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The map label for this gene is thrC [H]

Identifier: 108562523

GI number: 108562523

Start: 100097

End: 101557

Strand: Reverse

Name: thrC [H]

Synonym: HPAG1_0098

Alternate gene names: 108562523

Gene position: 101557-100097 (Counterclockwise)

Preceding gene: 108562527

Following gene: 108562522

Centisome position: 6.36

GC content: 41.27

Gene sequence:

>1461_bases
ATGCCTTTTGTCCCCACCCGTTCTTTGAAAGAAAAAAAGATTGATTTTATTGAAGCAATATTAAACCCCAACGCCCCAAA
AGGCGGGCTTTACACTTTAGAGCGTTTTGAAACATTACAATGGCAGGATTGTTTGAATCTGAGCTATAACGAGCTGGTAG
AATGCGTGTTTGAGCGGTTGGGTTTAGAGATCCCTAAGGGTTTATTGACAAGCGCTTTAAAACGCTATGAAAATTTTGAT
AACCCTAAAAATCCAGCCCCTATTTTTGCGCTCAATGAAAGGCTTTTTGTCCAAGAGCTCTACCATGGGCCTAGTTTGGC
GTTTAAAGACATGGCACTGCAGCCTTTAGCGAGCTTGTTTTCTAATCTAGCGGTAGGAAAAAATGAAAAGTATTTAATGC
TCGTTTCTACAAGTGGGGATACCGGCCCTGCGACTTTAGAAAGTTTGGCGGGCATGCCTAATGTTTTTGTGGTGTGTTTA
TACCCCAAAGACGGCACGAGTTTAGTCCAAAAACTCCAAATGGTTACCCAAAGCGCTAGCAATTTAAAGGTCTTTGGGAT
CAGTGGGGATTTTGATGATGCGCAAAACGCGCTCAAAAACCTTTTAAAAGACGATGATTTTAACGAAGCCCTAAAAACGC
ACCAACTAAAATTAAGCGTGGCTAATTCCGTGAATTTTGGGCGCATCGCTTTTCAAATCGTCTATCATATTTGGGGCTTT
TTAGAATTGTATAAAAAAGGCGCGATCAATTCTAAAGAAAAAATCACCCTAGCCATACCTAGCGGTAATTTTGGGAACGC
TTTAGGGGCGTTTTATGCCAAAAAAATGGGCTTGAATATCGCTAAAATCAAGGTCGTAACCAACAGCAACGATGTTTTAA
GGGAGTTTATAGAGACAGGGCGTTACGATTTAACCCATCGCTCTTTAAAGCAAACCTACTCGCCGGCTATGGATATTTTA
AAAAGCTCTAATGTGGAAAGGGCGCTTTTTGATCTCTTTGGGTTTGAACGCACGCTAGAATTGATGCAAGCTTTAGAAGA
AGAGAAATTTTATGCGTTAAAGCCTAAAGAATTAGCCCTTTTACAGGAGCATTTTTCTTGCGCGAGCTGCTCAGATGAAG
CTTGTTTGAAAACCATCCAAGAAGTTTATGCAGAGCACCAATACCTGATTGACCCCCACACCGCCACCGCTTTAAACGCC
AGCTTGAAAACCAACGAAAAAACCCTTGTTTCCGCCACCGCCTCTTATGAAAAATTCCCTAGAACCACCCTTTTAGCCCT
AAACGAGCAAAAGAAAAACGATAACGACAAAGTCGCTCTAGAAACGCTTAAAAACAGCTACAATACCCCGGATAGCCAGC
GCCTTGATGATTTATTTGAAAGAGGAATCAAGCACCAAGAAGTTTTAAAACTCAATGAGATCAAATCTTCTATCCTTTTG
TGGCTAGAAAGCCTACATTAA

Upstream 100 bases:

>100_bases
ACGATCAATCATTCTCATTAAAAAACCATTTAAGGTTGCATTCGCTCTTTTAGGGTATGCTACGGCTTAAAATTATCCAA
AGTATTAAGAAGGAAAAATC

Downstream 100 bases:

>100_bases
ATCTTTTTTAAGCCCTTATTCCTAATAAAATCTTAATTTTAAGTCAAACTACACTATAATAAGGAAATTCTAAACGAAAA
TTAAACTGAATGAAAGGAGT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MPFVPTRSLKEKKIDFIEAILNPNAPKGGLYTLERFETLQWQDCLNLSYNELVECVFERLGLEIPKGLLTSALKRYENFD
NPKNPAPIFALNERLFVQELYHGPSLAFKDMALQPLASLFSNLAVGKNEKYLMLVSTSGDTGPATLESLAGMPNVFVVCL
YPKDGTSLVQKLQMVTQSASNLKVFGISGDFDDAQNALKNLLKDDDFNEALKTHQLKLSVANSVNFGRIAFQIVYHIWGF
LELYKKGAINSKEKITLAIPSGNFGNALGAFYAKKMGLNIAKIKVVTNSNDVLREFIETGRYDLTHRSLKQTYSPAMDIL
KSSNVERALFDLFGFERTLELMQALEEEKFYALKPKELALLQEHFSCASCSDEACLKTIQEVYAEHQYLIDPHTATALNA
SLKTNEKTLVSATASYEKFPRTTLLALNEQKKNDNDKVALETLKNSYNTPDSQRLDDLFERGIKHQEVLKLNEIKSSILL
WLESLH

Sequences:

>Translated_486_residues
MPFVPTRSLKEKKIDFIEAILNPNAPKGGLYTLERFETLQWQDCLNLSYNELVECVFERLGLEIPKGLLTSALKRYENFD
NPKNPAPIFALNERLFVQELYHGPSLAFKDMALQPLASLFSNLAVGKNEKYLMLVSTSGDTGPATLESLAGMPNVFVVCL
YPKDGTSLVQKLQMVTQSASNLKVFGISGDFDDAQNALKNLLKDDDFNEALKTHQLKLSVANSVNFGRIAFQIVYHIWGF
LELYKKGAINSKEKITLAIPSGNFGNALGAFYAKKMGLNIAKIKVVTNSNDVLREFIETGRYDLTHRSLKQTYSPAMDIL
KSSNVERALFDLFGFERTLELMQALEEEKFYALKPKELALLQEHFSCASCSDEACLKTIQEVYAEHQYLIDPHTATALNA
SLKTNEKTLVSATASYEKFPRTTLLALNEQKKNDNDKVALETLKNSYNTPDSQRLDDLFERGIKHQEVLKLNEIKSSILL
WLESLH
>Mature_485_residues
PFVPTRSLKEKKIDFIEAILNPNAPKGGLYTLERFETLQWQDCLNLSYNELVECVFERLGLEIPKGLLTSALKRYENFDN
PKNPAPIFALNERLFVQELYHGPSLAFKDMALQPLASLFSNLAVGKNEKYLMLVSTSGDTGPATLESLAGMPNVFVVCLY
PKDGTSLVQKLQMVTQSASNLKVFGISGDFDDAQNALKNLLKDDDFNEALKTHQLKLSVANSVNFGRIAFQIVYHIWGFL
ELYKKGAINSKEKITLAIPSGNFGNALGAFYAKKMGLNIAKIKVVTNSNDVLREFIETGRYDLTHRSLKQTYSPAMDILK
SSNVERALFDLFGFERTLELMQALEEEKFYALKPKELALLQEHFSCASCSDEACLKTIQEVYAEHQYLIDPHTATALNAS
LKTNEKTLVSATASYEKFPRTTLLALNEQKKNDNDKVALETLKNSYNTPDSQRLDDLFERGIKHQEVLKLNEIKSSILLW
LESLH

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=472, Percent_Identity=35.1694915254237, Blast_Score=261, Evalue=8e-70,
Organism=Homo sapiens, GI149193323, Length=445, Percent_Identity=32.1348314606742, Blast_Score=186, Evalue=6e-47,
Organism=Escherichia coli, GI1786185, Length=334, Percent_Identity=29.940119760479, Blast_Score=143, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6319901, Length=444, Percent_Identity=32.8828828828829, Blast_Score=205, Evalue=2e-53,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 54735; Mature: 54604

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFVPTRSLKEKKIDFIEAILNPNAPKGGLYTLERFETLQWQDCLNLSYNELVECVFERL
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHH
GLEIPKGLLTSALKRYENFDNPKNPAPIFALNERLFVQELYHGPSLAFKDMALQPLASLF
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHH
SNLAVGKNEKYLMLVSTSGDTGPATLESLAGMPNVFVVCLYPKDGTSLVQKLQMVTQSAS
HHHCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCC
NLKVFGISGDFDDAQNALKNLLKDDDFNEALKTHQLKLSVANSVNFGRIAFQIVYHIWGF
CEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHH
LELYKKGAINSKEKITLAIPSGNFGNALGAFYAKKMGLNIAKIKVVTNSNDVLREFIETG
HHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHCC
RYDLTHRSLKQTYSPAMDILKSSNVERALFDLFGFERTLELMQALEEEKFYALKPKELAL
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHH
LQEHFSCASCSDEACLKTIQEVYAEHQYLIDPHTATALNASLKTNEKTLVSATASYEKFP
HHHHCCCCCCCHHHHHHHHHHHHHCCCEEECCCHHHHHCCHHCCCCHHEEEEHHHHHHCC
RTTLLALNEQKKNDNDKVALETLKNSYNTPDSQRLDDLFERGIKHQEVLKLNEIKSSILL
CCEEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
WLESLH
HHHHCC
>Mature Secondary Structure 
PFVPTRSLKEKKIDFIEAILNPNAPKGGLYTLERFETLQWQDCLNLSYNELVECVFERL
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHH
GLEIPKGLLTSALKRYENFDNPKNPAPIFALNERLFVQELYHGPSLAFKDMALQPLASLF
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHH
SNLAVGKNEKYLMLVSTSGDTGPATLESLAGMPNVFVVCLYPKDGTSLVQKLQMVTQSAS
HHHCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCC
NLKVFGISGDFDDAQNALKNLLKDDDFNEALKTHQLKLSVANSVNFGRIAFQIVYHIWGF
CEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHH
LELYKKGAINSKEKITLAIPSGNFGNALGAFYAKKMGLNIAKIKVVTNSNDVLREFIETG
HHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHCC
RYDLTHRSLKQTYSPAMDILKSSNVERALFDLFGFERTLELMQALEEEKFYALKPKELAL
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHH
LQEHFSCASCSDEACLKTIQEVYAEHQYLIDPHTATALNASLKTNEKTLVSATASYEKFP
HHHHCCCCCCCHHHHHHHHHHHHHCCCEEECCCHHHHHCCHHCCCCHHEEEEHHHHHHCC
RTTLLALNEQKKNDNDKVALETLKNSYNTPDSQRLDDLFERGIKHQEVLKLNEIKSSILL
CCEEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
WLESLH
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]