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The map label for this gene is gmd [H]

Identifier: 108562466

GI number: 108562466

Start: 43157

End: 44302

Strand: Direct

Name: gmd [H]

Synonym: HPAG1_0041

Alternate gene names: 108562466

Gene position: 43157-44302 (Clockwise)

Preceding gene: 108562465

Following gene: 108562467

Centisome position: 2.7

GC content: 41.19

Gene sequence:

>1146_bases
ATGAAAGAAAAAATCGCTTTAATCGCCGGGGTTACCGGGCAAGACGGGAGCTATCTGGCTGAATACTTGCTGAATTTGGG
TTATGAAGTGCATGGGTTAAAAAGGCGCTCTTCTAGCATCAACACTTCTAGGATCGATCATTTGTATGAAGATTTGCACA
GCGATCATAAAAGGCGTTTTTTCTTACACTATGGGGATATGACCGATAGCTCTAACCTCATCCATTTAATCGCTACCACT
AAGCCTACAGAGATTTATAATTTAGCCGCTCAAAGCCATGTGAAAGTCTCTTTTGAAACCCCAGAATACACCGCTAACGC
TGATGGTATTGGCACGCTAAGGATTTTAGAAGCCATGCGGATTTTAGGATTAGAAAATAAAACACGATTCTATCAAGCCA
GCACGAGCGAATTGTATGGCGAAGTCTTAGAAACCCCGCAAAATGAAAACACCCCCTTTAACCCACGAAGCCCCTATGCG
GTCGCTAAAATGTATGCCTTTTACATCACCAAAAATTACAGAGAGGCTTATAACTTGTTTGCGGTTAATGGCATTCTTTT
TAACCATGAGAGCAGGGTAAGGGGCGAAACTTTTGTAACCCGTAAAATCACACGAGCCGCTAGCGCGATAGCGTATAACT
TAACGGATTGCTTGTATTTAGGAAATTTAGACGCTAAAAGAGACTGGGGGCATGCCAAAGATTACGTGAAAATGATGCAT
TTAATGCTCCAAGCGCCCATCCCACAAGATTACGTGATCGCTACAGGGAAGACCACAAGCGTGCGCGATTTTGTGAAAAT
GAGCTTTGAATTTATCGGTATTGGTTTAGAATTTCAAAATACAGGGATTAAAGAAATCGGTTTGATTAAAAGCGTTGATG
AAAAAAGAGCGAACGCTTTACAATTAAACTTAAGCCATTTAAAAACAGGCCAAATCGTGGTGCGCATAGACGAGCGCTAT
TTCAGGCCTACTGAAGTGGATTTGCTTTTAGGCGATCCCACTAAGGCAGAAAAAGAGCTAGGCTGGGTTAGGGAATACGA
TTTAAAAGAGTTGGTTAAGGACATGTTAGAATACGATTTAAAAGAATGCCAGAAAAACCTTTACTTGCAAGATGGGGGCT
ATACTTTAAGGAATTTTTATGAATGA

Upstream 100 bases:

>100_bases
GCGAGTATGTCGGTGAAGACGATATTGTAAGGGTTGATGATGATTTTAACAGACAAAATCAAAACGCCTAATACAAGAAA
ATTTAATATAAGGAAAAATA

Downstream 100 bases:

>100_bases
GATTATTTTAATCACCGGTGCCTATGGCATGGTGGGGCAGAACACGGCGTTGTATTTTAAGAAAAATAAGCCTGATGTTA
CTTTACTCACCCCTAAAAAG

Product: GDP-D-mannose dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase; ORF13.7 [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MKEKIALIAGVTGQDGSYLAEYLLNLGYEVHGLKRRSSSINTSRIDHLYEDLHSDHKRRFFLHYGDMTDSSNLIHLIATT
KPTEIYNLAAQSHVKVSFETPEYTANADGIGTLRILEAMRILGLENKTRFYQASTSELYGEVLETPQNENTPFNPRSPYA
VAKMYAFYITKNYREAYNLFAVNGILFNHESRVRGETFVTRKITRAASAIAYNLTDCLYLGNLDAKRDWGHAKDYVKMMH
LMLQAPIPQDYVIATGKTTSVRDFVKMSFEFIGIGLEFQNTGIKEIGLIKSVDEKRANALQLNLSHLKTGQIVVRIDERY
FRPTEVDLLLGDPTKAEKELGWVREYDLKELVKDMLEYDLKECQKNLYLQDGGYTLRNFYE

Sequences:

>Translated_381_residues
MKEKIALIAGVTGQDGSYLAEYLLNLGYEVHGLKRRSSSINTSRIDHLYEDLHSDHKRRFFLHYGDMTDSSNLIHLIATT
KPTEIYNLAAQSHVKVSFETPEYTANADGIGTLRILEAMRILGLENKTRFYQASTSELYGEVLETPQNENTPFNPRSPYA
VAKMYAFYITKNYREAYNLFAVNGILFNHESRVRGETFVTRKITRAASAIAYNLTDCLYLGNLDAKRDWGHAKDYVKMMH
LMLQAPIPQDYVIATGKTTSVRDFVKMSFEFIGIGLEFQNTGIKEIGLIKSVDEKRANALQLNLSHLKTGQIVVRIDERY
FRPTEVDLLLGDPTKAEKELGWVREYDLKELVKDMLEYDLKECQKNLYLQDGGYTLRNFYE
>Mature_381_residues
MKEKIALIAGVTGQDGSYLAEYLLNLGYEVHGLKRRSSSINTSRIDHLYEDLHSDHKRRFFLHYGDMTDSSNLIHLIATT
KPTEIYNLAAQSHVKVSFETPEYTANADGIGTLRILEAMRILGLENKTRFYQASTSELYGEVLETPQNENTPFNPRSPYA
VAKMYAFYITKNYREAYNLFAVNGILFNHESRVRGETFVTRKITRAASAIAYNLTDCLYLGNLDAKRDWGHAKDYVKMMH
LMLQAPIPQDYVIATGKTTSVRDFVKMSFEFIGIGLEFQNTGIKEIGLIKSVDEKRANALQLNLSHLKTGQIVVRIDERY
FRPTEVDLLLGDPTKAEKELGWVREYDLKELVKDMLEYDLKECQKNLYLQDGGYTLRNFYE

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=362, Percent_Identity=55.2486187845304, Blast_Score=407, Evalue=1e-113,
Organism=Escherichia coli, GI1788366, Length=371, Percent_Identity=59.8382749326146, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI48994969, Length=324, Percent_Identity=23.1481481481481, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788353, Length=258, Percent_Identity=24.031007751938, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI133901790, Length=358, Percent_Identity=56.4245810055866, Blast_Score=408, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI133901788, Length=358, Percent_Identity=56.4245810055866, Blast_Score=408, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17539424, Length=358, Percent_Identity=56.4245810055866, Blast_Score=408, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17539422, Length=358, Percent_Identity=56.4245810055866, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI133901786, Length=358, Percent_Identity=56.4245810055866, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17507723, Length=358, Percent_Identity=56.9832402234637, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24158427, Length=365, Percent_Identity=57.5342465753425, Blast_Score=432, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 43727; Mature: 43727

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKIALIAGVTGQDGSYLAEYLLNLGYEVHGLKRRSSSINTSRIDHLYEDLHSDHKRRF
CCCCEEEEEECCCCCHHHHHHHHHHCCCEEECHHHHCCCCCHHHHHHHHHHHHCCCCEEE
FLHYGDMTDSSNLIHLIATTKPTEIYNLAAQSHVKVSFETPEYTANADGIGTLRILEAMR
EEEECCCCCCCCEEEEEEECCCCHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHH
ILGLENKTRFYQASTSELYGEVLETPQNENTPFNPRSPYAVAKMYAFYITKNYREAYNLF
HHCCCCCCCEEECCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHEE
AVNGILFNHESRVRGETFVTRKITRAASAIAYNLTDCLYLGNLDAKRDWGHAKDYVKMMH
EEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHH
LMLQAPIPQDYVIATGKTTSVRDFVKMSFEFIGIGLEFQNTGIKEIGLIKSVDEKRANAL
HHHHCCCCCCEEEECCCCCHHHHHHHHCEEEEEEEEEECCCCCHHHHHHHHHHHHCCCEE
QLNLSHLKTGQIVVRIDERYFRPTEVDLLLGDPTKAEKELGWVREYDLKELVKDMLEYDL
EEEHHHCCCCEEEEEEECCCCCCCCEEEEECCCCCHHHHHCCHHHCCHHHHHHHHHHHHH
KECQKNLYLQDGGYTLRNFYE
HHHHHCCEEECCCEEHHCCCC
>Mature Secondary Structure
MKEKIALIAGVTGQDGSYLAEYLLNLGYEVHGLKRRSSSINTSRIDHLYEDLHSDHKRRF
CCCCEEEEEECCCCCHHHHHHHHHHCCCEEECHHHHCCCCCHHHHHHHHHHHHCCCCEEE
FLHYGDMTDSSNLIHLIATTKPTEIYNLAAQSHVKVSFETPEYTANADGIGTLRILEAMR
EEEECCCCCCCCEEEEEEECCCCHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHH
ILGLENKTRFYQASTSELYGEVLETPQNENTPFNPRSPYAVAKMYAFYITKNYREAYNLF
HHCCCCCCCEEECCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHEE
AVNGILFNHESRVRGETFVTRKITRAASAIAYNLTDCLYLGNLDAKRDWGHAKDYVKMMH
EEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHH
LMLQAPIPQDYVIATGKTTSVRDFVKMSFEFIGIGLEFQNTGIKEIGLIKSVDEKRANAL
HHHHCCCCCCEEEECCCCCHHHHHHHHCEEEEEEEEEECCCCCHHHHHHHHHHHHCCCEE
QLNLSHLKTGQIVVRIDERYFRPTEVDLLLGDPTKAEKELGWVREYDLKELVKDMLEYDL
EEEHHHCCCCEEEEEEECCCCCCCCEEEEECCCCCHHHHHCCHHHCCHHHHHHHHHHHHH
KECQKNLYLQDGGYTLRNFYE
HHHHHCCEEECCCEEHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8932701 [H]