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The map label for this gene is algA [H]

Identifier: 108562465

GI number: 108562465

Start: 41715

End: 43127

Strand: Direct

Name: algA [H]

Synonym: HPAG1_0040

Alternate gene names: 108562465

Gene position: 41715-43127 (Clockwise)

Preceding gene: 108562464

Following gene: 108562466

Centisome position: 2.61

GC content: 39.35

Gene sequence:

>1413_bases
ATGAAAATTAAAAATATCTTACTGAGTGGGGGGAGCGGGAAACGCCTATGGCCTTTAAGCCGTAGCCTATACCCTAAGCA
ATTTTTAAAGCTTTTTGACCATAAAAGCTTGTTTGAATTGAGTTTTAAAAGAAACGCTTCCTTAGTGGATGAAACGCTCA
TTGTGTGCAATGAAAAACATTATTTTTTAGCCCTAGAAGAAATAGAGAATGAAATCAAAAACAAAAGCGTGGGTTTTTTA
TTAGAGAGCTTGAGTAAAAACACCGCTAACGCTATTGCTTTGAGCGCTTTAATGAGTGAGAGGGAAGATTTACTCATCGT
TACGCCAAGCGATCACTTGATTAAAGACCTTCAAGCGTATGAAAATGCAATCAAAAAAGCGATTGATTTAGCCCAAGAAG
GCTTTTTAGTCACTTTTGGGGTGAGTATTGAAAAACCCAACACGGAGTTTGGGTATATTGAAAGCCCTAATGGTTTAGAT
GTGAAGCGGTTCATTGAAAAGCCAAGTCTAGAAAAAGCGATAGAGTTTCAAAAAAGCGGGGGTTTTTATTTCAATAGCGG
CATGTTTGTTTTCCAGGCGGGCGTTTTTTTAGACGAACTAAAAAAGCATGCCCCTACTATTTTAAAGGGGTGCGAAAGAG
CGTTTGAATCGTTAGAAAACACGCATTTTTTTGAACAAAAGATCGCTCGTTTGAGCGAAAAGAGCATGCAAGATTTAGAA
GACGTGAGTATTGATATTGCCTTAATGCAACAAAGCCACAAAATCAAAATGGTAGGATTAAACGCCAAGTGGAGCGATTT
AGGGAATTTTAACGCTCTTTTTGAAGAAGCGGCTAACGAGCCTAAAGAAAATGTCAGCCTGAATCAAACGCCCATTTTTG
CCAAAGAGAGCCAGAATAATTTAGTGTTTTCTCATAAAGTGAGCGCTCTTTTAGGCGTTGAGGATTTAGCCATCATTGAC
ACTAAAGACGCTCTTTTAATCGCTCATAAAGACAAGGCTAAAGATTTAAAAGCTTTAGTGAGCGAGGTAGAAATAAATAA
CCAGGAATTGTTGCAAACGCACACTAAAGTGTATCGCCCTTGGGGGAGCTATGAAGTCTTGCATGAGAGCGGGTGTTACA
AGGTTAAGATTTTAGAAGTCAAACCTAACGCAAGGCTTTCTTTACAAAAGCATTTCCACAGGAGCGAGCACTGGGTGGTG
ATTAGCGGGATGGCGAGCGTGGAGTTGGATCATAAAATGTTTGAATTGCAAGCTAATGAGTCCACTTATATCCCTAAAAA
CACCTTACACCGCCTGGCTAATTACGGCAAAATCCCTTTAATTATCATAGAAGTTCAAGTGGGCGAGTATGTCGGTGAAG
ACGATATTGTAAGGGTTGATGATGATTTTAACAGACAAAATCAAAACGCCTAA

Upstream 100 bases:

>100_bases
GAATGAAGTCATCGCTGAGTTTTTGAAGTGACTCAAAAATCCCCAATTAAAAACGCTATAATAACCCTAAAAAATAAAAG
AGAGCCTGACAAGAAAACGC

Downstream 100 bases:

>100_bases
TACAAGAAAATTTAATATAAGGAAAAATAATGAAAGAAAAAATCGCTTTAATCGCCGGGGTTACCGGGCAAGACGGGAGC
TATCTGGCTGAATACTTGCT

Product: mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MKIKNILLSGGSGKRLWPLSRSLYPKQFLKLFDHKSLFELSFKRNASLVDETLIVCNEKHYFLALEEIENEIKNKSVGFL
LESLSKNTANAIALSALMSEREDLLIVTPSDHLIKDLQAYENAIKKAIDLAQEGFLVTFGVSIEKPNTEFGYIESPNGLD
VKRFIEKPSLEKAIEFQKSGGFYFNSGMFVFQAGVFLDELKKHAPTILKGCERAFESLENTHFFEQKIARLSEKSMQDLE
DVSIDIALMQQSHKIKMVGLNAKWSDLGNFNALFEEAANEPKENVSLNQTPIFAKESQNNLVFSHKVSALLGVEDLAIID
TKDALLIAHKDKAKDLKALVSEVEINNQELLQTHTKVYRPWGSYEVLHESGCYKVKILEVKPNARLSLQKHFHRSEHWVV
ISGMASVELDHKMFELQANESTYIPKNTLHRLANYGKIPLIIIEVQVGEYVGEDDIVRVDDDFNRQNQNA

Sequences:

>Translated_470_residues
MKIKNILLSGGSGKRLWPLSRSLYPKQFLKLFDHKSLFELSFKRNASLVDETLIVCNEKHYFLALEEIENEIKNKSVGFL
LESLSKNTANAIALSALMSEREDLLIVTPSDHLIKDLQAYENAIKKAIDLAQEGFLVTFGVSIEKPNTEFGYIESPNGLD
VKRFIEKPSLEKAIEFQKSGGFYFNSGMFVFQAGVFLDELKKHAPTILKGCERAFESLENTHFFEQKIARLSEKSMQDLE
DVSIDIALMQQSHKIKMVGLNAKWSDLGNFNALFEEAANEPKENVSLNQTPIFAKESQNNLVFSHKVSALLGVEDLAIID
TKDALLIAHKDKAKDLKALVSEVEINNQELLQTHTKVYRPWGSYEVLHESGCYKVKILEVKPNARLSLQKHFHRSEHWVV
ISGMASVELDHKMFELQANESTYIPKNTLHRLANYGKIPLIIIEVQVGEYVGEDDIVRVDDDFNRQNQNA
>Mature_470_residues
MKIKNILLSGGSGKRLWPLSRSLYPKQFLKLFDHKSLFELSFKRNASLVDETLIVCNEKHYFLALEEIENEIKNKSVGFL
LESLSKNTANAIALSALMSEREDLLIVTPSDHLIKDLQAYENAIKKAIDLAQEGFLVTFGVSIEKPNTEFGYIESPNGLD
VKRFIEKPSLEKAIEFQKSGGFYFNSGMFVFQAGVFLDELKKHAPTILKGCERAFESLENTHFFEQKIARLSEKSMQDLE
DVSIDIALMQQSHKIKMVGLNAKWSDLGNFNALFEEAANEPKENVSLNQTPIFAKESQNNLVFSHKVSALLGVEDLAIID
TKDALLIAHKDKAKDLKALVSEVEINNQELLQTHTKVYRPWGSYEVLHESGCYKVKILEVKPNARLSLQKHFHRSEHWVV
ISGMASVELDHKMFELQANESTYIPKNTLHRLANYGKIPLIIIEVQVGEYVGEDDIVRVDDDFNRQNQNA

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=480, Percent_Identity=37.7083333333333, Blast_Score=335, Evalue=3e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 53361; Mature: 53361

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKNILLSGGSGKRLWPLSRSLYPKQFLKLFDHKSLFELSFKRNASLVDETLIVCNEKH
CCCCEEEEECCCCCEECCCCCCCCHHHHHHHHCCCCCEEEHHCCCCCHHHCEEEEECCCC
YFLALEEIENEIKNKSVGFLLESLSKNTANAIALSALMSEREDLLIVTPSDHLIKDLQAY
EEEEHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHH
ENAIKKAIDLAQEGFLVTFGVSIEKPNTEFGYIESPNGLDVKRFIEKPSLEKAIEFQKSG
HHHHHHHHHHHHCCEEEEEEEEEECCCCCCCEEECCCCCCHHHHHCCCCHHHHHHHHHCC
GFYFNSGMFVFQAGVFLDELKKHAPTILKGCERAFESLENTHFFEQKIARLSEKSMQDLE
CEEEECCEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
DVSIDIALMQQSHKIKMVGLNAKWSDLGNFNALFEEAANEPKENVSLNQTPIFAKESQNN
HCEEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCHHCCCCCCCCEEEECCCCC
LVFSHKVSALLGVEDLAIIDTKDALLIAHKDKAKDLKALVSEVEINNQELLQTHTKVYRP
EEEEEHHHHHHCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
WGSYEVLHESGCYKVKILEVKPNARLSLQKHFHRSEHWVVISGMASVELDHKMFELQANE
CCCEEHHCCCCCEEEEEEEECCCCCCHHHHHHCCCCCEEEEECCEEEEECCEEEEEECCC
STYIPKNTLHRLANYGKIPLIIIEVQVGEYVGEDDIVRVDDDFNRQNQNA
CCCCCHHHHHHHHCCCCCEEEEEEEEECCCCCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure
MKIKNILLSGGSGKRLWPLSRSLYPKQFLKLFDHKSLFELSFKRNASLVDETLIVCNEKH
CCCCEEEEECCCCCEECCCCCCCCHHHHHHHHCCCCCEEEHHCCCCCHHHCEEEEECCCC
YFLALEEIENEIKNKSVGFLLESLSKNTANAIALSALMSEREDLLIVTPSDHLIKDLQAY
EEEEHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHH
ENAIKKAIDLAQEGFLVTFGVSIEKPNTEFGYIESPNGLDVKRFIEKPSLEKAIEFQKSG
HHHHHHHHHHHHCCEEEEEEEEEECCCCCCCEEECCCCCCHHHHHCCCCHHHHHHHHHCC
GFYFNSGMFVFQAGVFLDELKKHAPTILKGCERAFESLENTHFFEQKIARLSEKSMQDLE
CEEEECCEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
DVSIDIALMQQSHKIKMVGLNAKWSDLGNFNALFEEAANEPKENVSLNQTPIFAKESQNN
HCEEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCHHCCCCCCCCEEEECCCCC
LVFSHKVSALLGVEDLAIIDTKDALLIAHKDKAKDLKALVSEVEINNQELLQTHTKVYRP
EEEEEHHHHHHCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
WGSYEVLHESGCYKVKILEVKPNARLSLQKHFHRSEHWVVISGMASVELDHKMFELQANE
CCCEEHHCCCCCEEEEEEEECCCCCCHHHHHHCCCCCEEEEECCEEEEECCEEEEEECCC
STYIPKNTLHRLANYGKIPLIIIEVQVGEYVGEDDIVRVDDDFNRQNQNA
CCCCCHHHHHHHHCCCCCEEEEEEEEECCCCCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3089876; 10984043; 1846611 [H]