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The map label for this gene is citT [H]

Identifier: 108562566

GI number: 108562566

Start: 150364

End: 151812

Strand: Reverse

Name: citT [H]

Synonym: HPAG1_0141

Alternate gene names: 108562566

Gene position: 151812-150364 (Counterclockwise)

Preceding gene: 108562575

Following gene: 108562565

Centisome position: 9.51

GC content: 42.51

Gene sequence:

>1449_bases
ATGATTAAACAAACCCTCATCATTCTTGCCCCTTTTTTTATCGCAACGCTATTGTATTTTTTAGGCGCACCGGATGGTTT
AAACCCTAACGCATGGCTTTATTTTTGTATTTTCATGGGCATGATTATAGGGTTGATTTTAGAGCCGGTGCCATCAGGTT
TGATAGCGTTGAGCGCGTTAGTGTTGTGCGTGGCGTTAAAAATTGGAGCGAGCGATGGAGTAGAGAGCGCTAATAAGGCT
ATTTCGTGGGGTTTGAGCGGGTATGCGAATAAAACGGTGTGGCTTGTGTTTGTCGCTTTTATTTTGGGTTTAGGGTATGA
AAAAAGCTTGTTAGGGAAACGGATCGCTCTTTTACTGATTAGATTTTTAGGGCAAACCCCTTTAGGTTTGGGCTATGCGA
TCGGTTTGAGCGAATTGTGTCTAGCCCCCTTTATCCCTAGCAATTCCGCTAGAAGTGGGGGCATACTCTATCCCATAGTT
TCTTCTATCCCGCCTTTAATGGACTCTACCCCAAACAATAACCCTGACAAAATCGGCGCGTATTTGATGTGGGTCGCTTT
GGCTTCAACTTGCATCACTTCGTCCATGTTTTTAACCGCGCTCGCTCCTAACCCCCTAGCAATGGAAATTGCTGCCAAAA
TGGGGGTGAATGAAATCTCATGGTTTTCGTGGTTTTTAGCGTTCTTGCCTTGTGGGGTGGTTTTGATCTTACTCGTGCCT
TTATTGGCGTATAAAACCTGCAAACCCACCTTAAAAGGCTCAAAAGAAGTGAGTTTGTGGGCCAAAAAGGAATTAGAGGG
CATGGGGAGGTTTTCTTTAAAAGAAATTTTAATGCTCAGCCTCACTTTATTGGCTTTATTGGGTTGGATTTTTGGCAAAC
CTTTAGGCTTGCATGCGAGCGCGACGGCTTTGATTGTCATGGTTTTAATGGCGTTTTGTAAGATTGTAAGCTATGAAGAC
ATCATTAAAAACAAGAGCGCATTCAACATTTTTTTATTGCTGGGTTCGCTGCTCACGATGGCTGACGGGCTTAAAAATGT
AGGGTTTTTAAATTTTATCGGCAATGCGGCTCAAAATTTTTTAGAGCATGCCAACTTGGATCCGTTAATAGCGGTATTGT
TTATTGTAGCCCTCTTTTATCTGTCGCATTATTTTTTCGCAAGCATCACCGCTCATGTGAGCGCGTTATTTGCGCTTTTT
GTAGGGATTGGTTCACACATTCAAGGGGTCAATTTGCAAGAATTGAGCTTGTTTTTAATGTTTTCTTTAGGGATTATGGG
GATTTTAACCCCCTATGGCACAGGCCCATCCACCATTTATTACGGGAGCGGGTATATTTCAAGCAAGGATTTTTGGAAAT
GGGGGTTTATTTTTGGCTTTTTGTATTTAATCGTGTTTTTAAGCGTGTGTGTGCCTTGGGTCAAATTCATCGCTTACAGG
TGGTTGTAG

Upstream 100 bases:

>100_bases
GCTTAATTTTTAATCTTTTTCTGTAACATTGTAATAACTTAATCCCATTTGAATGGCATTTTTAAGCCAAATTGCTACTA
TCTTTGGCTAAAGGTTAAAC

Downstream 100 bases:

>100_bases
CTGGAAACTTTACACAACGCCCTTTTAAAATGGTATGAAGAATTTGGGCGCAAAGGTTTACCTTTTAGGAATTTAAAGGG
CATTAACGCTCCTTATGAAG

Product: C(4)-dicarboxylates and tricarboxylates/succinate antiporter

Products: NA

Alternate protein names: Citrate transporter; Citrate/succinate antiporter [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MIKQTLIILAPFFIATLLYFLGAPDGLNPNAWLYFCIFMGMIIGLILEPVPSGLIALSALVLCVALKIGASDGVESANKA
ISWGLSGYANKTVWLVFVAFILGLGYEKSLLGKRIALLLIRFLGQTPLGLGYAIGLSELCLAPFIPSNSARSGGILYPIV
SSIPPLMDSTPNNNPDKIGAYLMWVALASTCITSSMFLTALAPNPLAMEIAAKMGVNEISWFSWFLAFLPCGVVLILLVP
LLAYKTCKPTLKGSKEVSLWAKKELEGMGRFSLKEILMLSLTLLALLGWIFGKPLGLHASATALIVMVLMAFCKIVSYED
IIKNKSAFNIFLLLGSLLTMADGLKNVGFLNFIGNAAQNFLEHANLDPLIAVLFIVALFYLSHYFFASITAHVSALFALF
VGIGSHIQGVNLQELSLFLMFSLGIMGILTPYGTGPSTIYYGSGYISSKDFWKWGFIFGFLYLIVFLSVCVPWVKFIAYR
WL

