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The map label for this gene is ycgO [H]

Identifier: 108562477

GI number: 108562477

Start: 53815

End: 55305

Strand: Reverse

Name: ycgO [H]

Synonym: HPAG1_0052

Alternate gene names: 108562477

Gene position: 55305-53815 (Counterclockwise)

Preceding gene: 108562478

Following gene: 108562476

Centisome position: 3.46

GC content: 42.52

Gene sequence:

>1491_bases
ATGGGACATGTTGTTTTAAGCACCCCTATTGTTACGATGTTTATCGTTTATTCGCTGTTAATGCTCTATATTGGTTTTTA
TTTTTACAAACAAAATGAAACGACTGAAGATTATTTCTTAGGCGATCGCTCTATGGGCCCTGTGATTAGCGCTTTGAGCG
CGGGGGCGAGTGATATGAGCGGGTGGCTTTTAATGGGATTACCGGGAGCTTTATATGTGGGAGGCTTAATCAACTCGCAC
ATCGCCATAGGGTTGAGTTTAGGAGCACTCATCAACTGGGTTTTTGTGGCCAAACGCTTACGCATTTATACGAGCGTGAT
CGCTAATTCCATCACCATTTCAGATTATTTTGAAACGCGCTTTAGCGATGATAAACACATCTTGCGCTTGATTTCAGCTT
TTGTGATTTTAATCTTTTTTATTTTTTACATTTCTTCAGGGCTAGTGAGTGGGGCTAAACTCTTTGAAGCGACCTTTGGC
ATCCAATACAACTACGCTTTAAGCATTGGCACGCTGATTATTGTTTCTTACACCTTTTTAGGAGGGTATAAGGCGGTGTG
TTGGACGGATTTGATTCAAGGGCTTTTGATGATGAGCGCTTTAATCGTGGTGCCGATCGTTATGACAATCCATCTTGGCG
GGATTGGAGAGGGGATTAAAATCATTAAAGAAATCAAGCCTGAAAACCTTTCTTTCTTGCAAGGCTCTAGCGTAGTCGCT
ATTATTTCAAGCCTCGCTTGGGGGTTAGGCTATTTTGGGCAACCCCATATTTTAGTGCGTTTCATGTCTATCCGCTCCAT
TAGAGATGTGCCTAAAGCGACCACTATTGGGATTTCTTGGATGGTTATTTCTTTGATTGGGGCATGCGTTATGGGGCTTT
TAGGCGTTGCGTATGTGCATAAATTTGATTTGAGTTTAGAAGACCCTGAAAAGATTTTCATTGTGATGAGTCAATTGCTC
TTTAACCCTTGGATCACAGGCATTTTATTGAGCGCGATTTTAGCGGCGGTGATGAGCACGGCCAGTTCACAACTGCTTGT
AAGCTCTTCTACCATTGCTGAAGATTTCTATGCGACGATTTTCAACAAAAACGCCCCCCAAAAATTAGTGATGGTTATTT
CTAGGCTTTCGGTTTTAGGGGTGGCTTGCATCGCTTTTTTCATTTCAACGGATAGAAACGCTAGCATTCTCAGTATTGTG
AGTTACGCATGGGCTGGCTTTGGCGCGAGCTTTGGCTCTGTGATTTTATTCTCGCTTTTTTGGTCAAGAATGACACGCAT
TGGCGCGATTGCTGGCATGCTTTTTGGGGCTAGCACGGTGATTTTATACGATAAATTTGGCAAAAGCTTTTTGGATATTT
ATGAAATCGTTCCGGGCTTTATTGTAGCGAGTGCAGCTATTGTGGTGTTTAGTTTGTTTTCTAGCGTGCGAGCAGGCACT
AAAGAGGCTTTTGAAACCATGCTTAAAGAAATTGAGAGCTTGAGGCGTTGA

Upstream 100 bases:

>100_bases
ATCGTTACGGGAATTTAGGCTCAAGGGTTTTAAGGCAACCCACTTGCCACAAATCATGTTGTGCTGAAAAATAAATATTG
TATTAAATAAGGAGATCAAA

Downstream 100 bases:

>100_bases
GGCGCTTCAAATGAATTTGGTTTAATCCCTAAAACCCATGCTCTTTAATCAAACCTTAACCTATATTTCTTTATTTTCTG
GGGCAGGAGTGGGGTGCTAT

Product: sodium/proline symporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MGHVVLSTPIVTMFIVYSLLMLYIGFYFYKQNETTEDYFLGDRSMGPVISALSAGASDMSGWLLMGLPGALYVGGLINSH
IAIGLSLGALINWVFVAKRLRIYTSVIANSITISDYFETRFSDDKHILRLISAFVILIFFIFYISSGLVSGAKLFEATFG
IQYNYALSIGTLIIVSYTFLGGYKAVCWTDLIQGLLMMSALIVVPIVMTIHLGGIGEGIKIIKEIKPENLSFLQGSSVVA
IISSLAWGLGYFGQPHILVRFMSIRSIRDVPKATTIGISWMVISLIGACVMGLLGVAYVHKFDLSLEDPEKIFIVMSQLL
FNPWITGILLSAILAAVMSTASSQLLVSSSTIAEDFYATIFNKNAPQKLVMVISRLSVLGVACIAFFISTDRNASILSIV
SYAWAGFGASFGSVILFSLFWSRMTRIGAIAGMLFGASTVILYDKFGKSFLDIYEIVPGFIVASAAIVVFSLFSSVRAGT
KEAFETMLKEIESLRR

Sequences:

>Translated_496_residues
MGHVVLSTPIVTMFIVYSLLMLYIGFYFYKQNETTEDYFLGDRSMGPVISALSAGASDMSGWLLMGLPGALYVGGLINSH
IAIGLSLGALINWVFVAKRLRIYTSVIANSITISDYFETRFSDDKHILRLISAFVILIFFIFYISSGLVSGAKLFEATFG
IQYNYALSIGTLIIVSYTFLGGYKAVCWTDLIQGLLMMSALIVVPIVMTIHLGGIGEGIKIIKEIKPENLSFLQGSSVVA
IISSLAWGLGYFGQPHILVRFMSIRSIRDVPKATTIGISWMVISLIGACVMGLLGVAYVHKFDLSLEDPEKIFIVMSQLL
FNPWITGILLSAILAAVMSTASSQLLVSSSTIAEDFYATIFNKNAPQKLVMVISRLSVLGVACIAFFISTDRNASILSIV
SYAWAGFGASFGSVILFSLFWSRMTRIGAIAGMLFGASTVILYDKFGKSFLDIYEIVPGFIVASAAIVVFSLFSSVRAGT
KEAFETMLKEIESLRR
>Mature_495_residues
GHVVLSTPIVTMFIVYSLLMLYIGFYFYKQNETTEDYFLGDRSMGPVISALSAGASDMSGWLLMGLPGALYVGGLINSHI
AIGLSLGALINWVFVAKRLRIYTSVIANSITISDYFETRFSDDKHILRLISAFVILIFFIFYISSGLVSGAKLFEATFGI
QYNYALSIGTLIIVSYTFLGGYKAVCWTDLIQGLLMMSALIVVPIVMTIHLGGIGEGIKIIKEIKPENLSFLQGSSVVAI
ISSLAWGLGYFGQPHILVRFMSIRSIRDVPKATTIGISWMVISLIGACVMGLLGVAYVHKFDLSLEDPEKIFIVMSQLLF
NPWITGILLSAILAAVMSTASSQLLVSSSTIAEDFYATIFNKNAPQKLVMVISRLSVLGVACIAFFISTDRNASILSIVS
YAWAGFGASFGSVILFSLFWSRMTRIGAIAGMLFGASTVILYDKFGKSFLDIYEIVPGFIVASAAIVVFSLFSSVRAGTK
EAFETMLKEIESLRR

