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The map label for this gene is arlR [H]

Identifier: 108562587

GI number: 108562587

Start: 169071

End: 169748

Strand: Reverse

Name: arlR [H]

Synonym: HPAG1_0162

Alternate gene names: 108562587

Gene position: 169748-169071 (Counterclockwise)

Preceding gene: 108562588

Following gene: 108562586

Centisome position: 10.63

GC content: 38.5

Gene sequence:

>678_bases
ATGATAGAAGTTTTAATGATAGAAGATGATATAGAATTAGCCGAGTTTTTGAGCGAGTTTTTGCTCCAACATGGCATTCA
TGTAACCAATTACGATGAGCCATATACCGGTCTTAGTGCGGCTAACACACAAAATTATGATTTGTTGTTGTTGGATTTAA
CTTTGCCTAATTTAGACGGGCTTGAAGTGTGTAGGCGCATCTCCAAACAAAAACATATCCCTATTATTATTTCTTCAGCA
AGAAGCGATGTGGAAGATAAGATTAAAGCGCTAGATTATGGGGCTGATGATTACCTCCCTAAACCCTATGATCCTAAGGA
ATTATTAGCTCGCATCCAATCCTTGCTCAGGCGTTCTCACAAAAAAGAAGAAGTGAGTGAGCCAGGCGATGCGAATATCT
TTAGGGTGGATAAGGATAGCCGAGAAGTGTATATGCATGAAAAAAAGCTAGACTTAACTAGGGCTGAATATGAAATCCTT
TCGCTTCTCATTAGCAAAAAAGGTTATGTGTTTAGCCGTGAAAGCATTGCGATTGAGAGCGAGAGCATCAACCCTGAAAG
CTCTAATAAAAGCATTGATGTGATCATTGGCCGTTTGCGATCTAAGATTGAAAAAAATCCTAAACAACCGCAATATATCA
TCTCTGTTAGAGGGATTGGTTATAAATTAGAATACTGA

Upstream 100 bases:

>100_bases
GGTATCTTTAATAATAAAATGCTAGAATTAGTTCCCTAAAACATTAACAAAGTTAATCGTTTTTAAAGTTGTAGAAATCA
TTGAAGGAGTTAATTGAAGT

Downstream 100 bases:

>100_bases
TATTCTAATAAGGAGTTAAGGGGTTTTGCGTTTCTCTATCTTTTTTAAGGTTGTCGCTTTGTTTATGGTAACGCTCTTTA
GTTTTGGAGCGTTCGCTTAC

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MIEVLMIEDDIELAEFLSEFLLQHGIHVTNYDEPYTGLSAANTQNYDLLLLDLTLPNLDGLEVCRRISKQKHIPIIISSA
RSDVEDKIKALDYGADDYLPKPYDPKELLARIQSLLRRSHKKEEVSEPGDANIFRVDKDSREVYMHEKKLDLTRAEYEIL
SLLISKKGYVFSRESIAIESESINPESSNKSIDVIIGRLRSKIEKNPKQPQYIISVRGIGYKLEY

Sequences:

>Translated_225_residues
MIEVLMIEDDIELAEFLSEFLLQHGIHVTNYDEPYTGLSAANTQNYDLLLLDLTLPNLDGLEVCRRISKQKHIPIIISSA
RSDVEDKIKALDYGADDYLPKPYDPKELLARIQSLLRRSHKKEEVSEPGDANIFRVDKDSREVYMHEKKLDLTRAEYEIL
SLLISKKGYVFSRESIAIESESINPESSNKSIDVIIGRLRSKIEKNPKQPQYIISVRGIGYKLEY
>Mature_225_residues
MIEVLMIEDDIELAEFLSEFLLQHGIHVTNYDEPYTGLSAANTQNYDLLLLDLTLPNLDGLEVCRRISKQKHIPIIISSA
RSDVEDKIKALDYGADDYLPKPYDPKELLARIQSLLRRSHKKEEVSEPGDANIFRVDKDSREVYMHEKKLDLTRAEYEIL
SLLISKKGYVFSRESIAIESESINPESSNKSIDVIIGRLRSKIEKNPKQPQYIISVRGIGYKLEY

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=36.6071428571429, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=33.7719298245614, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=34.2342342342342, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=34.8017621145374, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=32.6086956521739, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=30.316742081448, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787375, Length=226, Percent_Identity=33.6283185840708, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=29.7777777777778, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=35.8744394618834, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=30.4932735426009, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=29.9559471365639, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=29.646017699115, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=25.5506607929515, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=29.7872340425532, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1790299, Length=123, Percent_Identity=34.1463414634146, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1790437, Length=120, Percent_Identity=32.5, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25856; Mature: 25856

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEVLMIEDDIELAEFLSEFLLQHGIHVTNYDEPYTGLSAANTQNYDLLLLDLTLPNLDG
CEEEEEECCCHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCH
LEVCRRISKQKHIPIIISSARSDVEDKIKALDYGADDYLPKPYDPKELLARIQSLLRRSH
HHHHHHHHHCCCCCEEEECCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KKEEVSEPGDANIFRVDKDSREVYMHEKKLDLTRAEYEILSLLISKKGYVFSRESIAIES
HHHHCCCCCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEEEC
ESINPESSNKSIDVIIGRLRSKIEKNPKQPQYIISVRGIGYKLEY
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEECC
>Mature Secondary Structure
MIEVLMIEDDIELAEFLSEFLLQHGIHVTNYDEPYTGLSAANTQNYDLLLLDLTLPNLDG
CEEEEEECCCHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCH
LEVCRRISKQKHIPIIISSARSDVEDKIKALDYGADDYLPKPYDPKELLARIQSLLRRSH
HHHHHHHHHCCCCCEEEECCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KKEEVSEPGDANIFRVDKDSREVYMHEKKLDLTRAEYEILSLLISKKGYVFSRESIAIES
HHHHCCCCCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEEEC
ESINPESSNKSIDVIIGRLRSKIEKNPKQPQYIISVRGIGYKLEY
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA