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The map label for this gene is clpA [H]

Identifier: 108562456

GI number: 108562456

Start: 33749

End: 35974

Strand: Direct

Name: clpA [H]

Synonym: HPAG1_0031

Alternate gene names: 108562456

Gene position: 33749-35974 (Clockwise)

Preceding gene: 108562455

Following gene: 108562457

Centisome position: 2.11

GC content: 39.76

Gene sequence:

>2226_bases
ATGGCTAAATTCAATCAAGATCTCAATGAAGTTCTAAACCAAGCTTTAAATTTAGCCCTGGATCTTAACCACGCCCTTTG
CACCACAGAGCATGTGCTACTAGTCATTTTAGAGCATGAGAGCGGGGCAAAGATTATTGGCGCTTTAGAAAGAGATGACT
ATGATAAATTAAAACAAATCCTTAAAGACTATTTGTTGCAATATGTGCCTTTAAAGAGCGATCCAGCCAAAATGCCTGCT
AGGAGTTTTGTGCTATTAAGAATGCTTAAAAGAATGTATGCGAGCTGTTTTGAGAGCGTGGGCGTGGAAGAATTGCTTAT
TTTAATGCTGGATCACCCCGATTGTTACGCTTCAAAACTCATGGATAGTTTTGGCATCGCTCATTTGTATTCTAATCCTG
CTTTATTGGATTTGGATAACCATGGTATTCCTAATGACATTAATGATAATGAAGAAGTGCCCAAAAACACTCCCTTAAAA
AAATACGCTAAAAATTTGAGCGCTTTAGCCCAAGACAACGCTTTAGATCCAGTCATTGGCAGAGAAGAAGAGATTTTAAG
AGTGATAGAAATTTTAGGGCGCAGAAAAAAGAATAACCCGCTTTTAATTGGCGAAGCGGGTGTAGGGAAAACCTCCATCG
CTGAAGCTTTGGCTTTAAAAATCGCTCAAAAAGAAGTGCCGGAGTTTTTGCAAGAATATGAAGTCTATTCTTTGGATTTA
GCTTTAATGGTGGCTGGGGCAAAATACAGAGGGGATTTTGAAAAACGCTTGAAAAAAACGCTCAAAGAAATCCAAGAAAA
CGGCCGCATCATTTTATTCATTGATGAAATCCACACCCTTTTAGGCGCAGGGAGCAGTAACGCTGGGAGCTTGGATGCGG
CGAATATATTAAAACCGGTTTTAACGGATGGGAGCTTGAAATGTTTAGGAGCGACCACTTTTGAAGAATACCGCAGCGTG
TTTGAAAAAGACAAGGCTTTTAATAGGCGTTTTTCAGTCATAAAAGTTGAAGAGCCTTCTAAAGAGGCGTGTTATTTGAT
TTTAAAAAAGATCGCTCCCCTTTATGAAGAACACCACCAGGTGCGTTATGATGAAAGCGTGTTTAAGGCATGCGTGGATC
TAACGAGTGATTACATGCATGATAAATTCTTGCCGGATAAAGCGATTGAATTATTAGATGAGGTGGGATCGAGGAAAAAA
ATCAGCCCTAAAAAGGGCAAAAAAATCGGCGTTGATGATGTGAAAGAAACGCTCGCTCTAAAGCTTAAAATCCCTAAAAT
GCGTTTGAGCAGCGACAAAAAAGCCCTTTTAAGGAACTTGGAAAAATCGCTTAAAAATAAGATTTTTGCCCAAGCAGAAG
CGATCAGCCTCGTCAGCAATGCGATTAAAATCCAGCATTGCGGGCTTTCTTCTAAAAATAAGCCTGTGGGGAGCTTTTTA
TTCGTGGGGCCTAGTGGGGTGGGGAAAACAGAATTGGCTAAAGAATTGGCCTTGAATTTGAATTTGCATTTTGAACGCTT
TGACATGAGCGAATACAAAGAAGCCCATAGCGTGGCAAAACTCATTGGGAGTCCTAGCGGTTATGTGGGGTTTGAGCAAG
GGGGGCTGTTGGTGAATGCGATTAAAAAACACCCGCATTGTTTGCTGCTTTTAGATGAGATAGAAAAAGCCCATTCTAAT
GTGTATGATCTGTTGTTGCAAGTGATGGATAACGCCACTTTGAGCGATAATTTAGGCAATCAGGCGAGTTTTAAGCATGT
GATTTTGATTATGACTTCAAATGTGGGGAGTAAGGATAAGGATACGCTAGGGTTTTTTAGCGCTAAAAACACCAAGTATG
ATAGAGCCGTTAAAGAGCTTTTGACCCCTGAATTACGCTCTAGGATTGATGCGATCGTGCCGTTTAACGCGCTCAATTTG
GAGGATTTTGAACGCATTGTTTCTGTGGAATTAGACAAATTAAAAGCCCTAGCGCTAGAGCAAGACATAACCTTAAAATT
CCATAAAGAAGTTGTGAAATCCATCGCGCAAAAAAGCTACCAAACGACTTTAGGAGCGAGAGAAATTAAAAAAATCATTC
ATAATGAAATCAAAACTAAATTAAGCGATATACTGCTCTTGCAATCGCTTAAAAAACCTTGTAAGATCGCTTGCTTGCTA
GAAAAAAACCAATTGGTTCTAAAAGAAATCAAGCGCACACAAAAGGTGAAAGAAAATGACTTTTGA

Upstream 100 bases:

>100_bases
TCTATCCTTATGATATTGCCAGGCATAGGGCAGCATGGGTTAGGGATAAGGCCAGAGAGCTAGATCTCCCCTTAAAATTA
TTGGTAGAAGAGATAAAATA

Downstream 100 bases:

>100_bases
AATGCTTTATAGTAAAATCCATAGGGCTACTATCACAGACGCTAATCTCAATTACATAGGCTCGATCACCATAGATGAGG
ATTTAGCCAAGCTCGCTAAG

Product: ATP-dependent C1p protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 741; Mature: 740

Protein sequence:

>741_residues
MAKFNQDLNEVLNQALNLALDLNHALCTTEHVLLVILEHESGAKIIGALERDDYDKLKQILKDYLLQYVPLKSDPAKMPA
RSFVLLRMLKRMYASCFESVGVEELLILMLDHPDCYASKLMDSFGIAHLYSNPALLDLDNHGIPNDINDNEEVPKNTPLK
KYAKNLSALAQDNALDPVIGREEEILRVIEILGRRKKNNPLLIGEAGVGKTSIAEALALKIAQKEVPEFLQEYEVYSLDL
ALMVAGAKYRGDFEKRLKKTLKEIQENGRIILFIDEIHTLLGAGSSNAGSLDAANILKPVLTDGSLKCLGATTFEEYRSV
FEKDKAFNRRFSVIKVEEPSKEACYLILKKIAPLYEEHHQVRYDESVFKACVDLTSDYMHDKFLPDKAIELLDEVGSRKK
ISPKKGKKIGVDDVKETLALKLKIPKMRLSSDKKALLRNLEKSLKNKIFAQAEAISLVSNAIKIQHCGLSSKNKPVGSFL
FVGPSGVGKTELAKELALNLNLHFERFDMSEYKEAHSVAKLIGSPSGYVGFEQGGLLVNAIKKHPHCLLLLDEIEKAHSN
VYDLLLQVMDNATLSDNLGNQASFKHVILIMTSNVGSKDKDTLGFFSAKNTKYDRAVKELLTPELRSRIDAIVPFNALNL
EDFERIVSVELDKLKALALEQDITLKFHKEVVKSIAQKSYQTTLGAREIKKIIHNEIKTKLSDILLLQSLKKPCKIACLL
EKNQLVLKEIKRTQKVKENDF

Sequences:

>Translated_741_residues
MAKFNQDLNEVLNQALNLALDLNHALCTTEHVLLVILEHESGAKIIGALERDDYDKLKQILKDYLLQYVPLKSDPAKMPA
RSFVLLRMLKRMYASCFESVGVEELLILMLDHPDCYASKLMDSFGIAHLYSNPALLDLDNHGIPNDINDNEEVPKNTPLK
KYAKNLSALAQDNALDPVIGREEEILRVIEILGRRKKNNPLLIGEAGVGKTSIAEALALKIAQKEVPEFLQEYEVYSLDL
ALMVAGAKYRGDFEKRLKKTLKEIQENGRIILFIDEIHTLLGAGSSNAGSLDAANILKPVLTDGSLKCLGATTFEEYRSV
FEKDKAFNRRFSVIKVEEPSKEACYLILKKIAPLYEEHHQVRYDESVFKACVDLTSDYMHDKFLPDKAIELLDEVGSRKK
ISPKKGKKIGVDDVKETLALKLKIPKMRLSSDKKALLRNLEKSLKNKIFAQAEAISLVSNAIKIQHCGLSSKNKPVGSFL
FVGPSGVGKTELAKELALNLNLHFERFDMSEYKEAHSVAKLIGSPSGYVGFEQGGLLVNAIKKHPHCLLLLDEIEKAHSN
VYDLLLQVMDNATLSDNLGNQASFKHVILIMTSNVGSKDKDTLGFFSAKNTKYDRAVKELLTPELRSRIDAIVPFNALNL
EDFERIVSVELDKLKALALEQDITLKFHKEVVKSIAQKSYQTTLGAREIKKIIHNEIKTKLSDILLLQSLKKPCKIACLL
EKNQLVLKEIKRTQKVKENDF
>Mature_740_residues
AKFNQDLNEVLNQALNLALDLNHALCTTEHVLLVILEHESGAKIIGALERDDYDKLKQILKDYLLQYVPLKSDPAKMPAR
SFVLLRMLKRMYASCFESVGVEELLILMLDHPDCYASKLMDSFGIAHLYSNPALLDLDNHGIPNDINDNEEVPKNTPLKK
YAKNLSALAQDNALDPVIGREEEILRVIEILGRRKKNNPLLIGEAGVGKTSIAEALALKIAQKEVPEFLQEYEVYSLDLA
LMVAGAKYRGDFEKRLKKTLKEIQENGRIILFIDEIHTLLGAGSSNAGSLDAANILKPVLTDGSLKCLGATTFEEYRSVF
EKDKAFNRRFSVIKVEEPSKEACYLILKKIAPLYEEHHQVRYDESVFKACVDLTSDYMHDKFLPDKAIELLDEVGSRKKI
SPKKGKKIGVDDVKETLALKLKIPKMRLSSDKKALLRNLEKSLKNKIFAQAEAISLVSNAIKIQHCGLSSKNKPVGSFLF
VGPSGVGKTELAKELALNLNLHFERFDMSEYKEAHSVAKLIGSPSGYVGFEQGGLLVNAIKKHPHCLLLLDEIEKAHSNV
YDLLLQVMDNATLSDNLGNQASFKHVILIMTSNVGSKDKDTLGFFSAKNTKYDRAVKELLTPELRSRIDAIVPFNALNLE
DFERIVSVELDKLKALALEQDITLKFHKEVVKSIAQKSYQTTLGAREIKKIIHNEIKTKLSDILLLQSLKKPCKIACLLE
KNQLVLKEIKRTQKVKENDF

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=319, Percent_Identity=32.9153605015674, Blast_Score=142, Evalue=9e-34,
Organism=Escherichia coli, GI1787109, Length=747, Percent_Identity=39.4912985274431, Blast_Score=561, Evalue=1e-161,
Organism=Escherichia coli, GI1788943, Length=252, Percent_Identity=50, Blast_Score=251, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6320464, Length=264, Percent_Identity=48.1060606060606, Blast_Score=245, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6323002, Length=249, Percent_Identity=50.6024096385542, Blast_Score=235, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83154; Mature: 83023

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKFNQDLNEVLNQALNLALDLNHALCTTEHVLLVILEHESGAKIIGALERDDYDKLKQI
CCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEEEECCCCCCEEEECCCCCHHHHHHH
LKDYLLQYVPLKSDPAKMPARSFVLLRMLKRMYASCFESVGVEELLILMLDHPDCYASKL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHH
MDSFGIAHLYSNPALLDLDNHGIPNDINDNEEVPKNTPLKKYAKNLSALAQDNALDPVIG
HHHHCHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
REEEILRVIEILGRRKKNNPLLIGEAGVGKTSIAEALALKIAQKEVPEFLQEYEVYSLDL
CHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEH
ALMVAGAKYRGDFEKRLKKTLKEIQENGRIILFIDEIHTLLGAGSSNAGSLDAANILKPV
HHHHCCCHHCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCCHHHHHHHH
LTDGSLKCLGATTFEEYRSVFEKDKAFNRRFSVIKVEEPSKEACYLILKKIAPLYEEHHQ
HCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
VRYDESVFKACVDLTSDYMHDKFLPDKAIELLDEVGSRKKISPKKGKKIGVDDVKETLAL
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHEE
KLKIPKMRLSSDKKALLRNLEKSLKNKIFAQAEAISLVSNAIKIQHCGLSSKNKPVGSFL
EEECCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEE
FVGPSGVGKTELAKELALNLNLHFERFDMSEYKEAHSVAKLIGSPSGYVGFEQGGLLVNA
EECCCCCCHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHH
IKKHPHCLLLLDEIEKAHSNVYDLLLQVMDNATLSDNLGNQASFKHVILIMTSNVGSKDK
HHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCC
DTLGFFSAKNTKYDRAVKELLTPELRSRIDAIVPFNALNLEDFERIVSVELDKLKALALE
CCCCEEECCCCHHHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHC
QDITLKFHKEVVKSIAQKSYQTTLGAREIKKIIHNEIKTKLSDILLLQSLKKPCKIACLL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
EKNQLVLKEIKRTQKVKENDF
CCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AKFNQDLNEVLNQALNLALDLNHALCTTEHVLLVILEHESGAKIIGALERDDYDKLKQI
CCCHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEEEECCCCCCEEEECCCCCHHHHHHH
LKDYLLQYVPLKSDPAKMPARSFVLLRMLKRMYASCFESVGVEELLILMLDHPDCYASKL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHH
MDSFGIAHLYSNPALLDLDNHGIPNDINDNEEVPKNTPLKKYAKNLSALAQDNALDPVIG
HHHHCHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
REEEILRVIEILGRRKKNNPLLIGEAGVGKTSIAEALALKIAQKEVPEFLQEYEVYSLDL
CHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEH
ALMVAGAKYRGDFEKRLKKTLKEIQENGRIILFIDEIHTLLGAGSSNAGSLDAANILKPV
HHHHCCCHHCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCCHHHHHHHH
LTDGSLKCLGATTFEEYRSVFEKDKAFNRRFSVIKVEEPSKEACYLILKKIAPLYEEHHQ
HCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
VRYDESVFKACVDLTSDYMHDKFLPDKAIELLDEVGSRKKISPKKGKKIGVDDVKETLAL
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHEE
KLKIPKMRLSSDKKALLRNLEKSLKNKIFAQAEAISLVSNAIKIQHCGLSSKNKPVGSFL
EEECCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEE
FVGPSGVGKTELAKELALNLNLHFERFDMSEYKEAHSVAKLIGSPSGYVGFEQGGLLVNA
EECCCCCCHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHH
IKKHPHCLLLLDEIEKAHSNVYDLLLQVMDNATLSDNLGNQASFKHVILIMTSNVGSKDK
HHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCC
DTLGFFSAKNTKYDRAVKELLTPELRSRIDAIVPFNALNLEDFERIVSVELDKLKALALE
CCCCEEECCCCHHHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHC
QDITLKFHKEVVKSIAQKSYQTTLGAREIKKIIHNEIKTKLSDILLLQSLKKPCKIACLL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
EKNQLVLKEIKRTQKVKENDF
CCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]