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The map label for this gene is hemC [H]

Identifier: 108562665

GI number: 108562665

Start: 244115

End: 245035

Strand: Reverse

Name: hemC [H]

Synonym: HPAG1_0240

Alternate gene names: 108562665

Gene position: 245035-244115 (Counterclockwise)

Preceding gene: 108562666

Following gene: 108562664

Centisome position: 15.35

GC content: 42.89

Gene sequence:

>921_bases
GTGGGAAATTTAGTGATTGGCTCTAGGGGGAGCGAACTAGCCTTATGGCAAGCGAATCACATTAAAGAACGCCTGAAAAA
AGAATGCTTGATAGAAAGCGAGATTCAAATCGTTAAGACTAAGGGCGATAAAATCTTAGACACCCCTTTAAATAAGATTG
GCGGTAAGGGGCTATTCACTAAGGAATTAGAAGAATTGCTTTTAAAAGGCGAAATTGATTTGGCGGTGCATTCTTTAAAA
GATGTGCCGGTCGTGTTTGAAAAGGGGTTAGACTTGGCATGCATCACTAAAAGGGCTGATGTGAGGGACACTTTTTTAAG
CGTGAAATTCCCTGATTTGATGAGCTTGCCCAAAGGGGCAAAGGTTGGCACGACTTCTTTAAGGCGCTCTATGCAGATCA
AACTGAAACGCCAGGATTTAGACACAGAAAGCTTAAGGGGGAATGTCCAAACCCGTTTGAAAAAGCTTGAATGCGGAGAA
TTTGACGCTATCATTTTAGCTGAAGCCGGGTTGTGCCGCCTAGAAATTCAAGGAGCGAAATACCGCAAGGCTTTTAGCGT
AAAAGAAATGATTCCTAGCATGGGTCAGGGGGCTTTAGGGGTAGAAATGCTCAAAAACCACAAGCATTTTATTACGCTTC
AAAAACTCAACGACGAGAAAAGCGCGTTTTGCTGCCGTTTAGAAAGGGAGTTTATCAAGGGGCTTAATGGGGGGTGTCAG
ATCCCTATTGGCGTGCATGCGAGTTTAATGGGCGATAGGGTTAAAATCCAGGCGGTTTTAGGCTTGCCTAACGGGAAAGA
AGTCATCGCTAAAGAAAAACAAGGGGATAAAACTAAAGCGTTTGATTTAGTTCAAGAGCTTTTAGAAGAATTTTTGCAAA
GCGGGGCTAAAGAGATTTTAGAAAAGGCGCAGTTGTTTTAA

Upstream 100 bases:

>100_bases
GAATGCATCAAACGCGCTAATTTAGAAAAACAAACGATCAAAGACATTGAATTAGAAGAAAAAATTTTAGAAATGTTAGC
AAGCGAATAAGGGGGAGTGA

Downstream 100 bases:

>100_bases
TGCGTTTGTTTATCGCGCTAGTTTTGGGGTGGTTAAGCTTGAACGCTAAGGAAGCGGATTTCATCTCTGATTTAGAATAC
GGGATGGCTCTTTATAAAAA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MGNLVIGSRGSELALWQANHIKERLKKECLIESEIQIVKTKGDKILDTPLNKIGGKGLFTKELEELLLKGEIDLAVHSLK
DVPVVFEKGLDLACITKRADVRDTFLSVKFPDLMSLPKGAKVGTTSLRRSMQIKLKRQDLDTESLRGNVQTRLKKLECGE
FDAIILAEAGLCRLEIQGAKYRKAFSVKEMIPSMGQGALGVEMLKNHKHFITLQKLNDEKSAFCCRLEREFIKGLNGGCQ
IPIGVHASLMGDRVKIQAVLGLPNGKEVIAKEKQGDKTKAFDLVQELLEEFLQSGAKEILEKAQLF

Sequences:

>Translated_306_residues
MGNLVIGSRGSELALWQANHIKERLKKECLIESEIQIVKTKGDKILDTPLNKIGGKGLFTKELEELLLKGEIDLAVHSLK
DVPVVFEKGLDLACITKRADVRDTFLSVKFPDLMSLPKGAKVGTTSLRRSMQIKLKRQDLDTESLRGNVQTRLKKLECGE
FDAIILAEAGLCRLEIQGAKYRKAFSVKEMIPSMGQGALGVEMLKNHKHFITLQKLNDEKSAFCCRLEREFIKGLNGGCQ
IPIGVHASLMGDRVKIQAVLGLPNGKEVIAKEKQGDKTKAFDLVQELLEEFLQSGAKEILEKAQLF
>Mature_305_residues
GNLVIGSRGSELALWQANHIKERLKKECLIESEIQIVKTKGDKILDTPLNKIGGKGLFTKELEELLLKGEIDLAVHSLKD
VPVVFEKGLDLACITKRADVRDTFLSVKFPDLMSLPKGAKVGTTSLRRSMQIKLKRQDLDTESLRGNVQTRLKKLECGEF
DAIILAEAGLCRLEIQGAKYRKAFSVKEMIPSMGQGALGVEMLKNHKHFITLQKLNDEKSAFCCRLEREFIKGLNGGCQI
PIGVHASLMGDRVKIQAVLGLPNGKEVIAKEKQGDKTKAFDLVQELLEEFLQSGAKEILEKAQLF

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=250, Percent_Identity=42.8, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI66933009, Length=250, Percent_Identity=42.8, Blast_Score=172, Evalue=4e-43,
Organism=Escherichia coli, GI48994974, Length=300, Percent_Identity=46.3333333333333, Blast_Score=247, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6319996, Length=321, Percent_Identity=37.0716510903427, Blast_Score=169, Evalue=5e-43,
Organism=Drosophila melanogaster, GI20130425, Length=256, Percent_Identity=39.84375, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34010; Mature: 33878

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNLVIGSRGSELALWQANHIKERLKKECLIESEIQIVKTKGDKILDTPLNKIGGKGLFT
CCCEEECCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEECCCCEEHHCCHHHHCCCCCCH
KELEELLLKGEIDLAVHSLKDVPVVFEKGLDLACITKRADVRDTFLSVKFPDLMSLPKGA
HHHHHHHHCCCHHHHHHHHCCCCHHHHCCCCEEEEECCCCHHHHHEEEECCHHHCCCCCC
KVGTTSLRRSMQIKLKRQDLDTESLRGNVQTRLKKLECGEFDAIILAEAGLCRLEIQGAK
CCCHHHHHHHHHEEEECCCCCHHHHCCHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCH
YRKAFSVKEMIPSMGQGALGVEMLKNHKHFITLQKLNDEKSAFCCRLEREFIKGLNGGCQ
HHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEE
IPIGVHASLMGDRVKIQAVLGLPNGKEVIAKEKQGDKTKAFDLVQELLEEFLQSGAKEIL
EEECCHHHHCCCEEEEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKAQLF
HHHCCC
>Mature Secondary Structure 
GNLVIGSRGSELALWQANHIKERLKKECLIESEIQIVKTKGDKILDTPLNKIGGKGLFT
CCEEECCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEECCCCEEHHCCHHHHCCCCCCH
KELEELLLKGEIDLAVHSLKDVPVVFEKGLDLACITKRADVRDTFLSVKFPDLMSLPKGA
HHHHHHHHCCCHHHHHHHHCCCCHHHHCCCCEEEEECCCCHHHHHEEEECCHHHCCCCCC
KVGTTSLRRSMQIKLKRQDLDTESLRGNVQTRLKKLECGEFDAIILAEAGLCRLEIQGAK
CCCHHHHHHHHHEEEECCCCCHHHHCCHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCH
YRKAFSVKEMIPSMGQGALGVEMLKNHKHFITLQKLNDEKSAFCCRLEREFIKGLNGGCQ
HHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEE
IPIGVHASLMGDRVKIQAVLGLPNGKEVIAKEKQGDKTKAFDLVQELLEEFLQSGAKEIL
EEECCHHHHCCCEEEEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKAQLF
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA