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The map label for this gene is ureI [H]

Identifier: 108562497

GI number: 108562497

Start: 72425

End: 73012

Strand: Reverse

Name: ureI [H]

Synonym: HPAG1_0072

Alternate gene names: 108562497

Gene position: 73012-72425 (Counterclockwise)

Preceding gene: 108562498

Following gene: 108562496

Centisome position: 4.57

GC content: 43.2

Gene sequence:

>588_bases
ATGCTAGGACTTGTATTGTTATATGTTGGGATTGTTTTAATCAGCAATGGGATTTGCGGGTTAACCAAAGTCGATCCTAA
AAGCACTGCGGTGATGAACTTTTTTGTGGGCGGACTTTCCATTATTTGTAATATAGTTGTCATCACTTATTCTGCTCTCC
ACCCTACAGCCCCTGTAGAAGGTGCTGAAGATATTGCTCAAGTATCGCACCATTTGACTAGTTTCTATGGGCCAGCGACT
GGGTTATTGTTTGGTTTTACCTACTTGTATGCGGCTATCAACCACACTTTTGGTTTGGATTGGAGGCCGTATTCTTGGTA
TAGCTTATTCGTAGCGATCAACGCTGTTCCTGCTGCGATTTTATCCCACTATAGCGATATGCTTGATGACCACAAAGTGT
TAGGCATCACTGAAGGCGATTGGTGGGCGATCATATGGTTGGCTTGGGGTGTTTTGTGGCTTACCGCTTTCATTGAAAAC
ATCTTGAAAATCCCTTTAGGGAAATTCACTCCATGGCTTACTATCATTGAGGGTATTTTAACCGCTTGGATCCCTGCTTG
GTTACTCTTTATCCAACACTGGGTGTGA

Upstream 100 bases:

>100_bases
TTTTGTCAATTTACTATTTTTCTTTATGATTAGCTCAAGCAACAAAAGTTATTCGTAAGGTGCGTTTGTTGTAAAAATTT
TTGTTTGGAAGGAAAAGGCA

Downstream 100 bases:

>100_bases
GATGATCATAGAGCGTTTAGTTGGCAATCTAAGGGATTTAAACCCCTTGGATTTCAATGTGGATCATGTGGATTTGGAAT
GGTTTGAAACGAGGAAAAAA

Product: urease accessory protein/pH-dependent urea-transporter UreI

Products: NA

Alternate protein names: Urease accessory protein ureI [H]

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MLGLVLLYVGIVLISNGICGLTKVDPKSTAVMNFFVGGLSIICNIVVITYSALHPTAPVEGAEDIAQVSHHLTSFYGPAT
GLLFGFTYLYAAINHTFGLDWRPYSWYSLFVAINAVPAAILSHYSDMLDDHKVLGITEGDWWAIIWLAWGVLWLTAFIEN
ILKIPLGKFTPWLTIIEGILTAWIPAWLLFIQHWV

Sequences:

>Translated_195_residues
MLGLVLLYVGIVLISNGICGLTKVDPKSTAVMNFFVGGLSIICNIVVITYSALHPTAPVEGAEDIAQVSHHLTSFYGPAT
GLLFGFTYLYAAINHTFGLDWRPYSWYSLFVAINAVPAAILSHYSDMLDDHKVLGITEGDWWAIIWLAWGVLWLTAFIEN
ILKIPLGKFTPWLTIIEGILTAWIPAWLLFIQHWV
>Mature_195_residues
MLGLVLLYVGIVLISNGICGLTKVDPKSTAVMNFFVGGLSIICNIVVITYSALHPTAPVEGAEDIAQVSHHLTSFYGPAT
GLLFGFTYLYAAINHTFGLDWRPYSWYSLFVAINAVPAAILSHYSDMLDDHKVLGITEGDWWAIIWLAWGVLWLTAFIEN
ILKIPLGKFTPWLTIIEGILTAWIPAWLLFIQHWV

Specific function: Functions as a specific, H(+)-activated urea channel that increases the rate of urea entry into the cytoplasm, resulting in activation of cytoplasmic urease at acidic medium pH. Is essential for H.pylori gastric survival and colonization. Is necessary for

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AmiS/UreI family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003211 [H]

Pfam domain/function: PF02293 AmiS_UreI [H]

EC number: NA

Molecular weight: Translated: 21692; Mature: 21692

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGLVLLYVGIVLISNGICGLTKVDPKSTAVMNFFVGGLSIICNIVVITYSALHPTAPVE
CHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GAEDIAQVSHHLTSFYGPATGLLFGFTYLYAAINHTFGLDWRPYSWYSLFVAINAVPAAI
CHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LSHYSDMLDDHKVLGITEGDWWAIIWLAWGVLWLTAFIENILKIPLGKFTPWLTIIEGIL
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
TAWIPAWLLFIQHWV
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MLGLVLLYVGIVLISNGICGLTKVDPKSTAVMNFFVGGLSIICNIVVITYSALHPTAPVE
CHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GAEDIAQVSHHLTSFYGPATGLLFGFTYLYAAINHTFGLDWRPYSWYSLFVAINAVPAAI
CHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LSHYSDMLDDHKVLGITEGDWWAIIWLAWGVLWLTAFIENILKIPLGKFTPWLTIIEGIL
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
TAWIPAWLLFIQHWV
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]