Sequences:

>Translated_482_residues
MIKQTLIILAPFFIATLLYFLGAPDGLNPNAWLYFCIFMGMIIGLILEPVPSGLIALSALVLCVALKIGASDGVESANKA
ISWGLSGYANKTVWLVFVAFILGLGYEKSLLGKRIALLLIRFLGQTPLGLGYAIGLSELCLAPFIPSNSARSGGILYPIV
SSIPPLMDSTPNNNPDKIGAYLMWVALASTCITSSMFLTALAPNPLAMEIAAKMGVNEISWFSWFLAFLPCGVVLILLVP
LLAYKTCKPTLKGSKEVSLWAKKELEGMGRFSLKEILMLSLTLLALLGWIFGKPLGLHASATALIVMVLMAFCKIVSYED
IIKNKSAFNIFLLLGSLLTMADGLKNVGFLNFIGNAAQNFLEHANLDPLIAVLFIVALFYLSHYFFASITAHVSALFALF
VGIGSHIQGVNLQELSLFLMFSLGIMGILTPYGTGPSTIYYGSGYISSKDFWKWGFIFGFLYLIVFLSVCVPWVKFIAYR
WL
>Mature_482_residues
MIKQTLIILAPFFIATLLYFLGAPDGLNPNAWLYFCIFMGMIIGLILEPVPSGLIALSALVLCVALKIGASDGVESANKA
ISWGLSGYANKTVWLVFVAFILGLGYEKSLLGKRIALLLIRFLGQTPLGLGYAIGLSELCLAPFIPSNSARSGGILYPIV
SSIPPLMDSTPNNNPDKIGAYLMWVALASTCITSSMFLTALAPNPLAMEIAAKMGVNEISWFSWFLAFLPCGVVLILLVP
LLAYKTCKPTLKGSKEVSLWAKKELEGMGRFSLKEILMLSLTLLALLGWIFGKPLGLHASATALIVMVLMAFCKIVSYED
IIKNKSAFNIFLLLGSLLTMADGLKNVGFLNFIGNAAQNFLEHANLDPLIAVLFIVALFYLSHYFFASITAHVSALFALF
VGIGSHIQGVNLQELSLFLMFSLGIMGILTPYGTGPSTIYYGSGYISSKDFWKWGFIFGFLYLIVFLSVCVPWVKFIAYR
WL

Specific function: Responsible for the uptake of citrate in exchange to the efflux of succinate. Has a relatively broad specificity for C(4)- dicarboxylates and tricarboxylates [H]

COG id: COG0471

COG function: function code P; Di- and tricarboxylate transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SLC13A transporter (TC 2.A.47) family. SODIT1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786829, Length=474, Percent_Identity=41.9831223628692, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1789444, Length=478, Percent_Identity=40.7949790794979, Blast_Score=348, Evalue=3e-97,
Organism=Escherichia coli, GI1786986, Length=463, Percent_Identity=35.2051835853132, Blast_Score=256, Evalue=3e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001898 [H]

Pfam domain/function: PF00939 Na_sulph_symp [H]

EC number: NA

Molecular weight: Translated: 52513; Mature: 52513

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQTLIILAPFFIATLLYFLGAPDGLNPNAWLYFCIFMGMIIGLILEPVPSGLIALSAL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VLCVALKIGASDGVESANKAISWGLSGYANKTVWLVFVAFILGLGYEKSLLGKRIALLLI
HHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RFLGQTPLGLGYAIGLSELCLAPFIPSNSARSGGILYPIVSSIPPLMDSTPNNNPDKIGA
HHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCCHHHHHH
YLMWVALASTCITSSMFLTALAPNPLAMEIAAKMGVNEISWFSWFLAFLPCGVVLILLVP
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LLAYKTCKPTLKGSKEVSLWAKKELEGMGRFSLKEILMLSLTLLALLGWIFGKPLGLHAS
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
ATALIVMVLMAFCKIVSYEDIIKNKSAFNIFLLLGSLLTMADGLKNVGFLNFIGNAAQNF
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
LEHANLDPLIAVLFIVALFYLSHYFFASITAHVSALFALFVGIGSHIQGVNLQELSLFLM
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
FSLGIMGILTPYGTGPSTIYYGSGYISSKDFWKWGFIFGFLYLIVFLSVCVPWVKFIAYR
HHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WL
CC
>Mature Secondary Structure
MIKQTLIILAPFFIATLLYFLGAPDGLNPNAWLYFCIFMGMIIGLILEPVPSGLIALSAL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VLCVALKIGASDGVESANKAISWGLSGYANKTVWLVFVAFILGLGYEKSLLGKRIALLLI
HHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RFLGQTPLGLGYAIGLSELCLAPFIPSNSARSGGILYPIVSSIPPLMDSTPNNNPDKIGA
HHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCCHHHHHH
YLMWVALASTCITSSMFLTALAPNPLAMEIAAKMGVNEISWFSWFLAFLPCGVVLILLVP
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LLAYKTCKPTLKGSKEVSLWAKKELEGMGRFSLKEILMLSLTLLALLGWIFGKPLGLHAS
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
ATALIVMVLMAFCKIVSYEDIIKNKSAFNIFLLLGSLLTMADGLKNVGFLNFIGNAAQNF
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
LEHANLDPLIAVLFIVALFYLSHYFFASITAHVSALFALFVGIGSHIQGVNLQELSLFLM
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
FSLGIMGILTPYGTGPSTIYYGSGYISSKDFWKWGFIFGFLYLIVFLSVCVPWVKFIAYR
HHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]