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The map label for this gene is hemB [H]

Identifier: 108562585

GI number: 108562585

Start: 166719

End: 167690

Strand: Reverse

Name: hemB [H]

Synonym: HPAG1_0160

Alternate gene names: 108562585

Gene position: 167690-166719 (Counterclockwise)

Preceding gene: 108562586

Following gene: 108562584

Centisome position: 10.5

GC content: 39.4

Gene sequence:

>972_bases
ATGTTCAAACGATTGAGAAGATTACGAAGCAGCGAAAATTTAAGAGCGATGTTAAGAGAAACGCGCCTAAATATTGATGA
TTTCATCGCTCCCTTATTTGTCATAGAAAGCGGTAGTTATATTAAAAATGAAATTAACTCCATGCCTGGCGTGTATCAAA
TGAGTATAGAACCTCTTTTAAAAGAATGCGAAGAATTAGTGGGTTTAGGCGTCAAAGCCGTTTTATTGTTTGGCATTCCT
AAACATAAGGACGCTACAGGAAGCCATGCACTAAATAAGGATCACATTGTCGCAAAAGCCGCTAGAGCGATTAAAAAACG
ATTCAAGGATTTAATCGTTATAGCGGATTTGTGTTTTTGTGAATACACCGACCATGGGCATTGCGGGATTTTAGAAAACG
ATTCTGTGTCTAACGACAAAACGCTAGAGATTTTAAATCTTCAAGGGCTTATTTTGGCTGAAAGCGGTGTGGATATTCTA
GCCCCAAGCAACATGATGGATGGCAATGTTTTGAGCTTGAGAAAAGCGCTAGATAAGGCCGGGTATTTTCACACGCCCAT
CATGAGCTATTCCACTAAATTTGCGAGCAGTTATTACGGGCCTTTTAGAGATGTAGCCAATTCTGCGCCGAGTTTTGGCG
ATCGCAAAAGCTATCAAATGGATTACGCTAACCAAAAAGAAGCGCTTTTAGAAAGTTTAGAAGATGAAAAGCAGGGTGCG
GATATTTTAATGGTGAAACCGGCTTTGGCGTATCTAGATATTGTTAAAGAAATCAGAGATCACACTTTGCTCCCTTTAGC
GCTCTATAATGTGAGCGGGGAATACGCCATGCTCAAACTCGCTCAAAAACACAACCTGATCAACTATGAAAGCGTTTTAT
TAGAAACGATGACTTGTTTTAAAAGAGCGGGAGCGGATATGATTATTAGCTATCATGCTAAAGAAATAGCTAACTTATTA
CAAAGGAATTGA

Upstream 100 bases:

>100_bases
AGCTACCCCCCCCCCCCCCGAAAATTTGAGAGAGGTGAGCGGAATGAAGGGGATAGAAAAAGCCAATTGTGGGGTTAAAG
AAAAACAATAAAGAGAGAAC

Downstream 100 bases:

>100_bases
ATGGGACGAGCGTTTGAATACAGAAGAGCGGCTAAAGAAAAACGATGGGATAAGATGAGTAAGGTTTTCCCCAAGCTAGC
TAAAGCGATCACTCTAGCGG

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MFKRLRRLRSSENLRAMLRETRLNIDDFIAPLFVIESGSYIKNEINSMPGVYQMSIEPLLKECEELVGLGVKAVLLFGIP
KHKDATGSHALNKDHIVAKAARAIKKRFKDLIVIADLCFCEYTDHGHCGILENDSVSNDKTLEILNLQGLILAESGVDIL
APSNMMDGNVLSLRKALDKAGYFHTPIMSYSTKFASSYYGPFRDVANSAPSFGDRKSYQMDYANQKEALLESLEDEKQGA
DILMVKPALAYLDIVKEIRDHTLLPLALYNVSGEYAMLKLAQKHNLINYESVLLETMTCFKRAGADMIISYHAKEIANLL
QRN

Sequences:

