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The map label for this gene is hcpE [H]

Identifier: 108562663

GI number: 108562663

Start: 242589

End: 243656

Strand: Reverse

Name: hcpE [H]

Synonym: HPAG1_0238

Alternate gene names: 108562663

Gene position: 243656-242589 (Counterclockwise)

Preceding gene: 108562664

Following gene: 108562658

Centisome position: 15.26

GC content: 41.01

Gene sequence:

>1068_bases
ATGAGTGTCAAAATTTTAAAAATATTAGTTTGCGGGTTATTTTTTTGGAGCTTGAATGCCCATTTATGGGGGAAATCAGA
CAATAGCTTTTTGGGGGTTGCTGAAAGAGCCTATAAAAGCGGGAATTATTCTAAAGCCACATCTTATTTTAAAAAAGCAT
GCAACGATGGGGTGAGTGAAGGTTGCACGCAATTAGGAATCATTTATGAAAACGGGCAAGGCACTAGAATAGATTATAAA
AAAGCCCTAGAATATTATAAAACCGCATGCCAAGCTGATGATAGGGAAGGGTGTTTTGGTTTAGGGGGGCTTTATGATGA
GGGGTTAGGCACGACTCAAAATTATCAAGAGGCCATTGACGCTTATGCTAAGGCGTGCGTTTTAAAACACCCTGAGAGTT
GCTACAATTTAGGCATTATTTATGACCGAAAAATCAAAGGTAATGCCGATCAAACGGTTACCTACTACCAAAAAAGCTGT
AATTTTGATATGGCTAAGGGGTGTTATGTTTTGGGCGTGGCTTATGAAAAAGGCTTTTTAGAAGTCAAACAAAGCAACCA
TAAAGCCGTCATCTATTATTTGAAAGCGTGCCGATTGGATGATGGGCAAGCTTGTCGCGCGTTAGGGAGTTTGTTTGAAA
ATGGCGATGCAGGGCTTGATGAAGATTTTGAAGTGGCGTTTGATTATTTGCAAAAAGCTTGCGGGTTAAACAATTCTGGT
GGTTGCGCGAGTTTAGGCTCTATGTATATGTTAGGCAGGTATGTCAAAAAAGATCCCCAAAAGGCTTTTAATTTTTTCAA
ACAAGCATGCGATATGGGGAGTGCGGTGAGTTGCTCTAGGATGGGCTTTATGTATTCGCAAGGGGACGCTGTTCCAAAAG
ACTTGAGGAAAGCCCTTGATAATTATGAAAGGGGTTGCGATATGGGCGATGAAGTGGGTTGCTTCGCTCTAGCGGGCATG
TATTACAACATGAAAGATAAAGAAAACGCCATAATGATTTATGACAAGGGCTGTAAGCTAGGCATGAAACAAGCATGCGA
AAACCTCACCAAACTTAGGGGGTATTGA

Upstream 100 bases:

>100_bases
GCCTTAATCAAAGCGCTTGATTTATGCTAAAATGGAGCGTTGCATTTTTTGTTTTGATTAAAGAAGGGTTCTAAAAATCA
GAATTTAAAAGAAGGTAGAA

Downstream 100 bases:

>100_bases
AAAATTTAAACCAACCCCCTAAATTATCATCGTGTTTGACTCAAAACTTTTCAAAGATTTGGCTCTGTTTTAAGAGCTAA
AGCAGAAAGCCACCCTATTA

Product: cysteine-rich protein E

Products: NA

Alternate protein names: Cysteine-rich protein E [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MSVKILKILVCGLFFWSLNAHLWGKSDNSFLGVAERAYKSGNYSKATSYFKKACNDGVSEGCTQLGIIYENGQGTRIDYK
KALEYYKTACQADDREGCFGLGGLYDEGLGTTQNYQEAIDAYAKACVLKHPESCYNLGIIYDRKIKGNADQTVTYYQKSC
NFDMAKGCYVLGVAYEKGFLEVKQSNHKAVIYYLKACRLDDGQACRALGSLFENGDAGLDEDFEVAFDYLQKACGLNNSG
GCASLGSMYMLGRYVKKDPQKAFNFFKQACDMGSAVSCSRMGFMYSQGDAVPKDLRKALDNYERGCDMGDEVGCFALAGM
YYNMKDKENAIMIYDKGCKLGMKQACENLTKLRGY

Sequences:

>Translated_355_residues
MSVKILKILVCGLFFWSLNAHLWGKSDNSFLGVAERAYKSGNYSKATSYFKKACNDGVSEGCTQLGIIYENGQGTRIDYK
KALEYYKTACQADDREGCFGLGGLYDEGLGTTQNYQEAIDAYAKACVLKHPESCYNLGIIYDRKIKGNADQTVTYYQKSC
NFDMAKGCYVLGVAYEKGFLEVKQSNHKAVIYYLKACRLDDGQACRALGSLFENGDAGLDEDFEVAFDYLQKACGLNNSG
GCASLGSMYMLGRYVKKDPQKAFNFFKQACDMGSAVSCSRMGFMYSQGDAVPKDLRKALDNYERGCDMGDEVGCFALAGM
YYNMKDKENAIMIYDKGCKLGMKQACENLTKLRGY
>Mature_354_residues
SVKILKILVCGLFFWSLNAHLWGKSDNSFLGVAERAYKSGNYSKATSYFKKACNDGVSEGCTQLGIIYENGQGTRIDYKK
ALEYYKTACQADDREGCFGLGGLYDEGLGTTQNYQEAIDAYAKACVLKHPESCYNLGIIYDRKIKGNADQTVTYYQKSCN
FDMAKGCYVLGVAYEKGFLEVKQSNHKAVIYYLKACRLDDGQACRALGSLFENGDAGLDEDFEVAFDYLQKACGLNNSGG
CASLGSMYMLGRYVKKDPQKAFNFFKQACDMGSAVSCSRMGFMYSQGDAVPKDLRKALDNYERGCDMGDEVGCFALAGMY
YNMKDKENAIMIYDKGCKLGMKQACENLTKLRGY

Specific function: May hydrolyze 6-aminopenicillinic acid and 7- aminocephalosporanic acid (ACA) derivatives [H]

COG id: COG0790

COG function: function code R; FOG: TPR repeat, SEL1 subfamily

Gene ontology:

Cell location: Secreted (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 8 TPR repeats [H]

Homologues:

Organism=Homo sapiens, GI19923669, Length=322, Percent_Identity=27.639751552795, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI151301150, Length=323, Percent_Identity=23.5294117647059, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI87081769, Length=260, Percent_Identity=25.7692307692308, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17537799, Length=231, Percent_Identity=29.004329004329, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17563256, Length=330, Percent_Identity=24.8484848484848, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6319410, Length=274, Percent_Identity=24.4525547445255, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355295, Length=284, Percent_Identity=27.112676056338, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI116007256, Length=221, Percent_Identity=28.0542986425339, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006597
- InterPro:   IPR011990 [H]

Pfam domain/function: PF08238 Sel1 [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 39412; Mature: 39281

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
8.7 %Cys+Met (Translated Protein)
5.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
8.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKILKILVCGLFFWSLNAHLWGKSDNSFLGVAERAYKSGNYSKATSYFKKACNDGVSE
CCHHHHHHHHHHHHHHHHCCEEECCCCCCEEHHHHHHHHCCCCHHHHHHHHHHHCCCHHH
GCTQLGIIYENGQGTRIDYKKALEYYKTACQADDREGCFGLGGLYDEGLGTTQNYQEAID
HHHEEEEEEECCCCCEEHHHHHHHHHHHHHCCCCCCCCEECCCCHHCCCCCCHHHHHHHH
AYAKACVLKHPESCYNLGIIYDRKIKGNADQTVTYYQKSCNFDMAKGCYVLGVAYEKGFL
HHHHHHHHCCCHHHHCCCEEEECCCCCCCCCHHHHHHHHCCCCCCCCEEEEEEEHHCCCC
EVKQSNHKAVIYYLKACRLDDGQACRALGSLFENGDAGLDEDFEVAFDYLQKACGLNNSG
EECCCCCCEEEEEEEHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCC
GCASLGSMYMLGRYVKKDPQKAFNFFKQACDMGSAVSCSRMGFMYSQGDAVPKDLRKALD
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHCCEECCCCCCHHHHHHHHH
NYERGCDMGDEVGCFALAGMYYNMKDKENAIMIYDKGCKLGMKQACENLTKLRGY
HHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SVKILKILVCGLFFWSLNAHLWGKSDNSFLGVAERAYKSGNYSKATSYFKKACNDGVSE
CHHHHHHHHHHHHHHHHCCEEECCCCCCEEHHHHHHHHCCCCHHHHHHHHHHHCCCHHH
GCTQLGIIYENGQGTRIDYKKALEYYKTACQADDREGCFGLGGLYDEGLGTTQNYQEAID
HHHEEEEEEECCCCCEEHHHHHHHHHHHHHCCCCCCCCEECCCCHHCCCCCCHHHHHHHH
AYAKACVLKHPESCYNLGIIYDRKIKGNADQTVTYYQKSCNFDMAKGCYVLGVAYEKGFL
HHHHHHHHCCCHHHHCCCEEEECCCCCCCCCHHHHHHHHCCCCCCCCEEEEEEEHHCCCC
EVKQSNHKAVIYYLKACRLDDGQACRALGSLFENGDAGLDEDFEVAFDYLQKACGLNNSG
EECCCCCCEEEEEEEHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCC
GCASLGSMYMLGRYVKKDPQKAFNFFKQACDMGSAVSCSRMGFMYSQGDAVPKDLRKALD
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHCCEECCCCCCHHHHHHHHH
NYERGCDMGDEVGCFALAGMYYNMKDKENAIMIYDKGCKLGMKQACENLTKLRGY
HHHHCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]