Specific function: Catalyzes the sodium-dependent uptake of extracellular amino acids [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=494, Percent_Identity=46.9635627530364, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI256985183, Length=429, Percent_Identity=23.0769230769231, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI4507035, Length=394, Percent_Identity=23.8578680203046, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI110835708, Length=527, Percent_Identity=23.719165085389, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1787251, Length=483, Percent_Identity=50.9316770186335, Blast_Score=473, Evalue=1e-134,
Organism=Escherichia coli, GI87082237, Length=487, Percent_Identity=27.1047227926078, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1790503, Length=455, Percent_Identity=23.2967032967033, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17539284, Length=369, Percent_Identity=26.0162601626016, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24645928, Length=373, Percent_Identity=28.1501340482574, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI221459588, Length=434, Percent_Identity=26.2672811059908, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281362918, Length=465, Percent_Identity=27.3118279569892, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24651741, Length=463, Percent_Identity=25.7019438444924, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221459584, Length=355, Percent_Identity=25.3521126760563, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221459586, Length=385, Percent_Identity=25.4545454545455, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221459582, Length=359, Percent_Identity=28.4122562674095, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28573698, Length=408, Percent_Identity=25.4901960784314, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24651739, Length=465, Percent_Identity=24.5161290322581, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24640370, Length=344, Percent_Identity=25.8720930232558, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24650192, Length=342, Percent_Identity=24.2690058479532, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 54131; Mature: 54000

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHVVLSTPIVTMFIVYSLLMLYIGFYFYKQNETTEDYFLGDRSMGPVISALSAGASDMS
CCCEEEHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHCCCCCCCHHHHHHHHCCCCCCC
GWLLMGLPGALYVGGLINSHIAIGLSLGALINWVFVAKRLRIYTSVIANSITISDYFETR
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
FSDDKHILRLISAFVILIFFIFYISSGLVSGAKLFEATFGIQYNYALSIGTLIIVSYTFL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHH
GGYKAVCWTDLIQGLLMMSALIVVPIVMTIHLGGIGEGIKIIKEIKPENLSFLQGSSVVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHH
IISSLAWGLGYFGQPHILVRFMSIRSIRDVPKATTIGISWMVISLIGACVMGLLGVAYVH
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFDLSLEDPEKIFIVMSQLLFNPWITGILLSAILAAVMSTASSQLLVSSSTIAEDFYATI
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEHHHHHHHHHHHH
FNKNAPQKLVMVISRLSVLGVACIAFFISTDRNASILSIVSYAWAGFGASFGSVILFSLF
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
WSRMTRIGAIAGMLFGASTVILYDKFGKSFLDIYEIVPGFIVASAAIVVFSLFSSVRAGT
HHHHHHHHHHHHHHHCCHHEEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
KEAFETMLKEIESLRR
HHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GHVVLSTPIVTMFIVYSLLMLYIGFYFYKQNETTEDYFLGDRSMGPVISALSAGASDMS
CCEEEHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHCCCCCCCHHHHHHHHCCCCCCC
GWLLMGLPGALYVGGLINSHIAIGLSLGALINWVFVAKRLRIYTSVIANSITISDYFETR
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
FSDDKHILRLISAFVILIFFIFYISSGLVSGAKLFEATFGIQYNYALSIGTLIIVSYTFL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHH
GGYKAVCWTDLIQGLLMMSALIVVPIVMTIHLGGIGEGIKIIKEIKPENLSFLQGSSVVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHH
IISSLAWGLGYFGQPHILVRFMSIRSIRDVPKATTIGISWMVISLIGACVMGLLGVAYVH
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFDLSLEDPEKIFIVMSQLLFNPWITGILLSAILAAVMSTASSQLLVSSSTIAEDFYATI
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEHHHHHHHHHHHH
FNKNAPQKLVMVISRLSVLGVACIAFFISTDRNASILSIVSYAWAGFGASFGSVILFSLF
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
WSRMTRIGAIAGMLFGASTVILYDKFGKSFLDIYEIVPGFIVASAAIVVFSLFSSVRAGT
HHHHHHHHHHHHHHHCCHHEEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
KEAFETMLKEIESLRR
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]