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The map label for this gene is gltA [H]

Identifier: 108562449

GI number: 108562449

Start: 27207

End: 28487

Strand: Reverse

Name: gltA [H]

Synonym: HPAG1_0024

Alternate gene names: 108562449

Gene position: 28487-27207 (Counterclockwise)

Preceding gene: 108562452

Following gene: 108562448

Centisome position: 1.78

GC content: 44.03

Gene sequence:

>1281_bases
ATGTCTGTTACTTTAATCAATAATGAAAATAATGAACGCTATGAATTTGAGATGATTGAATGCACTCGTGGGCCTAAAGC
GGTGGATTTTTCCAAGCTTTTTGAAACGACCGGGTTTTTTTCTTACGATCCAGGGTATTCTTCTACCGCTGGGTGCCAAT
CTAAGATCAGCTATATCAACGGCAAAAAAGGCGAATTGTATTACAGAGGGCATAGAATAGAAGATTTAGTCGCCAAATAC
AAATATGTAGATGTGTGCAAATTGCTCCTCACAGGGGAATTACCCAAAAATCAAGAAGAAAGCTTGGAATTTGAATTGGA
ATTGCGCCACAGAAGCTTTGTGCATGAGAGCTTGTTGAACATGTTTTCAGCCTTCCCTAGTAACGCCCACCCTATGGCGA
AACTCTCTAGCGGCGTGTCTATTTTATCCACCCTTTATTCCACGCACCAAAACATGCACACTGAAGAAGATTACCAAACG
ATGGCCAGAAGGATTGTCGCTAAAATCCCCACGCTTGCGGCTATTTGCTATCGTAATGAAGTAGGAGCGCCCATTATTTA
TCCGGACATCGCGCGCTCTTATGTGGAAAATATCCTTTTCATGCTGAGAGGATATCCTTATAGCCGCTTAAAACACACCA
CTCAAGGCGAAGTAGAAATCACGCCCCTAGAAGTGGAAGCCTTTGATAAAATCCTAACTTTGCACGCTGACCATGGGCAA
AACGCCTCTTCTACCACGGTAAGGAATGTCGCTAGCACCGGCGTGCATCCTTATGCCGCCATAAGTGCTGGCATTAGCGC
TTTATGGGGGCATTTGCATGGCGGGGCGAATGAAAAAGTGCTTTTACAATTAGAAGAAATCGGCGATGTGAAAAATGTGG
ATAAATACATTGCACGCGTGAAAGACAAAAACGACAATTTCAAACTCATGGGCTTTGGGCATAGGGTGTATAAGAGCTAC
GATCCGCGCGCCAAAATCTTAAAAGGCTTGAAAGACGAACTGCATAAAAAAGGCGTTAAAATGGACGAGAGGTTGAGCGA
AATCGCTGCGAAAGTGGAAGAAATCGCGCTAAAAGACGAGTATTTCATTGAAAGGAATCTCTACCCTAATGTGGATTTTT
ACTCCGGCACGATTTTAAGGGCTTTAAAAATCCCGGTGCGTTTTTTCACACCGGTGTTTGTCATTGGCAGAACCGTGGGC
TGGTGCGCTCAATTATTAGAGCATGTCAAAAGCCCGCAAGCTAGGATCACGCGCCCAAGACAAGTTTATGTAGGGGATTA
A

Upstream 100 bases:

>100_bases
ACTTGAAATAAAACGAAATGTTTTTAAAAGAAATCATTTAATTTTTTGGCTTATAATGGGGTGCTATCATTCTAAAAACT
TAAGGACTTAAGGAAGTCAA

Downstream 100 bases:

>100_bases
TGTTAGGCTAGGCTTTGTTTTATAAGCGTTGATGATAGTTTAAGAAACGCTTCAAAGCCTTGTTTAAAAGAGTAAGAATC
TCGCACCAAGCAAGCGGTAA

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSVTLINNENNERYEFEMIECTRGPKAVDFSKLFETTGFFSYDPGYSSTAGCQSKISYINGKKGELYYRGHRIEDLVAKY
KYVDVCKLLLTGELPKNQEESLEFELELRHRSFVHESLLNMFSAFPSNAHPMAKLSSGVSILSTLYSTHQNMHTEEDYQT
MARRIVAKIPTLAAICYRNEVGAPIIYPDIARSYVENILFMLRGYPYSRLKHTTQGEVEITPLEVEAFDKILTLHADHGQ
NASSTTVRNVASTGVHPYAAISAGISALWGHLHGGANEKVLLQLEEIGDVKNVDKYIARVKDKNDNFKLMGFGHRVYKSY
DPRAKILKGLKDELHKKGVKMDERLSEIAAKVEEIALKDEYFIERNLYPNVDFYSGTILRALKIPVRFFTPVFVIGRTVG
WCAQLLEHVKSPQARITRPRQVYVGD

Sequences:

>Translated_426_residues
MSVTLINNENNERYEFEMIECTRGPKAVDFSKLFETTGFFSYDPGYSSTAGCQSKISYINGKKGELYYRGHRIEDLVAKY
KYVDVCKLLLTGELPKNQEESLEFELELRHRSFVHESLLNMFSAFPSNAHPMAKLSSGVSILSTLYSTHQNMHTEEDYQT
MARRIVAKIPTLAAICYRNEVGAPIIYPDIARSYVENILFMLRGYPYSRLKHTTQGEVEITPLEVEAFDKILTLHADHGQ
NASSTTVRNVASTGVHPYAAISAGISALWGHLHGGANEKVLLQLEEIGDVKNVDKYIARVKDKNDNFKLMGFGHRVYKSY
DPRAKILKGLKDELHKKGVKMDERLSEIAAKVEEIALKDEYFIERNLYPNVDFYSGTILRALKIPVRFFTPVFVIGRTVG
WCAQLLEHVKSPQARITRPRQVYVGD
>Mature_425_residues
SVTLINNENNERYEFEMIECTRGPKAVDFSKLFETTGFFSYDPGYSSTAGCQSKISYINGKKGELYYRGHRIEDLVAKYK
YVDVCKLLLTGELPKNQEESLEFELELRHRSFVHESLLNMFSAFPSNAHPMAKLSSGVSILSTLYSTHQNMHTEEDYQTM
ARRIVAKIPTLAAICYRNEVGAPIIYPDIARSYVENILFMLRGYPYSRLKHTTQGEVEITPLEVEAFDKILTLHADHGQN
ASSTTVRNVASTGVHPYAAISAGISALWGHLHGGANEKVLLQLEEIGDVKNVDKYIARVKDKNDNFKLMGFGHRVYKSYD
PRAKILKGLKDELHKKGVKMDERLSEIAAKVEEIALKDEYFIERNLYPNVDFYSGTILRALKIPVRFFTPVFVIGRTVGW
CAQLLEHVKSPQARITRPRQVYVGD

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=335, Percent_Identity=28.3582089552239, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1786939, Length=412, Percent_Identity=43.9320388349515, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI1786527, Length=367, Percent_Identity=28.8828337874659, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17555174, Length=391, Percent_Identity=26.8542199488491, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319850, Length=365, Percent_Identity=26.8493150684932, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6324328, Length=352, Percent_Identity=27.8409090909091, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325257, Length=346, Percent_Identity=28.9017341040462, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356863, Length=448, Percent_Identity=27.4553571428571, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24640124, Length=345, Percent_Identity=27.536231884058, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24640126, Length=345, Percent_Identity=27.536231884058, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48409; Mature: 48278

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTLINNENNERYEFEMIECTRGPKAVDFSKLFETTGFFSYDPGYSSTAGCQSKISYIN
CEEEEEECCCCCEEEEEEEEECCCCCCCCHHHHHHHCCCCEECCCCCCCCCHHHHHHHCC
GKKGELYYRGHRIEDLVAKYKYVDVCKLLLTGELPKNQEESLEFELELRHRSFVHESLLN
CCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHH
MFSAFPSNAHPMAKLSSGVSILSTLYSTHQNMHTEEDYQTMARRIVAKIPTLAAICYRNE
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
VGAPIIYPDIARSYVENILFMLRGYPYSRLKHTTQGEVEITPLEVEAFDKILTLHADHGQ
CCCCEECHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEEEHHHHHHHHEEECCCCC
NASSTTVRNVASTGVHPYAAISAGISALWGHLHGGANEKVLLQLEEIGDVKNVDKYIARV
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHCCHHHHHHHHHHH
KDKNDNFKLMGFGHRVYKSYDPRAKILKGLKDELHKKGVKMDERLSEIAAKVEEIALKDE
CCCCCCEEEEECCHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCH
YFIERNLYPNVDFYSGTILRALKIPVRFFTPVFVIGRTVGWCAQLLEHVKSPQARITRPR
HHEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHCCCCC
QVYVGD
EEEECC
>Mature Secondary Structure 
SVTLINNENNERYEFEMIECTRGPKAVDFSKLFETTGFFSYDPGYSSTAGCQSKISYIN
EEEEEECCCCCEEEEEEEEECCCCCCCCHHHHHHHCCCCEECCCCCCCCCHHHHHHHCC
GKKGELYYRGHRIEDLVAKYKYVDVCKLLLTGELPKNQEESLEFELELRHRSFVHESLLN
CCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHH
MFSAFPSNAHPMAKLSSGVSILSTLYSTHQNMHTEEDYQTMARRIVAKIPTLAAICYRNE
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
VGAPIIYPDIARSYVENILFMLRGYPYSRLKHTTQGEVEITPLEVEAFDKILTLHADHGQ
CCCCEECHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEEEHHHHHHHHEEECCCCC
NASSTTVRNVASTGVHPYAAISAGISALWGHLHGGANEKVLLQLEEIGDVKNVDKYIARV
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHCCHHHHHHHHHHH
KDKNDNFKLMGFGHRVYKSYDPRAKILKGLKDELHKKGVKMDERLSEIAAKVEEIALKDE
CCCCCCEEEEECCHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCH
YFIERNLYPNVDFYSGTILRALKIPVRFFTPVFVIGRTVGWCAQLLEHVKSPQARITRPR
HHEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHCCCCC
QVYVGD
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]