAGCAGCGGACATTGTGAGCTTTAACAACGA
TATTAAATCGGTTTATAGCGCGATTAAATTAAGCCAAGCGACCATTAAAAATATCAAAGAAAATTTGTTTTGGGCTTTTT
GTTATAATAGCGTGTTTATCCCTTTAGCTTGTGGGGTTCTTTATAAGGCTAATATCATGTTAAGCCCGGCGATTGCGGGT
TTAGCGATGAGTTTAAGCTCTGTGAGTGTGGTCTTAAACTCCCAAAGGCTAAGGAATTTTAAAATTAAGGATCATTGA

Upstream 100 bases:

>100_bases
TAGAAGCTTTAAGCGTGTTTATGGGACTGTATTTGATTTATGGCATCATTCGGTGGCTCTTTTTAATGGTAAAAATTATT
TTTAATAAAAATAAAAGTGC

Downstream 100 bases:

>100_bases
ATGAAAGCAACTTTTCAAGTGCCAAGCATTACTTGCAACCATTGCGTGGATAAAATTGAAAAATTTGTGGGTGAAATTGA
AGGCGTGAGCTTTATTGATG

Product: copper-transporting ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 745; Mature: 745

Protein sequence:

>745_residues
MKESFYIEGMTCTACSSGIERSLGRKSFVKKIEVSLLNKSANIEFNENETNLDEIFKLIEKLGYSPKKTLAEEKKEFFSP
NVKLALAVIFTLFVVYLSMGAMLSPSLLPESLLTINNHSNFLNACLQLIGTLIVMHWGRDFYIQGFKALWHRQPNMSSLI
AIGTSAALISSLWQLYLVYTNHYTDQWSYGHYYFESVCVILMFVMVGKRIENVSKDKALDAMQALMKNAPKTALKMQNNQ
QIEVLVDSIVVGDILKVLPGSAIAVDGEIIEGEGELDESMLSGEALPVYKKVGDKVFSGTFNSHTSFLMKATQNNKNSTL
TQIIEMIHNAQSSKAEISRLADKVSSVFVPSVISIAILAFVVWLIIAPKPDFWWNFGIALEVFVSVLVISCPCALGLATP
MSILVANQKASSLGLFFKDAKSLEKARLVNTIVFDKTGTLTNGKPVVKSVHSNIELLELLSLAGSIEKSSEHVIAKGIVE
YAKERNAPLKEMSEVKVKTGFGISAKTDYQGAKEIIKVGNSEFFNPINTLEIKENGILVFVGRMINEKEDELLGVFVLED
LPKKSVKEHIAQIKNLGINTFLLSGDNRENVKKCALELGIDGYISNAKPQDKLNKIKELKEKGQIVMMVGDGLNDAPSLA
MSDVAVVMAKGSDVSVQAADIVSFNNDIKSVYSAIKLSQATIKNIKENLFWAFCYNSVFIPLACGVLYKANIMLSPAIAG
LAMSLSSVSVVLNSQRLRNFKIKDH

Sequences:

