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The map label for this gene is lpxD

Identifier: 108562615

GI number: 108562615

Start: 196756

End: 197766

Strand: Direct

Name: lpxD

Synonym: HPAG1_0190

Alternate gene names: 108562615

Gene position: 196756-197766 (Clockwise)

Preceding gene: 108562614

Following gene: 108562616

Centisome position: 12.33

GC content: 42.93

Gene sequence:

>1011_bases
ATGAAATTAAGCGAATTGTTGAGCACCTATTCTATTGAAACGGAATTTTCAAACGATTTTGAAGTGCATGCCTTAGCGGA
ATTAGATAAGGCTACGCCTAATGATATTAGCTATATTGACCAAGCGCGTTACCTTAAACTTTTAAAAGATTCCAAAGCCG
GGGCGGTGTTTATCCGTAAAAAAGAATCTTCTAAAGTGCCAAAACGCATGCAAGCTTTAATCGTGGATAACCCGCATTTA
GCCTTTGCCAAAGCTTCGCATGCCTTTAAAATCCCTTTTTTTAAAAACCCAGAAAGCGTTAGCGAGCCTAAACATTTTAA
AAAAGTAACGATCATGCCTAATGTGATGATTGGAGAGGGCGTAGAAATTGGCGAAAACTCTTTGATTTATCCGGGTGTGG
TGATCGCTGATGGGGTCAAAATCGGTAAAAATTGCGTTTTGTATCCTCGTGTCATTTTGTATCAAAACACGATTTTAGAA
GACAATGTTACTATCCATGCAGGCAGTGTGATCGGAGGCGATGGCTTTGGTTATGCGCACACCGCTTTAGGAGAGCATGT
CAAAATTGAGCATGTGGGGATTGTTAGGATTCAAAAAAATGTAGAAATTGGCGCTAACACGGCGATTGATAGGGCGGTGT
TTGGCGAGACTTTGATTAAAGAGGGCGTTAAGATTGATAACCTGGTTCAAATCGGGCATAATTGCGTTTTAGGCGAGCAC
AGCATCGTCGTCTCTCAAGTGGGCTTGAGCGGCTCTACAACCACTGGCCGTAATGTGGTTTTTGGCGGTCAAGTGGGCAT
TGGGGGGCATTTGCATGTGGGCGAATTCACTCAAATTGGGGGTAAAAGCGCGGTGGGTAAAGACTTGCCCCCTAACACTA
ATTTTGCCGGAGCGATCCCTGCTATGGAAATCCATGAATGGCACCATTTCCTGGCTCATTTACGGACGAATTTCAGGAAA
CAGCAAAAAACGAGTTTGTTGCAAAAAGCTAAAGGGTTTTTTAAGTCTTAA

Upstream 100 bases:

>100_bases
TTGTGGATGCTGGCTATCATGTGATGGGCATGGGGGCTGTGGAAGAAAAAGATAATAAAGCTACGCTGTTGTGGGATTTG
CAGAACAATAAGGGGTATTG

Downstream 100 bases:

>100_bases
AGAATGAAATAAGCTATAATAAGCCCATTTTGAATACGAATGATTATTTTAATAAGGACAATCAATGAAAGATAGTTTTC
TTTTCACTTCTGAATCAGTA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKLSELLSTYSIETEFSNDFEVHALAELDKATPNDISYIDQARYLKLLKDSKAGAVFIRKKESSKVPKRMQALIVDNPHL
AFAKASHAFKIPFFKNPESVSEPKHFKKVTIMPNVMIGEGVEIGENSLIYPGVVIADGVKIGKNCVLYPRVILYQNTILE
DNVTIHAGSVIGGDGFGYAHTALGEHVKIEHVGIVRIQKNVEIGANTAIDRAVFGETLIKEGVKIDNLVQIGHNCVLGEH
SIVVSQVGLSGSTTTGRNVVFGGQVGIGGHLHVGEFTQIGGKSAVGKDLPPNTNFAGAIPAMEIHEWHHFLAHLRTNFRK
QQKTSLLQKAKGFFKS

Sequences:

>Translated_336_residues
MKLSELLSTYSIETEFSNDFEVHALAELDKATPNDISYIDQARYLKLLKDSKAGAVFIRKKESSKVPKRMQALIVDNPHL
AFAKASHAFKIPFFKNPESVSEPKHFKKVTIMPNVMIGEGVEIGENSLIYPGVVIADGVKIGKNCVLYPRVILYQNTILE
DNVTIHAGSVIGGDGFGYAHTALGEHVKIEHVGIVRIQKNVEIGANTAIDRAVFGETLIKEGVKIDNLVQIGHNCVLGEH
SIVVSQVGLSGSTTTGRNVVFGGQVGIGGHLHVGEFTQIGGKSAVGKDLPPNTNFAGAIPAMEIHEWHHFLAHLRTNFRK
QQKTSLLQKAKGFFKS
>Mature_336_residues
MKLSELLSTYSIETEFSNDFEVHALAELDKATPNDISYIDQARYLKLLKDSKAGAVFIRKKESSKVPKRMQALIVDNPHL
AFAKASHAFKIPFFKNPESVSEPKHFKKVTIMPNVMIGEGVEIGENSLIYPGVVIADGVKIGKNCVLYPRVILYQNTILE
DNVTIHAGSVIGGDGFGYAHTALGEHVKIEHVGIVRIQKNVEIGANTAIDRAVFGETLIKEGVKIDNLVQIGHNCVLGEH
SIVVSQVGLSGSTTTGRNVVFGGQVGIGGHLHVGEFTQIGGKSAVGKDLPPNTNFAGAIPAMEIHEWHHFLAHLRTNFRK
QQKTSLLQKAKGFFKS

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=319, Percent_Identity=30.7210031347962, Blast_Score=143, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_HELPH (Q1CUW5)

Other databases:

- EMBL:   CP000241
- RefSeq:   YP_626931.1
- ProteinModelPortal:   Q1CUW5
- STRING:   Q1CUW5
- GeneID:   4099264
- GenomeReviews:   CP000241_GR
- KEGG:   hpa:HPAG1_0190
- eggNOG:   COG1044
- HOGENOM:   HBG469615
- OMA:   CFVGKNT
- ProtClustDB:   PRK00892
- BioCyc:   HPYL357544:HPAG1_0190-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 36639; Mature: 36639

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSELLSTYSIETEFSNDFEVHALAELDKATPNDISYIDQARYLKLLKDSKAGAVFIRK
CCHHHHHHHHEEEECCCCCEEEEEEEHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEE
KESSKVPKRMQALIVDNPHLAFAKASHAFKIPFFKNPESVSEPKHFKKVTIMPNVMIGEG
CCCCCCHHHHHEEEECCCCEEEEECCCEEECCCCCCCCCCCCCCHHEEEEECCCEEECCC
VEIGENSLIYPGVVIADGVKIGKNCVLYPRVILYQNTILEDNVTIHAGSVIGGDGFGYAH
CEECCCCEECCCEEEECCEEECCCEEECCEEEEEECEEECCCEEEEECCEECCCCCCHHH
TALGEHVKIEHVGIVRIQKNVEIGANTAIDRAVFGETLIKEGVKIDNLVQIGHNCVLGEH
HHCCCCEEEEEEEEEEEECCCEECCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCEEECCC
SIVVSQVGLSGSTTTGRNVVFGGQVGIGGHLHVGEFTQIGGKSAVGKDLPPNTNFAGAIP
EEEEEEECCCCCCCCCCEEEEECCCCCCCEEECCCHHHCCCCCCCCCCCCCCCCCCCCCC
AMEIHEWHHFLAHLRTNFRKQQKTSLLQKAKGFFKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLSELLSTYSIETEFSNDFEVHALAELDKATPNDISYIDQARYLKLLKDSKAGAVFIRK
CCHHHHHHHHEEEECCCCCEEEEEEEHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEE
KESSKVPKRMQALIVDNPHLAFAKASHAFKIPFFKNPESVSEPKHFKKVTIMPNVMIGEG
CCCCCCHHHHHEEEECCCCEEEEECCCEEECCCCCCCCCCCCCCHHEEEEECCCEEECCC
VEIGENSLIYPGVVIADGVKIGKNCVLYPRVILYQNTILEDNVTIHAGSVIGGDGFGYAH
CEECCCCEECCCEEEECCEEECCCEEECCEEEEEECEEECCCEEEEECCEECCCCCCHHH
TALGEHVKIEHVGIVRIQKNVEIGANTAIDRAVFGETLIKEGVKIDNLVQIGHNCVLGEH
HHCCCCEEEEEEEEEEEECCCEECCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCEEECCC
SIVVSQVGLSGSTTTGRNVVFGGQVGIGGHLHVGEFTQIGGKSAVGKDLPPNTNFAGAIP
EEEEEEECCCCCCCCCCEEEEECCCCCCCEEECCCHHHCCCCCCCCCCCCCCCCCCCCCC
AMEIHEWHHFLAHLRTNFRKQQKTSLLQKAKGFFKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA