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The map label for this gene is icd [H]

Identifier: 108562450

GI number: 108562450

Start: 28696

End: 29973

Strand: Direct

Name: icd [H]

Synonym: HPAG1_0025

Alternate gene names: 108562450

Gene position: 28696-29973 (Clockwise)

Preceding gene: 108562445

Following gene: 108562451

Centisome position: 1.8

GC content: 42.72

Gene sequence:

>1278_bases
ATGGCTTACAACCCTAAAATTTTACAAAAGCCTAAAGAGGGCGAAGAAATTACGATTAAAGACAACAAATTGCATGTGCC
AAACCACCCCATTATCCCTTTCATTGAGGGCGATGGCATTGGATCAGATATTACCCCGGCGATGATTAAAGTCGTGGATA
GTGCGGTTCAAAAAGCGTATAAGGGCGAGAAAAAAATCGCATGGTATGAGGTGTTTGTGGGCGAAAAATGCTATCAAAAA
TTTAAAGATCACAAAGAATTAAGCCCAGAAGAGCAATGGCTCTTACCGGACACTATTGAAGCGATCAACCATTATAAAGT
CTCTATTAAAGGGCCTTTGACCACGCCTATTGGTGAGGGGTTTAGATCTTTGAATGTAGCGTTACGCCAAAAAATGGATC
TGTATGTGTGCTTGAGACCGGTTCGGTGGTATGGGAGTCCTAGCCCGGTTAAAGAACCAGAAAAAGTGGATATGGTGATT
TTTAGAGAAAATTCTGAAGACATTTATGCGGGCATTGAATGGCAAGAAGGCAGTGCGGAAGCGAAAAAACTCATCCATTT
TTTACAAGATGAACTAAAGGTTAAAAAAATCCGCTTCCCTGAAAGCAGCGGCATAGGGATAAAACCCATCAGTAAGGAAG
GCACAGAGAGATTGGTTAGGAAATCGATTGAATACGCTATTGATAACGACAAGCCAAGCGTAACTTTTGTGCATAAAGGT
AACATCATGAAATACACTGAGGGGGCGTTCATGAAATGGGGCTATGCGCTCGCTCAAAAAGAATTTAACGCTCAAGTCAT
TGATAAAGGCCCATGGTGTTCTTTGAAAAACCCTAAAACCGGTAAAGAAATCATCATTAAAGACATGATTGCTGATGCGT
TCTTGCAACAAATCTTATTGCGTCCTAGCGAATACAGCGTCATTGCGACCATGAATTTGAACGGGGATTATATCTCTGAT
GCGTTAGCGGCGATGGTGGGGGGTATTGGTATCGCTCCTGGGGCTAATCTCAATGACACGGTGGGCATGTTTGAAGCCAC
CCATGGCACCGCTCCTAAATACGCCGGGTTGGATAAAGTCAATCCGGGGTCTATTATTTTGAGCGCGGAAATGATGTTAA
GGCATATGGGTTGGGTGGAAGCGGCTGATTTGATCGTTTCTGCGATGGAAAAAGCGATTAAAAGCAAGAAAGTAACTTAC
GATTTCGCTCGTTTAATGGATGGGGCTAAAGAAGTGAAATGCTCTGAATTTGCTAGCGTGATGATTGAAAACATGTGA

Upstream 100 bases:

>100_bases
ACCGCTACTTTTAAACACGCATTCAAAAAAAAGATTTTTAGGGGTTATATAGTATTTTTGCGCTAGTATAGTTACTTAAA
TTTTATAAAAAGGATAAGAG

Downstream 100 bases:

>100_bases
AAGAGCGTTTTTTAAGCTCTGGTGTTTGAATGCGAAAAAAGGCTAATACTATCATAAGGAATGAAGTTGATAAAATTTGT
GCGTAATGTGGTTTTATTCA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MAYNPKILQKPKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQK
FKDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPEKVDMVI
FRENSEDIYAGIEWQEGSAEAKKLIHFLQDELKVKKIRFPESSGIGIKPISKEGTERLVRKSIEYAIDNDKPSVTFVHKG
NIMKYTEGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISD
ALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRHMGWVEAADLIVSAMEKAIKSKKVTY
DFARLMDGAKEVKCSEFASVMIENM

Sequences:

>Translated_425_residues
MAYNPKILQKPKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQK
FKDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPEKVDMVI
FRENSEDIYAGIEWQEGSAEAKKLIHFLQDELKVKKIRFPESSGIGIKPISKEGTERLVRKSIEYAIDNDKPSVTFVHKG
NIMKYTEGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISD
ALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRHMGWVEAADLIVSAMEKAIKSKKVTY
DFARLMDGAKEVKCSEFASVMIENM
>Mature_424_residues
AYNPKILQKPKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKF
KDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPEKVDMVIF
RENSEDIYAGIEWQEGSAEAKKLIHFLQDELKVKKIRFPESSGIGIKPISKEGTERLVRKSIEYAIDNDKPSVTFVHKGN
IMKYTEGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDA
LAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRHMGWVEAADLIVSAMEKAIKSKKVTYD
FARLMDGAKEVKCSEFASVMIENM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=390, Percent_Identity=32.3076923076923, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI28178838, Length=372, Percent_Identity=24.7311827956989, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI28178821, Length=367, Percent_Identity=24.7956403269755, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI28178816, Length=401, Percent_Identity=24.9376558603491, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4758582, Length=348, Percent_Identity=25.2873563218391, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI28178819, Length=184, Percent_Identity=27.7173913043478, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1787381, Length=416, Percent_Identity=70.1923076923077, Blast_Score=613, Evalue=1e-177,
Organism=Escherichia coli, GI1788101, Length=386, Percent_Identity=25.3886010362694, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87081683, Length=406, Percent_Identity=24.8768472906404, Blast_Score=85, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71986051, Length=390, Percent_Identity=31.7948717948718, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI25144293, Length=306, Percent_Identity=27.7777777777778, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17505779, Length=302, Percent_Identity=29.8013245033113, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17550882, Length=398, Percent_Identity=23.6180904522613, Blast_Score=92, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324709, Length=401, Percent_Identity=30.6733167082294, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324291, Length=379, Percent_Identity=27.9683377308707, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322097, Length=373, Percent_Identity=28.4182305630027, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24643270, Length=390, Percent_Identity=32.5641025641026, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24643268, Length=392, Percent_Identity=32.1428571428571, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24661184, Length=402, Percent_Identity=30.5970149253731, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI161078635, Length=301, Percent_Identity=27.2425249169435, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI161078637, Length=301, Percent_Identity=27.2425249169435, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI161078633, Length=301, Percent_Identity=27.2425249169435, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24650122, Length=301, Percent_Identity=27.2425249169435, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI161078639, Length=306, Percent_Identity=26.797385620915, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI20130355, Length=396, Percent_Identity=24.2424242424242, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI281362242, Length=406, Percent_Identity=25.3694581280788, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24648872, Length=406, Percent_Identity=25.3694581280788, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 47525; Mature: 47393

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYNPKILQKPKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMIKVVDSAVQKAY
CCCCCCHHCCCCCCCEEEEECCEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
KGEKKIAWYEVFVGEKCYQKFKDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEG
CCCCCEEEEEEHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCEEEEEEECCCCCCHHHH
FRSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPEKVDMVIFRENSEDIYAGIEWQEGSAE
HHHHHHHHHHCCCEEEEEEEHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCHH
AKKLIHFLQDELKVKKIRFPESSGIGIKPISKEGTERLVRKSIEYAIDNDKPSVTFVHKG
HHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECC
NIMKYTEGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILL
CEEEECCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
RPSEYSVIATMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKV
CCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHEEECCCCCCCCCCCCCC
NPGSIILSAEMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASV
CCCCEEEEHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHH
MIENM
HHCCC
>Mature Secondary Structure 
AYNPKILQKPKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMIKVVDSAVQKAY
CCCCCHHCCCCCCCEEEEECCEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
KGEKKIAWYEVFVGEKCYQKFKDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEG
CCCCCEEEEEEHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCEEEEEEECCCCCCHHHH
FRSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPEKVDMVIFRENSEDIYAGIEWQEGSAE
HHHHHHHHHHCCCEEEEEEEHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCHH
AKKLIHFLQDELKVKKIRFPESSGIGIKPISKEGTERLVRKSIEYAIDNDKPSVTFVHKG
HHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECC
NIMKYTEGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILL
CEEEECCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
RPSEYSVIATMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKV
CCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHEEECCCCCCCCCCCCCC
NPGSIILSAEMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASV
CCCCEEEEHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHH
MIENM
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]