>Translated_323_residues
MFKRLRRLRSSENLRAMLRETRLNIDDFIAPLFVIESGSYIKNEINSMPGVYQMSIEPLLKECEELVGLGVKAVLLFGIP
KHKDATGSHALNKDHIVAKAARAIKKRFKDLIVIADLCFCEYTDHGHCGILENDSVSNDKTLEILNLQGLILAESGVDIL
APSNMMDGNVLSLRKALDKAGYFHTPIMSYSTKFASSYYGPFRDVANSAPSFGDRKSYQMDYANQKEALLESLEDEKQGA
DILMVKPALAYLDIVKEIRDHTLLPLALYNVSGEYAMLKLAQKHNLINYESVLLETMTCFKRAGADMIISYHAKEIANLL
QRN
>Mature_323_residues
MFKRLRRLRSSENLRAMLRETRLNIDDFIAPLFVIESGSYIKNEINSMPGVYQMSIEPLLKECEELVGLGVKAVLLFGIP
KHKDATGSHALNKDHIVAKAARAIKKRFKDLIVIADLCFCEYTDHGHCGILENDSVSNDKTLEILNLQGLILAESGVDIL
APSNMMDGNVLSLRKALDKAGYFHTPIMSYSTKFASSYYGPFRDVANSAPSFGDRKSYQMDYANQKEALLESLEDEKQGA
DILMVKPALAYLDIVKEIRDHTLLPLALYNVSGEYAMLKLAQKHNLINYESVLLETMTCFKRAGADMIISYHAKEIANLL
QRN

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=306, Percent_Identity=41.8300653594771, Blast_Score=244, Evalue=7e-65,
Organism=Escherichia coli, GI87081728, Length=318, Percent_Identity=51.5723270440252, Blast_Score=318, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6321398, Length=313, Percent_Identity=36.741214057508, Blast_Score=204, Evalue=1e-53,
Organism=Drosophila melanogaster, GI21358291, Length=302, Percent_Identity=36.7549668874172, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36272; Mature: 36272

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKRLRRLRSSENLRAMLRETRLNIDDFIAPLFVIESGSYIKNEINSMPGVYQMSIEPLL
CHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHCCCCEEEHHHHHHH
KECEELVGLGVKAVLLFGIPKHKDATGSHALNKDHIVAKAARAIKKRFKDLIVIADLCFC
HHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYTDHGHCGILENDSVSNDKTLEILNLQGLILAESGVDILAPSNMMDGNVLSLRKALDKA
CCCCCCCCCEECCCCCCCCCEEEEEECCEEEEECCCCCEECCCCCCCCHHHHHHHHHHHC
GYFHTPIMSYSTKFASSYYGPFRDVANSAPSFGDRKSYQMDYANQKEALLESLEDEKQGA
CCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
DILMVKPALAYLDIVKEIRDHTLLPLALYNVSGEYAMLKLAQKHNLINYESVLLETMTCF
CEEEECHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHH
KRAGADMIISYHAKEIANLLQRN
HHCCCHHEEHHHHHHHHHHHHCC
>Mature Secondary Structure
MFKRLRRLRSSENLRAMLRETRLNIDDFIAPLFVIESGSYIKNEINSMPGVYQMSIEPLL
CHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHCCCCEEEHHHHHHH
KECEELVGLGVKAVLLFGIPKHKDATGSHALNKDHIVAKAARAIKKRFKDLIVIADLCFC
HHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYTDHGHCGILENDSVSNDKTLEILNLQGLILAESGVDILAPSNMMDGNVLSLRKALDKA
CCCCCCCCCEECCCCCCCCCEEEEEECCEEEEECCCCCEECCCCCCCCHHHHHHHHHHHC
GYFHTPIMSYSTKFASSYYGPFRDVANSAPSFGDRKSYQMDYANQKEALLESLEDEKQGA
CCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
DILMVKPALAYLDIVKEIRDHTLLPLALYNVSGEYAMLKLAQKHNLINYESVLLETMTCF
CEEEECHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHH
KRAGADMIISYHAKEIANLLQRN
HHCCCHHEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]