>Translated_745_residues
MKESFYIEGMTCTACSSGIERSLGRKSFVKKIEVSLLNKSANIEFNENETNLDEIFKLIEKLGYSPKKTLAEEKKEFFSP
NVKLALAVIFTLFVVYLSMGAMLSPSLLPESLLTINNHSNFLNACLQLIGTLIVMHWGRDFYIQGFKALWHRQPNMSSLI
AIGTSAALISSLWQLYLVYTNHYTDQWSYGHYYFESVCVILMFVMVGKRIENVSKDKALDAMQALMKNAPKTALKMQNNQ
QIEVLVDSIVVGDILKVLPGSAIAVDGEIIEGEGELDESMLSGEALPVYKKVGDKVFSGTFNSHTSFLMKATQNNKNSTL
TQIIEMIHNAQSSKAEISRLADKVSSVFVPSVISIAILAFVVWLIIAPKPDFWWNFGIALEVFVSVLVISCPCALGLATP
MSILVANQKASSLGLFFKDAKSLEKARLVNTIVFDKTGTLTNGKPVVKSVHSNIELLELLSLAGSIEKSSEHVIAKGIVE
YAKERNAPLKEMSEVKVKTGFGISAKTDYQGAKEIIKVGNSEFFNPINTLEIKENGILVFVGRMINEKEDELLGVFVLED
LPKKSVKEHIAQIKNLGINTFLLSGDNRENVKKCALELGIDGYISNAKPQDKLNKIKELKEKGQIVMMVGDGLNDAPSLA
MSDVAVVMAKGSDVSVQAADIVSFNNDIKSVYSAIKLSQATIKNIKENLFWAFCYNSVFIPLACGVLYKANIMLSPAIAG
LAMSLSSVSVVLNSQRLRNFKIKDH
>Mature_745_residues
MKESFYIEGMTCTACSSGIERSLGRKSFVKKIEVSLLNKSANIEFNENETNLDEIFKLIEKLGYSPKKTLAEEKKEFFSP
NVKLALAVIFTLFVVYLSMGAMLSPSLLPESLLTINNHSNFLNACLQLIGTLIVMHWGRDFYIQGFKALWHRQPNMSSLI
AIGTSAALISSLWQLYLVYTNHYTDQWSYGHYYFESVCVILMFVMVGKRIENVSKDKALDAMQALMKNAPKTALKMQNNQ
QIEVLVDSIVVGDILKVLPGSAIAVDGEIIEGEGELDESMLSGEALPVYKKVGDKVFSGTFNSHTSFLMKATQNNKNSTL
TQIIEMIHNAQSSKAEISRLADKVSSVFVPSVISIAILAFVVWLIIAPKPDFWWNFGIALEVFVSVLVISCPCALGLATP
MSILVANQKASSLGLFFKDAKSLEKARLVNTIVFDKTGTLTNGKPVVKSVHSNIELLELLSLAGSIEKSSEHVIAKGIVE
YAKERNAPLKEMSEVKVKTGFGISAKTDYQGAKEIIKVGNSEFFNPINTLEIKENGILVFVGRMINEKEDELLGVFVLED
LPKKSVKEHIAQIKNLGINTFLLSGDNRENVKKCALELGIDGYISNAKPQDKLNKIKELKEKGQIVMMVGDGLNDAPSLA
MSDVAVVMAKGSDVSVQAADIVSFNNDIKSVYSAIKLSQATIKNIKENLFWAFCYNSVFIPLACGVLYKANIMLSPAIAG
LAMSLSSVSVVLNSQRLRNFKIKDH

Specific function: Probably involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=789, Percent_Identity=30.5449936628644, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI115529486, Length=825, Percent_Identity=29.2121212121212, Blast_Score=354, Evalue=2e-97,
Organism=Homo sapiens, GI55743073, Length=516, Percent_Identity=31.5891472868217, Blast_Score=265, Evalue=2e-70,
Organism=Homo sapiens, GI48762691, Length=163, Percent_Identity=28.8343558282209, Blast_Score=77, Evalue=9e-14,
Organism=Homo sapiens, GI48762687, Length=163, Percent_Identity=28.8343558282209, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI48762685, Length=163, Percent_Identity=28.8343558282209, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI48762689, Length=163, Percent_Identity=28.8343558282209, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI118498343, Length=167, Percent_Identity=28.1437125748503, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1786691, Length=761, Percent_Identity=32.5886990801577, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1789879, Length=706, Percent_Identity=27.1954674220963, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1786914, Length=466, Percent_Identity=27.0386266094421, Blast_Score=147, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17556548, Length=786, Percent_Identity=30.0254452926209, Blast_Score=295, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6320475, Length=755, Percent_Identity=30.1986754966887, Blast_Score=310, Evalue=8e-85,
Organism=Saccharomyces cerevisiae, GI6319772, Length=702, Percent_Identity=28.7749287749288, Blast_Score=274, Evalue=4e-74,
Organism=Saccharomyces cerevisiae, GI6321430, Length=545, Percent_Identity=22.9357798165138, Blast_Score=127, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6325221, Length=554, Percent_Identity=23.1046931407942, Blast_Score=124, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6321271, Length=169, Percent_Identity=28.4023668639053, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221329854, Length=846, Percent_Identity=27.1867612293144, Blast_Score=250, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24668708, Length=161, Percent_Identity=27.3291925465839, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24668704, Length=161, Percent_Identity=27.3291925465839, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281366617, Length=161, Percent_Identity=27.3291925465839, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24668696, Length=161, Percent_Identity=27.3291925465839, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI161085803, Length=161, Percent_Identity=27.3291925465839, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45551169, Length=275, Percent_Identity=26.1818181818182, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45551167, Length=275, Percent_Identity=26.1818181818182, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45552131, Length=275, Percent_Identity=26.1818181818182, Blast_Score=69, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161076319, Length=277, Percent_Identity=25.6317689530686, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.4 [H]

Molecular weight: Translated: 82077; Mature: 82077

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKESFYIEGMTCTACSSGIERSLGRKSFVKKIEVSLLNKSANIEFNENETNLDEIFKLIE
CCCCEEECCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHH
KLGYSPKKTLAEEKKEFFSPNVKLALAVIFTLFVVYLSMGAMLSPSLLPESLLTINNHSN
HHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEECCCCH
FLNACLQLIGTLIVMHWGRDFYIQGFKALWHRQPNMSSLIAIGTSAALISSLWQLYLVYT
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHCHHHHHHHHHHHHHHHHC
NHYTDQWSYGHYYFESVCVILMFVMVGKRIENVSKDKALDAMQALMKNAPKTALKMQNNQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCC
QIEVLVDSIVVGDILKVLPGSAIAVDGEIIEGEGELDESMLSGEALPVYKKVGDKVFSGT
HHHHHHHHHHHHHHHHHCCCCEEEECCEEECCCCCHHHHHHCCCCCHHHHHHCHHHHCCC
FNSHTSFLMKATQNNKNSTLTQIIEMIHNAQSSKAEISRLADKVSSVFVPSVISIAILAF
CCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVWLIIAPKPDFWWNFGIALEVFVSVLVISCPCALGLATPMSILVANQKASSLGLFFKDA
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHEEECCCCHHHHHHHHHH
KSLEKARLVNTIVFDKTGTLTNGKPVVKSVHSNIELLELLSLAGSIEKSSEHVIAKGIVE
HHHHHHHHHHHHEECCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHH
YAKERNAPLKEMSEVKVKTGFGISAKTDYQGAKEIIKVGNSEFFNPINTLEIKENGILVF
HHHHCCCCHHHHHHHEHCCCCCCCCCCCHHHHHHHHHCCCCHHCCCCCEEEEECCCEEEE
VGRMINEKEDELLGVFVLEDLPKKSVKEHIAQIKNLGINTFLLSGDNRENVKKCALELGI
ECCHHCCCCHHHEEEHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCC
DGYISNAKPQDKLNKIKELKEKGQIVMMVGDGLNDAPSLAMSDVAVVMAKGSDVSVQAAD
CCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHEEEEECCCCCEEEHHH
IVSFNNDIKSVYSAIKLSQATIKNIKENLFWAFCYNSVFIPLACGVLYKANIMLSPAIAG
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECHHHHH
LAMSLSSVSVVLNSQRLRNFKIKDH
HHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKESFYIEGMTCTACSSGIERSLGRKSFVKKIEVSLLNKSANIEFNENETNLDEIFKLIE
CCCCEEECCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHH
KLGYSPKKTLAEEKKEFFSPNVKLALAVIFTLFVVYLSMGAMLSPSLLPESLLTINNHSN
HHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEECCCCH
FLNACLQLIGTLIVMHWGRDFYIQGFKALWHRQPNMSSLIAIGTSAALISSLWQLYLVYT
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHCHHHHHHHHHHHHHHHHC
NHYTDQWSYGHYYFESVCVILMFVMVGKRIENVSKDKALDAMQALMKNAPKTALKMQNNQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCC
QIEVLVDSIVVGDILKVLPGSAIAVDGEIIEGEGELDESMLSGEALPVYKKVGDKVFSGT
HHHHHHHHHHHHHHHHHCCCCEEEECCEEECCCCCHHHHHHCCCCCHHHHHHCHHHHCCC
FNSHTSFLMKATQNNKNSTLTQIIEMIHNAQSSKAEISRLADKVSSVFVPSVISIAILAF
CCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVWLIIAPKPDFWWNFGIALEVFVSVLVISCPCALGLATPMSILVANQKASSLGLFFKDA
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHEEECCCCHHHHHHHHHH
KSLEKARLVNTIVFDKTGTLTNGKPVVKSVHSNIELLELLSLAGSIEKSSEHVIAKGIVE
HHHHHHHHHHHHEECCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHH
YAKERNAPLKEMSEVKVKTGFGISAKTDYQGAKEIIKVGNSEFFNPINTLEIKENGILVF
HHHHCCCCHHHHHHHEHCCCCCCCCCCCHHHHHHHHHCCCCHHCCCCCEEEEECCCEEEE
VGRMINEKEDELLGVFVLEDLPKKSVKEHIAQIKNLGINTFLLSGDNRENVKKCALELGI
ECCHHCCCCHHHEEEHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCC
DGYISNAKPQDKLNKIKELKEKGQIVMMVGDGLNDAPSLAMSDVAVVMAKGSDVSVQAAD
CCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHEEEEECCCCCEEEHHH
IVSFNNDIKSVYSAIKLSQATIKNIKENLFWAFCYNSVFIPLACGVLYKANIMLSPAIAG
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECHHHHH
LAMSLSSVSVVLNSQRLRNFKIKDH
HHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7752900; 8961555 [H]